Structure-activity relationships of mu-conotoxin GIIIA: structure determination of active and inactive sodium channel blocker peptides by NMR and simulated annealing calculations.

No abstract is available for this paper.

• Publication year

  1994

• Venue

  Biochemistry

• Publication date

  1994-01-31

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/BI00165A006PMID 1335283
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Solution structure of μ‐conotoxin GIIIA analysed by 2D‐NMR and distance geometry calculations

  1991cited by this paper
• Tertiary structure of conotoxin GIIIA in aqueous solution.

  1991cited by this paper
• Conotoxins.

  1991cited by this paper
• Mapping the site of block by tetrodotoxin and saxitoxin of sodium channel II

  1991cited by this paper
• Active site of mu-conotoxin GIIIA, a peptide blocker of muscle sodium channels.

  1991cited by this paper
• Diversity of Conus neuropeptides.

  1990cited by this paper
• Disulfide pairings in geographutoxin I, a peptide neurotoxin from Conus geographus

  1990cited by this paper
• Solution structure of recombinant hirudin and the Lys-47----Glu mutant: a nuclear magnetic resonance and hybrid distance geometry-dynamical simulated annealing study.

  1990cited by this paper
• Determination of three-dimensional structures of proteins by simulated annealing with interproton distance restraints. Application to crambin, potato carboxypeptidase inhibitor and barley serine proteinase inhibitor 2.

  1988cited by this paper
• Peptide toxins from venomous Conus snails.

  1988cited by this paper
• Application of molecular dynamics with interproton distance restraints to three-dimensional protein structure determination. A model study of crambin.

  1986cited by this paper
• Specific inhibition of [3H] saxitoxin binding to skeletal muscle sodium channels by geographutoxin II, a polypeptide channel blocker.

  1986cited by this paper
• Peptide neurotoxins from fish-hunting cone snails.

  1985cited by this paper
• Two-dimensional correlation of connected NMR transitions

  1985cited by this paper
• Structural determinants of the affinity of saxitoxin for neuronal sodium channels. Electrophysiological studies on frog peripheral nerve

  1984cited by this paper
• Isolation and amino acid compositions of geographutoxin I and II from the marine snail Conus geographus.

  1983cited by this paper
• The amino acid sequences of homologous hydroxyproline‐containing myotoxins from the marine snal Conus geographus venom

  1983cited by this paper
• Improved spectral resolution in cosy 1H NMR spectra of proteins via double quantum filtering.

  1983cited by this paper
• CHARMM: A program for macromolecular energy, minimization, and dynamics calculations

  1983cited by this paper
• Active groups of saxitoxin and tetrodotoxin as deduced from actions of saxitoxin analogues on frog muscle and squid axon.

  1982cited by this paper
• Exchangeable proton NMR without base-line distorsion, using new strong-pulse sequences

  1982cited by this paper
• Two-dimensional chemical exchange and cross-relaxation spectroscopy of coupled nuclear spins

  1981cited by this paper
• Investigation of exchange processes by two‐dimensional NMR spectroscopy

  1979cited by this paper

• Historical Perspective of the Characterization of Conotoxins Targeting Voltage-Gated Sodium Channels

  2023cites this paper
• Inferring Pathways of Oxidative Folding from Prefolding Free Energy Landscapes of Disulfide-Rich Toxins

  2022cites this paper
• Voltage-Gated Sodium Channels: A Prominent Target of Marine Toxins

  2021cites this paper
• Virtual insights on G protein inhibition and ion channel block – a computer-based study

  2019cites this paper
• Effects of C-Terminal Carboxylation on α-Conotoxin LsIA Interactions with Human α7 Nicotinic Acetylcholine Receptor: Molecular Simulation Studies

  2019cites this paper
• Insights into the Folding of Disulfide-Rich μ-Conotoxins

  2018cites this paper
• NMR Structure of μ-Conotoxin GIIIC: Leucine 18 Induces Local Repacking of the N-Terminus Resulting in Reduced NaV Channel Potency

  2018cites this paper
• The Role of Individual Disulfide Bonds of μ-Conotoxin GIIIA in the Inhibition of NaV1.4

  2016cites this paper
• Conopeptides, marine natural products from venoms: Biomedical applications and future research applications

  2016cites this paper
• Computational Study of Binding of μ-Conotoxin GIIIA to Bacterial Sodium Channels NaVAb and NaVRh.

