The antimicrobial peptide parabutoporin competes with p47phox as a PKC‐substrate and inhibits NADPH oxidase in human neutrophils

No abstract is available for this paper.

• Publication year

  2006

• Venue

  FEBS Letters

• Publication date

  2006-11-13

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.febslet.2006.10.024PMID 17069809
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Parabutoporin--an antibiotic peptide from scorpion venom--can both induce activation and inhibition of granulocyte cell functions.

  2004cited by this paper
• Antimicrobial peptides from scorpion venom induce Ca(2+) signaling in HL-60 cells.

  2003cited by this paper
• Antibacterial and antifungal properties of alpha-helical, cationic peptides in the venom of scorpions from southern Africa.

  2002cited by this paper
• Cationic peptides from scorpion venom can stimulate and inhibit polymorphonuclear granulocytes.

  2002cited by this paper
• Phosphorylation of p47phox sites by PKC alpha, beta II, delta, and zeta: effect on binding to p22phox and on NADPH oxidase activation.

  2002cited by this paper
• Structure-function relationship in the interaction of mastoparan analogs with neutrophil NADPH oxidase.

  2001cited by this paper
• Protein Kinase C ζ Phosphorylates a Subset of Selective Sites of the NADPH Oxidase Component p47phox and Participates in Formyl Peptide-Mediated Neutrophil Respiratory Burst

  2001cited by this paper
• Rac2 Is an Essential Regulator of Neutrophil Nicotinamide Adenine Dinucleotide Phosphate Oxidase Activation in Response to Specific Signaling Pathways1

  2001cited by this paper
• NADPH oxidase: an update.

  1999cited by this paper
• Scorpion toxins specific for Na+-channels.

  1999cited by this paper
• Protein kinase C (PKC) isoforms translocate to Triton-insoluble fractions in stimulated human neutrophils: correlation of conventional PKC with activation of NADPH oxidase.

  1999cited by this paper
• Evidence of ζ Protein Kinase C Involvement in Polymorphonuclear Neutrophil Integrin-dependent Adhesion and Chemotaxis*

  1998cited by this paper
• Determination of the Specific Substrate Sequence Motifs of Protein Kinase C Isozymes*

  1997cited by this paper
• Opsonized zymosan stimulates the redistribution of protein kinase C isoforms in human neutrophils.

  1997cited by this paper
• Assembly of the phagocyte NADPH oxidase: molecular interaction of oxidase proteins

  1996cited by this paper
• Phosphorylation of the respiratory burst oxidase subunit p47phox as determined by two-dimensional phosphopeptide mapping. Phosphorylation by protein kinase C, protein kinase A, and a mitogen-activated protein kinase.

  1996cited by this paper
• PR-39, a proline-rich antibacterial peptide that inhibits phagocyte NADPH oxidase activity by binding to Src homology 3 domains of p47 phox.

  1996cited by this paper
• The phosphorylation targets of p47phox, a subunit of the respiratory burst oxidase. Functions of the individual target serines as evaluated by site-directed mutagenesis.

  1995cited by this paper
• Cell-free activation of the respiratory burst oxidase by protein kinase C.

  1995cited by this paper
• Isolation of a complex of respiratory burst oxidase components from resting neutrophil cytosol.

  1994cited by this paper
• Reciprocal interactions between protein kinase C and components of the NADPH oxidase complex may regulate superoxide production by neutrophils stimulated with a phorbol ester.

  1994cited by this paper
• Phosphorylation of neutrophil 47-kDa cytosolic oxidase factor. Translocation to membrane is associated with distinct phosphorylation events.

  1990cited by this paper
• A possible role for protein phosphorylation in the activation of the respiratory burst in human neutrophils. Evidence from studies with cells from patients with chronic granulomatous disease.

  1986cited by this paper
• Oxygen-dependent microbial killing by phagocytes (first of two parts).

  1978cited by this paper
• Oxygen-dependent microbial killing by phagocytes (second of two parts).

  1978cited by this paper

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• Scorpion venom components as potential candidates for drug development

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• Eicosapentaenoic (EPA) and Docosahexaenoic (DHA) Acid Differentially Modulate Rat Neutrophil Function In Vitro

  2013cites this paper
• Scorpion Peptides: Potential Use for New Drug Development

  2013cites this paper
• ERIODICTYOL DECREASES REACTIVE OXYGEN SPECIES PRODUCTION AND INHIBITS P47PHOX CLUSTERING AND TRANSLOCATION IN MONOCYTES

  2013cites this paper
• Characterization of BmKbpp, a multifunctional peptide from the Chinese scorpion Mesobuthus martensii Karsch: gaining insight into a new mechanism for the functional diversification of scorpion venom peptides.

  2012cites this paper
• Roles of reactive oxygen and nitrogen species in pain.

  2011cites this paper
• PKCδ activation mediates angiogenesis via NADPH oxidase activity in PC‐3 prostate cancer cells

  2011cites this paper
• Specific activation of human neutrophils by scorpion venom: a flow cytometry assessment.

  2011cites this paper
• Zinc activates neutrophils’ oxidative burst

  2010cites this paper
• Nickel induces oxidative burst, NF-κB activation and interleukin-8 production in human neutrophils

  2010cites this paper
• Parabutoporin, a cationic amphipathic peptide from scorpion venom: much more than an antibiotic.

  2010cites this paper
• Metal-induced oxidative burst in isolated human neutrophils

  2010cites this paper
• Inhibition of spontaneous neutrophil apoptosis by parabutoporin acts independently of NADPH oxidase inhibition but by lipid raft‐dependent stimulation of Akt

  2009influential citation
• Decreased Superoxide Production in Macrophages of Long-lived p66Shc Knock-out Mice*

  2009cites this paper
• Southern African scorpion toxins: an overview.

  2008cites this paper
• Role of Bcl-2 proteins in neutrophil activation and delayed apoptosis in crystal-induced arthritis

  2008cites this paper
• Author Index

  2006cites this paper