Biscoclaurine alkaloid cepharanthine protects DNA in TK6 lymphoblastoid cells from constitutive oxidative damage.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Pharmacological Reports

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  PMID 18276990PMCID PMC2577765
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cytometric assessment of DNA damage by exogenous and endogenous oxidants reports aging‐related processes

  2007cited by this paper
• ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis

  2007cited by this paper
• The effects of biscoclaurine alkaloid cepharanthine on mammalian cells: implications for cancer, shock, and inflammatory diseases.

  2007cited by this paper
• ATM activation accompanies histone H2AX phosphorylation in A549 cells upon exposure to tobacco smoke

  2007cited by this paper
• Constitutive histone H2AX phosphorylation and ATM activation are strongly amplified during mitogenic stimulation of lymphocytes

  2007cited by this paper
• Antimalarial activity of alkaloids isolated from Stephania rotunda.

  2007cited by this paper
• Cytometry of ATM activation and histone H2AX phosphorylation to estimate extent of DNA damage induced by exogenous agents

  2007cited by this paper
• Preventive effects of a biscoclaurine alkaloid, cepharanthine, on endotoxin or tumor necrosis factor-alpha-induced septic shock symptoms: involvement of from cell death in L929 cells and nitric oxide production in raw 264.7 cells.

  2007cited by this paper
• Constitutive Histone H2AX Phosphorylation and ATM Activation, the Reporters of DNA Damage by Endogenous Oxidants

  2006cited by this paper
• Constitutive histone H2AX phosphorylation on Ser-139 in cells untreated by genotoxic agents is cell-cycle phase specific and attenuated by scavenging reactive oxygen species.

  2006cited by this paper
• 2-Deoxy-D-glucose Reduces the Level of Constitutive Activation of ATM and Phosphorylation of Histone H2AX

  2006cited by this paper
• Extent of constitutive histone H2AX phosphorylation on Ser‐139 varies in cells with different TP53 status

  2006cited by this paper
• Nitrogen Oxide-Releasing Aspirin Induces Histone H2AX Phosphorylation, ATM Activation and Apoptosis Preferentially in S-Phase Cells: Involvement of Reactive Oxygen Species

  2006cited by this paper
• Sequential phosphorylation of Ser‐10 on histone H3 and ser‐139 on histone H2AX and ATM activation during premature chromosome condensation: Relationship to cell‐cycle phase and apoptosis

  2006cited by this paper
• Phosphorylation of Histone H2AX on Ser 139 and Activation of ATM During Oxidative Burst in Phorbol Ester-Treated Human Leukocytes

  2006cited by this paper
• Cancer chemoprevention by the antioxidant tempol acts partially via the p53 tumor suppressor.

  2005cited by this paper
• Cepharanthine inhibits two-stage tumor promotion by 12-O-tetradecanoylphorbol 13-acetate and mezerein on skin tumor formation in mice initiated with 7,12-dimethylbenz[a]anthracene

  2005cited by this paper
• The antioxidant function of the p53 tumor suppressor

  2005cited by this paper
• Histone H2AX Phosphorylation after Cell Irradiation with UV-B: Relationship to Cell Cycle Phase and Induction of Apoptosis

  2005cited by this paper
• Making ends meet in old age: DSB repair and aging.

  2005cited by this paper
• Cytometric assessment of DNA damage in relation to cell cycle phase and apoptosis

  2005cited by this paper
• ATM Activation in Normal Human Tissues and Testicular Cancer

  2005influential reference
• The Mre11/Rad50/Nbs1 Complex and Its Role as a DNA Double-Strand Break Sensor for ATM

  2005cited by this paper
• Initiating cellular stress responses.

  2004influential reference
• Role of p53 in Sensing Oxidative DNA Damage in Response to Reactive Oxygen Species-Generating Agents

  2004cited by this paper
• Endogenous DNA double-strand breaks: Production, fidelity of repair, and induction of cancer

  2003cited by this paper
• The TP53 Dependence of Radiation-Induced Chromosome Instability in Human Lymphoblastoid Cells

  2003cited by this paper
• Direct radical scavenging by the bisbenzylisoquinoline alkaloid cepharanthine.

  2003cited by this paper
• Cepharanthine exerts antitumor activity on oral squamous cell carcinoma cell lines by induction of p27Kip1.

  2003cited by this paper
• Interactions of fluorochrome‐labeled caspase inhibitors with apoptotic cells: A caution in data interpretation

  2003cited by this paper
• Re-evaluation of antitumor activity of Cepharanthin.

  2002cited by this paper
• Quantitative Detection of 125IdU-Induced DNA Double-Strand Breaks with γ-H2AX Antibody

  2002influential reference
• Quantitative detection of (125)IdU-induced DNA double-strand breaks with gamma-H2AX antibody.

  2002cited by this paper
• Seventeen Cases of Alopecia Areata: Combination of SADBE Topical Immunotherapy with Other Therapies

  2002cited by this paper
• Suppression of cytokine production and neural cell death by the anti-inflammatory alkaloid cepharanthine: a potential agent against HIV-1 encephalopathy.

  2001cited by this paper
• Pharmacological characterization of cepharanthin in chronic idiopathic thrombocytopenic purpura

  2001cited by this paper
• Protection of T cells from radiation-induced apoptosis by Cepharanthin.

  2001cited by this paper
• Potent antiperoxidation activity of the bisbenzylisoquinoline alkaloid cepharanthine: the amine moiety is responsible for its pH-dependent radical scavenge activity.

