High doses of atorvastatin and simvastatin induce key enzymes involved in VLDL production

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Lipids

• Publication date

  2002-05-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1007/s11745-002-0916-0PMID 12056585
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Increase in hepatic expression of SREBP-2 by gemfibrozil administration to rats.

  2001cited by this paper
• Roles of acyl-coenzyme A : cholesterol acyltransferase-1 and -2

  2001cited by this paper
• Induction of LPL gene expression by sterols is mediated by a sterol regulatory element and is independent of the presence of multiple E boxes.

  2000cited by this paper
• Triglyceride synthesis: insights from the cloning of diacylglycerol acyltransferase.

  2000cited by this paper
• Activation of phosphatidylinositol 3-kinase is required for transcriptional activity of F-type 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: assessment of the role of protein kinase B and p70 S6 kinase.

  2000cited by this paper
• The assembly and secretion of apolipoprotein B-containing lipoproteins.

  1999cited by this paper
• The Magnitude of Decrease in Hepatic Very Low Density Lipoprotein Apolipoprotein B Secretion Is Determined by the Extent of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibition in Miniature Pigs1.

  1999cited by this paper
• 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) induce hepatic expression of the phospholipid translocase mdr2 in rats.

  1999cited by this paper
• Different effect of simvastatin and atorvastatin on key enzymes involved in VLDL synthesis and catabolism in high fat/cholesterol fed rabbits

  1999cited by this paper
• 3‐Hydroxy‐3‐methylglutaryl CoA reductase inhibitors reduce serum triglyceride levels through modulation of apolipoprotein C‐III and lipoprotein lipase

  1999cited by this paper
• Uncoupling protein-3 mRNA levels are increased in white adipose tissue and skeletal muscle of bezafibrate-treated rats.

  1999cited by this paper
• The magnitude of decrease in hepatic very low density lipoprotein apolipoprotein B secretion is determined by the extent of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibition in miniature pigs.

  1999cited by this paper
• Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis.

  1999cited by this paper
• Sterol Regulatory Element-binding Protein Negatively Regulates Microsomal Triglyceride Transfer Protein Gene Transcription*

  1999cited by this paper
• Differential regulation of apolipoprotein B secretion from HepG2 cells by two HMG-CoA reductase inhibitors, atorvastatin and simvastatin.

  1999cited by this paper
• Effects of atorvastatin on the intracellular stability and secretion of apolipoprotein B in HepG2 cells.

  1998cited by this paper
• Atorvastatin action involves diminished recovery of hepatic HMG-CoA reductase activity.

  1998cited by this paper
• Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.

  1998cited by this paper
• Enhanced expression of hepatic acyl‐coenzyme A synthetase and microsomal triglyceride transfer protein messenger RNAs in the obese and hypertriglyceridemic rat with visceral fat accumulation

  1998cited by this paper
• Obesity-related Overexpression of Fatty-acid Synthase Gene in Adipose Tissue Involves Sterol Regulatory Element-binding Protein Transcription Factors*

  1998cited by this paper
• Effect of hypolipidemic drugs on key enzyme activities related to lipid metabolism in normolipidemic rabbits.

  1998cited by this paper
• Comparison of statins in hypertriglyceridemia.

  1998cited by this paper
• Comparative dose efficacy study of atorvastatin versus simvastatin, pravastatin, lovastatin, and fluvastatin in patients with hypercholesterolemia (the CURVES study)

  1998cited by this paper
• 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors and hepatic apolipoprotein B secretion.

  1997cited by this paper
• Identification of Glycerol-3-phosphate Acyltransferase as an Adipocyte Determination and Differentiation Factor 1- and Sterol Regulatory Element-binding Protein-responsive Gene*

  1997cited by this paper
• Fatty acid regulation of very low density lipoprotein production.

  1997cited by this paper
• Coordinate Regulation of Lipogenesis, the Assembly and Secretion of Apolipoprotein B-containing Lipoproteins by Sterol Response Element Binding Protein 1*

  1997cited by this paper
• Sterol-dependent Transcriptional Regulation of Sterol Regulatory Element-binding Protein-2*

  1996cited by this paper
• Role of cholesterol in regulating apolipoprotein B secretion by the liver.

