Predicting Particle Size During Fluid Bed Granulation Using Process Measurement Data

No abstract is available for this paper.

• Publication year

  2009

• Venue

  AAPS PharmSciTech

• Publication date

  2009-10-30

• Fields of study

  Medicine, Materials Science, Mathematics, Engineering

• Identifiers
  DOI 10.1208/s12249-009-9310-6PMID 19876742PMCID PMC2799576
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Gaining fluid bed process understanding by in-line particle size analysis.

  2009influential reference
• A New Rapid On-Line Imaging Method to Determine Particle Size Distribution of Granules

  2008cited by this paper
• Controlling granule size by granulation liquid feed pulsing.

  2008influential reference
• Study growth kinetics in fluidized bed granulation with at-line FBRM.

  2008cited by this paper
• Determination of fluidized bed granulation end point using near-infrared spectroscopy and phenomenological analysis.

  2005cited by this paper
• New perspectives for visual characterization of pharmaceutical solids.

  2004cited by this paper
• Characterization of particle sizes in bulk pharmaceutical solids using digital image information

  2003cited by this paper
• Chemometric evaluation of pharmaceutical properties of antipyrine granules by near-infrared spectroscopy

  2003cited by this paper
• Using experimental design to optimize the process parameters in fluidized bed granulation on a semi-full scale.

  2001cited by this paper
• Direct control of wet granulation processes by image processing system

  2001cited by this paper
• PLS-regression: a basic tool of chemometrics

  2001cited by this paper
• In-line moisture measurement during granulation with a four-wavelength near infrared sensor: an evaluation of particle size and binder effects.

  2000cited by this paper
• Online-Messung der Produktfeuchte und Korngrösse in der Wirbelschicht mit der Nah-Infrarot-Spektroskopie

  1998cited by this paper
• Process control and end-point determination of a fluid bed granulation by application of near infra-red spectroscopy

  1997influential reference
• IR absorption characteristics of an IR moisture sensor and mechanism of water transfer in fluidized bed granulation

  1996cited by this paper
• The effect of raw material and atomizing air pressure on the properties of granules prepared in a fluidized bed granulator

  1996cited by this paper
• Mathematical Model in the Kinetics of Agitation Fluidized Bed Granulation. Effects of Moisture Content, Damping Speed and Operation Time on Granule Growth Rate.

  1996cited by this paper
• Particle Size Analysis: A comparative study of various methods

  1995cited by this paper
• An Evaluation of Process Variables in wet Granulation

  1995cited by this paper
• Experimental Design for a Granulation Process with “Priori” Criterias

  1995cited by this paper
• Kinetics of Granule Growth in Fluidized Bed Granulation with Moisture Control

  1995cited by this paper
• Influence of granulation and compression process variables on flow rate of granules and on tablet properties, with special reference to weight variation

  1994cited by this paper
• Process Considerations in Reducing Tablet Friability and Their Effect on in vitro Dissolution

  1994cited by this paper
• Directly compressible acetaminophen compositions prepared by fluidized-bed granulation

  1994cited by this paper
• Characterization of wet granulation process parameters using response surface methodology. 1. Top-spray fluidized bed.

  1994cited by this paper
• Attrition of theophylline granules during drying in a fluidized bed granulator

  1994cited by this paper
• Analysis of growth of granules in a fluidized bed granulator

  1992cited by this paper
• Partial least-squares methods for spectral analyses. 1. Relation to other quantitative calibration methods and the extraction of qualitative information

  1988cited by this paper
• The construction and uses of factorial designs in the preparation of solid dosage forms. Part 2: Granulation in a fluidized bed.

  1981cited by this paper
• The construction and uses of factorial designs in the preparation of solid dosage forms. Part 2: Granulation in a fluidized bed.

  1981cited by this paper
• Batch production of pharmaceutical granulations in a fluidized bed. 3. Binder dilution effects on granulation.

  1973cited by this paper
• Batch production of pharmaceutical granulations in a fluidized bed. II. Effects of various binders and their concentrations on granulations and compressed tablets.

  1972cited by this paper
• Batch production of pharmaceutical granulations in a fluidized bed. I. Effects of process variables on physical properties of final granulation.

  1971cited by this paper

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  2019cites this paper
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  2016cites this paper
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  2016cites this paper
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