Selection of Similar Naive T Cell Repertoires but Induction of Distinct T Cell Responses by Native and Modified Antigen1

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Journal of Immunology

• Publication date

  2004-03-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.172.6.3447PMID 15004144
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Costimulation via OX40L Expressed by B Cells Is Sufficient to Determine the Extent of Primary CD4 Cell Expansion and Th2 Cytokine Secretion In Vivo

  2003cited by this paper
• Gene gun-based co-immunization of merozoite surface protein-1 cDNA with IL-12 expression plasmid confers protection against lethal Plasmodium yoelii in A/J mice.

  2003cited by this paper
• CDR3 loop flexibility contributes to the degeneracy of TCR recognition

  2003cited by this paper
• T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens

  2002cited by this paper
• Chronic Soluble Antigen Sensitization Primes a Unique Memory/Effector T Cell Repertoire Associated with Th2 Phenotype Acquisition In Vivo1

  2002cited by this paper
• The Biological Outcome of CD40 Signaling Is Dependent on the Duration of CD40 Ligand Expression

  2002cited by this paper
• Tracking T cell clonotypes in complex T lymphocyte populations by real-time quantitative PCR using fluorogenic complementarity-determining region-3-specific probes.

  2002cited by this paper
• Antigen Specific Immunotherapy of Multiple Sclerosis

  2001cited by this paper
• A T Cell Clone’s Avidity Is a Function of Its Activation State1

  2001cited by this paper
• Increased TCR avidity after T cell activation: a mechanism for sensing low-density antigen.

  2001cited by this paper
• CD4‐independent T cells impair TCR triggering of CD4‐dependent T cells: a putative mechanism for T cell affinity maturation

  2001cited by this paper
• The molecular basis of T helper 1 and T helper 2 cell differentiation.

  2000cited by this paper
• Transcriptional regulation of Th1/Th2 polarization.

  2000cited by this paper
• T Cell Receptor Complementarity Determining Region 3 Length Analysis Reveals the Absence of a Characteristic Public T Cell Repertoire in Neonatal Tolerance

  2000cited by this paper
• Selective activation and expansion of high-affinity CD4+ T cells in resistant mice upon infection with Leishmania major.

  2000cited by this paper
• Interleukin 4–Producing Cd4 T Cells Arise from Different Precursors Depending on the Conditions of Antigen Exposure in Vivo

  2000cited by this paper
• Modulation of Th2 Responses by Peptide Analogues in a Murine Model of Allergic Asthma: Amelioration or Deterioration of the Disease Process Depends on the Th1 or Th2 Skewing Characteristics of the Therapeutic Peptide1

  2000cited by this paper
• Processing and Reactivity of T Cell Epitopes Containing Two Cysteine Residues from Hen Egg-White Lysozyme (HEL74–90)1

  2000cited by this paper
• Site of antigen delivery can influence T cell priming: pulmonary environment promotes preferential Th2‐type differentiation

  2000cited by this paper
• The interplay between the duration of TCR and cytokine signaling determines T cell polarization

  1999cited by this paper
• T lymphocyte costimulation mediated by reorganization of membrane microdomains.

  1999cited by this paper
• CD8α+ and CD8α− Subclasses of Dendritic Cells Direct the Development of Distinct T Helper Cells In Vivo

  1999cited by this paper
• Distinct dendritic cell subsets differentially regulate the class of immune response in vivo.

  1999cited by this paper
• Adjuvant-guided type-1 and type-2 immunity: infectious/noninfectious dichotomy defines the class of response.

  1999cited by this paper
• Modulation of T cell cytokine profiles and peptide-MHC complex availability in vivo by delivery to scavenger receptors via antigen maleylation.

  1998influential reference
• Th1 cells induce and Th2 inhibit antigen‐dependent IL‐12 secretion by dendritic cells

  1998cited by this paper
• Normal B cells fail to secrete interleukin‐12

  1997cited by this paper
• Functional rafts in cell membranes

  1997cited by this paper
• Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches.

  1997cited by this paper
• The mode of protein antigen administration determines preferential presentation of peptide-class II complexes by lymph node dendritic or B cells.

  1997cited by this paper
• B cells solicit their own help from T cells

  1996cited by this paper
• Selective development of T helper (Th)2 cells induced by continuous administration of low dose soluble proteins to normal and beta(2)- microglobulin-deficient BALB/c mice

  1996cited by this paper
• Functional diversity of helper T lymphocytes

  1996cited by this paper
• Naive and effector CD4 T cells differ in their requirements for T cell receptor versus costimulatory signals.

  1996cited by this paper
• Dendritic cells but not B cells present antigenic complexes to class II- restricted T cells after administration of protein in adjuvant

  1996cited by this paper
• The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model

  1995cited by this paper
• Successful T cell priming in B cell-deficient mice

  1995cited by this paper
• T cell genetic background determines default T helper phenotype development in vitro

  1995cited by this paper
• Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells

  1995cited by this paper
• Major histocompatibility complex binding affinity of an antigenic determinant is crucial for the differential secretion of interleukin 4/5 or interferon gamma by T cells.

  1995cited by this paper
• IL-12 enhances vaccine-induced immunity to Schistosoma mansoni in mice and decreases T helper 2 cytokine expression, IgE production, and tissue eosinophilia.

  1995cited by this paper
• Constitutive presentation of dominant epitopes from endogenous naturally processed self-beta 2-microglobulin to class II-restricted T cells leads to self-tolerance.

