Molecular conservation of marsupial and eutherian placentation and lactation

Eutherians are often mistakenly termed ‘placental mammals’, but marsupials also have a placenta to mediate early embryonic development. Lactation is necessary for both infant and fetal development in eutherians and marsupials, although marsupials have a far more complex milk repertoire that facilitates morphogenesis of developmentally immature young. In this study, we demonstrate that the anatomically simple tammar placenta expresses a dynamic molecular program that is reminiscent of eutherian placentation, including both fetal and maternal signals. Further, we provide evidence that genes facilitating fetal development and nutrient transport display convergent co-option by placental and mammary gland cell types to optimize offspring success. DOI: http://dx.doi.org/10.7554/eLife.27450.001

• Publication year

  2017

• Venue

  eLife

• Publication date

  2017-09-12

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.7554/eLife.27450PMID 28895534PMCID 5595433
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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