  1996cited by this paper
• Aging-induced up-regulation of nuclear binding activities of oxidative stress responsive NF-kB transcription factor in mouse cardiac muscle.

  1996cited by this paper
• Lovastatin induces synthesis of cholesterol, which acts as a secretagogue of biliary phospholipids in rats.

  1995cited by this paper
• Synthesis and secretion of apolipoprotein B from cultured liver cells

  1995cited by this paper
• Lysophosphatidylcholine and 1-O-Octadecyl-2-O-Methyl-rac- Glycero-3-Phosphocholine Inhibit the CDP-Choline Pathway of Phosphatidylcholine Synthesis at the CTP:Phosphocholine Cytidylyltransferase Step (*)

  1995cited by this paper
• Nutrition and therapeutics: where we are and where we should be going.

  1995cited by this paper
• Microsomal triglyceride transfer protein (MTP) regulation in HepG2 cells: insulin negatively regulates MTP gene expression.

  1995cited by this paper
• Lipid-lowering activity of atorvastatin and lovastatin in rodent species: triglyceride-lowering in rats correlates with efficacy in LDL animal models.

  1995influential reference
• Tissue-specific Expression and Cholesterol Regulation of Acylcoenzyme A:Cholesterol Acyltransferase (ACAT) in Mice

  1995cited by this paper
• Phosphatidylcholine cycle and regulation of phosphatidylcholine biosynthesis by enzyme translocation.

  1994cited by this paper
• Transcriptional regulation of human and hamster microsomal triglyceride transfer protein genes. Cell type-specific expression and response to metabolic regulators.

  1994cited by this paper
• HMG-CoA reductase inhibitors: a look back and a look ahead.

  1992cited by this paper
• Boehringer Mannheim Award lecture. Phosphatidylcholine metabolism: masochistic enzymology, metabolic regulation, and lipoprotein assembly.

  1990cited by this paper
• Regulation of the mevalonate pathway

  1990cited by this paper
• Regulation of the biosynthesis of triacylglycerol, phosphatidylcholine and phosphatidylethanolamine in the liver.

  1989cited by this paper
• The effect of fatty acid exposure on the biosynthesis of glycerolipids by cultured hepatocytes.

  1983cited by this paper
• Dopamine receptors: selective agonists and antagonists of functionally distinct types within the feline brain.

  1976cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper

• Effect of PCSK9 Inhibitors on Regulators of Lipoprotein Homeostasis, Inflammation and Coagulation

  2025cites this paper
• A Dual Pharmacological Strategy against COVID-19: The Therapeutic Potential of Metformin and Atorvastatin

  2024cites this paper
• Attenuation of high-fat high-sucrose diet and CCl4-induced non-alcoholic steatohepatitis in rats by activating autophagy and SIGMAR1/GRP78/ITPR1 signaling using berberine-loaded albumin nanoparticles: in vivo prediction and in-silico molecular modeling

  2024cites this paper
• Statin use and development and progression of non-alcohol fatty liver disease based on ultrasonography: a cohort study.

  2024cites this paper
• A Proof-of-Concept for a Hypolipidemic Brown Trout Model

  2024influential citation
• Carbon dioxide regulates cholesterol levels through SREBP2

  2023cites this paper
• Metabolic reprogramming by Acly inhibition using SB-204990 alters glucoregulation and modulates molecular mechanisms associated with aging

  2023cites this paper
• The Potential Therapeutic Application of Simvastatin for Brain Complications and Mechanisms of Action

  2023cites this paper
• Statin Usage Increases White Matter Hyperintensities

  2022cites this paper
• Statins in Alcoholic and Non-Alcoholic Fatty Liver Disease and Chronically Elevated Liver Enzymes

  2022cites this paper
• Estrogen Mediates an Atherosclerotic-Protective Action via Estrogen Receptor Alpha/SREBP-1 Signaling

  2022cites this paper
• High-fat diet induced alterations in plasma membrane cholesterol content impairs insulin receptor binding and signalling in mouse liver but is ameliorated by atorvastatin.

