Structure–activity relationships of strigolactones via a novel, quantitative in planta bioassay

The biological activity of natural and novel strigolactone D-lactam analogues is assessed using a novel bioassay based on Arabidopsis transgenic lines expressing AtD14 fused to firefly luciferase.

• Publication year

  2018

• Venue

  Journal of Experimental Botany

• Publication date

  2018-03-15

• Fields of study

  Biology, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1093/jxb/ery092PMID 29554337PMCID 5913603
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Stability of strigolactone analog GR24 toward nucleophiles.

  2018cited by this paper
• Strigolactones: mediators of osmotic stress responses with a potential for agrochemical manipulation of crop resilience

  2018cited by this paper
• The elusive ligand complexes of the DWARF14 strigolactone receptor

  2018cited by this paper
• Recent advances in the synthesis of analogues of phytohormones strigolactones with ring-closing metathesis as a key step.

  2017cited by this paper
• The perception of strigolactones in vascular plants.

  2017cited by this paper
• Simplified strigolactams as potent analogues of strigolactones for the seed germination induction of Orobanche cumana Wallr.

  2016cited by this paper
• Strigolactones: how far is their commercial use for agricultural purposes?

  2016cited by this paper
• Structural biology: Signal locked in

  2016cited by this paper
• Strigolactone Analogues with a D‐Ring Modified at C‐2

  2016cited by this paper
• An histidine covalent receptor/butenolide complex mediates strigolactone perception

  2016influential reference
• DWARF14 is a non-canonical hormone receptor for strigolactone

  2016cited by this paper
• A Pipeline To Enhance Ligand Virtual Screening: Integrating Molecular Dynamics and Fingerprints for Ligand and Proteins

  2015cited by this paper
• Heterocyclic ring cleavage upon collision-induced dissociation of deprotonated 3-hydroxy-1,2,5-oxadiazoles (3-hydroxyfurazans).

  2015cited by this paper
• Probing strigolactone receptors in Striga hermonthica with fluorescence

  2015cited by this paper
• A Selaginella moellendorffii Ortholog of KARRIKIN INSENSITIVE2 Functions in Arabidopsis Development but Cannot Mediate Responses to Karrikins or Strigolactones[OPEN]

  2015cited by this paper
• Strigolactones, a novel carotenoid-derived plant hormone.

  2015cited by this paper
• Structure-function analysis identifies highly sensitive strigolactone receptors in Striga

  2015influential reference
• Refining the chemical toolbox to be fit for educational and practical purpose for drug discovery in the 21st Century.

  2015cited by this paper
• Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-ligase signaling effector DWARF3

  2015influential reference
• Strigolactone analogs act as new anti-cancer agents in inhibition of breast cancer in xenograft model

  2015cited by this paper
• Strigolactam: New potent strigolactone analogues for the germination of Orobanche cumana.

  2015cited by this paper
• Convergent evolution of strigolactone perception enabled host detection in parasitic plants

  2015cited by this paper
• Detection of parasitic plant suicide germination compounds using a high-throughput Arabidopsis HTL/KAI2 strigolactone perception system.

  2014cited by this paper
• A novel concept for the control of parasitic weeds by decomposing germination stimulants prior to action

  2014cited by this paper
• New strigolactone analogs as plant hormones with low activities in the rhizosphere.

  2014cited by this paper
• Strigolactone Promotes Degradation of DWARF14, an α/β Hydrolase Essential for Strigolactone Signaling in Arabidopsis[W]

  2014cited by this paper
• Crystal structures of two phytohormone signal-transducing α/β hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14

  2013cited by this paper
• Structure-function relations of strigolactone analogs: activity as plant hormones and plant interactions.

  2013cited by this paper
• Structure-Activity Relationship Studies of Strigolactone-Related Molecules for Branching Inhibition in Garden Pea: Molecule Design for Shoot Branching1[W]

  2012cited by this paper
• Faculty Opinions recommendation of DAD2 is an α/β hydrolase likely to be involved in the perception of the plant branching hormone, strigolactone.

  2012influential reference
• New Potent Fluorescent Analogues of Strigolactones: Synthesis and Biological Activity in Parasitic Weed Germination and Fungal Branching

  2011cited by this paper
• The computational-based structure of Dwarf14 provides evidence for its role as potential strigolactone receptor in plants

  2011cited by this paper
• New branching inhibitors and their potential as strigolactone mimics in rice.

  2011cited by this paper
• A new class of conjugated strigolactone analogues with fluorescent properties: synthesis and biological activity.

  2009cited by this paper
• A Common Reference Framework for Analyzing/Comparing Proteins and Ligands. Fingerprints for Ligands And Proteins (FLAP): Theory and Application

  2007cited by this paper
• Development of series of gateway binary vectors, pGWBs, for realizing efficient construction of fusion genes for plant transformation.

  2007cited by this paper
• Synthesis and biological evaluation of 2'-carbamate-linked and 2'-carbonate-linked prodrugs of paclitaxel: selective activation by the tumor-associated protease plasmin.

  2000cited by this paper
• Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana.

  1998cited by this paper
• Life Sciences

  1983influential reference
• A revised medium for rapid growth and bio assays with tobacco tissue cultures

  1962influential reference

• Genotype-Dependent Strigolactones Effect on Stimulation of Striga hermonthica (Del.) Benth Seed Germination and Induced Systemic Resistance Indicators in Reducing Striga Weed Population

  2025cites this paper
• Synthesis and characterization of strigolactone analogue loaded mesoporous silica nanoparticles

  2025cites this paper
• Novel mechanisms of strigolactone-induced DWARF14 degradation in Arabidopsis thaliana

  2024cites this paper
• Strigolactones as a hormonal hub for the acclimation and priming to environmental stress in plants

  2022cites this paper
• Strategies for the synthesis of canonical, non-canonical and analogues of strigolactones, and evaluation of their parasitic weed germination activity

  2022influential citation
• A structural homologue of the plant receptor D14 mediates responses to strigolactones in the fungal phytopathogen Cryphonectria parasitica

  2022cites this paper
• Karrikin perception and signalling.

  2022cites this paper
• Efficiency and bioavailability of new synthetic strigolactone mimics with potential for sustainable agronomical applications

  2021cites this paper
• Rapid analysis of strigolactone receptor activity in a Nicotiana benthamiana dwarf14 mutant

  2021cites this paper
• Glowing plants can light up the night sky? A review

  2021cites this paper
• Evaluation of Bioactivity of Strigolactone-Related Molecules by a Quantitative Luminometer Bioassay.

  2021cites this paper
• A Luciferase-EGFP Reporter System for the Evaluation of DNA Methylation in Mammalian Cells

  2021cites this paper
• Strigolactones, from Plants to Human Health: Achievements and Challenges

  2021cites this paper
• Rational design of novel fluorescent enzyme biosensors for direct detection of strigolactones

  2020cites this paper
• Total synthesis of (-)-2-methoxy-2-butenolide-3-cinnamate and its antimicrobial potentials

  2020cites this paper
• From synthetic control to natural products: a focus on N-heterocycles.

  2019cites this paper
• Strigolactone: Pflanzenhormone mit vielversprechenden Eigenschaften

  2019cites this paper
• Strigolactones. A New Plant Hormone with Promising Features.

  2019cites this paper