Efficiency Alleles of the Pctr1 Modifier Locus for Plasmacytoma Susceptibility

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Molecular and Cellular Biology

• Publication date

  2001-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.21.1.310-318.2001PMID 11113205PMCID PMC88804
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Retinoblastoma Protein and Cell Cycle Control Review

  2004cited by this paper
• Molecular Cloning: A Laboratory Manual

  2001cited by this paper
• A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

  2000cited by this paper
• Clonal diversification of primary BALB/c plasmacytomas harboring T(12;15) chromosomal translocations

  2000cited by this paper
• Analysis of point mutation in exon 2 of CYP2E1 gene in renal cell/urothelial cancer patients in comparison with control population.

  2000cited by this paper
• Germline CDKN2A mutation implicated in predisposition to multiple myeloma.

  2000cited by this paper
• Association of the alpha-fibrinogen Thr312Ala polymorphism with poststroke mortality in subjects with atrial fibrillation.

  1999cited by this paper
• Somatic ATM mutations indicate a pathogenic role of ATM in B-cell chronic lymphocytic leukemia.

  1999cited by this paper
• A possible hot spot in exon 21 of the retinoblastoma gene predisposing to a low penetrant retinoblastoma phenotype?

  1999cited by this paper
• P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2.

  1999cited by this paper
• Analysis of Cell-Cycle Profiles in Transfected Cells Using a Membrane-Targeted GFP

  1999cited by this paper
• Molecular analysis of the APC gene in 205 families: extended genotype-phenotype correlations in FAP and evidence for the role of APC amino acid changes in colorectal cancer predisposition

  1999cited by this paper
• Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53.

  1999cited by this paper
• Analysis of the hereditary pancreatitis-associated cationic trypsinogen gene mutations in exons 2 and 3 by enzymatic mutation detection from a single 2.2-kb polymerase chain reaction product.

  1999cited by this paper
• Drug-induced apoptosis is delayed and reduced in XPD lymphoblastoid cell lines: possible role of TFIIH in p53-mediated apoptotic cell death

  1999cited by this paper
• ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways.

  1998cited by this paper
• p16/INK4a and p15/INK4b gene methylation and absence of p16/INK4a mRNA and protein expression in Burkitt's lymphoma.

  1998cited by this paper
• Cdkn2a, the cyclin-dependent kinase inhibitor encoding p16INK4a and p19ARF, is a candidate for the plasmacytoma susceptibility locus, Pctr1.

  1998cited by this paper
• p14ARF links the tumour suppressors RB and p53

  1998cited by this paper
• Analysis of cell-cycle profiles in transfected cells using a membrane-targeted GFP.

  1998cited by this paper
• Cdkn 2 a , the cyclin-dependent kinase inhibitor encoding p 16 INK 4 a and p 19 ARF , is a candidate for the plasmacytoma susceptibility locus , Pctr 1

  1998cited by this paper
• The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53.

  1998cited by this paper
• Toward an understanding of the functional complexity of the E2F and retinoblastoma families.

  1998cited by this paper
• Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia–lymphoma cells

  1998cited by this paper
• The plasmacytoma resistance gene, Pctr2, delays the onset of tumorigenesis and resides in the telomeric region of chromosome 4.

  1997cited by this paper
• IL-6 triggers cell growth via the Ras-dependent mitogen-activated protein kinase cascade.

  1997cited by this paper
• Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame

  1997cited by this paper
• Analysis of the p16INK4A, p15INK4B and p18INK4C genes in multiple myeloma

  1997cited by this paper
• Frequent hypermethylation of p16 and p15 genes in multiple myeloma.

  1997cited by this paper
• Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF.

  1997cited by this paper
• Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis

  1997cited by this paper
• Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF.

  1997cited by this paper
• p16ink4a gene and hematological malignancies.

  1996cited by this paper
• Role of the INK4a locus in tumor suppression and cell mortality.

  1996cited by this paper
• Interleukin‐6 induces tyrosine phosphorylation of the Ras activating protein Shc, and its complex formation with Grb2 in the human multiple myeloma cell line LP‐1

  1996cited by this paper
• An Acute Phase Response Factor/NF-B Site Downstream of the junB Gene That Mediates Responsiveness to Interleukin-6 in a Murine Plasmacytoma (*)

  1995cited by this paper
• The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia.

