Metabolomic profiling identifies biochemical pathways associated with castration-resistant prostate cancer.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Journal of Proteome Research

• Publication date

  2014-02-07

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1021/pr401106hPMID 24359151PMCID PMC3975657
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• [Oncogene].

  2019cited by this paper
• Cell Proliferation and Apoptosis in ADPKD.

  2016cited by this paper
• A comprehensive evaluation of normalization methods for Illumina high-throughput RNA sequencing data analysis

  2013cited by this paper
• Persistent androgen receptor-mediated transcription in castration-resistant prostate cancer under androgen-deprived conditions

  2012cited by this paper
• Integrated Proteomic, Transcriptomic, and Biological Network Analysis of Breast Carcinoma Reveals Molecular Features of Tumorigenesis and Clinical Relapse*

  2012cited by this paper
• Cancer statistics, 2012

  2012cited by this paper
• The Mutational Landscape of Lethal Castrate Resistant Prostate Cancer

  2012cited by this paper
• Differential expression of the androgen-conjugating UGT2B15 and UGT2B17 enzymes in prostate tumor cells during cancer progression.

  2012cited by this paper
• Androgen Receptor Variants Occur Frequently in Castration Resistant Prostate Cancer Metastases

  2011cited by this paper
• Key pathways involved in prostate cancer based on gene set enrichment analysis and meta analysis.

  2011cited by this paper
• Metabolomic Profiling Reveals a Role for Androgen in Activating Amino Acid Metabolism and Methylation in Prostate Cancer Cells

  2011cited by this paper
• Expression of Androgen Receptor Splice Variants in Prostate Cancer Bone Metastases is Associated with Castration-Resistance and Short Survival

  2011cited by this paper
• The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis

  2011cited by this paper
• Impact of biochemical recurrence in prostate cancer among US veterans.

  2010cited by this paper
• Androgen receptor-mTOR crosstalk is regulated by testosterone availability: implication for prostate cancer cell survival.

  2010cited by this paper
• Regulation of androgen receptor transactivity and mTOR–S6 kinase pathway by Rheb in prostate cancer cell proliferation

  2010cited by this paper
• Integrative genomic profiling of human prostate cancer.

  2010cited by this paper
• PI3K-AKT-mTOR Pathway is Dominant over Androgen Receptor Signaling in Prostate Cancer Cells

  2010cited by this paper
• Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer.

  2009cited by this paper
• Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer.

  2009cited by this paper
• Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression

  2009cited by this paper
• Quantitative Proteomic Profiling of Prostate Cancer Reveals a Role for miR-128 in Prostate Cancer*

  2009cited by this paper
• Microarray coupled to quantitative RT–PCR analysis of androgen-regulated genes in human LNCaP prostate cancer cells

  2009cited by this paper
• Optimizing molecular signatures for predicting prostate cancer recurrence

  2009cited by this paper
• A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth.

  2009cited by this paper
• Proteomic Interrogation of Androgen Action in Prostate Cancer Cells Reveals Roles of Aminoacyl tRNA Synthetases

  2009cited by this paper
• Reactivation of androgen receptor-regulated TMPRSS2:ERG gene expression in castration-resistant prostate cancer.

  2009cited by this paper
• Multiple Oncogenic Pathway Signatures Show Coordinate Expression Patterns in Human Prostate Tumors

  2008cited by this paper
• The role of SPINK1 in ETS rearrangement-negative prostate cancers.

  2008cited by this paper
• Androgen receptor mediates the expression of UDP‐glucuronosyltransferase 2 B15 and B17 genes

  2008cited by this paper
• UDP-glucuronosyltransferase 2B15 (UGT2B15) and UGT2B17 Enzymes Are Major Determinants of the Androgen Response in Prostate Cancer LNCaP Cells*

  2007cited by this paper
• Targeted treatment of prostate cancer

  2007cited by this paper
• Oncomine 3.0: genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles.

  2007cited by this paper
• Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression.

  2005cited by this paper
• From the Cover: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

  2005cited by this paper
• Cell proliferation and apoptosis in prostate tumors and adjacent non‐malignant prostate tissue in patients at different time‐points after castration treatment

  2005cited by this paper
• Gene expression profiling predicts clinical outcome of prostate cancer.

  2004cited by this paper
• ONCOMINE: a cancer microarray database and integrated data-mining platform.

  2004cited by this paper
• Expression and function of androgen receptor coactivators in prostate cancer.

  2004cited by this paper
• Identification and validation of novel androgen-regulated genes in prostate cancer.

  2004cited by this paper
• Transcriptional silencing of zinc finger protein 185 identified by expression profiling is associated with prostate cancer progression.

  2003cited by this paper
• Reprints and Subscriptions Permissions

  2003cited by this paper
• The long-term clinical impact of biochemical recurrence of prostate cancer 5 or more years after radical prostatectomy.