  2022cites this paper
• Physical activity to reduce PCSK9 levels

  2022cites this paper
• Drugs Used in Dyslipidemia

  2021cites this paper
• Dysregulated Brain Cholesterol Metabolism Is Linked to Neuroinflammation in Huntington's Disease

  2020cites this paper
• Novel targeted therapies for the management of liver fibrosis

  2020cites this paper
• Atorvastatin Decreases Renal Menaquinone-4 Formation in C57BL/6 Male Mice.

  2019cites this paper
• The Potential of Isoprenoids in Adjuvant Cancer Therapy to Reduce Adverse Effects of Statins

  2019cites this paper
• Statins: Old drugs as new therapy for liver diseases?

  2019cites this paper
• Atorvastatin alters gene expression and cholesterol synthesis in primary rainbow trout (Oncorhynchus mykiss) hepatocytes.

  2017cites this paper
• INVESTIGATION THE ANTI-HYPERLIPIDEMIC EFFECTS OF SAFFRON PETALS' OF HYDROALCOHOLIC EXTRACT IN RATS

  2017cites this paper
• Statins redux: A re-assessment of how statins lower plasma cholesterol

  2017cites this paper
• Statins increase hepatic cholesterol synthesis and stimulate fecal cholesterol elimination in mice

  2016cites this paper
• Harnessing the trophic and modulatory potential of statins in a dopaminergic cell line

  2016cites this paper
• Combined Effects of Rosuvastatin and Exercise on Gene Expression of Key Molecules Involved in Cholesterol Metabolism in Ovariectomized Rats

  2016cites this paper
• Lovastatin reversed the enhanced sphingomyelin caused by 27-hydroxycholesterol in cultured vascular endothelial cells

  2015cites this paper
• Statin-mediated inhibition of cholesterol synthesis induces cytoprotective autophagy in human leukemic cells.

  2015cites this paper
• Modulation of the expression and function of dopaminergic presynaptic proteins by the statins : Potential implication for the therapeutic intervention in Parkinson’s disease.

  2015cites this paper
• Statin therapy is associated with a reduced risk of non-alcoholic fatty liver in overweight individuals.

  2014cites this paper
• Simvastatin Induced Neurite Outgrowth Unveils Role of Cell Surface Cholesterol and Acetyl CoA Carboxylase in SH-SY5Y Cells

  2013cites this paper
• Rosuvastatin ameliorates high‐fat and high‐cholesterol diet‐induced nonalcoholic steatohepatitis in rats

  2013cites this paper
• Statins-induced inhibition of cholesterol synthesis in liver and very low density lipoproteins. Statins, fatty acids and insulin resistance

  2013cites this paper
• EFFECT OF ALCOHOLIC EXTRACT OF THYMBRA SPICATA ON BLOOD LIPID PROFILE IN COMPARED WITH LOVASTATIN IN MALE RATS

  2012cites this paper
• Differential regulation of cPLA2 and iPLA2 expression in the brain

  2012influential citation
• Influence of atorvastatin and carboxymethylated glucan on the serum lipoprotein profile and MMP activity of mice with lipemia induced by poloxamer 407.

  2012cites this paper
• The PPAR / Activator GW 501516 Prevents the Down-Regulation of AMPK Caused by a High-Fat Diet in Liver and Amplifies the PGC-1-Lipin 1-PPAR Pathway Leading to Increased Fatty Acid Oxidation

  2011cites this paper
• Improved efficacy for ezetimibe and rosuvastatin by attenuating the induction of PCSK9[S]

  2011cites this paper
• Cholesterol and chronic hepatitis C virus infection

  2011cites this paper
• The PPARβ/δ activator GW501516 prevents the down-regulation of AMPK caused by a high-fat diet in liver and amplifies the PGC-1α-Lipin 1-PPARα pathway leading to increased fatty acid oxidation.

