Preeclampsia, Hypoxia, Thrombosis, and Inflammation

Reductions in uteroplacental flow initiate a cascade of molecular effects leading to hypoxia, thrombosis, inflammation, and endothelial cell dysfunction resulting in untoward pregnancy outcomes. In this review, we detail these effects and their relationship to preeclampsia (PE) and intrauterine growth restriction (IUGR).

• Publication year

  2011

• Venue

  Journal of Pregnancy

• Publication date

  2011-12-11

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.1155/2012/374047PMID 22175023PMCID 3235807
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular Mechanisms of Preeclampsia

  2012cited by this paper
• Mutations in Complement Regulatory Proteins Predispose to Preeclampsia: A Genetic Analysis of the PROMISSE Cohort

  2011cited by this paper
• Contemporary prediction of preeclampsia

  2011cited by this paper
• Decidual Hemostasis, Inflammation, and Angiogenesis in Pre-Eclampsia

  2011cited by this paper
• Preeclampsia 2-Methoxyestradiol Induces Cytotrophoblast Invasion and Vascular Development Specifically under Hypoxic Conditions

  2010cited by this paper
• Pre-eclampsia

  2010cited by this paper
• Progestin and thrombin regulate tissue factor expression in human term decidual cells.

  2009cited by this paper
• Overview of Maternal Morbidity During Hospitalization for Labor and Delivery in the United States: 1993–1997 and 2001–2005

  2009cited by this paper
• Hypertensive Pregnancy Disorders and Subsequent Cardiovascular Morbidity and Type 2 Diabetes Mellitus in the Mother

  2009cited by this paper
• The two stage model of preeclampsia: variations on the theme.

  2009cited by this paper
• [Endotelial activation markers--possibilities of their detection and clinical signification in gynaecology and obstetric].

  2009cited by this paper
• Elevated circulating soluble thrombomodulin activity, tissue factor activity and circulating procoagulant phospholipids: new and useful markers for pre-eclampsia?

  2009cited by this paper
• Tissue factor and the endometrium: from physiology to pathology.

  2009cited by this paper
• Preeclampsia: the role of angiogenic factors in its pathogenesis.

  2009cited by this paper
• Molecular mechanisms of preeclampsia.

  2008cited by this paper
• Preeclampsia pathogenesis: "triple a rating"-autoantibodies and antiangiogenic factors.

  2008cited by this paper
• The spectrum of complement alternative pathway‐mediated diseases

  2008cited by this paper
• Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia

  2008influential reference
• The C5b-9 membrane attack complex of complement activation localizes to villous trophoblast injury in vivo and modulates human trophoblast function in vitro.

  2008cited by this paper
• Pathophysiology of hypertension during preeclampsia: linking placental ischemia with endothelial dysfunction.

  2008cited by this paper
• Alternative complement pathway activation fragment Bb in early pregnancy as a predictor of preeclampsia.

  2008cited by this paper
• Pre-Eclampsia: Clinical Manifestations and Molecular Mechanisms

  2007cited by this paper
• Thrombin regulates monocyte chemoattractant protein-1 expression in human first trimester and term decidual cells.

  2007cited by this paper
• Tissue factor expression as a possible determinant of thromboembolism in ovarian cancer

  2007cited by this paper
• Risk of early or severe pre-eclampsia related to pre-existing conditions.

  2007cited by this paper
• The role of inflammation in venous thromboembolism and the link between arterial and venous thrombosis.

  2007cited by this paper
• High risk for venous thromboembolism in diabetics with hyperosmolar state: comparison with other acute medical illnesses

  2007cited by this paper
• Risk of venous thromboembolism in lung cancer

  2007cited by this paper
• Thrombin activation of endometrial endothelial cells: A possible role in intrauterine growth restriction

  2007influential reference
• Tissue factor-positive microparticles: Cellular origin and association with coagulation activation in patients with colorectal cancer

  2006cited by this paper
• Tissue factor in hemostasis and thrombosis.