  1995cited by this paper
• Role of antigen‐presenting cells in the polarized development of helper T cell subsets: evidence for differential cytokine production by Th0 cells in response to antigen presentation by B cells and macrophages

  1994cited by this paper
• Interferon‐γ‐ and interleukin‐4‐producing T cells can be primed on dendritic cells in vivo and do not require the presence of B cells

  1994cited by this paper
• Public and private V beta T cell receptor repertoires against hen egg white lysozyme (HEL) in nontransgenic versus HEL transgenic mice

  1994cited by this paper
• Vaccination of the Leishmania major susceptible BALB/c mouse. I. The precise selection of peptide determinant influences CD4+ T cell subset expression.

  1994cited by this paper
• Interferon-gamma- and interleukin-4-producing T cells can be primed on dendritic cells in vivo and do not require the presence of B cells.

  1994cited by this paper
• Chemically modified antigen preferentially elicits induction of Th1- like cytokine synthesis patterns in vivo

  1993cited by this paper
• Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production.

  1991cited by this paper
• Interaction of an immunodominant epitope with Ia molecules in T-cell activation.

  1988cited by this paper
• Epitope specificity of the T cell proliferative response to lysozyme: proliferative T cells react predominantly to different determinants from those recognized by B cells

  1980influential reference
• Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine.

  1969cited by this paper

• Liposome-based nanoparticles impact on regulatory and effector phenotypes of macrophages and T cells in multiple Sclerosis patients.

  2023cites this paper
• Restricted T-Cell Repertoire in the Epicardial Adipose Tissue of Non-ST Segment Elevation Myocardial Infarction Patients

  2022cites this paper
• Haemophilus parasuis (Glaesserella parasuis) as a Potential Driver of Molecular Mimicry and Inflammation in Rheumatoid Arthritis

  2021cites this paper
• Selective Inhibitors of T Cell Receptor Recognition of Antigen-MHC Complexes for Rheumatoid Arthritis.

  2019cites this paper
• PIF* promotes brain re-myelination locally while regulating systemic inflammation- clinically relevant multiple sclerosis M.smegmatis model

  2017cites this paper
• T cell repertoire in DQ5-positive MuSK-positive myasthenia gravis patients.

  2014cites this paper
• M tuberculosis in the Adjuvant Modulates Time of Appearance of CNS-Specific Effector T Cells in the Spleen through a Polymorphic Site of TLR2

  2013cites this paper
• and Limits of Its Therapeutic Efficacy Latent Low-Avidity T Cells: Potential Antibody Response and Reveals Regulatory T Cell Deletion Enhances Erbb2 DNA Vaccine Combined with

  2010cites this paper
• Erbb2 DNA Vaccine Combined with Regulatory T Cell Deletion Enhances Antibody Response and Reveals Latent Low-Avidity T Cells: Potential and Limits of Its Therapeutic Efficacy

  2010cites this paper
• Its Therapeutic Efficacy Low-Avidity T Cells: Potential and Limits of Antibody Response and Reveals Latent Regulatory T Cell Deletion Enhances Erbb2 DNA Vaccine Combined with

  2010cites this paper
• Surface Expression of MPT64 as a Fusion with the PE Domain of PE_PGRS33 Enhances Mycobacterium bovis BCG Protective Activity against Mycobacterium tuberculosis in Mice

  2010cites this paper
• This Antigen Spontaneously Responsive In Vitro to T Cells Distinct from Those Primes 139151 Administration of PLP

  2010cites this paper
• Encephalomyelitis Experimental Autoimmune Response and Induces a Relapsing T Cell Repertoire Favoring a CD 8-Mediated 151 Reorganizes the PLP-Specific − ( PLP ) 139 Chimeric Protein MPT 64-Proteolipid Protein Expressing a Mycobacterium smegmatis

  2009cites this paper
• Mycobacterium smegmatis Expressing a Chimeric Protein MPT64-Proteolipid Protein (PLP) 139–151 Reorganizes the PLP-Specific T Cell Repertoire Favoring a CD8-Mediated Response and Induces a Relapsing Experimental Autoimmune Encephalomyelitis

  2009cites this paper
• Administration of PLP139–151 Primes T Cells Distinct from Those Spontaneously Responsive In Vitro to This Antigen1

  2008cites this paper
• Recent advances in the understanding of egg allergens: basic, industrial, and clinical perspectives.

  2008cites this paper
• Collagen-specific T-cell repertoire in blood and synovial fluid varies with disease activity in early rheumatoid arthritis

  2008cites this paper
• Transgenic BALB/c Mice Vaccination in Wild-Type and HER-2 Receptor Repertoires Expanded by DNA Distinct and Non-Overlapping T Cell

  2006cites this paper
• SARS coronavirus nucleocapsid immunodominant T-cell epitope cluster is common to both exogenous recombinant and endogenous DNA-encoded immunogens

  2006cites this paper
• Distinct and Non-Overlapping T Cell Receptor Repertoires Expanded by DNA Vaccination in Wild-Type and HER-2 Transgenic BALB/c Mice1

  2006cites this paper
• Mycobacterium tuberculosis in the adjuvant modulates the balance of Th immune response to self-antigen of the CNS without influencing a "core" repertoire of specific T cells.

  2006cites this paper
• The Relationship of T-Cell Epitopes and Allergen Structure

  2006cites this paper
• New insights in antigen processing and epitope selection: development of novel immunotherapeutic strategies for cancer, autoimmunity and infectious diseases.

  2005cites this paper
• Redirecting the Humoral Immune Response against Streptococcus mutans Antigen P1 with Monoclonal Antibodies

  2004cites this paper