Differential behavioral and molecular alterations upon protracted abstinence from cocaine versus morphine, nicotine, THC and alcohol

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Addiction Biology

• Publication date

  2017-09-01

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1111/adb.12405PMID 27126842PMCID PMC5085894
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Treatment-refractory substance use disorder: Focus on alcohol, opioids, and cocaine.

  2016cited by this paper
• Diagnostic and Statistical Manual of Mental Disorders (DSM-5)

  2015cited by this paper
• Dorsal raphe 5-HT(2C) receptor and GABA networks regulate anxiety produced by cocaine withdrawal.

  2015cited by this paper
• Commonalities and Distinctions Among Mechanisms of Addiction to Alcohol and Other Drugs.

  2015cited by this paper
• Reduced dopamine release in the nucleus accumbens core of adult rats following adolescent binge alcohol exposure: age and dose-dependent analysis

  2015cited by this paper
• Differential vulnerability to relapse into heroin versus cocaine-seeking as a function of setting

  2015cited by this paper
• Extended access to nicotine leads to a CRF1 receptor dependent increase in anxiety‐like behavior and hyperalgesia in rats

  2015cited by this paper
• Effects of ethanol exposure and withdrawal on dendritic morphology and spine density in the nucleus accumbens core and shell.

  2015cited by this paper
• Adolescent nicotine alters dendritic morphology in the bed nucleus of the stria terminalis.

  2015cited by this paper
• Polysubstance use, mental health and high-risk behaviours: Results from the 2012 Global Drug Survey.

  2015cited by this paper
• Downregulation of the endogenous opioid peptides in the dorsal striatum of human alcoholics

  2015cited by this paper
• The Development and Maintenance of Drug Addiction

  2014cited by this paper
• Social cognition deficits and associations with drinking history in alcoholic men and women.

  2014cited by this paper
• The “addicted” spine

  2014cited by this paper
• Natural neural projection dynamics underlying social behavior.

  2014cited by this paper
• Distinct Mu, Delta, and Kappa Opioid Receptor Mechanisms Underlie Low Sociability and Depressive-Like Behaviors During Heroin Abstinence

  2014influential reference
• Impaired fear recognition and attentional set-shifting is associated with brain structural changes in alcoholic patients

  2014cited by this paper
• Hostility and cigarette use: a comparison between smokers and nonsmokers in a matched sample of adolescents.

  2014cited by this paper
• Functional changes of the reward system underlie blunted response to social gaze in cocaine users

  2014cited by this paper
• Extinction of drug seeking: Neural circuits and approaches to augmentation.

  2014cited by this paper
• Addiction as a stress surfeit disorder.

  2014cited by this paper
• Cocaine Dysregulates Opioid Gating of GABA Neurotransmission in the Ventral Pallidum

  2014cited by this paper
• Addiction science: Uncovering neurobiological complexity.

  2014cited by this paper
• The Oxytocin Analogue Carbetocin Prevents Emotional Impairment and Stress-Induced Reinstatement of Opioid-Seeking in Morphine-Abstinent Mice

  2014cited by this paper
• Adolescent nicotine-induced dendrite remodeling in the nucleus accumbens is rapid, persistent, and D1-dopamine receptor dependent

  2014cited by this paper
• Modulation of Risky Choices in Recently Abstinent Dependent Cocaine Users: A Transcranial Direct-Current Stimulation Study

  2014cited by this paper
• Fibromyalgia, autism, and opioid addiction as natural and induced disorders of the endogenous opioid hormonal system.

  2014cited by this paper
• Dissociation of heroin-induced emotional dysfunction from psychomotor activation and physical dependence among inbred mouse strains

  2014cited by this paper
• Autistic-Like Syndrome in Mu Opioid Receptor Null Mice is Relieved by Facilitated mGluR4 Activity

  2014influential reference
• Impaired Hippocampus-Dependent and Facilitated Striatum-Dependent Behaviors in Mice Lacking the Delta Opioid Receptor

  2013cited by this paper
• ΔFosB Induction in Striatal Medium Spiny Neuron Subtypes in Response to Chronic Pharmacological, Emotional, and Optogenetic Stimuli

  2013cited by this paper
• Protracted withdrawal from ethanol and enhanced responsiveness stress: regulation via the dynorphin/kappa opioid receptor system.

  2013cited by this paper
• Social reward requires coordinated activity of accumbens oxytocin and 5HT

  2013cited by this paper
• A history of chronic morphine exposure during adolescence increases despair-like behaviour and strain-dependently promotes sociability in abstinent adult mice.

  2013cited by this paper
• Ethopharmacological analysis of the open elevated plus-maze in mice.

