Ingenuity pathways analysis of urine metabonomics phenotypes toxicity of gentamicin in multiple organs.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Molecular Biosystems

• Publication date

  2010-10-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1039/c0mb00064gPMID 20714645
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Use of transcriptomics in understanding mechanisms of drug-induced toxicity.

  2010cited by this paper
• MetExplore: a web server to link metabolomic experiments and genome-scale metabolic networks

  2010cited by this paper
• Evaluation of the usefulness of urinary biomarkers for nephrotoxicity in rats.

  2010cited by this paper
• Assessment of candidate biomarkers of drug-induced hepatobiliary injury in preclinical toxicity studies.

  2010cited by this paper
• Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening.

  2010cited by this paper
• Urinary clusterin, cystatin C, β2-microglobulin and total protein as markers to detect drug-induced kidney injury

  2010cited by this paper
• A twenty eight-day repeated dose toxicity study of black soybean extract in Sprague-Dawley rats.

  2010cited by this paper
• Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular meshwork cells

  2009cited by this paper
• Metabolic Profiles in Urine Reflect Nephrotoxicity of Sirolimus and Cyclosporine following Rat Kidney Transplantation

  2009cited by this paper
• Discovery of Metabolomics Biomarkers for Early Detection of Nephrotoxicity

  2009cited by this paper
• Inhibitory effect of estrogens, phytoestrogens, and caloric restriction on oxidative stress and hepato-toxicity in aged rats.

  2009cited by this paper
• Differences in Immunolocalization of Kim-1, RPA-1, and RPA-2 in Kidneys of Gentamicin-, Cisplatin-, and Valproic Acid-Treated Rats: Potential Role of iNOS and Nitrotyrosine

  2009cited by this paper
• Comparative analysis of novel noninvasive renal biomarkers and metabonomic changes in a rat model of gentamicin nephrotoxicity.

  2009cited by this paper
• Atorvastatin Prevents Gentamicin-Induced Renal Damage in Rats through the Inhibition of p38-MAPK and NF-kB Pathways

  2009cited by this paper
• Prostaglandins and Other Lipid Mediators elecoxib exacerbates hepatic fibrosis and induces hepatocellular ecrosis in rats treated with porcine serum

  2009cited by this paper
• Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression

  2009cited by this paper
• Does nicotinic acid (niacin) lower blood pressure?

  2009cited by this paper
• Inhibition of cyclooxygenase-2 aggravates secretory phospholipase A2-mediated progression of acute liver injury.

  2008cited by this paper
• Metabolic urinary profiling of alcohol hepatotoxicity and intervention effects of Yin Chen Hao Tang in rats using ultra-performance liquid chromatography/electrospray ionization quadruple time-of-flight mass spectrometry.

  2008cited by this paper
• Biomarkers, metabonomics, and drug development: Can inborn errors of metabolism help in understanding drug toxicity?

  2007cited by this paper
• [Niacin in therapy].

  2007cited by this paper
• Integrated metabonomic analysis of bromobenzene-induced hepatotoxicity: novel induction of 5-oxoprolinosis.

  2006cited by this paper
• Metabonomic modeling of drug toxicity.

  2006cited by this paper
• Comparative metabonomics of differential hydrazine toxicity in the rat and mouse.

  2005cited by this paper
• Prediction of Nephrotoxicant Action and Identification of Candidate Toxicity-Related Biomarkers

  2005cited by this paper
• Metabonomic deconvolution of embedded toxicity: application to thioacetamide hepato- and nephrotoxicity.

  2005cited by this paper
• Endogenous ursodeoxycholic acid and cholic acid in liver disease due to cystic fibrosis

  2004cited by this paper
• Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis

  2004cited by this paper
• Use of metabonomics to identify impaired fatty acid metabolism as the mechanism of a drug-induced toxicity.

  2004cited by this paper
• Hepatotoxin-induced hypercreatinaemia and hypercreatinuria: their relationship to one another, to liver damage and to weakened nutritional status

  2004cited by this paper
• A role for superoxide in gentamicin-mediated nephropathy in rats.

  2002cited by this paper
• Results of a Prospective Study of Acute Liver Failure at 17 Tertiary Care Centers in the United States

  2002cited by this paper
• Gentamicin inhibits renal protein and phospholipid metabolism in rats: implications involving intracellular trafficking.

  2001cited by this paper
• Prostaglandin E2 protects against liver injury after Escherichia coli infection but hampers the resolution of the infection in mice.

  1998cited by this paper
• Urinary proton magnetic resonance studies of early ifosfamide-induced nephrotoxicity and encephalopathy.

  1997cited by this paper
• Evaluation of Liver Function by Co‐administration Methodology Using 13C‐Labelled Benzoic Acid and Hippuric Acid Coupled with Nuclear Magnetic Resonance Spectroscopy

  1997cited by this paper
• Use of urinary taurine and creatine as biomarkers of organ dysfunction and metabolic perturbations

  1995cited by this paper
• A study of the nephrotoxicity of three cephalosporins in rabbits using 1H NMR spectroscopy.

  1995cited by this paper
• Characterization of serum and urinary bile acids in patients with primary biliary cirrhosis by gas-liquid chromatography-mass spectrometry: effect of ursodeoxycholic acid treatment.

  1989cited by this paper
• Comparison of cyclosporine nephrotoxicity with aminoglycoside nephrotoxicity.

  1986cited by this paper
• Comparison of cyclosporine nephrotoxicity with aminoglycoside nephrotoxicity.

