Decreased hepatic insulin extraction precedes overt noninsulin dependent (Type II) diabetes in obese monkeys.

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Obesity Research

• Publication date

  1993-07-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1002/J.1550-8528.1993.TB00619.XPMID 16353355
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Beta-cell hyperresponsiveness: earliest event in development of diabetes in monkeys.

  1990cited by this paper
• Hepatic glucose production and insulin sensitivity preceding diabetes in monkeys.

  1989cited by this paper
• Glucose disappearance rate in rhesus monkeys: Some technical considerations

  1988cited by this paper
• Quantitative study of insulin secretion and clearance in normal and obese subjects.

  1988cited by this paper
• Insulin Secretion and Clearance: Comparison After Oral and Intravenous Glucose

  1987cited by this paper
• The kinetics of insulin in man. II. Role of the liver.

  1987cited by this paper
• In vivo kinetics of insulin action on peripheral glucose disposal and hepatic glucose output in normal and obese subjects.

  1986cited by this paper
• Current approaches to measurement of insulin secretion.

  1986cited by this paper
• Splanchnic insulin metabolism in obesity. Influence of body fat distribution.

  1986cited by this paper
• Heterogeneity of insulin responses: phases leading to Type 2 (non-insulin-dependent) diabetes mellitus in the rhesus monkey

  1986cited by this paper
• Peripheral hyperinsulinemia of simple obesity: pancreatic hypersecretion or impaired insulin metabolism?

  1984cited by this paper
• C-Peptide as a Measure of the Secretion and Hepatic Extraction of Insulin: Pitfalls and Limitations

  1984cited by this paper
• Hepatic extraction of exogenous insulin in depancreatized conscious dogs.

  1984cited by this paper
• Assessment of insulin resistance and its role in non-insulin-dependent diabetes mellitus.

  1984cited by this paper
• Hepatic disposal of biosynthetic human insulin and porcine C-peptide in humans.

  1984cited by this paper
• Differences in the hepatic and renal extraction of insulin and glucagon in the dog: evidence for saturability of insulin metabolism.

  1983cited by this paper
• Hyperinsulinemia of obesity is due to decreased clearance of insulin.

  1983cited by this paper
• Reduced hepatic insulin extraction in obesity: relationship with plasma insulin levels.

  1983cited by this paper
• Hepatic removal of insulin in normal man: dose response to endogenous insulin secretion.

  1983cited by this paper
• Feedback inhibition by biosynthetic human insulin of insulin release in healthy human subjects.

  1982cited by this paper
• Influence of Age on Clearance of Insulin in Man

  1982cited by this paper
• Rapid oscillations in plasma insulin, glucagon, and glucose in obese and normal weight humans.

  1982cited by this paper
• Decreased insulin removal contributes to hyperinsulinemia in obesity.

  1981cited by this paper
• Insulin metabolism and degradation.

  1981cited by this paper
• Prolongation of insulin removal by perfused liver from spontaneously obese rats

  1979cited by this paper
• C-Peptide and insulin secretion in Pima Indians and Caucasians: constant fractional hepatic extraction over a wide range of insulin concentrations and in obesity.

  1979cited by this paper
• Cyclic oscillations of basal plasma glucose and insulin concentrations in human beings.

  1979cited by this paper
• Hyperinsulinemia in obesity syndromes: its metabolic consequences and possible etiology.

  1978cited by this paper
• Insulin and obesity 1

  1978cited by this paper
• Determination of Free and Total Insulin and C-Peptide in Insulin-treated Diabetics

  1977cited by this paper
• Insulin, glucagon, and glucose exhibit synchronous, sustained oscillations in fasting monkeys.

  1977cited by this paper
• A comparative study on the metabolism of human insulin and porcine proinsulin in man.

  1973cited by this paper
• The significance of basal insulin levels in the evaluation of the insulin response to glucose in diabetic and nondiabetic subjects.

  1967cited by this paper
• Immunoassay of Insulin: Two Antibody System: Plasma Insulin Levels of Normal, Subdiabetic and Diabetic Rats

  1963cited by this paper
• Studies on body composition; use of radioactive hydrogen for measurement in vivo of total body water.

  1947cited by this paper

• Insulin Clearance in Health and Disease.

  2022cites this paper
• Regulation of Insulin Clearance by Non-Esterified Fatty Acids

  2022cites this paper
• HIF-1α inhibitor PX-478 preserves pancreatic β cell function in diabetes

  2022cites this paper
• Assessment of Insulin Secretion and Insulin Resistance in Human

  2021cites this paper
• Glucocorticoid treatment facilitates development of a metabolic syndrome in ovariectomized Macaca Mulatta fed a high fat diet

  2017cites this paper
• Phenotyping of adipose, liver, and skeletal muscle insulin resistance and response to pioglitazone in spontaneously obese rhesus monkeys.

  2017cites this paper
• Hyperinsulinemia caused by dexamethasone treatment is associated with reduced insulin clearance and lower hepatic activity of insulin-degrading enzyme.

  2016cites this paper
• Endurance Training Inhibits Insulin Clearance and IDE Expression in Swiss Mice

  2015cites this paper
• Assessment of β-Cell Function

  2015cites this paper
• Pioglitazone Increases Whole Body Insulin Sensitivity in Obese, Insulin-Resistant Rhesus Monkeys

  2015cites this paper
• High-fat diet combined with low-dose streptozotocin injections induces metabolic syndrome in Macaca mulatta

  2015cites this paper
• Animal Models of Obesity: Nonhuman Primates

  2014cites this paper
• Quantification of β-cell insulin secretory function using a graded glucose infusion with C-peptide deconvolution in dysmetabolic, and diabetic cynomolgus monkeys

  2013cites this paper
• Ciliary neurotrophic factor (CNTF) protects non-obese Swiss mice against type 2 diabetes by increasing beta cell mass and reducing insulin clearance

  2012cites this paper
• Effects of aleglitazar, a balanced dual peroxisome proliferator-activated receptor α/γ agonist on glycemic and lipid parameters in a primate model of the metabolic syndrome

  2011cites this paper
• Reduction of Hepatic CEACAM1 Levels: an Early Mechanism of Insulin Resistance Induced by High-Fat Diet

  2008cites this paper
• Causes of Obesity and Consequences of Obesity Prevention in Non-human Primates and Other Animal Models

  2002cites this paper
• Lack of defect in insulin action on hepatic glycogen synthase and phosphorylase in insulin-resistant monkeys

  1998cites this paper
• Lack of defect in insulin action on hepatic glycogen synthase and phosphorylase in insulin-resistant monkeys.

  1998cites this paper
• O R I G I N a L I N V E S T I G a T I O N Open Access

  year unknowncites this paper