  2013cited by this paper
• Deficits in social perception in opioid maintenance patients, abstinent opioid users and non-opioid users.

  2013cited by this paper
• Protracted abstinence from distinct drugs of abuse shows regulation of a common gene network

  2012influential reference
• Nicotine-induced anxiety-like behavior in a rat model of the novelty-seeking phenotype is associated with long-lasting neuropeptidergic and neuroplastic adaptations in the amygdala: effects of the cannabinoid receptor 1 antagonist AM251.

  2012cited by this paper
• Optogenetic dissection of neural circuits underlying emotional valence and motivated behaviors.

  2012cited by this paper
• Enhanced Anxiety Observed in Cocaine Withdrawn Rats Is Associated with Altered Reactivity of the Dorsomedial Prefrontal Cortex

  2012cited by this paper
• Neuropsychological consequences of chronic opioid use: a quantitative review and meta-analysis.

  2012cited by this paper
• Nucleus accumbens D2- and D1-receptor expressing medium spiny neurons are selectively activated by morphine withdrawal and acute morphine, respectively.

  2012cited by this paper
• Activation of brain NOP receptors attenuates acute and protracted alcohol withdrawal symptoms in the rat.

  2011cited by this paper
• Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling.

  2011cited by this paper
• Endocannabinoid Regulation of Acute and Protracted Nicotine Withdrawal: Effect of FAAH Inhibition

  2011cited by this paper
• Chronic intermittent ethanol exposure in early adolescent and adult male rats: effects on tolerance, social behavior, and ethanol intake.

  2011cited by this paper
• Cocaine-Induced Plasticity in the Nucleus Accumbens Is Cell Specific and Develops without Prolonged Withdrawal

  2011cited by this paper
• Impaired emotional-like behavior and serotonergic function during protracted abstinence from chronic morphine.

  2011influential reference
• Opiate versus psychostimulant addiction: the differences do matter

  2011influential reference
• Promising medications for cocaine dependence treatment.

  2011cited by this paper
• Neurobiology of the incubation of drug craving.

  2011cited by this paper
• Substance abuse and movement disorders

  2010cited by this paper
• Reduced emotional and corticosterone responses to stress in mu-opioid receptor knockout mice.

  2010cited by this paper
• Addiction: Decreased reward sensitivity and increased expectation sensitivity conspire to overwhelm the brain's control circuit

  2010cited by this paper
• The pleasures of play: pharmacological insights into social reward mechanisms.

  2010cited by this paper
• Relationship between anxiety disorders and opiate dependence--a systematic review of the literature: implications for diagnosis and treatment.

  2010cited by this paper
• Neural systems underlying approach and avoidance in anxiety disorders

  2010cited by this paper
• Ambience and drug choice: cocaine- and heroin-taking as a function of environmental context in humans and rats.

  2009cited by this paper
• Reward processing by the opioid system in the brain.

  2009cited by this paper
• Time-Dependent Neuroendocrine Alterations and Drug Craving during the First Month of Abstinence in Heroin Addicts

  2009cited by this paper
• Cocaine addiction: from habits to stereotypical-repetitive behaviors and punding.

  2008cited by this paper
• The Role of Amygdalar Mu-Opioid Receptors in Anxiety-Related Responses in Two Rat Models

  2008influential reference
• Application of a translational profiling approach for the comparative analysis of CNS cell types.

  2008influential reference
• From ultrasocial to antisocial: a role for oxytocin in the acute reinforcing effects and long‐term adverse consequences of drug use?

  2008cited by this paper
• Withdrawal from chronic administration of cocaine decreases delta opioid receptor signaling and increases anxiety- and depression-like behaviors in the rat.

  2008cited by this paper
• Remission and resurgence of anxiety-like behavior across protracted withdrawal stages in ethanol-dependent rats.

  2007cited by this paper
• Cocaine-induced dendritic spine formation in D1 and D2 dopamine receptor-containing medium spiny neurons in nucleus accumbens.

  2006cited by this paper
• Persistent and Reversible Morphine Withdrawal‐Induced Morphological Changes in the Nucleus Accumbens

  2006cited by this paper
• Cognitive consequences of cannabis use: comparison with abuse of stimulants and heroin with regard to attention, memory and executive functions.

  2005cited by this paper
• Conditioning of morphine-induced locomotor activity and stereotyped behaviour in rats

  2005cited by this paper
• Anticraving medications for relapse prevention: a possible new class of psychoactive medications.

  2005cited by this paper
• The mouse brain in stereotaxic coordinates

  2003cited by this paper
• Mixed emotions: alcoholics' impairments in the recognition of specific emotional facial expressions.

