Induction of intrachromosomal homologous recombination in human cells by raltitrexed, an inhibitor of thymidylate synthase.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  DNA Repair

• Publication date

  2008-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.dnarep.2008.06.006PMID 18603020PMCID PMC2586641
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Uracil incorporation into genomic DNA does not predict toxicity caused by chemotherapeutic inhibition of thymidylate synthase.

  2008cited by this paper
• Accurate Homologous Recombination Is a Prominent Double-Strand Break Repair Pathway in Mammalian Chromosomes and Is Modulated by Mismatch Repair Protein Msh2

  2007cited by this paper
• Molecular basis of antifolate resistance

  2007influential reference
• Determination of apoptosis, uracil incorporation, DNA strand breaks, and sister chromatid exchanges under conditions of thymidylate deprivation in a model of BER deficiency.

  2005cited by this paper
• Raltitrexed increases tumorigenesis as a single agent yet exhibits anti-tumor synergy with 5-fluorouracil in ApcMin/+ Mice1

  2004cited by this paper
• Mating-type switching in yeast is induced by thymine nucleotide depletion

  2004cited by this paper
• Modulation of error-prone double-strand break repair in mammalian chromosomes by DNA mismatch repair protein Mlh1.

  2004cited by this paper
• Isolation and genetic characterization of a thymineless death-resistant mutant of Escherichia coli K12: Identification of a new mutation (recQ1) that blocks the RecF recombination pathway

  2004cited by this paper
• Incorporation of dUMP into DNA is a major source of spontaneous DNA damage, while excision of uracil is not required for cytotoxicity of fluoropyrimidines in mouse embryonic fibroblasts.

  2004cited by this paper
• Involvement of base excision repair in response to therapy targeted at thymidylate synthase.

  2004cited by this paper
• Pathways for mitotic homologous recombination in mammalian cells.

  2003influential reference
• 5-Fluorouracil: mechanisms of action and clinical strategies

  2003cited by this paper
• Expression of uracil DNA glycosylase (UDG) does not affect cellular sensitivity to thymidylate synthase (TS) inhibition.

  2003cited by this paper
• Anticancer antifolates: current status and future directions.

  2003cited by this paper
• The Role of Uracil Misincorporation in Thymineless Death

  1999influential reference
• Fluoropyrimidines as Antifolate Drugs

  1999cited by this paper
• Antifolate Drugs in Cancer Therapy

  1999cited by this paper
• Thymine metabolism and thymineless death in prokaryotes and eukaryotes.

  1998cited by this paper
• Cell cycle effects of antifolate antimetabolites: implications for cytotoxicity and cytostasis

  1997cited by this paper
• DNA damage and p53 induction do not cause ZD1694-induced cell cycle arrest in human colon carcinoma cells.

  1996cited by this paper
• Ratio of 2'-deoxyadenosine-5'-triphosphate/thymidine-5'-triphosphate influences the commitment of human colon carcinoma cells to thymineless death.

  1995cited by this paper
• Cellular heterogeneity in DNA damage and growth inhibition induced by ICI D1694, thymidylate synthase inhibitor, using single cell assays.

  1994cited by this paper
• Thymine starvation-induced structural changes in Escherichia coli DNA. Detection by pulsed field gel electrophoresis and evidence for involvement of homologous recombination.

  1994cited by this paper
• Induction of resistance to fluorodeoxyuridine cytotoxicity and DNA damage in human tumor cells by expression of Escherichia coli deoxyuridinetriphosphatase.

  1994cited by this paper
• ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study.

  1991cited by this paper
• Thymidylate stress induces homologous recombination activity in mammalian cells.

  1991cited by this paper
• Thymineless death in Escherichia coli mutants deficient in the RecF recombination pathway.

  1988cited by this paper
• Deoxyribonucleoside triphosphate imbalance. 5-Fluorodeoxyuridine-induced DNA double strand breaks in mouse FM3A cells and the mechanism of cell death.

  1987cited by this paper
• Induction, by thymidylate stress, of genetic recombination as evidenced by deletion of a transferred genetic marker in mouse FM3A cells

  1986cited by this paper
• Induction of intrachromosomal recombination in yeast by inhibition of thymidylate biosynthesis.

  1986cited by this paper
• Thymineless death and genetic events in mammalian cells.

  1985cited by this paper
• Chromosome breakage induced by thymidylate stress in thymidylate synthase-negative mutants of mouse FM3A cells.

  1984influential reference
• Thymidylate stress and sister chromatid exchanges.

  1984cited by this paper
• Inhibition of thymidylate biosynthesis induces mitotic unequal sister chromatid recombination in Saccharomyces cerevisiae

  1984cited by this paper
• Accumulation of DNA strand breaks during thymineless death in thymidylate synthase-negative mutants of mouse FM3A cells.

  1983cited by this paper
• Recombination-deficient mutations and thymineless death in Escherichia coli K12: reciprocal effects of recBC and recF and indifference of recA mutations.

  1982cited by this paper
• Nucleotide sequence of the thymidine kinase gene of herpes simplex virus type 1.

  1981cited by this paper
• Methotrexate-induced misincorporation of uracil into DNA.

  1980cited by this paper
• Induction of mitotic recombination in yeast by starvation for thymine nucleotides.

  1980cited by this paper

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  2026cites this paper
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  2024cites this paper
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  2021cites this paper
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  2020cites this paper
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  2019cites this paper
• Inhibition of thymidylate synthase affects neural tube development in mice.

  2018cites this paper
• Study on the Solubilities of Mononitro-Substituted Products of Nitration of m-Toluic Acid in Several Solvents at Temperatures between 297.65 and 351.75 K

  2017cites this paper
• Intrachromosomal recombination between highly diverged DNA sequences is enabled in human cells deficient in Bloom helicase.

  2016cites this paper
• Thymineless Death Lives On: New Insights into a Classic Phenomenon.

  2015cites this paper
• Alterations of DNA repair genes in the NCI-60 cell lines and their predictive value for anticancer drug activity.

  2015cites this paper
• Elucidating a role for uracil DNA glycosylase (UNG)-initiated DNA base excision repair in the cellular sensitivity to the antifolate, pemetrexed

  2014cites this paper
• Uracil DNA glycosylase (UNG) loss enhances DNA double strand break formation in human cancer cells exposed to pemetrexed

  2014cites this paper
• Raltitrexed’s effect on the development of neural tube defects in mice is associated with DNA damage, apoptosis, and proliferation

  2014cites this paper
• SMUG1 but not UNG DNA glycosylase contributes to the cellular response to recovery from 5-fluorouracil induced replication stress.

  2013cites this paper
• Expression and regulation of RAD51 mediate cellular responses to chemotherapeutics.

  2012cites this paper
• Avaliação dos mecanismos envolvidos na resposta aos danos no DNA induzidos pelo agente antitumoral 5-fluorouracil

  2012cites this paper
• New mechanisms for an old drug; DHFR- and non-DHFR-mediated effects of methotrexate in cancer cells.

  2012cites this paper
• Depletion of the bloom syndrome helicase stimulates homology-dependent repair at double-strand breaks in human chromosomes.

  2011cites this paper
• DNA replication initiation as a key element in thymineless death.

  2011cites this paper
• Oligo/Polynucleotide-Based Gene Modification: Strategies and Therapeutic Potential

  2011cites this paper
• Effect of dietary folate restriction on colon carcinogenesis in DNA polymerase beta haploinsufficient mice

  2010cites this paper
• DNA damage and homologous recombination signaling induced by thymidylate deprivation.

  2008cites this paper