  2016cites this paper
• Roles of Basic Amino Acid Residues in the Activity of μ‐Conotoxin GIIIA and GIIIB, Peptide Blockers of Muscle Sodium Channels

  2015cites this paper
• Organic toxins as tools to understand ion channel mechanisms and structure.

  2015cites this paper
• Synthetic Peptides and Drug Discovery

  2015cites this paper
• Cone shell envenomation: epidemiology, pharmacology and medical care.

  2015cites this paper
• Conotoxins That Could Provide Analgesia through Voltage Gated Sodium Channel Inhibition

  2015cites this paper
• Interactions of disulfide‐deficient selenocysteine analogs of μ‐conotoxin BuIIIB with the α‐subunit of the voltage‐gated sodium channel subtype 1.3

  2014cites this paper
• The Activation Effect of Hainantoxin-I, a Peptide Toxin from the Chinese Spider, Ornithoctonus hainana, on Intermediate-Conductance Ca2+-Activated K+ Channels

  2014cites this paper
• Systematic Study of Binding of µ-Conotoxins to the Sodium Channel NaV1.4

  2014cites this paper
• Molecular Dynamics Study of Binding of µ-Conotoxin GIIIA to the Voltage-Gated Sodium Channel Nav1.4

  2014cites this paper
• Structure and function of μ-conotoxins, peptide-based sodium channel blockers with analgesic activity.

  2014cites this paper
• Characterization of a Novel Conus bandanus Conopeptide Belonging to the M-Superfamily Containing Bromotryptophan

  2014cites this paper
• Roles of Hyp Residues in the Folding and Activity of μ-Conotoxin GIIIA, a Peptide Blocker of Muscle Sodium Channels

  2014cites this paper
• Mechanism of μ-Conotoxin PIIIA Binding to the Voltage-Gated Na+ Channel NaV1.4

  2014cites this paper
• Roles of Individual Disulfide Bridges in the Conformation and Activity of μ-Conotoxin GIIIA, a Peptide Blocker of Muscle Sodium Channels

  2014cites this paper
• Computational Studies of Marine Toxins Targeting Ion Channels

  2013cites this paper
• A novel m-conopeptide , CnIIIC , exerts potent and preferential inhibition of NaV 1 . 2 / 1 . 4 channels and blocks neuronal nicotinic acetylcholine receptors

  2012cites this paper
• Conotoxins Targeting Neuronal Voltage-Gated Sodium Channel Subtypes: Potential Analgesics?

  2012cites this paper
• Structurally diverse μ-conotoxin PIIIA isomers block sodium channel NaV 1.4.

  2012cites this paper
• Strukturell diverse Isomere des μ‐Conotoxins PIIIA blockieren den Natriumkanal NaV1.4

  2012cites this paper
• A novel µ‐conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors

  2012cites this paper
• µ-Conotoxins as Leads in the Development of New Analgesics

  2010cites this paper
• Structurally Minimized μ‐Conotoxin Analogues as Sodium Channel Blockers: Implications for Designing Conopeptide‐Based Therapeutics

  2009cites this paper
• Solid-state NMR and molecular dynamics characterization of cannabinoid receptor-1 (CB1) helix 7 conformational plasticity in model membranes.

  2009cites this paper
• Dissertation zur Erlangung des Grades eines Doktors der Naturwissenschaften

  2009cites this paper
• Structure, dynamics, and selectivity of the sodium channel blocker mu-conotoxin SIIIA.

