Studies on the regioselective nucleophilic aromatic substitution (S(N)Ar) reaction of 2-substituted 3,5-dichloropyrazines.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Organic Letters

• Publication date

  2013-04-19

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/ol4006695PMID 23600718
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Interplay between acoustic/phonetic and semantic processes during spoken sentence comprehension: an ERP study.

  2011cited by this paper
• Minisci reactions: Versatile CH-functionalizations for medicinal chemists

  2011cited by this paper
• Aminopyrazine Inhibitors Binding to an Unusual Inactive Conformation of the Mitotic Kinase Nek2: SAR and Structural Characterization†

  2010cited by this paper
• 2,3-Diaminopyrazines as Rho kinase inhibitors.

  2010cited by this paper
• An analysis of the regioselectivity of 1,3-Dipolar cycloaddition reactions of benzonitrile N-Oxides based on global and local electrophilicity and nucleophilicity indices

  2009cited by this paper
• Design, Synthesis, and Structure−Activity Relationships of Novel 2-Substituted Pyrazinoylguanidine Epithelial Sodium Channel Blockers: Drugs for Cystic Fibrosis and Chronic Bronchitis

  2006cited by this paper
• The formal total synthesis of dragmacidin B, trans-dragmacidin C, and cis- and trans-dihydrohamacanthins A

  2005cited by this paper
• Selectivity descriptors for the Michael addition reaction as obtained from density functional based approaches.

  2005cited by this paper
• Synthesis and cytotoxicity evaluation of novel indolylpyrimidines and indolylpyrazines as potential antitumor agents.

  2001cited by this paper
• Prediction of the aroma quality and the threshold values of some pyrazines using artificial neural networks.

  2001cited by this paper
• New imidazo(1,2-a)pyrazine derivatives with bronchodilatory and cyclic nucleotide phosphodiesterase inhibitory activities.

  1999cited by this paper
• Synthesis and antiviral evaluation of certain novel pyrazinoic acid C-nucleosides.

  1998cited by this paper
• Reduced surface: an efficient way to compute molecular surfaces.

  1996cited by this paper
• An Efficient Protocol for the Synthesis of Unsymmetrical Pyrazines. Total Synthesis of Dihydrocephalostatin 11

  1996cited by this paper
• Synthesis and antibronchospastic activity of 8-alkoxy- and 8-(alkylamino)imidazo[1,2-a]pyrazines.

  1992cited by this paper
• Metalation of diazines

  1991cited by this paper
• Polar effects in free-radical reactions. New synthetic developments in the functionalization of heteroaromatic bases by nucleophilic radicals

  1985cited by this paper
• Density functional approach to the frontier-electron theory of chemical reactivity

  1984cited by this paper
• Piperazinylimidazo[1,2-a]pyrazines with selective affinity for in vitro alpha-adrenergic receptor subtypes.

  1983cited by this paper
• Role of frontier orbitals in chemical reactions.

  1982cited by this paper
• Nucleophilic character of alkyl radicals—VI : A new convenient selective alkylation of heteroaromatic bases

  1971cited by this paper
• A new selective type of aromatic substitution: homolytic amidation

  1970cited by this paper
• Indolopyrone und pyridone

  1960cited by this paper

• Nitrogen-Based Organofluorine Functional Molecules: Synthesis and Applications.

  2025cites this paper
• Predicting Reaction Feasibility and Selectivity of Aromatic C─H Thianthrenation with a QM-ML Hybrid Approach.

  2025cites this paper
• Visible-Light-Driven Tandem Cyclization of o-Hydroxyaryl Enaminones: Access to 3-(α-Arylsulfonamido)trifluoroethyl Chromones.

  2025cites this paper
• Computational tools for the prediction of site- and regioselectivity of organic reactions

  2025cites this paper
• Scalable Synthesis of 6-Chloro-1H-pyrazolo[3,4-b]pyrazine via a Continuous Flow Formylation/Hydrazine Cyclization Cascade

  2024cites this paper
• The ReactALL Platform: Experimental Data and Case Studies

  2024cites this paper
• SNAr Regioselectivity Predictions: Machine Learning Triggering DFT Reaction Modeling through Statistical Threshold

  2023cites this paper
• Near‐Infrared OLEDs Based on Functional Pyrazinyl Azolate Os(II) Phosphors and Deuteration

  2022cites this paper
• A broadly applicable quantitative relative reactivity model for nucleophilic aromatic substitution (SNAr) using simple descriptors

  2022cites this paper
• Photoredox catalyzed C-H trifluoroethylamination of heteroarenes.

  2022cites this paper
• Solvent‐Controlled Regioselectivity in Nucleophilic Substitution Reactions of 1‐X‐2,4‐Difluorobenzenes with Morpholine Using Deep Eutectic Solvents

  2021cites this paper
• Single crystal to single crystal transformation of spin-crossover coordination polymers from 3D frameworks to 2D layers

  2021cites this paper
• Pyrazines and Their Benzo Derivatives

  2021cites this paper
• High-Throughput Experimentation and Continuous Flow Evaluation of Nucleophilic Aromatic Substitution Reactions.

  2020cites this paper
• Novel Effect of Thiourea/Urea Additives on the Nucleophilic Aromatic Substitution of 2,4‐Dimethoxynitrobenzene

  2019cites this paper
• The mechanistic study of reaction between N-benzoyl carbamates and aliphatic/aromatic amines for synthesis of substituted N-benzoyl urea derivatives: a DFT approach

  2018cites this paper
• Carbonylation as a novel method for the assembly of pyrazine based oligoamide alpha-helix mimetics.

  2017cites this paper
• Nucleophilic aromatic substitution in chlorinated aromatic systems with a glutathione thiolate model

  2017cites this paper
• Transetherification of 2,4-dimethoxynitrobenzene by aromatic nucleophilic substitution

  2017cites this paper
• Cycloaddition of CS2 to N‐benzylaziridine to synthesize N‐benzylthiazolidine‐2‐thione: a novel reaction route proposed by DFT Study

  2016cites this paper
• Regioselective nucleophilic aromatic substitution reactions of 5,7-dinitroquinazoline-4-one and 5,7-dinitroquinazoline-4-thione with methylamine: a mechanistic consideration

  2015cites this paper
• Nonpolar Solvent a Key for Highly Regioselective SNAr Reaction in the Case of 2,4-Difluoronitrobenzene

  2014cites this paper
• DFT study of mechanism of cycloaddition of carbondioxide with tertiary-aziridine

  2014cites this paper
• Studies on the Regioselective Nucleophilic Aromatic Substitution (SNAr) Reaction of 2‐Substituted 3,5‐Dichloropyrazines.

  2013cites this paper