  1995influential reference
• Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest.

  1995cited by this paper
• Nonrandom chromosomal change (trisomy 11) in murine plasmacytomas induced by an ABL-MYC retrovirus.

  1995cited by this paper
• Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition

  1995cited by this paper
• The retinoblastoma protein and cell cycle control.

  1995cited by this paper
• p16INK4A and p15INK4B gene deletions in primary leukemias.

  1995influential reference
• Identification of two genes on chromosome 4 that determine resistance to plasmacytoma induction in mice.

  1994cited by this paper
• Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse.

  1993influential reference
• Genetic mapping of tumor susceptibility genes involved in mouse plasmacytomagenesis.

  1993cited by this paper
• Elevation of interleukin-6 in response to a chronic inflammatory stimulus in mice: inhibition by indomethacin.

  1992influential reference
• The bovine papillomavirus E5 oncogene can cooperate with ras: identification of p21 amino acids critical for transformation by c-rasH but not v-rasH

  1991cited by this paper
• Site-directed mutagenesis by overlap extension using the polymerase chain reaction.

  1989cited by this paper
• Rapid induction of IgM-secreting murine plasmacytomas by pristane and an immunoglobulin heavy-chain promoter/enhancer-driven c-myc/v-Ha-ras retrovirus.

  1988cited by this paper
• The genetics of susceptibility to RIM-induced plasmacytomagenesis.

  1988cited by this paper
• Development of plasma-cell neoplasms in BALB/c mice after intraperitoneal injection of paraffin-oil adjuvant, heart-killed Staphylococcus mixtures.

  1960influential reference

• Drug combinations identified by high-throughput screening promote cell cycle transition and upregulate Smad pathways in myeloma.

  2023cites this paper
• Pla2g2a promotes innate Th2-type immunity lymphocytes to increase B1a cells

  2022cites this paper
• Laboratory Mice – A Driving Force in Immunopathology and Immunotherapy Studies of Human Multiple Myeloma

  2021cites this paper
• Conditional deletion of mTOR discloses its essential role in early B‐cell development

  2021cites this paper
• Genetic modifiers regulating DNA replication and double strand break repair are associated with differences in mammary tumors in mouse models of Li-Fraumeni Syndrome

  2021cites this paper
• Mouse tumor susceptibility genes identify drug combinations for multiple myeloma

  2020cites this paper
• Differences in T regulatory cells between mouse strains frequently used in immunological research: Treg cell quantities and subpopulations in NOD, B6 and BALB/c mice.

  2020cites this paper
• Experimental model systems for preclinical research on Waldenström macroglobulinemia

  2019cites this paper
• Activated gp130 signaling selectively targets B cell differentiation to induce mature lymphoma and plasmacytoma.

  2019cites this paper
• A Polymorphic Variant in p19Arf Confers Resistance to Chemically Induced Skin Tumors by Activating the p53 Pathway.

  2019cites this paper
• The transcription factor MZF1 differentially regulates murine Mtor promoter variants linked to tumor susceptibility

  2019cites this paper
• This information is current as like Neoplasia in Aged Mice − Cell Lymphoma the Capacity To Progress To Become Mantle Derived B Cells Have − Early Generated B-1

  2018cites this paper
• Early Generated B-1–Derived B Cells Have the Capacity To Progress To Become Mantle Cell Lymphoma–like Neoplasia in Aged Mice

  2018cites this paper
• Opposing impact of AID deficiency on BCL-2 and IL-6 driven B-lymphoma development in BALB/c mice

  2017cites this paper
• Canine Mammary Carcinomas: A Comparative Analysis of Altered Gene Expression

  2015cites this paper
• TORC1 and class I HDAC inhibitors synergize to suppress mature B cell neoplasms

  2014cites this paper
• Altered Expression Profiles and Defects in a Group of Cell Cycle Regulators and Tumor Suppressor Genes (INK4) and Evaluation of Comprehensive Expression Profiles of Canine miRNAs in Spontaneous Canine Breast Cancer Models