  1986cited by this paper
• Bemerkungen zu dem Aufsatze der Amsterdammer Chemiker über das vorgebliche kohligsaure Gas

  year unknowncited by this paper
• Ueber künstliche Bildung des Harnstoffs

  year unknowncited by this paper

• NPC1L1 on pancreatic adenocarcinoma cell functions as a two-pronged checkpoint against antitumor activity

  2025cites this paper
• Current trends in nanomaterials-mediated biosensing platforms and signal amplification strategies for antibiotics detection in dairy products

  2024cites this paper
• The protective capability of Hedyotis diffusa Willd on lupus nephritis by attenuating the IL-17 expression in MRL/lpr mice

  2022cites this paper
• The anti-inflammatory effects of Hedyotis diffusa Willd on SLE with STAT3 as a key target.

  2022cites this paper
• NMR-Based Metabolomics

  2021cites this paper
• Adaptive ordering and filament polymerization of cell cytoskeleton by tunable nanoarrays

  2020cites this paper
• Long non-coding RNA expression profiles and related regulatory networks in areca nut chewing-induced tongue squamous cell carcinoma.

  2020cites this paper
• Metabolomics in pharmacology - a delve into the novel field of pharmacometabolomics

  2020cites this paper
• Bioinformatics for differential proteomics data between triple-negative breast cancer and luminal A subtype breast cancer

  2020cites this paper
• Heterogeneity of luminal A and HER2-positive breast cancer based on DIA quantitative proteomics and bioinformatics analysis techniques

  2020cites this paper
• Mass spectrometry based targeted metabolomics precisely characterized new functional metabolites that regulate biofilm formation in Escherichia coli.

  2020cites this paper
• Lipid metabolic signatures deviate in sepsis survivors compared to non-survivors

  2020cites this paper
• UHPLC/MS based large-scale targeted metabolomics method for multiple-biological matrix assay

  2019cites this paper
• CADM1 inhibits ovarian cancer cell proliferation and migration by potentially regulating the PI3K/Akt/mTOR pathway.

  2019cites this paper
• Precision-targeted metabolomics method characterizes differential metabolomes in multiple-biological matrixes and cell-mitochondria

  2019cites this paper
• A REVIEW ON METABOLOME ANALYSIS

  2018cites this paper
• Regulation of Cellular Senescence by miR-34a in Alcoholic Liver Injury.

  2017cites this paper
• Prolonged exposure to low-dose microcystin induces nonalcoholic steatohepatitis in mice: a systems toxicology study

  2016cites this paper
• THE USE OF CLINICAL PHARMACOKINETICS IN THE DESIGN AND CONTROL OF MEDICAL PRESCRIPTION

  2016cites this paper
• A quinazoline-based HDAC inhibitor affects gene expression pathways involved in cholesterol biosynthesis and mevalonate in prostate cancer cells.

  2016cites this paper
• Urinary metabolomics and biomarkers of aristolochic acid nephrotoxicity by UPLC-QTOF/HDMS.

  2015cites this paper
• Toxic effects of gentamicin in the third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ)Bg9

  2014cites this paper
• Metabolomics in nephrotoxicity.

  2014cites this paper
• EGR1 decreases the malignancy of human non-small cell lung carcinoma by regulating KRT18 expression

  2014cites this paper
• The Transcriptional Profiling of Glycogenes Associated with Hepatocellular Carcinoma Metastasis

  2014cites this paper
• Modulation of Epigenetic regulation as a novel mechanism in antiinflammatory and anticancer drugs

  2014cites this paper
• From -omics to personalized medicine in nephrology: integration is the key.

  2013cites this paper
• Metabolomics in neonatology: fact or fiction?

  2013cites this paper
• MS-based metabolomics facilitates the discovery of in vivo functional small molecules with a diversity of biological contexts.

  2013cites this paper
• Serum metabonomics coupled with Ingenuity Pathway Analysis characterizes metabolic perturbations in response to hypothyroidism induced by propylthiouracil in rats.

  2013cites this paper
• Metabolite profiling of astilbin in rat sera using UPLC/MS(E) and impact of its metabolites on immunosuppressive activity.

  2013cites this paper
• Mass spectrometry-based metabolomics towards understanding of gene functions with a diversity of biological contexts.

  2013cites this paper
• Discovery of early urinary biomarkers in preclinical study of gentamicin-induced kidney injury and recovery in rats

  2012cites this paper
• Metabonomics for discovering biomarkers of hepatotoxicity and nephrotoxicity.

  2012cites this paper
• Hepatic injury to the newborn liver due to drugs.

  2012cites this paper
• A developmental approach to drug-induced liver injury in newborns and children.

  2012cites this paper
• Modern analytical techniques in metabolomics analysis.

  2012cites this paper
• Urinary metabolomics in newborns and infants.

  2012cites this paper
• Apolipoprotein A-I mimetic peptide inhibits atherosclerosis by altering plasma metabolites in hypercholesterolemia.

  2012influential citation
• Pharma-metabolomics in neonatology: is it a dream or a fact?

  2012cites this paper
• Clinicopathological studies on gentamicin toxicity in White Leghorn commercial layers.

  2011cites this paper
• Controlled drug release characteristics and enhanced antibacterial effect of graphene nanosheets containing gentamicin sulfate.

  2011cites this paper
• Pubertal mouse mammary gland development - transcriptome analysis and the investigation of Fbln2 expression and function

  2011cites this paper
• Ultra-performance liquid chromatography coupled to mass spectrometry as a sensitive and powerful technology for metabolomic studies.

  2011cites this paper