Analysis of the expression patterns of the cytokine receptor family B (CRFB) and interferon gamma receptor (IFNGR) in Dabry's sturgeon (Acipenser dabryanus)

&NA; Teleost fish have more complex interferon receptor systems than mammals. In the present study, genes encoding four cytokine receptor family B (CRFBs) and two interferon gamma receptors (IFNGRs) in Dabry's sturgeon (Acipenser dabryanus) were identified by RNA‐sequencing. Sequence analysis revealed that the Dabry's sturgeon CRFBs and IFNGRs contained several conserved characteristics features, including signal peptides and a transmembrane domain. Phylogenetic analysis suggested that they belong to the CRFB3, CRFB5, and IFNGR protein families, and were named CRFB3a, CRFB3b, CRFB5a, CRFB5b, IFNGR1, and IFNGR2. The expression patterns of the CRFB and IFNGR genes were investigated in Dabry's sturgeon. The expression levels of CRFB5a, CRFB5b, and IFNGR1 showed no significant changes, suggesting that those genes do not mediate embryonic development. By contrast, the high expression levels of CRFB3a, CRFB3b, and IFNGR2 in the fertilized egg, 16‐cell phase, and initial blastula stage implied the existence of maternally expression in the oocyte and association with embryonic development. Tissue distribution analysis revealed that the CRFB and IFNGR proteins have potential functions in immune and non‐immune tissue compartments. Comprehensive analysis in Dabry's sturgeon revealed that the expression fold changes of CRFB3a, CRFB3b, CRFB5a, and CRFB5b in Dabry's sturgeon stimulated with poly I:C were higher than those in fish administrated with lipopolysaccharide (LPS). Conversely, the fold changes IFNGRs mRNA levels stimulated with LPS were higher than those in fish administrated with poly I: C. CRFB5a and IFNGR2 genes showed the earliest responses to the poly I: C, and the CRFB5a and IFNGR1 genes showed the earliest responses to LPS. These results implied that CRFB5a has important role in the IFN immune response. Our findings indicated that the Dabry's sturgeon CRFB and IFNGR genes have important functions in antiviral and antibacterial immune responses. The differential responses of these genes to poly I: C and LPS implied differences in the defense mechanisms against viruses and bacteria.

• Publication year

  2018

• Venue

  Developmental and Comparative Immunology

• Publication date

  2018-03-16

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.dci.2018.03.011PMID 29555551
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Analysis of the expression patterns of the novel large multigene TRIM gene family (finTRIM) in zebrafish

  2017cited by this paper
• Poly I:C facilitates the phosphorylation of Ctenopharyngodon idellus type I IFN receptor subunits and JAK kinase

  2017cited by this paper
• Bioinformatics and expression analysis of finTRIM genes in grass carp, Ctenopharyngodon idella

  2017cited by this paper
• Identification of 2 novel type I IFN genes in Japanese flounder, Paralichthys olivaceus

  2017cited by this paper
• Expression pattern analysis of IRF4 and its related genes revealed the functional differentiation of IRF4 paralogues in teleost

  2017cited by this paper
• Evolution of Interferons and Interferon Receptors

  2017cited by this paper
• Effects of IFNγ administration on allograft rejection in ginbuna crucian carp.

  2016cited by this paper
• Identification of Two Subgroups of Type I IFNs in Perciforme Fish Large Yellow Croaker Larimichthys crocea Provides Novel Insights into Function and Regulation of Fish Type I IFNs

  2016cited by this paper
• Analysis of interferon gamma protein expression in zebrafish (Danio rerio).

  2016cited by this paper
• Type I interferons in viral control and immune regulation

  2016cited by this paper
• Type I interferons in infectious disease

  2015cited by this paper
• Regulation of antiviral T cell responses by type I interferons

  2015cited by this paper
• Two IFNGR1 homologues in Tetraodon nigroviridis: Origin, expression analysis and ligand-binding preference.

  2014cited by this paper
• IFN-λ4: The Paradoxical New Member of the Interferon Lambda Family

  2014cited by this paper
• Salmonids Have an Extraordinary Complex Type I IFN System: Characterization of the IFN Locus in Rainbow Trout Oncorhynchus mykiss Reveals Two Novel IFN Subgroups

  2014cited by this paper
• Atlantic salmon possesses two clusters of type I interferon receptor genes on different chromosomes, which allows for a larger repertoire of interferon receptors than in zebrafish and mammals.