  2006cited by this paper
• The complement system in the pathophysiology of pregnancy.

  2006cited by this paper
• Sources of tissue factor.

  2006cited by this paper
• Soluble endoglin and other circulating antiangiogenic factors in preeclampsia.

  2006influential reference
• Soluble endoglin contributes to the pathogenesis of preeclampsia

  2006cited by this paper
• Prevalence of overweight and obesity in the United States, 1999-2004.

  2006cited by this paper
• Excess syncytiotrophoblast microparticle shedding is a feature of early-onset pre-eclampsia, but not normotensive intrauterine growth restriction.

  2006cited by this paper
• Tissue factor in infection and severe inflammation.

  2006cited by this paper
• WHO analysis of causes of maternal death: a systematic review.

  2006cited by this paper
• The pre-eclampsia community guideline (PRECOG): how to screen for and detect onset of pre-eclampsia in the community

  2005cited by this paper
• Uterine artery Doppler screening for adverse pregnancy outcome

  2005cited by this paper
• Extra-placental expression of vascular endothelial growth factor receptor-1, (Flt-1) and soluble Flt-1 (sFlt-1), by peripheral blood mononuclear cells (PBMCs) in normotensive and preeclamptic pregnant women.

  2005cited by this paper
• Haemostasis in normal pregnancy: a balancing act?

  2005cited by this paper
• Deep vein thrombosis and malignancy: a surgical oncologist's perspective.

  2004cited by this paper
• Macrophages and Apoptotic Cell Clearance During Pregnancy

  2004cited by this paper
• Magnesium sulfate prophylaxis in preeclampsia: Lessons learned from recent trials.

  2004cited by this paper
• Evidence of endothelial dysfunction in preeclampsia: decreased endothelial nitric oxide synthase expression is associated with increased cell permeability in endothelial cells from preeclampsia.

  2004cited by this paper
• Haemostatic changes in pregnancy.

  2004cited by this paper
• Human cell‐derived microparticles promote thrombus formation in vivo in a tissue factor‐dependent manner

  2003cited by this paper
• Role of Risk Factors in the Modulation of Tissue Factor Activity and Blood Thrombogenicity

  2003cited by this paper
• Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) could contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia

  2003cited by this paper
• 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF.

  2003cited by this paper
• Increased placental expression of tissue factor is associated with abnormal uterine and umbilical Doppler waveforms in severe preeclampsia with fetal growth restriction.

  2003cited by this paper
• Hemostasis during Normal Pregnancy and Puerperium

  2003cited by this paper
• Pre-eclampsia and the hypertensive disorders of pregnancy.

  2003cited by this paper
• Mechanism of action of 2-methoxyestradiol: new developments.

  2003cited by this paper
• Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia.

  2003cited by this paper
• Methoxyestradiols Mediate Estradiol-Induced Antimitogenesis in Human Aortic SMCs

  2002cited by this paper
• ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002.

  2002cited by this paper
• Catechol-O-Methyltransferase (COMT)-mediated methylation metabolism of endogenous bioactive catechols and modulation by endobiotics and xenobiotics: importance in pathophysiology and pathogenesis.

  2002cited by this paper
• Pathophysiology of hypertension during preeclampsia linking placental ischemia with endothelial dysfunction.

  2001cited by this paper
• Preeclampsia and Fetal Loss in Women With a History of Venous Thromboembolism

  2001cited by this paper
• ACOG practice bulletin

  2001cited by this paper
• Tissue factor (TF) and tissue factor pathway inhibitor (TFPI) in amniotic fluid and blood plasma: implications for the mechanism of amniotic fluid embolism.

