Cyclosporine and chloroquine synergistically inhibit the interferon-gamma production by CD4 positive and CD8 positive synovial T cell clones derived from a patient with rheumatoid arthritis.

No abstract is available for this paper.

• Publication year

  1992

• Venue

  Journal of Rheumatology

• Publication date

  1992-09-01

• Fields of study

  Medicine

• Identifiers
  PMID 1432999
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Penetration of cyclosporin into synovial fluid in rheumatoid arthritis

  2004cited by this paper
• Effect of cyclosporin on serum creatinine in patients with rheumatoid arthritis

  2004cited by this paper
• Comparison of cyclosporine and D-penicillamine for rheumatoid arthritis: a randomized, double blind, multicenter study.

  1991cited by this paper
• Longterm cyclosporine therapy in rheumatoid arthritis.

  1991cited by this paper
• IFN-gamma regulates the expression of the adhesion molecule ELAM-1 and IL-6 production by human endothelial cells in vitro.

  1990cited by this paper
• Low-dose cyclosporin versus placebo in patients with rheumatoid arthritis.

  1990cited by this paper
• Synergistic and additive effects of disease modifying anti-rheumatic drugs combined with chloroquine on the mitogen-driven stimulation of mononuclear cells.

  1990cited by this paper
• Reversible nephrotoxicity of cyclosporine in rheumatoid arthritis.

  1990cited by this paper
• Cyclosporine.

  1989cited by this paper
• Endogenous release of interferon-gamma and diminished response of peripheral blood mononuclear cells to antigenic stimulation.

  1989cited by this paper
• Cyclosporin in rheumatoid arthritis: a double blind, placebo controlled study in 52 patients.

  1988cited by this paper
• Effects of anti-rheumatic drugs on in vitro mitogenic stimulation of peripheral blood mononuclear cells.

  1988cited by this paper
• Cyclosporin A in severe, treatment-refractory rheumatoid arthritis. A randomized study.

  1988cited by this paper
• Detection of activated T cell products in the rheumatoid joint using cDNA probes to Interleukin-2 (IL-2) IL-2 receptor and IFN-gamma.

  1988cited by this paper
• Interferon-gamma in vivo. Induction and loss of class II MHC antigens and immature myelomonocytic cells in rat organs.

  1988cited by this paper
• Efficient Propagation and Cloning of Human T Cells in the Absence of Antigen by Means of OKT3, Interleukin 2, and Antigen‐Presenting Cells

  1988cited by this paper
• Obligatory role of IFN-gamma in induction of lymphokine-activated and T lymphocyte killer activity, but not in boosting of natural cytotoxicity.

  1988cited by this paper
• Effects of cyclosporine A on T lymphocytes and accessory cells from human blood.

  1988cited by this paper
• Cytokines in synovial fluid: II. The presence of tumour necrosis factor and interferon.

  1988cited by this paper
• Phenotypic analysis of synovial tissue and peripheral blood lymphocytes isolated from patients with rheumatoid arthritis.

  1988cited by this paper
• Peripheral blood and synovial fluid monocyte activation in inflammatory arthritis. II. Low levels of synovial fluid and synovial tissue interferon suggest that gamma-interferon is not the primary macrophage activating factor.

  1987cited by this paper
• Combined D-penicillamine and chloroquine treatment of rheumatoid arthritis--a comparative study.

  1987cited by this paper
• Cyclosporin A treatment of refractory rheumatoid arthritis.

  1987cited by this paper
• Effect of chloroquine on human lymphocyte proliferation.

  1986cited by this paper
• Gamma interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin 1, and urokinase genes, which are controlled by short-lived repressors

  1986cited by this paper
• Side effects of cyclosporin A treatment in patients with rheumatoid arthritis.

  1986cited by this paper
• Cyclosporin treatment for rheumatoid arthritis: a placebo controlled, double blind, multicentre study.

  1986cited by this paper
• Interferon-gamma induction of LFA-1-mediated homotypic adhesion of human monocytes.

  1986cited by this paper
• Monoclonal antibodies to interferon-gamma inhibit interleukin 2-dependent induction of growth and maturation in lectin/antigen-reactive cytolytic T lymphocyte precursors.

  1986cited by this paper
• Immunohistochemical studies of interleukin-2 and gamma-interferon in rheumatoid arthritis.

  1985cited by this paper
• Monoclonal antibodies to human immune interferon and their use in a sensitive solid-phase ELISA.

  1985cited by this paper
• Immune function in severe, active rheumatoid arthritis. A relationship between peripheral blood mononuclear cell proliferation to soluble antigens and synovial tissue immunohistologic characteristics.

  1984cited by this paper
• Controlled trial of hydroxychloroquine and D-penicillamine singly and in combination in the treatment of rheumatoid arthritis.

  1984cited by this paper
• Ia antigens and associated invariant chain are induced simultaneously in lines of T-dependent mast cells by recombinant interferon-gamma.

  1984cited by this paper
• Immunosuppressive potential of antimalarials.

  1983cited by this paper
• Recombinant interferon-gamma increases HLA-DR synthesis and expression.

  1983cited by this paper
• Chloroquine inhibits lysosomal enzyme pinocytosis and enhances lysosomal enzyme secretion by impairing receptor recycling

  1980cited by this paper
• Synergy, additivism and antagonism in immunosuppression. A critical review.

  1977cited by this paper

• Renal Manifestations of Rheumatoid Arthritis.

  2018cites this paper
• Anti-inflammatory activity of chloroquine and amodiaquine through p21-mediated suppression of T cell proliferation and Th1 cell differentiation.

  2016cites this paper
• Targeting CD4(+) T cells for the treatment of sarcoidosis: a promising strategy?

