Developmentally defined forebrain circuits regulate appetitive and aversive olfactory learning

Postnatal and adult neurogenesis are region- and modality-specific, but the significance of developmentally distinct neuronal populations remains unclear. We demonstrate that chemogenetic inactivation of a subset of forebrain and olfactory neurons generated at birth disrupts responses to an aversive odor. In contrast, novel appetitive odor learning is sensitive to inactivation of adult-born neurons, revealing that developmentally defined sets of neurons may differentially participate in hedonic aspects of sensory learning.

• Publication year

  2016

• Venue

  Nature Neuroscience

• Publication date

  2016-11-05

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1038/nn.4452PMID 27918532PMCID 5191939
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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