The in vitro metabolism of bupropion revisited: concentration dependent involvement of cytochrome P450 2C19

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Xenobiotica; the fate of foreign compounds in biological systems

• Publication date

  2010-07-14

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.3109/00498254.2010.492880PMID 20528624
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Identification of bupropion urinary metabolites by liquid chromatography/mass spectrometry.

  2007cited by this paper
• The functional role of CYP2B6 in human drug metabolism: substrates and inhibitors in vitro, in vivo and in silico.

  2006cited by this paper
• Cytochrome P450 2B6 activity as measured by bupropion hydroxylation: Effect of induction by rifampin and ethnicity

  2006influential reference
• Effect of Clopidogrel and Ticlopidine on Cytochrome P450 2B6 Activity as Measured by Bupropion Hydroxylation

  2005influential reference
• The disposition of bupropion and its metabolites in healthy male volunteers after single and multiple doses

  2004cited by this paper
• Bupropion and 4-OH-bupropion pharmacokinetics in relation to genetic polymorphisms in CYP2B6.

  2003influential reference
• Evaluation of the contribution of cytochrome P450 3A4 to human liver microsomal bupropion hydroxylation.

  2001influential reference
• CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants.

  2000influential reference
• Validation of bupropion hydroxylation as a selective marker of human cytochrome P450 2B6 catalytic activity.

  2000influential reference
• Further characterization of the expression in liver and catalytic activity of CYP2B6.

  1998cited by this paper
• Human cytochrome P4502B6: interindividual hepatic expression, substrate specificity, and role in procarcinogen activation.

  1997cited by this paper
• The identification of in vitro metabolites of bupropion using ion trap mass spectrometry

  1995cited by this paper
• Pharmacological significance of the species differences in bupropion metabolism.

  1987cited by this paper
• Pharmacokinetics of bupropion and its major basic metabolites in normal subjects after a single dose

  1985cited by this paper
• Clinical pharmacokinetics of bupropion: a review.

  1983cited by this paper
• Metabolism and kinetics of bupropion.

  1983influential reference

• Pharmacogenetic influence on bupropion bioactivation and clinical outcomes in major depressive disorder.

  2026cites this paper
• Nutrient environment improves drug metabolic activity in human iPSC-derived hepatocytes and HepG2

  2025cites this paper
• Comprehensive Review of CYP2B6 Transcriptional Modulators, Variants, and Their Role in Drug Interactions

  2025cites this paper
• Pharmacogenetic Influence on Stereoselective Steady-State Disposition of Bupropion

  2024cites this paper
• Physiologically Based Pharmacokinetic Modeling of Bupropion and Its Metabolites in a CYP2B6 Drug-Drug-Gene Interaction Network

  2021influential citation
• Subtherapeutic bupropion and hydroxybupropion serum concentrations in a patient with CYP2C19*1/*17 genotype suggesting a rapid metabolizer status

  2020cites this paper
• Characterization of the Effect of Upadacitinib on the Pharmacokinetics of Bupropion, a Sensitive Cytochrome P450 2B6 Probe Substrate

  2020cites this paper
• Nonresponse to high-dose bupropion for depression in a patient carrying CYP2B6*6 and CYP2C19*17 variants: a case report.

  2020cites this paper
• In vitro and in vivo studies of triacetone triperoxide (TATP) metabolism in humans

  2020cites this paper
• Genotoxicity and pharmacokinetic characterization of Cereus jamacaru ethanolic extract in rats

  2018cites this paper
• A CYP2B6-humanized mouse model and its potential applications.

  2018cites this paper
• Common Polymorphisms of CYP2B6 Influence Stereoselective Bupropion Disposition

  2018cites this paper
• Pharmacogenetic Optimization of Smoking Cessation Treatment.

  2017cites this paper
• Identification and Structural Characterization of Three New Metabolites of Bupropion in Humans.

  2016cites this paper
• Pharmacokinetics of Bupropion and Its Pharmacologically Active Metabolites in Pregnancy

  2016cites this paper
• Stereoselective Metabolism of Bupropion to OH-bupropion, Threohydrobupropion, Erythrohydrobupropion, and 4′-OH-bupropion in vitro

  2016cites this paper
• Inhibition of Cytochrome P450 2B6 Activity by Voriconazole Profiled Using Efavirenz Disposition in Healthy Volunteers

  2016cites this paper
• Identification of non‐reported bupropion metabolites in human plasma

  2016cites this paper
• Rifampin enhances cytochrome P450 (CYP) 2B6-mediated efavirenz 8-hydroxylation in healthy volunteers.

  2016cites this paper
• Characterization of CYP2B6 in a CYP2B6-Humanized Mouse Model: Inducibility in the Liver by Phenobarbital and Dexamethasone and Role in Nicotine Metabolism In Vivo

  2015cites this paper
• Synthesis of deuterium-labeled hydroxybupropion.

  2015cites this paper
• Metabolism of Bupropion by Carbonyl Reductases in Liver and Intestine

  2015cites this paper
• Fluvoxamine-associated oscillopsia and a role for personalized medication dosing

  2015cites this paper
• Effect of CYP2B6*6 on Steady-State Serum Concentrations of Bupropion and Hydroxybupropion in Psychiatric Patients: A Study Based on Therapeutic Drug Monitoring Data

  2015cites this paper
• Deeper insight into the reducing biotransformation of bupropion in the human liver.

  2014cites this paper
• Carbonyl reduction pathways in drug metabolism

  2014cites this paper
• Gene Variants in CYP 2 C 19 Are Associated with Altered In Vivo Bupropion Pharmacokinetics but Not Bupropion-Assisted Smoking Cessation Outcomes s

  2014influential citation
• Gene Variants in CYP2C19 Are Associated with Altered In Vivo Bupropion Pharmacokinetics but Not Bupropion-Assisted Smoking Cessation Outcomes

  2014influential citation
• Characterization of CYP 2 B 6 in a CYP 2 B 6-Humanized Mouse Model : Inducibility in the Liver by Phenobarbital and Dexamethasone and Role in Nicotine Metabolism In Vivo s

  2014cites this paper
• Influence of CYP2B6 genetic variants on plasma and urine concentrations of bupropion and metabolites at steady state

  2013cites this paper
• Bupropion Hydroxylation as a Selective Marker of Rat CYP2B1 Catalytic Activity

  2012cites this paper
• Complex Drug Interactions of HIV Protease Inhibitors 2: In Vivo Induction and In Vitro to In Vivo Correlation of Induction of Cytochrome P450 1A2, 2B6, and 2C9 by Ritonavir or Nelfinavir

  2011cites this paper
• Metabolism of bupropion by baboon hepatic and placental microsomes.

  2011cites this paper
• Polymorphic Variants of Cytochrome P450 2B6 (CYP2B6.4–CYP2B6.9) Exhibit Altered Rates of Metabolism for Bupropion and Efavirenz: A Charge-Reversal Mutation in the K139E Variant (CYP2B6.8) Impairs Formation of a Functional Cytochrome P450-Reductase Complex

  2011cites this paper
• Advances in structure elucidation of small molecules using mass spectrometry

  2010cites this paper