  2014cites this paper
• Preclinical validation of interleukin 6 as a therapeutic target in multiple myeloma

  2014cites this paper
• Preclinical validation of interleukin 6 as a therapeutic target in multiple myeloma

  2014cites this paper
• Waldenström Macroglobulinemia: Clinical and Immunological Aspects, Natural History, Cell of Origin, and Emerging Mouse Models

  2013cites this paper
• A novel rapid-onset high-penetrance plasmacytoma mouse model driven by deregulation of cMYC cooperating with KRAS12V in BALB/c mice

  2013cites this paper
• S-Driven Pancreatic Cancer

  2010cites this paper
• Identification of susceptibility loci in a mouse model of KRASG12D-driven pancreatic cancer.

  2010cites this paper
• Cancer esearch cular and Cellular Pathobiology tification of Susceptibility Loci in a Mouse Model of R SG 12 D-Driven Pancreatic Cancer

  2010cites this paper
• Genetic Determinants of Cancer Susceptibility

  2010cites this paper
• Features of Plasma Cell-Related Neoplasms in Mice

  2010cites this paper
• Two Loci Controlling Susceptibility to Radiation-Induced Lymphomagenesis on Mouse Chromosome 4: Cdkn2a, a Candidate for One Locus, and a Novel Locus Distinct from Cdkn2a

  2010cites this paper
• Mndal, a new interferon-inducible family member, is highly polymorphic, suppresses cell growth, and may modify plasmacytoma susceptibility.

  2009cites this paper
• Modeling INK4/ARF tumor suppression in the mouse.

  2007cites this paper
• Target cell frequency is a genetically determined risk factor in radiation leukaemogenesis.

  2007cites this paper
• Mouse models of human myeloma.

  2007cites this paper
• Methylation and expression of the p16INK4A tumor suppressor gene in multiple myeloma.

  2007cites this paper
• Paradoxical expression of INK4c in proliferative multiple myeloma tumors: bi-allelic deletion vs increased expression

  2006cites this paper
• Multilocus inheritance determines predisposition to α‐radiation induced bone tumourigenesis in mice

  2006cites this paper
• Hepatocellular carcinoma as a complex polygenic disease. Interpretive analysis of recent developments on genetic predisposition.

  2006cites this paper
• Myc translocations in B cell and plasma cell neoplasms.

  2006cites this paper
• Insertion of Myc into Igh accelerates peritoneal plasmacytomas in mice.

  2005cites this paper
• Strategies for mapping and cloning quantitative trait genes in rodents

  2005cites this paper
• Defining the oncogenic function of the TEL/AML1 (ETV6/RUNX1) fusion protein in a mouse model

  2005cites this paper
• Biology of plasma cells.

  2005cites this paper
• Heterogeneous tumor evolution initiated by loss of pRb function in a preclinical prostate cancer model.

  2005cites this paper
• c-Myc rapidly induces acute myeloid leukemia in mice without evidence of lymphoma-associated antiapoptotic mutations.

  2005cites this paper
• Cell cycle in mouse development

  2005cites this paper
• INK4a/ARF: a multifunctional tumor suppressor locus.

  2005cites this paper
• Molecular regulation of angiogenesis and tumorigenesis by signal transduction pathways: evidence of predictable and reproducible patterns of synergy in diverse neoplasms.

  2004cites this paper
• Genetic mapping of a Ptch1-associated rhabdomyosarcoma susceptibility locus on mouse chromosome 2.

  2004cites this paper
• CHAPTER 24 – Classification and Characteristics of Mouse B Cell—Lineage Lymphomas

  2004cites this paper
• Selenium deficiency abrogates inflammation-dependent plasma cell tumors in mice.

  2004cites this paper
• Loss of CCAAT/enhancer binding protein δ promotes chromosomal instability

  2004cites this paper
• p16Ink4a Interferes with Abelson Virus Transformation by Enhancing Apoptosis

  2004cites this paper
• Susceptibility to neoplastic and non-neoplastic pulmonary diseases in mice: genetic similarities.