  2003cited by this paper
• Inactivation of androgens by UDP-glucuronosyltransferase enzymes in humans.

  2003cited by this paper
• Androgen-induced expression of endoplasmic reticulum (ER) stress response genes in prostate cancer cells

  2002cited by this paper
• Quantitative expression profile of androgen‐regulated genes in prostate cancer cells and identification of prostate‐specific genes

  2001cited by this paper
• Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor

  2000cited by this paper
• Switch from antagonist to agonist of the androgen receptor blocker bicalutamide is associated with prostate tumour progression in a new model system

  1999cited by this paper
• Apoptosis and other mechanisms in androgen ablation treatment and androgen independent progression of prostate cancer: a review.

  1998cited by this paper
• Bilateral orchiectomy with or without flutamide for metastatic prostate cancer.

  1998cited by this paper
• Establishment of two human prostate cancer cell lines derived from a single bone metastasis.

  1997cited by this paper
• The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence.

  1997cited by this paper
• Androgen receptor gene amplification: a novel molecular mechanism for endocrine therapy resistance in human prostate cancer.

  1996cited by this paper
• Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer.

  1995cited by this paper
• Prostate

  1995cited by this paper
• Derivation of androgen‐independent human LNCaP prostatic cancer cell sublines: Role of bone stromal cells

  1994cited by this paper
• Unusual specificity of the androgen receptor in the human prostate tumor cell line LNCaP: high affinity for progestagenic and estrogenic steroids.

  1990cited by this paper
• A controlled trial of leuprolide with and without flutamide in prostatic carcinoma.

  1989cited by this paper
• LNCaP model of human prostatic carcinoma.

  1983cited by this paper
• Studies on prostatic cancer. I. The effect of castration, of estrogen and androgen injection on serum phosphatases in metastatic carcinoma of the prostate.

  1941cited by this paper

• Ammonium metabolism rewiring in the prostate cancer microenvironment: Mechanisms and clinical prospects

  2025cites this paper
• Prostate cancer-derived extracellular vesicles metabolic biomarkers: Emerging roles for diagnosis and prognosis.

  2024cites this paper
• Glutamine Metabolism and Prostate Cancer

  2024cites this paper
• Targeting Glutamine Metabolism in Prostate Cancer

  2023cites this paper
• Management of Advanced Prostate Cancer in the Precision Oncology Era

  2023cites this paper
• Uridine Diphosphate Glucuronosyl Transferase 2B28 (UGT2B28) Promotes Tumor Progression and Is Elevated in African American Prostate Cancer Patients

  2022cites this paper
• Metabolic changes during prostate cancer development and progression

  2022cites this paper
• Extensive metabolic consequences of human glycosyltransferase gene knockouts in prostate cancer

  2022cites this paper
• Androgen receptor (AR) antagonism triggers acute succinate‐mediated adaptive responses to reactivate AR signaling

  2021cites this paper
• Two Novel Ceramide-Like Molecules and miR-5100 Levels as Biomarkers Improve Prediction of Prostate Cancer in Gray-Zone PSA

  2021cites this paper
• The Expression Profiles and Deregulation of UDP-Glycosyltransferase (UGT) Genes in Human Cancers and Their Association with Clinical Outcomes

  2021cites this paper
• Resistance to Androgen Deprivation Leads to Altered Metabolism in Human and Murine Prostate Cancer Cell and Tumor Models

  2021cites this paper
• Metabolic reprogramming as an emerging mechanism of resistance to endocrine therapies in prostate cancer

  2021cites this paper
• Distinct metabolic signatures of hormone-sensitive and castration-resistant prostate cancer revealed by a 1H NMR-based metabolomics of biopsy tissue.

  2020cites this paper
• Exploring the role of glucose‑6‑phosphate dehydrogenase in cancer (Review).

  2020cites this paper
• The HIPPO Transducer YAP and Its Targets CTGF and Cyr61 Drive a Paracrine Signalling in Cold Atmospheric Plasma-Mediated Wound Healing

  2020cites this paper
• Emerging roles for UDP-glucuronosyltransferases in drug resistance and cancer progression

  2020cites this paper
• Alternative promoters control UGT2B17-dependent androgen catabolism in prostate cancer and its influence on progression

  2020cites this paper
• Correction: Disruption of gap junctions attenuates acute myeloid leukemia chemoresistance induced by bone marrow mesenchymal stromal cells

  2019cites this paper
• Bioinformatic identification of differentially expressed genes associated with prognosis of locally advanced lymph node-positive prostate cancer

  2019cites this paper
• NMR-based metabolomics analysis identifies discriminatory metabolic disturbances in tissue and biofluid samples for progressive prostate cancer.