  2008cites this paper
• Neuronally Selective μ-Conotoxins from Conus striatus Utilize an α-Helical Motif to Target Mammalian Sodium Channels*

  2008cites this paper
• NMR Studies of Ion-Transporting Biological Channels

  2008cites this paper
• Voltage-gated sodium channel toxins

  2007cites this paper
• µO-Conotoxins Inhibit NaV Channels by Interfering with their Voltage Sensors in Domain-2

  2007cites this paper
• Prolylproline unit in model peptides and in fragments from databases

  2007cites this paper
• Conotoxins down under.

  2006cites this paper
• NMR of conotoxins: structural features and an analysis of chemical shifts of post‐translationally modified amino acids

  2006cites this paper
• Modeling P-loops domain of sodium channel: homology with potassium channels and interaction with ligands.

  2005cites this paper
• Identification of a Novel Pharmacophore for Peptide Toxins Interacting with K+ Channels*

  2005cites this paper
• Using the deadly m-conotoxins as probes of voltage-gated sodium channels

  2004cites this paper
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  2004cites this paper
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  2004cites this paper
• Effects of modification at the fifth residue of mu-conotoxin GIIIA with bulky tags on the electrically stimulated contraction of the rat diaphragm.

  2004cites this paper
• Structure-Activity Relationships of Hainantoxin-IV and Structure Determination of Active and Inactive Sodium Channel Blockers*

  2004cites this paper
• Using the deadly mu-conotoxins as probes of voltage-gated sodium channels.

  2004cites this paper
• Peptide Toxin Inhibition of Voltage Gated Calcium Channels

  2004cites this paper
• Sodium channel toxins--receptor targeting and therapeutic potential.

  2004cites this paper
• Using the deadly μ-conotoxins as probes of voltage-gated sodium channels

  2004cites this paper
• Novel interactions identified between micro -Conotoxin and the Na+ channel domain I P-loop: implications for toxin-pore binding geometry.

  2003influential citation
• Conotoxins as Sensors of Local pH and Electrostatic Potential in the Outer Vestibule of the Sodium Channel

  2003cites this paper
• Dependence of mu-conotoxin block of sodium channels on ionic strength but not on the permeating [Na+]: implications for the distinctive mechanistic interactions between Na+ and K+ channel pore-blocking toxins and their molecular targets.

  2003cites this paper
• Molecular Basis of Isoform-specific μ-Conotoxin Block of Cardiac, Skeletal Muscle, and Brain Na+ Channels*

  2003cites this paper
• Structural Basis for Tetrodotoxin-resistant Sodium Channel Binding by μ-Conotoxin SmIIIA*

  2003cites this paper
• Sodium channel modulating activity in a delta-conotoxin from an Indian marine snail.

  2003cites this paper
• Function and solution structure of hainantoxin‐I, a novel insect sodium channel inhibitor from the Chinese bird spider Selenocosmia hainana1

  2003cites this paper
• Sodium channel modulating activity in a δ‐conotoxin from an Indian marine snail

  2003cites this paper
• Generation of polyclonal antibody against mu-conotoxin GIIIA using an immunogen of [Cys(5)]mu-conotoxin GIIIA site-specifically conjugated with bovine serum albumin.

  2002cites this paper
• Electrostatic and Steric Contributions to Block of the Skeletal Muscle Sodium Channel by μ-Conotoxin

  2002cites this paper
• Structure of a Novel P-superfamily Spasmodic Conotoxin Reveals an Inhibitory Cystine Knot Motif* 210

  2002cites this paper
• Charge conversion enables quantification of the proximity between a normally‐neutral μ‐conotoxin (GIIIA) site and the Na+ channel pore

  2002cites this paper
• Bases structurales de la specificite de reconnaissance entre les toxines animales et les canaux ioniques

  2002cites this paper
• Role of Thr(11) in the binding of omega-conotoxin MVIIC to N-type Ca2+ channels.