  2001cited by this paper
• Macrophage-Induced Apoptosis Limits Endovascular Trophoblast Invasion in the Uterine Wall of Preeclamptic Women

  2001cited by this paper
• ACCUMULATING MONOCYTES IN THE VASCULATURE OF RAT RENAL ALLOGRAFTS: PHENOTYPE, CYTOKINE, INDUCIBLE NO SYNTHASE, AND TISSUE FACTOR mRNA EXPRESSION1

  2001cited by this paper
• The Tissue Factor Pathway in Disseminated Intravascular Coagulation

  2001cited by this paper
• Amniotic Fluid–Soluble Vascular Endothelial Growth Factor Receptor‐1 in Preeclampsia

  2000cited by this paper
• Circulating tissue factor and thrombosis

  2000cited by this paper
• Pre-eclampsia

  2000cited by this paper
• Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy.

  2000cited by this paper
• In situ detection of tissue factor within the coronary intima in rat cardiac allograft vasculopathy.

  1999cited by this paper
• Aberrant positioning of trophoblast and lymphocytes in the feto-maternal interface with pre-eclampsia

  1999cited by this paper
• The Decidua Regulates Hemostasis in Human Endometrium

  1999cited by this paper
• Thrombosis in pregnancy: maternal and fetal issues.

  1999cited by this paper
• Tissue factor is required for uterine hemostasis and maintenance of the placental labyrinth during gestation.

  1999cited by this paper
• [Tissue factor pathway in disseminated intravascular coagulation].

  1999cited by this paper
• Reduction in erythrocyte complement receptor 1 (CR1, CD35) and decay accelerating factor (DAF, CD55) during normal pregnancy.

  1996cited by this paper
• The Role of Progestationally Regulated Stromal Cell Tissue Factor and Type‐1 Plasminogen Activator Inhibitor (PAI‐1) in Endometrial Hemostasis and Menstruation

  1994cited by this paper
• Regulation of endothelial cell tissue factor expression by minimally oxidized LDL and lipopolysaccharide.

  1993cited by this paper
• Susceptibility of human trophoblast to killing by human complement and the role of the complement regulatory proteins.

  1993cited by this paper
• Steroid-modulated stromal cell tissue factor expression: a model for the regulation of endometrial hemostasis and menstruation

  1993cited by this paper
• Progestational regulation of human endometrial stromal cell tissue factor expression during decidualization.

  1993cited by this paper
• Steroid-modulated stromal cell tissue factor expression: a model for the regulation of endometrial hemostasis and menstruation.

  1993cited by this paper
• Amniotic fluid contains tissue factor, a potent initiator of coagulation

  1992cited by this paper
• Activation of the Complement Pathway: Comparison of Normal Pregnancy, Preeclampsia, and Systemic Lupus Erythematosus During Pregnancy

  1992cited by this paper
• Anchoring villi in human placental basal plate: lymphocytes, macrophages and coagulation.

  1991cited by this paper
• Immunohistochemical detection of terminal complement complex and S protein in normal and pre‐eclamptic placentae

  1990cited by this paper
• Fibrinoid and trophoblastic necrosis with massive chronic intervillositis: an extreme variant of villitis of unknown etiology.

  1987cited by this paper
• Maternal vascular lesions in pre-eclampsia and intrauterine growth retardation: light microscopy and immunofluorescence.

  1985cited by this paper
• Immunological studies of human placentae: complement components in pre-eclamptic chorionic villi.

  1984cited by this paper
• An ultrastructural study of utero-placental spiral arteries in hypertensive and normotensive pregnancy and fetal growth retardation.

  1982cited by this paper

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  2025cites this paper
• Evaluation of coagulation parameters in preeclamptic pregnancy: a prospective observational study

  2025cites this paper
• An in vitro study of coagulation evaluation in obstetric hemorrhage for pregnancy-induced hypertension with coagulation and platelet function analyzer

  2024cites this paper
• A meta-analysis on first-trimester blood count parameters—is the neutrophil-to-lymphocyte ratio a potentially novel method for first-trimester preeclampsia screening?

  2024cites this paper
• Protective Effects of Aspirin Supplemented With Quercetin in L-NAME-Induced Preeclampsia-Like Rats.

