Cdc42 induces EGF receptor protein accumulation and promotes EGF receptor nuclear transport and cellular transformation

Cdc42 is a Ras‐related small GTP‐binding protein. A previous study has shown that Cdc42 binding to the γ subunit of the coatomer protein complex (γCOP) is essential for Cdc42‐regulated cellular transformation, but the molecular mechanism involved is not well understood. Here, we demonstrate that constitutively‐active Cdc42 binding to γCOP induced the accumulation of epithelial growth factor receptor (EGFR) in the cells, sustained EGF‐stimulated extracellular signal‐regulated kinase (ERK), JUN amino‐terminal kinase (JNK) and phosphoinositide 3‐kinase (PI3K) signaling and promoted cell division. Moreover, constitutive Cdc42 activity facilitated the nuclear translocation of EGFR, and this indicates a novel mechanism through which Cdc42 might promote cellular transformation.

• Publication year

  2015

• Venue

  FEBS Letters

• Publication date

  2015-01-16

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.febslet.2014.11.049PMID 25497016
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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