  2014cited by this paper
• A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus

  2013cited by this paper
• Intracellular Interferons in Fish: A Unique Means to Combat Viral Infection

  2013cited by this paper
• Regulation of type I interferon responses

  2013cited by this paper
• The antiviral innate immune response in fish: evolution and conservation of the IFN system.

  2013cited by this paper
• Molecular regulation of interferon antiviral response in fish.

  2012cited by this paper
• Isolation and characterization of twenty-six microsatellite loci for the tetraploid fish Dabry’s sturgeon (Acipenser dabryanus)

  2012cited by this paper
• Present status and risk for extinction of the Dabry’s sturgeon (Acipenser dabryanus) in the Yangtze River watershed: a concern for intensified rehabilitation needs

  2011cited by this paper
• Teleost fish interferons and their role in immunity.

  2011cited by this paper
• Type I interferon: friend or foe?

  2010cited by this paper
• In Vivo Analysis of Ifn-γ1 and Ifn-γ2 Signaling in Zebrafish

  2010cited by this paper
• The Two Groups of Zebrafish Virus-Induced Interferons Signal via Distinct Receptors with Specific and Shared Chains1

  2009cited by this paper
• Molecular characterization of novel interferon gamma receptor 1 isoforms in zebrafish (Danio rerio) and goldfish (Carassius auratus L.).

  2009cited by this paper
• Identification of an additional two-cysteine containing type I interferon in rainbow trout Oncorhynchus mykiss provides evidence of a major gene duplication event within this gene family in teleosts

  2009cited by this paper
• LPS response and tolerance in the zebrafish (Danio rerio).

  2009cited by this paper
• Molecular characterisation and structural analysis of an interferon homologue in sea bass (Dicentrarchus labrax L.).

  2009cited by this paper
• Structural conservation of interferon gamma among vertebrates.

  2009cited by this paper
• Differential expression of two interferon-gamma genes in common carp (Cyprinus carpio L.).

  2008cited by this paper
• Conservation and divergence of gene families encoding components of innate immune response systems in zebrafish

  2007cited by this paper
• Identification of a Second Group of Type I IFNs in Fish Sheds Light on IFN Evolution in Vertebrates1

  2007cited by this paper
• Identification of the Zebrafish IFN Receptor: Implications for the Origin of the Vertebrate IFN System12

  2007cited by this paper
• An unexpected discovery of two interferon gamma-like genes along with interleukin (IL)-22 and -26 from teleost: IL-22 and -26 genes have been described for the first time outside mammals.

  2006cited by this paper
• Promoters of type I interferon genes from Atlantic salmon contain two main regulatory regions

  2006cited by this paper
• Differential responsiveness to IFN-alpha and IFN-beta of human mature DC through modulation of IFNAR expression.

  2006cited by this paper
• Identification and expression analysis of cDNAs encoding channel catfish type I interferons.

  2006cited by this paper
• Type I interferons in host defense.

  2006cited by this paper
• In Vitro Effects of Recombinant Zebrafish IFN on Spring Viremia of Carp Virus and Infectious Hematopoietic Necrosis Virus

  2006cited by this paper
• Differential responsiveness to IFN‐α and IFN‐β of human mature DC through modulation of IFNAR expression

  2006cited by this paper
• Identification and Bioactivities of IFN-γ in Rainbow Trout Oncorhynchus mykiss: The First Th1-Type Cytokine Characterized Functionally in Fish1

  2005cited by this paper
• A review of sturgeon virosis

  2005cited by this paper
• Interferons, interferon‐like cytokines, and their receptors

  2004cited by this paper
• Identification of an interferon gamma homologue in Fugu, Takifugu rubripes.

  2004cited by this paper
• Atlantic Salmon Interferon Genes: Cloning, Sequence Analysis, Expression, and Biological Activity

  2003cited by this paper
• Comparative genomic analysis reveals independent expansion of a lineage-specific gene family in vertebrates: The class II cytokine receptors and their ligands in mammals and fish

  2003cited by this paper
• Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses.

  2002cited by this paper
• Differential Nuclear Localization of the IFNGR-1 and IFNGR-2 Subunits of the IFN-γ Receptor Complex Following Activation by IFN-γ

  2000cited by this paper
• Differential nuclear localization of the IFNGR-1 and IFNGR-2 subunits of the IFN-gamma receptor complex following activation by IFN-gamma.

