2-Chlorohexadecanal and 2-Chlorohexadecanoic Acid Induce COX-2 Expression in Human Coronary Artery Endothelial Cells

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Lipids

• Publication date

  2008-05-21

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s11745-008-3189-yPMID 18493808PMCID PMC2752647
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Differential regulation of cyclooxygenase‐2 and inducible nitric oxide synthase by 4‐hydroxynonenal in human osteoarthritic chondrocytes through ATF‐2/CREB‐1 transactivation and concomitant inhibition of NF‐κB signaling cascade

  2007cited by this paper
• Differential regulation of cyclooxygenase-2 and inducible nitric oxide synthase by 4-hydroxynonenal in human osteoarthritic chondrocytes through ATF-2/CREB-1 transactivation and concomitant inhibition of NF-kappaB signaling cascade.

  2007cited by this paper
• Selective plasmenylcholine oxidation by hypochlorous acid: formation of lysophosphatidylcholine chlorohydrins.

  2006cited by this paper
• Metabolism of Myeloperoxidase-derived 2-Chlorohexadecanal*

  2006influential reference
• Signal transduction pathways of inflammatory gene expressions and therapeutic implications.

  2006cited by this paper
• Up-regulation of cyclooxygenase-2 by interleukin-1beta in colon carcinoma cells.

  2006cited by this paper
• Cyclooxygenase-2 Induction and Prostacyclin Release by Protease-activated Receptors in Endothelial Cells Require Cooperation between Mitogen-activated Protein Kinase and NF-κB Pathways*

  2006cited by this paper
• Diversity and similarity in signaling events leading to rapid Cox-2 induction by tumor necrosis factor-alpha and phorbol ester in human endothelial cells.

  2005cited by this paper
• Neutrophil-mediated accumulation of 2-ClHDA during myocardial infarction: 2-ClHDA-mediated myocardial injury.

  2005cited by this paper
• Control of cyclooxygenase-2 transcriptional activation by pro-inflammatory mediators.

  2005cited by this paper
• Transcriptional regulation of cyclooxygenase-2 in the Human Microvascular Endothelial Cell Line, HMEC-1: Control by the combinatorial actions of AP2, NF-IL-6 and CRE elements

  2004cited by this paper
• 2-Chlorohexadecanal Derived From Hypochlorite-Modified High-Density Lipoprotein–Associated Plasmalogen Is a Natural Inhibitor of Endothelial Nitric Oxide Biosynthesis

  2004influential reference
• A Lipid Peroxidation-derived Inflammatory Mediator

  2004cited by this paper
• Myeloperoxidase-derived Reactive Chlorinating Species from Human Monocytes Target Plasmalogens in Low Density Lipoprotein*

  2003cited by this paper
• Identification of &agr;-Chloro Fatty Aldehydes and Unsaturated Lysophosphatidylcholine Molecular Species in Human Atherosclerotic Lesions

  2003cited by this paper
• Identification of alpha-chloro fatty aldehydes and unsaturated lysophosphatidylcholine molecular species in human atherosclerotic lesions.

  2003cited by this paper
• Reactive Chlorinating Species Produced during Neutrophil Activation Target Tissue Plasmalogens

  2002influential reference
• TNF-alpha, inefficient by itself, potentiates IL-1beta-induced PGHS-2 expression in human pulmonary microvascular endothelial cells: requirement of NF-kappaB and p38 MAPK pathways.

  2002cited by this paper
• Transcriptional and Posttranscriptional Regulation of Cyclooxygenase-2 Expression by Fluid Shear Stress in Vascular Endothelial Cells

  2002cited by this paper
• Induction of cyclooxygenase-2 by heat shock protein 60 in macrophages and endothelial cells.

  2002cited by this paper
• TNF‐α, inefficient by itself, potentiates IL‐1β‐induced PGHS‐2 expression in human pulmonary microvascular endothelial cells: requirement of NF‐κB and p38 MAPK pathways

  2002cited by this paper
• Reactive Chlorinating Species Produced by Myeloperoxidase Target the Vinyl Ether Bond of Plasmalogens

  2001influential reference
• Post-transcriptional Control of Cyclooxygenase-2 Gene Expression

  2000cited by this paper
• An Essential Role of the Nuclear Factor of Activated T Cells in the Regulation of the Expression of the Cyclooxygenase-2 Gene in Human T Lymphocytes*

  2000cited by this paper
• Sp1 Increases Expression of Cyclooxygenase-2 in Hypoxic Vascular Endothelium

  2000cited by this paper
• NF-kappaB and AP-1 are required for cyclo-oxygenase 2 gene expression in amnion epithelial cell line (WISH).

  2000cited by this paper
• Augmented expression of cyclooxygenase-2 in human atherosclerotic lesions.

  1999cited by this paper
• Molecular Chlorine Generated by the Myeloperoxidase-Hydrogen Peroxide-Chloride System of Phagocytes Converts Low Density Lipoprotein Cholesterol into a Family of Chlorinated Sterols*

  1996cited by this paper
• Transcriptional Regulation of Human Prostaglandin-endoperoxide Synthase-2 Gene by Lipopolysaccharide and Phorbol Ester in Vascular Endothelial Cells

  1995cited by this paper
• Characterization of the human gene (PTGS2) encoding prostaglandin-endoperoxide synthase 2.

  1994cited by this paper
• Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions.

  1994cited by this paper
• Electrospray ionization mass spectroscopic analysis of human erythrocyte plasma membrane phospholipids.

  1994cited by this paper
• Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines.

  1993cited by this paper
• Endogenous glucocorticoids regulate an inducible cyclooxygenase enzyme.