  2015cites this paper
• This information is current as Langerhans-like Cells Release by Monocyte-Derived T Cells via p 38-Dependent IL-23 + CD 4 Chloroquine Promotes IL-17 Production by Günther Weindl

  2014cites this paper
• Chloroquine Promotes IL-17 Production by CD4+ T Cells via p38-Dependent IL-23 Release by Monocyte-Derived Langerhans-like Cells

  2014cites this paper
• The Effect of Chloroquine on Pro-Inflammatory Cytokines Levels in Graves’ Disease: Historical Cohort from a Pilot Randomized Controlled Trial

  2013cites this paper
• Combination Therapy with Cyclosporin in Rheumatoid Arthritis

  2012cites this paper
• New concepts in antimalarial use and mode of action in dermatology

  2007cites this paper
• Relationship between antipyretic effects and cytokine levels in uncomplicated falciparum malaria during different treatment regimes.

  2006cites this paper
• The Cardiac Safety of Chloroquine Phosphate Treatment in Patients with Systemic Lupus Erythematosus: The Influence on Arrhythmia, Heart Rate Variability and Repolarization Parameters

  2006cites this paper
• Optimal Use of Antimalarials in Treating Cutaneous Lupus Erythematosus

  2005cites this paper
• A randomized, double-blind, multicenter, controlled clinical trial of cyclosporine plus chloroquine vs. cyclosporine plus placebo in early-onset rheumatoid arthritis.

  2004cites this paper
• Plasmodium falciparum infection of the placenta affects newborn immune responses

  2003cites this paper
• An open, randomized comparison study of cyclosporine A, cyclosporine A + methotrexate and cyclosporine A + hydroxychloroquine in the treatment of early severe rheumatoid arthritis

  2003cites this paper
• Antipyretic, parasitologic, and immunologic effects of combining sulfadoxine/pyrimethamine with chloroquine or paracetamol for treating uncomplicated Plasmodium falciparum malaria.

  2003cites this paper
• Antimalarials in cutaneous lupus erythematosus: mechanisms of therapeutic benefit

  2002cites this paper
• Chloroquine Enhances the Number of IL‐10 Producing Cells and the Expression of B7‐2 and ICAM‐1 in In Vitro‐Cultured PBMC

  2002cites this paper
• Antimalarials: unapproved uses or indications.

  2000cites this paper
• Hydroxychloroquine inhibits calcium signals in T cells: a new mechanism to explain its immunomodulatory properties.

  2000cites this paper
• Combination cyclosporine and (hydroxy)chloroquine in rheumatoid arthritis.

  1999cites this paper
• Combination cyclosporine and (hydroxy)chloroquine in rheumatoid arthritis

  1999cites this paper
• Long-term efficacy and toxicity of cyclosporin A + fluocortolone + methotrexate in the treatment of rheumatoid arthritis.

  1999cites this paper
• Compounds Chloroquine , and Structurally Related CpG-Oligodeoxynucleotides by Quinacrine , Antagonism of Immunostimulatory

  1998cites this paper
• Combination therapy in recent onset rheumatoid arthritis: a randomized double blind trial of the addition of low dose cyclosporine to patients treated with low dose chloroquine.

  1998cites this paper
• Antagonism of immunostimulatory CpG-oligodeoxynucleotides by quinacrine, chloroquine, and structurally related compounds.

  1998cites this paper
• Immune suppression by lysosomotropic amines and cyclosporine on T-cell responses to minor and major histocompatibility antigens: does synergy exist?

  1997cites this paper
• CD4 and CD8 antigen coexpression: a flow cytometric study of peripheral blood, bone marrow, body fluid, and solid lymphoreticular specimens.

  1997cites this paper
• [The effect of cyclosporin A (Sandimmun) on the level of soluble interleukin-2 receptors in rheumatoid arthritis].

  1997cites this paper
• Chloroquine and hydroxychloroquine equally affect tumor necrosis factor-alpha, interleukin 6, and interferon-gamma production by peripheral blood mononuclear cells.

  1997cites this paper
• Combination therapy of cyclosporine A with methotrexate or hydroxychloroquine in refractory rheumatoid arthritis.

  1996cites this paper
• Effects of antirheumatic agents on cytokines.

  1996cites this paper
• Cyclosporine, FK-506, rapamycin, and other immunomodulators.

  1996cites this paper
• Synergy between lysosomotropic amines and cyclosporin A on human T cell responses to an exogenous protein antigen, tetanus toxoid.

  1996cites this paper
• The Use of Slower-Acting (Class III) Symptom-Modifying Antirheumatic Drugs in Rheumatoid Arthritis

  1996cites this paper
• [Cyclosporine-chloroquine interactions].

  1996cites this paper
• Combination therapy with cyclosporin in rheumatoid arthritis.

  1996cites this paper
• Chloroquine inhibits T cell proliferation by interfering with IL‐2 production and responsiveness

  1995cites this paper
• Immobilized anti-CD3 antibody activates T cell clones to induce the production of interstitial collagenase, but not tissue inhibitor of metalloproteinases, in monocytic THP-1 cells and dermal fibroblasts.

  1995cites this paper
• Tenidap, but not Nonsteroidal Anti‐Inflammatory Drugs, Inhibits T‐Cell Proliferation and Cytokine Induction

  1995cites this paper
• Antimalarial agents and lupus.

  1994cites this paper
• A randomized, double-blind, 24-week controlled study of low-dose cyclosporine versus chloroquine for early rheumatoid arthritis.

  1994cites this paper
• The effect of hydroxychloroquine therapy on serum levels of immunoregulatory molecules in patients with systemic lupus erythematosus.

  1994cites this paper
• Cyclosporin a in rheumatoid arthritis: A critical review

  1993cites this paper