  2024cites this paper
• Plasma Cells as the Key Players of IVF Failure? Unlocking the Enigma of Infertility and In Vitro Fertilization Failure in the Light of Uterine Inflammation

  2024cites this paper
• Changes of coagulation function and platelet parameters in preeclampsia and their correlation with pregnancy outcomes

  2024cites this paper
• A Dual-Fluorescence Molecular "Open Bridge" for Evaluating Gestational Hypoxia and Hypertension under the Stress of SARS-Cov-2.

  2024cites this paper
• Insights into the role of miR-877 and histidine-rich glycoprotein in preeclampsia

  2024cites this paper
• ESTIMATION LEVELS OF SERUM CALCIUM, MAGNESIUM, URIC ACID AND C-REACTIVE PROTEIN IN MILD PREECLAMPSIA COMPARED TO LEVEL NORMAL PREGNANT WOMEN TO EARLY PREDICT SEVER PREECLAMPSIA

  2023influential citation
• Trimester-specific reference intervals of hemostasis biomarkers for healthy pregnancy

  2023cites this paper
• H3K27me3-modulated Hofbauer cell BMP2 signalling enhancement compensates for shallow trophoblast invasion in preeclampsia

  2023cites this paper
• Classification of preeclampsia according to molecular clusters with the goal of achieving personalized prevention.

  2023cites this paper
• Intrinsic sexual dimorphism in the placenta determines the differential response to benzene exposure

  2023cites this paper
• The Effects of Preeclamptic Milieu on Cord Blood Derived Endothelial Colony-Forming Cells

  2023cites this paper
• Molecular subclasses of preeclampsia characterized by a longitudinal maternal proteomics study: distinct biomarkers, disease pathways and options for prevention

  2022cites this paper
• Platelet hemostasis in the implementation of placental dysfunction

  2022cites this paper
• Endothelial protein C receptor is increased in preterm preeclampsia and fetal growth restriction

  2022cites this paper
• Role of ADAM and ADAMTS Disintegrin and Metalloproteinases in Normal Pregnancy and Preeclampsia.

  2022cites this paper
• Role and estimation of serum calcium, serum uric acid and C-RP in preeclamptic and normal pregnant women in Dhiraj General Hospital of Sumandeep Vidyapeeth Vadodara

  2022cites this paper
• Evaluation of the hemostasis system in pregnant women with placental dysfunction by the method of rotational thromboelastometry

  2022cites this paper
• Association of neutrophil gelatinase associated lipocalin, ischemia modified albumin with uric acid in the etiopathogenesis of preeclampsia

  2022cites this paper
• Тромбоцитарний гемостаз за реалізації плацентарної дисфункції

  2022cites this paper
• КОРРЕКЦИЯ МОРФОФУНКЦИОНАЛЬНЫХ НАРУШЕНИЙ ПРИ ЭКСПЕРИМЕНТАЛЬНОЙ ПРЕЭКЛАМПСИИ СОЧЕТАННЫМ ПРИМЕНЕНИЕМ ТРИМЕТАЗИДИНА И ОЧИЩЕННОЙ МИКРОНИЗИРОВАННОЙ ФЛАВОНОИДНОЙ ФРАКЦИЕЙ, А ТАКЖЕ ИХ КОМБИНАЦИЙ С МЕТИЛДОПОЙ

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• An exploratory study of white blood cell proportions across preeclamptic and normotensive pregnancy by self-identified race in individuals with overweight or obesity

  2021cites this paper
• Low chorionic villous succinate accumulation associates with recurrent spontaneous abortion risk

  2021cites this paper
• Distinct placental molecular processes associated with early-onset and late-onset preeclampsia

  2021cites this paper
• Cellular Functions of ER Chaperones in Regulating Protein Misfolding and Aggregation: An Emerging Therapeutic Approach for Preeclampsia

  2021cites this paper
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  2021cites this paper
• Contribution of -1031T/C and -376G/A tumor necrosis factor alpha polymorphisms and haplotypes to preeclampsia risk in Tunisia (North Africa).