  2011cites this paper
• Influence of atorvastatin on fractional and subfractional composition of serum lipoproteins and MMP activity in mice with Triton WR 1339‐induced lipaemia

  2011cites this paper
• Effects of simvastatin and 6-hydroxydopamine on histaminergic H1 receptor binding density in rat brains.

  2010cites this paper
• for resistance to Strong induction of PCSK9 gene expression through HNF1 (cid:2) and SREBP2: mechanism for the resistance to LDL-cholesterol lowering effect of statins in dyslipidemic hamsters

  2010cites this paper
• Clinical and genetic factors influencing cardiovascular risk in patients with familial hypercholesterolemia

  2010cites this paper
• Bedeutung des Organischen-Anionen-Transport-Polypeptides 2B1 für die Wirkung von Atorvastatin auf Herzmuskelzellen

  2010cites this paper
• Strong induction of PCSK9 gene expression through HNF1α and SREBP2: mechanism for the resistance to LDL-cholesterol lowering effect of statins in dyslipidemic hamsters

  2010cites this paper
• Effect of mevalonate biosynthesis inhibitor on some biochemical parameters during pregnancy in rats

  2009cites this paper
• Effect of cholesterol biosynthesis inhibitor on some biochemical parameters in normal male rats

  2009cites this paper
• Effects of atherogenic diet and atorvastatin treatment on gene expression profiles in the C57BL/6J mouse liver.

  2008cites this paper
• Atorvastatin effects on SREBF1a and SCAP gene expression in mononuclear cells and its relation with lowering-lipids response.

  2008cites this paper
• Statins as effectors of key activities involved in apoE-dependent VLDL metabolism: review and hypothesis.

  2008cites this paper
• Review article: diagnosis and treatment of non‐alcoholic fatty liver disease

  2008cites this paper
• Statins in non-alcoholic fatty liver disease and chronically elevated liver enzymes: a histopathological follow-up study.

  2007cites this paper
• Δ5 desaturase mRNA levels are increased by simvastatin via SREBP-1 at early stages, not via PPARα, in THP-1 cells

  2007cites this paper
• Delta5 desaturase mRNA levels are increased by simvastatin via SREBP-1 at early stages, not via PPARalpha, in THP-1 cells.

  2007cites this paper
• Roles of nuclear receptors in the up-regulation of hepatic cholesterol 7alpha-hydroxylase by cholestyramine in rats.

  2007cites this paper
• Effects of lipoprotein lipase and statins on cholesterol uptake into heart and skeletal muscles⃞ Published, JLR Papers in Press, December 22, 2006.

  2007cites this paper
• Statin therapy induces ultrastructural damage in skeletal muscle in patients without myalgia

  2006cites this paper
• Statins and hepatic steatosis: Perspectives from the Dallas Heart Study

  2006cites this paper
• Pleiotropic effects of statins and related pharmacological experimental approaches.

  2006cites this paper
• Effects of high dose of simvastatin on levels of dopamine and its reuptake in prefrontal cortex and striatum among SD rats.

  2006cites this paper
• Cholesterol uptake into heart and skeletal muscle of lipoprotein lipase transgenic mice : Evidence that statin therapy increases muscle lipid uptake

  2006cites this paper
• Tryptophan–NAD+ pathway metabolites as putative biomarkers and predictors of peroxisome proliferation

  2005influential citation
• Regulation of Fatty Acid Synthesis by Farnesyl Pyrophosphate*

  2005cites this paper
• High doses of simvastatin upregulate dopamine D1 and D2 receptor expression in the rat prefrontal cortex: possible involvement of endothelial nitric oxide synthase

  2005cites this paper
• Atorvastatin reverses age‐related reduction in rat hepatic PPARα and HNF‐4

  2005influential citation
• Atorvastatin reverses age-related reduction in rat hepatic PPARalpha and HNF-4.

  2005cites this paper
• Vascular Endothelial Growth Factor Activation of Sterol Regulatory Element Binding Protein: A Potential Role in Angiogenesis

  2004cites this paper
• Enzymes of triacylglycerol synthesis and their regulation.

  2004cites this paper