  2004cites this paper
• Moderate Hypermutability of a Transgenic lacZ Reporter Gene in Myc-Dependent Inflammation-Induced Plasma Cell Tumors in Mice

  2004cites this paper
• Ink 4 a Interferes with Abelson Virus Transformation by Enhancing Apoptosis

  2004cites this paper
• Loss of CCAAT/enhancer binding protein delta promotes chromosomal instability.

  2004cites this paper
• Genetics and Cytogenetics of Multiple Myeloma

  2004cites this paper
• Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging.

  2004cites this paper
• Novel targeted deregulation of c-Myc cooperates with Bcl-X(L) to cause plasma cell neoplasms in mice.

  2004influential citation
• Genetics and Cytogenetics of Multiple Myeloma: A Workshop Report

  2004cites this paper
• Comparison of mammary gland involution between 129S1 and C57BL/6 inbred mouse strains: differential regulation of Bcl2a1, Trp53, Cebpb, and Cebpd expression

  2004cites this paper
• Consistent inactivation of p19Arf but not p15Ink4b in murine myeloid cells transformed in vivo by deregulated c-Myc

  2003cites this paper
• p16INK4a gene promoter variation and differential binding of a repressor, the ras-responsive zinc-finger transcription factor, RREB

  2003cites this paper
• Frap, FKBP12 rapamycin-associated protein, is a candidate gene for the plasmacytoma resistance locus Pctr2 and can act as a tumor suppressor gene

  2003cites this paper
• 10 years of mouse cancer modifier loci: human relevance.

  2003cites this paper
• Review 10 Years of Mouse Cancer Modifier Loci : Human Relevance 1

  2003cites this paper
• BCL2 accelerates inflammation-induced BALB/c plasmacytomas and promotes novel tumors with coexisting T(12;15) and T(6;15) translocations.

  2003cites this paper
• B lymphoid neoplasms of mice: characteristics of naturally occurring and engineered diseases and relationships to human disorders.

  2003cites this paper
• Genomic approaches to identification of tumour-susceptibility genes using mouse models.

  2003cites this paper
• Neoplastic development in plasma cells

  2003cites this paper
• The latent membrane protein 1 of Epstein-Barr virus and loss of the INK4a locus: paradoxes resolve to cooperation in carcinogenesis in vivo.

  2003cites this paper
• Cell‐cycle control of plasma cell differentiation and tumorigenesis

  2003cites this paper
• BALB/c alleles for Prkdc and Cdkn2a interact to modify tumor susceptibility in Trp53+/- mice.

  2003cites this paper
• Tumor modifier genes

  2002cites this paper
• Role of genetic and epigenetic changes in Burkitt lymphoma.

  2002cites this paper
• From QTL to gene: the harvest begins

  2002cites this paper
• Obligate Roles for p16Ink4a and p19Arf-p53 in the Suppression of Murine Pancreatic Neoplasia

  2002cites this paper
• IL-6 transgenic mouse model for extraosseous plasmacytoma

  2002cites this paper
• Tlag2, an N‐methyl‐N‐nitrosourea susceptibility locus, maps to mouse chromosome 4

  2002cites this paper
• Understanding the human condition: experimental strategies in mammalian genetics.

  2002cites this paper
• Positron emission tomography imaging analysis of G2A as a negative modifier of lymphoid leukemogenesis initiated by the BCR-ABL oncogene.

  2002cites this paper
• Multiple myeloma: evolving genetic events and host interactions

  2002cites this paper
• A new locus for resistance to γ-radiation-induced thymic lymphoma identified using inter-specific consomic and inter-specific recombinant congenic strains of mice

  2002cites this paper
• Cancer as a complex genetic trait: tumor susceptibility in humans and mouse models.

  2002cites this paper
• A strong candidate gene for the Papg1 locus on mouse chromosome 4 affecting lung tumor progression

  2002influential citation
• p14ARF homozygous deletion or MDM2 overexpression in Burkitt lymphoma lines carrying wild type p53

  2001cites this paper
• Non-Hodgkin lymphomas of mice.

  2001cites this paper
• Deregulated c-Myb expression in murine myeloid leukemias prevents the up-regulation of p15INK4b normally associated with differentiation

  2001influential citation
• Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

  2001cites this paper