  2021cites this paper
• CORRECTION OF MORPHOFUNCTIONAL DISORDERS IN EXPERIMENTAL PREECLAMPSY BY COMBINED USE OF TRIMETAZIDINE AND PURIFIED MICRONIZED FLAVONOID FRACTION AS WELL AS THEIR COMBINATIONS WITH METHYLAMPSY

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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
• Protein Misfolding during Pregnancy: New Approaches to Preeclampsia Diagnostics

  2019cites this paper
• Serum Calcium, Magnesium, Uric Acid and C-Reactive Protein in Preeclampsia and Normal Pregnant Women

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  2018cites this paper
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  2018cites this paper
• Placental pathology varies in hypertensive conditions of pregnancy

  2018cites this paper
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  2018cites this paper
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  2018cites this paper
• Histological Features of Shallow Placental Implantation Unify Early-Onset and Late-Onset Preeclampsia

  2018cites this paper
• The effect of placental hypoxia on endothelial damage in preeclampsia

  2018cites this paper
• Association between placental insufficiency and manifestations of preeclampsia

  2018cites this paper
• The placental vascular endothelial growth factor polymorphisms and preeclampsia/preeclampsia severity

  2017cites this paper
• Association of Maternal Hypertension with Intrauterine Growth Retardation

  2017cites this paper
• The effects of sildenafil citrate on uterine angiogenic status and serum inflammatory markers in an L‐NAME rat model of pre‐eclampsia

  2017cites this paper
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  2017cites this paper
• PATHOGENETIC MECHANISMS OF THROMBOEMBOLIC COMPLICATIONS OF THE METABOLIC SYNDROME IN PREGNANCY

  2016cites this paper
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  2016cites this paper
• Relationship between preeclampsia and SERPINE1 (PAI-1-675 G4/G5) gene polymorphism. Systematic review. A metaanalysis

  2016cites this paper
• Macroscopic and histological characteristics of retained placenta: A prospectively collected case-control study.

  2016cites this paper
• Body Mass Index, Weight Gain, and Hypertensive Disorders in Pregnancy.

  2016cites this paper
• Serum level of Kisspeptin in Pregnant Women with Preeclampsia

  2016cites this paper
• Coagulation way of hemostasis in pregnant women and puerperae with pre-eclampsia in whom caesarean section was performed

  2016cites this paper
• Advanced maternal age : identifying mechanisms underlying vulnerability to stillbirth

  2016cites this paper
• Importance of cholesterol and cholesterol transporters in the placental trophoblast during pregnancy

  2015cites this paper
• Caractérisation et rôles du récepteur apparenté aux récepteurs des oestrogènes-γ (ERRγ) dans le placenta humain normal et pathologique

  2015cites this paper
• Concentraciones de quimiocina RANTES en preeclámpticas y embarazadas normotensas sanas

  2014cites this paper
• Protein misfolding, congophilia, oligomerization, and defective amyloid processing in preeclampsia

  2014cites this paper
• Hypoxic treatment of human dual placental perfusion induces a preeclampsia-like inflammatory response

  2014cites this paper
• Feto-maternal correlation of PTX3, sFlt-1 and PlGF in physiological and pre-eclamptic pregnancies

  2014cites this paper
• Influencing factors for late-onset preeclampsia

  2013cites this paper
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  2013cites this paper
• Disseminated intravascular coagulation.

  2013cites this paper
• MicroRNA analysis in placentas from patients with preeclampsia: comparison of new and published results

  2013cites this paper
• Pre-eclampsia – Possible A Biochemical and Epidemiological Study

  2012cites this paper
• Expression of Downstream Targets of mTOR in Response to a Model of Maternal Undernutrition and Hypoxia

  2012cites this paper
• Preeclampsia 2012

  2012cites this paper
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  2012cites this paper