  1992cited by this paper
• Prostaglandin endoperoxide synthase gene structure: identification of the transcriptional start site and 5'-flanking regulatory sequences.

  1992cited by this paper
• Chlorohydrin formation from unsaturated fatty acids reacted with hypochlorous acid.

  1992cited by this paper
• Profiling of bisenoic prostaglandins and thromboxane B2 in bronchoalveolar fluid from the lower respiratory tract of human subjects by combined capillary gas chromatography-mass spectrometry.

  1988cited by this paper
• Plasmalogen content and distribution in the sarcolemma of cultured neonatal rat myocytes

  1988cited by this paper
• Simultaneous determination of prostanoids in plasma by gas chromatography-negative-ion chemical-ionization mass spectrometry.

  1985cited by this paper
• High plasmalogen and arachidonic acid content of canine myocardial sarcolemma: a fast atom bombardment mass spectroscopic and gas chromatography-mass spectroscopic characterization.

  1984cited by this paper
• Production of prostacyclin by vascular endothelial cells.

  1979cited by this paper
• Synthesis of prostaglandin I2 (prostacyclin) by human and bovine endothelial cells

  1977cited by this paper
• Prostacyclin (PGX) is the endogeneous metabolite responsible for relaxation of coronary arteries induced by arachidonic acid

  1977cited by this paper
• Synthesis of prostaglandin I2 (prostacyclin) by cultured human and bovine endothelial cells.

  1977cited by this paper
• Prostacyclin (PGX) is the endogenous metabolite responsible for relaxation of coronary arteries induced by arachindonic acid.

  1977cited by this paper
• Studies on the chlorinating activity of myeloperoxidase.

  1976cited by this paper
• An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

  1976cited by this paper
• The chemical structure of prostaglandin X (prostacyclin).

  1976cited by this paper
• A rapid method of total lipid extraction and purification.

  1959cited by this paper

• Human lung microvascular endothelial cell protein modification by 2-chlorohexadecanoic acid: RhoA mediates 2-chlorohexadecanoic acid-elicited endothelial activation

  2025cites this paper
• Determination of biomarkers of chlorine exposure from biological samples: a review of analysis techniques

  2024cites this paper
• Chronic inflammation, neuroglia dysfunction, and plasmalogen deficiency as a new pathobiological hypothesis addressing the overlap between post-COVID-19 symptoms and myalgic encephalomyelitis/chronic fatigue syndrome.

  2023cites this paper
• 2-Hexadecenal Regulates ROS Production and Induces Apoptosis in Polymorphonuclear Leucocytes

  2022cites this paper
• The lipid biology of sepsis

  2021cites this paper
• 2-Chlorofatty acids are biomarkers of sepsis mortality and mediators of barrier dysfunction in rats[S]

  2020cites this paper
• Myeloperoxidase: A versatile mediator of endothelial dysfunction and therapeutic target during cardiovascular disease.

  2020cites this paper
• Western Diet-Fed, Aortic-Banded Ossabaw Swine

  2019cites this paper
• Chlorinated Lipids Elicit Inflammatory Responses in vitro and in vivo

  2018cites this paper
• The chlorinated lipidome originating from myeloperoxidase-derived HOCl targeting plasmalogens: Metabolism, clearance, and biological properties.

  2018cites this paper
• Myeloperoxidase-derived 2-chlorofatty acids contribute to human sepsis mortality via acute respiratory distress syndrome.

  2017cites this paper
• Chlorinated lipid induce inflammatory responses in the microcirculation

  2017cites this paper
• Peroxisome proliferator-activated receptor-α accelerates α-chlorofatty acid catabolism[S]

  2017cites this paper
• Formation of chlorinated lipids post-chlorine gas exposure

  2016cites this paper
• Assessment of electrophile damage in a human brain endothelial cell line utilizing a clickable alkyne analog of 2-chlorohexadecanal.

  2016cites this paper
• Differential effects of chlorinated and oxidized phospholipids in vascular tissue: implications for neointima formation.

  2015cites this paper
• Identification of glutathione adducts of α-chlorofatty aldehydes produced in activated neutrophils

  2015cites this paper
• Covalent adduct formation between the plasmalogen-derived modification product 2-chlorohexadecanal and phloretin

  2015cites this paper
• Halogenated Lipids: Products of Peroxidase-Derived Reactive Halogenating Species Targeting Conventional Lipids

  2015cites this paper
• An Introduction to Redox Balance and Lipid Oxidation

  2015cites this paper
• Alpha-Chlorofatty Acid and Coronary Artery or Aorta Calcium Scores in Women with Systemic Lupus Erythematosus. A Pilot Study

  2014cites this paper
• Alpha-Chlorofatty Acid Accumulates in Activated Monocytes and Causes Apoptosis Through Reactive Oxygen Species Production and Endoplasmic Reticulum Stress

  2014cites this paper
• The involvement of modified lipids in vascular injury and disease

  2013cites this paper
• Approaches for the analysis of chlorinated lipids.

  2013cites this paper
• Strategies for the analysis of chlorinated lipids in biological systems.

  2013cites this paper
• Myeloperoxidase-Derived Oxidants Induce Blood-Brain Barrier Dysfunction In Vitro and In Vivo

  2013cites this paper
• Phloretin ameliorates 2-chlorohexadecanal-mediated brain microvascular endothelial cell dysfunction in vitro

  2012cites this paper
• Simple Lipids with Only One Component

  2012cites this paper
• Lipid oxidation by hypochlorous acid: chlorinated lipids in atherosclerosis and myocardial ischemia

  2010cites this paper