  2001cites this paper
• Role of Thr11 in the binding of ω‐conotoxin MVIIC to N‐type Ca2+ channels

  2001cites this paper
• Latent specificity of molecular recognition in sodium channels engineered to discriminate between two "indistinguishable" mu-conotoxins.

  2001cites this paper
• Solution structure of hpTX2, a toxin from Heteropoda venatoria spider that blocks Kv4.2 potassium channel.

  2001cites this paper
• Clockwise Domain Arrangement of the Sodium Channel Revealed by μ-Conotoxin (GIIIA) Docking Orientation*

  2001cites this paper
• Novel structural determinants of mu-conotoxin (GIIIB) block in rat skeletal muscle (mu1) Na+ channels.

  2000cites this paper
• Conotoxins - new vistas for peptide therapeutics.

  2000cites this paper
• μ-Conotoxin Giiia Interactions with the Voltage-Gated Na+ Channel Predict a Clockwise Arrangement of the Domains

  2000cites this paper
• A new fold in the scorpion toxin family, associated with an activity on a ryanodine‐sensitive calcium channel

  2000cites this paper
• [Chemistry of conotoxins from cone snails].

  1999cites this paper
• Conus peptides targeted to specific nicotinic acetylcholine receptor subtypes.

  1999cites this paper
• Three-dimensional structure of α-conotoxin EI determined by1H NMR spectroscopy

  1999cites this paper
• Pore-blocking toxins as probes of voltage-dependent channels.

  1999cites this paper
• Artificial receptors: molecular imprints discern closely related toxins

  1999cites this paper
• Functional and structural features of γ‐zeathionins, a new class of sodium channel blockers

  1998cites this paper
• Functional and structural features of gamma-zeathionins, a new class of sodium channel blockers.

  1998cites this paper
• Structure and Function of Peptide and Protein Toxins from Marine Organisms

  1998cites this paper
• Folding motifs induced and stabilized by distinct cystine frameworks.

  1998cites this paper
• Three-dimensional solution structure of conotoxin psi-PIIIE, an acetylcholine gated ion channel antagonist.

  1998cites this paper
• Solution structure of the sodium channel antagonist conotoxin GS: a new molecular caliper for probing sodium channel geometry.

  1997cites this paper
• Pore residues critical for mu-CTX binding to rat skeletal muscle Na+ channels revealed by cysteine mutagenesis.

  1997cites this paper
• Three-dimensional structure of a gamma-carboxyglutamic acid-containing conotoxin, conantokin G, from the marine snail Conus geographus: the metal-free conformer.

  1997cites this paper
• Interactions between a pore-blocking peptide and the voltage sensor of the sodium channel: an electrostatic approach to channel geometry.

  1996cites this paper
• Three-dimensional solution structure of mu-conotoxin GIIIB, a specific blocker of skeletal muscle sodium channels.

  1996cites this paper
• Primary structural motifs of Conus peptides.

  1996cites this paper
• Trajectory analysis of NMR structure calculations

  1995cites this paper
• Characterizing the mu-conotoxin binding site on voltage-sensitive sodium channels with toxin analogs and channel mutations.

  1995cites this paper
• New sodium channel-blocking conotoxins also affect calcium currents in Lymnaea neurons.

  1995cites this paper
• A new cysteine framework in sodium channel blocking conotoxins.

  1995cites this paper
• Essential hydrogen bonds for the folding and activities of ω-conotoxin GVIA, a specific blocker of the N-type calcium channel

  1995cites this paper
• Hydroxyl group of Tyr13 is essential for the activity of omega-conotoxin GVIA, a peptide toxin for N-type calcium channel.

  1994cites this paper
• Proteinase inhibitor homologues as potassium channel blockers

  1994cites this paper
• Secondary structure and protein folding of recombinant chloroplastic thioredoxin Ch2 from the green alga Chlamydomonas reinhardtii as determined by 1H NMR.

  1993cites this paper
• Role of basic residues for the binding of omega-conotoxin GVIA to N-type calcium channels.

  1993cites this paper