  2019cites this paper
• UPLC-MS/MS-based metabolomic characterization and comparison of pancreatic adenocarcinoma tissues using formalin-fixed, paraffin-embedded and optimal cutting temperature-embedded materials

  2019cites this paper
• Revealing Metabolic Liabilities of Ralaniten To Enhance Novel Androgen Receptor Targeted Therapies.

  2019cites this paper
• Prognostic biomarkers of cervical squamous cell carcinoma identified via plasma metabolomics

  2019cites this paper
• Disruption of gap junctions attenuates acute myeloid leukemia chemoresistance induced by bone marrow mesenchymal stromal cells

  2019cites this paper
• Applications of metabolomics to study cancer metabolism.

  2018cites this paper
• Metabolomics and transcriptomics profiles reveal the dysregulation of the tricarboxylic acid cycle and related mechanisms in prostate cancer

  2018cites this paper
• A k-mer based transcriptomics approach for antisense drug discovery targeting the Ewing’s family of tumors

  2018cites this paper
• SPARC Inhibits Metabolic Plasticity in Ovarian Cancer

  2018cites this paper
• Association between bivariate expression of key oncogenes and metabolic phenotypes of patients with prostate cancer

  2018cites this paper
• Metabolic Profiling in Formalin-Fixed and Paraffin-Embedded Prostate Cancer Tissues

  2017cites this paper
• Enterolactone glucuronide and β-glucuronidase in antibody directed enzyme prodrug therapy for targeted prostate cancer cell treatment

  2017cites this paper
• Cartilaginous Metabolomic Study Reveals Potential Mechanisms of Osteophyte Formation in Osteoarthritis.

  2017cites this paper
• Strategy for comparative untargeted metabolomics reveals honey markers of different floral and geographic origins using ultrahigh-performance liquid chromatography-hybrid quadrupole-orbitrap mass spectrometry.

  2017cites this paper
• Transcriptomic features of primary prostate cancer and their prognostic relevance to castration-resistant prostate cancer

  2017cites this paper
• Flaxseed Lignan Supplementation as Possible Adjuvant Therapy for Prostate and Breast Cancer

  2017cites this paper
• Cancer Genetics, Cancer Biology, and Tumor Growth and Metastasis

  2017cites this paper
• Environmental Effects on Natural Tissues

  2017cites this paper
• Amino Acid Profiling of Zinc Resistant Prostate Cancer Cell Lines: Associations With Cancer Progression

  2017cites this paper
• The UGT2B28 Sex-steroid Inactivation Pathway Is a Regulator of Steroidogenesis and Modifies the Risk of Prostate Cancer Progression.

  2016cites this paper
• Steroidogenesis and Modifies the Risk of Prostate Cancer Progression

  2016cites this paper
• Redox‐regulation of activator protein 1 family members in blood cancer cell lines exposed to cold physical plasma‐treated medium

  2016cites this paper
• Drug discovery in advanced prostate cancer: translating biology into therapy

  2016cites this paper
• Epigenetic regulation of steroid inactivating UDP-glucuronosyltransferases by microRNAs in prostate cancer.

  2016cites this paper
• High-Throughput Metabolic Profiling of Soybean Leaves by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry.

  2016cites this paper
• Metabolomics Profile Recognition for Cancer Diagnostics

  2016cites this paper
• High throughput microscopy identifies bisphenol AP, a bisphenol A analog, as a novel AR down-regulator

  2016cites this paper
• Biomarker Discovery in Human Prostate Cancer: an Update in Metabolomics Studies

  2016cites this paper
• Analyse bio-informatique de données de séquençage de nouvelle génération pour l'étude transcriptomique d'enzymes du métabolisme

  2016cites this paper
• Non-thermal Plasma Activates Human Keratinocytes by Stimulation of Antioxidant and Phase II Pathways

  2015cites this paper
• EMT-induced metabolite signature identifies poor clinical outcome

  2015cites this paper
• Metabolomic profiling for the identification of novel diagnostic markers in prostate cancer

  2015cites this paper
• Platelet-Synthesized Testosterone in Men with Prostate Cancer Induces Androgen Receptor Signaling1

  2015cites this paper
• Metabolomic profiling of hormone-dependent cancers: a bird's eye view.

  2015cites this paper
• Metabolomics Approaches and Applications in Prostate Cancer Research

  2014cites this paper
• Tyrosine kinase inhibitors in the treatment of prostate cancer: taking the next step in clinical development

  2014cites this paper
• Study of cellular oncometabolism via multidimensional protein identification technology.

  2014cites this paper
• Strategies for modern biomarker and drug development in oncology

  2014cites this paper
• Regulation of the pentose phosphate pathway by an androgen receptor–mTOR-mediated mechanism and its role in prostate cancer cell growth

  2014cites this paper
• The Promise of Single Cell Omics for Onco-therapy

  2014cites this paper