  1999cited by this paper
• DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139*

  1998cited by this paper
• An oxidative stress-mediated death pathway in irradiated human leukemia cells mapped using multilaser flow cytometry.

  1998cited by this paper
• A model for p53-induced apoptosis

  1997cited by this paper
• Oxidative Decay of DNA*

  1997cited by this paper
• Therapeutic experience of venomous snakebites by the Japanese viper (Agkistrodon halys Blomhoffii) with low dose of antivenin: report of 43 consecutive cases.

  1997cited by this paper
• Histamine release inhibition activity of bisbenzylisoquinoline alkaloids.

  1992cited by this paper
• Selective inhibition of T-cell-dependent immune responses by bisbenzylisoquinoline alkaloids in vivo.

  1992cited by this paper
• Cepharanthine (biscoclaurine alkaloid) treatment in endotoxic shock of suckling rats

  1991cited by this paper
• Inhibition of 12-O-tetradecanoyl phorbol-13-acetate promoted tumorigenesis by cepharanthine, a biscoclaurine alkaloid, in relation to the inhibitory effect on protein kinase C.

  1991cited by this paper
• Inhibition of active oxygen generation in guinea-pig neutrophils by biscoclaurine alkaloids.

  1990cited by this paper
• Inhibition of active oxygen generation in guinea-pig neutrophils by biscoclaurine alkaloids.

  1990cited by this paper
• [Effect of cepharanthin on radiotherapy induced leukopenia].

  1990cited by this paper
• Reversal of resistance to doxorubicin with cepharanthine in murine P388 leukemia cells.

  1990cited by this paper
• [Mode of the anti-allergic action of cepharanthine on an experimental model of allergic rhinitis].

  1987cited by this paper
• In vitro anti-sickling effect on cepharanthine.

  1982cited by this paper
• Inhibition by biscoclaurine alkaloid of lipid peroxidation in biological membranes.

  1980cited by this paper

• Cepharanthine, a valuable sanative alternative for hepatocellular carcinoma through regulating Hippo-Yes-associated protein signal transduction.

  2026cites this paper
• Cepharanthine as a Biofactor: Molecular Functions, Signaling Pathway Modulation and Therapeutic Relevance in Cancer and Drug Resistance

  2025cites this paper
• Cepharantine prevents hypertrophic scarring by regulating the TGF-β/SMAD pathway

  2025cites this paper
• Identification of cepharanthine as an effective inhibitor of African swine fever virus replication

  2024cites this paper
• Pharmacological Activity of Cepharanthine

  2023cites this paper
• Cepharanthine Exerts Antioxidant and Anti-Inflammatory Effects in Lipopolysaccharide (LPS)-Induced Macrophages and DSS-Induced Colitis Mice

  2023cites this paper
• Revealing and evaluation of antivirals targeting multiple druggable sites of RdRp complex in SARS-CoV-2

  2023cites this paper
• Disturbing effect of cepharanthine on valve interstitial cells calcification via regulating glycolytic metabolism pathways

  2022cites this paper
• Alkaloids in genus stephania (Menispermaceae): A comprehensive review of its ethnopharmacology, phytochemistry, pharmacology and toxicology.

  2022cites this paper
• Cepharanthine attenuates cerebral ischemia/reperfusion injury by reducing NLRP3 inflammasome-induced inflammation and oxidative stress via inhibiting 12/15-LOX signaling.

  2020cites this paper
• Declining BRCA-Mediated DNA Repair in Sperm Aging and its Prevention by Sphingosine-1-Phosphate

  2020cites this paper
• Synthetic 3-alkylpyridine alkaloid analogues as a new scaffold against leukemic cell lines: cytotoxic evaluation and mode of action

  2019cites this paper
• Cepharanthine: An update of its mode of action, pharmacological properties and medical applications

  2019cites this paper
• Cepharanthine and Piperine ameliorate diabetic nephropathy in rats: role of NF-κB and NLRP3 inflammasome.

  2016cites this paper
• FK-3000 isolated from Stephania delavayi Diels. inhibits MDA-MB-231 cell proliferation by decreasing NF-κB phosphorylation and COX-2 expression

  2015cites this paper
• In search of antiaging modalities: Evaluation of mTOR‐ and ROS/DNA damage‐signaling by cytometry

  2014cites this paper
• Ethnobotany, phytochemistry and pharmacology of Stephania rotunda Lour.

  2014cites this paper
• Cepharanthine: A Therapeutic Potential Candidate for Psoriasis

  2012cites this paper
• Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling

  2012cites this paper
• Cepharanthine improves renal ischemia-reperfusion injury in rats.

  2011cites this paper
• Genome protective effect of metformin as revealed by reduced level of constitutive DNA damage signaling

  2011cites this paper
• Therapeutic potential of the biscoclaurine alkaloid, cepharanthine, for a range of clinical conditions

  2011cites this paper
• Simple, sensitive and rapid HPLC-MS/MS method for the determination of cepharanthine in human plasma.

  2010cites this paper
• Fluoroquinolones lower constitutive H2AX and ATM phosphorylation in TK6 lymphoblastoid cells via modulation of the intracellular redox status

  2009cites this paper
• Biscoclaurine alkaloid cepharanthine inhibits the growth of primary effusion lymphoma in vitro and in vivo and induces apoptosis via suppression of the NF‐κB pathway

  2009cites this paper
• Antioxidative Effects and Anti-proliferative Effects of MeOH, BuOH and Ethyl Acetate Fractionated from Stephania delavayi Diels

  2009influential citation
• Remarkable enhancement of cytotoxicity of onconase and cepharanthine when used in combination on various tumor cell lines

  2008cites this paper