ENUMERATION OF ANTIBODY-FORMING CELLS IN THE PERIPHERAL BLOOD OF IMMUNIZED RABBITS.

Rabbits were injected with sheep erythrocytes, and their blood leukocytes were separated at intervals and examined by the agar plaque technique for cells producing specific antibody. In a typical experiment, no active cells appeared after the first injection, but a second stimulus consistently produced antibody-forming cells in considerable numbers (up to several hundred/ml of blood). These cells first appeared on the 2nd day after the second antigen injection, reached a maximum on the 3rd day and rapidly declined. Subsequent injections gave rise to smaller responses. An attempt was made to estimate the efficiency of the separation procedure. Splenectomy of the rabbit had no significant effect on the occurrence of antibody-forming cells in the blood.

• Publication year

  1965

• Venue

  Journal of Immunology

• Publication date

  1965-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.95.1.109PMID 14322568
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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