  2000cited by this paper
• The Blood Group Antigen Factsbook

  1997cited by this paper
• Immune Specific Induction of Interferon Production in Cultures of Human Blood Lymphocytes

  1969cited by this paper

• Genetic differences and selection signatures of four Nile Tilapia (Oreochromis niloticus) populations as determined by whole-genome resequencing

  2026cites this paper
• Types and structural analysis of interferons from four kinds of sturgeon.

  2025cites this paper
• Characterization of fish‐specific IFNγ‐related binding with a unique receptor complex and signaling through a novel pathway

  2024cites this paper
• SIGIRR plays a dual role in zebrafish infected with Edwardsiella piscicida: boosting digestive system wellness and mitigating inflammation.

  2024cites this paper
• Mechanism of Chinese sturgeon IFN-γ inhibition on Mycobacterium marinum (Acipenser sinensis).

  2024cites this paper
• Pathogenicity and detection method based on interferon release assay of mycobacteria marinum isolated from sturgeon

  2023cites this paper
• CRFB5a, a Subtype of Japanese Eel (Anguilla japonica) Type I IFN Receptor, Regulates Host Antiviral and Antimicrobial Functions through Activation of IRF3/IRF7 and LEAP2

  2023cites this paper
• Novel Dimeric Architecture of an IFN-γ-Related Cytokine Provides Insights into Subfunctionalization of Type II IFNs in Teleost Fish.

  2022cites this paper
• Identification and expression of IL-1β in the endangered Dabry’s sturgeon (Acipenser dabryanus)

  2021cites this paper
• The immune system of sturgeons and paddlefish (Acipenseriformes): a review with new data from a chromosome‐scale sturgeon genome

  2021cites this paper
• Molecular characterization and expression analysis of double‐stranded RNA‐dependent protein kinase (PKR) in Dabry’s sturgeon ( Acipenser dabryanus )

  2021cites this paper
• Comprehensive comparison of thirteen kinds of cytokine receptors from the endangered fish Chinese sturgeon (Acipenser sinensis).

  2021cites this paper
• The influence of dietary arachidonic acid on growth, fatty acid profile and sex steroid hormones of F2 generation Chinese sturgeon (Acipenser sinensis)

  2021cites this paper
• Effects of three kinds of bacteria on DIGIRR signaling pathway in the Chinese Sturgeon (Acipenser sinensis)

  2021cites this paper
• Molecular characterization and expression patterns of adenosine deaminases acting on tRNAs in Dabry’s sturgeon ( Acipenser dabryanus )

  2021cites this paper
• Fish type I and type II interferons: composition, receptor usage, production and function

  2020cites this paper
• Cloning and characterisation of type I interferon receptor 1 in orange-spotted grouper (Epinephelus coioides) for response to nodavirus infection.

  2020cites this paper
• Molecular characterization, expression pattern and evolution of nine suppressors of cytokine signaling (SOCS) gene in the swamp eel (Monopterus albus).

  2019cites this paper
• Evaluation of the potential probiotic Bacillus subtilis isolated from two ancient sturgeons on growth performance, serum immunity and disease resistance of Acipenser dabryanus.

  2019cites this paper
• Insights into teleost interferon-gamma biology: An update.

  2019cites this paper
• Receptor complex and signalling pathway of the two type II IFNs, IFN‐&ggr; and IFN‐&ggr;rel in mandarin fish or the so‐called Chinese perch Siniperca chuatsi

  2019cites this paper
• Sequence analysis and characterization of type I interferon and type II interferon from the critically endangered sturgeon species, A. dabryanus and A. sinensis.

  2019cites this paper
• Molecular characterization and expression analysis of Asian swamp eel (Monopterus albus) CXC chemokine receptor (CXCR) 1a, CXCR1b, CXCR2, CXCR3a, CXCR3b, and CXCR4 after bacteria and poly I:C challenge.

  2019cites this paper
• Gene characterization and expression pattern of Mx and Viperin genes in Dabry’s sturgeonAcipenser dabryanus

  2019cites this paper
• Transcriptome analysis of the critically endangered Dabry's sturgeon (Acipenser dabryanus) head kidney response to Aeromonas hydrophila

  2018cites this paper