  2003cited by this paper
• Neurobiology of Relapse to Heroin and Cocaine Seeking: A Review

  2002cited by this paper
• Effects of long-term moderate alcohol consumption on agonistic and affiliative behavior of socially housed female cynomolgus monkeys (Macaca fascicularis)

  2002cited by this paper
• Accentuated decrease in social interaction in rats subjected to repeated ethanol withdrawals.

  2002cited by this paper
• The relationship between anxiety and substance use disorders among individuals with severe affective disorders.

  2002cited by this paper
• Marijuana abstinence effects in marijuana smokers maintained in their home environment.

  2001cited by this paper
• Mice deficient for δ- and μ-opioid receptors exhibit opposing alterations of emotional responses

  2000cited by this paper
• Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses.

  2000cited by this paper
• Society for the study of addiction.

  1999cited by this paper
• Neostriatal cell subtypes and their functional roles.

  1997cited by this paper
• An ethological analysis of the effects of chlordiazepoxide and bretazenil (Ro 16–6028) in the murine elevated plus‐maze

  1993cited by this paper
• Intrinsic GABAergic neurons in the rat central extended amygdala

  1993cited by this paper
• Chronic cocaine alters brain mu opioid receptors.

  1992cited by this paper
• Evidence for the role of dopamine D1 receptors in morphine induced stereotypic behavior.

  1989cited by this paper
• Stereotypic wall climbing in mice during ethanol withdrawal: a new measure of physical dependence.

  1987cited by this paper

• Role of opioid tapering in rescuing anxiety and social novelty deficits in morphine-withdrawn male rats.

  2025cites this paper
• Corticotropin-releasing hormone signaling from piriform cortex to amygdala mediates social homophily in opioid addiction.

  2025cites this paper
• Effect of morphine dependence and withdrawal on operant social interaction in male and female rats

  2025cites this paper
• Paternal heroin self-administration in rats increases drug-seeking behavior in male offspring via miR-19b downregulation in the nucleus accumbens

  2025cites this paper
• Perinatal exposure to the autism-linked metabolite p-Cresol has limited impact on early development in mice but lasting effects on adult social behavior

  2025cites this paper
• Three-day delta-9-tetrahydrocannabinol (THC) exposure eliminates long-term depression in ventral tegmental area of young, but not adult mice

  2025cites this paper
• Suppression of binge alcohol drinking by an inhibitory neuronal ensemble in the mouse medial orbitofrontal cortex

  2025cites this paper
• Translating human drug use patterns into rat models: exploring spontaneous interindividual differences via refined drug self-administration procedures

  2024cites this paper
• Comparing withdrawal- and anxiety-like behaviors following oral and subcutaneous oxycodone administration in C57BL/6 mice

  2024cites this paper
• Characterization and validation of a spontaneous acute and protracted oxycodone withdrawal model in male and female mice.

  2024cites this paper
• Design of Animal Experiments in Pharmacological Research

  2024cites this paper
• Differential effects of acute and prolonged morphine withdrawal on motivational and goal‐directed control over reward‐seeking behaviour

  2024cites this paper
• Effects of CB1 receptor negative allosteric modulator Org27569 on oxycodone withdrawal symptoms in mice

  2024cites this paper
• Protracted opioid withdrawal behaviors are reduced by nitric oxide inhibition in mice

  2024cites this paper
• Mu opioid receptor-positive neurons in the dorsal raphe nucleus are impaired by morphine abstinence.

  2023cites this paper
• Advances in the characterization of negative affect caused by acute and protracted opioid withdrawal using animal models.

  2023cites this paper
• Differential effects of acute and prolonged morphine withdrawal on motivational and goal-directed control over reward-seeking behavior

  2023cites this paper
• Kratom (M. speciosa) exposure during adolescence caused long-lasting cognitive behavioural deficits associated with perturbated brain metabolism pathways in adult rats.

  2023cites this paper
• Alcohol-specific transcriptional dynamics of memory reconsolidation and relapse

  2023cites this paper
• Striatal μ-opioid receptor activation triggers direct-pathway GABAergic plasticity and induces negative affect

  2023cites this paper
• Transcriptomics in the nucleus accumbens shell reveal sex- and reinforcer-specific signatures associated with morphine and sucrose craving

  2022cites this paper
• Neural circuits regulating prosocial behaviors

  2022cites this paper
• Negative emotional behavior during fentanyl abstinence is mediated by adaptations in nucleus accumbens neuron subtypes

  2022cites this paper
• Balance between direct and indirect pathways of the nucleus accumbens controls social behavior in mice

  2022cites this paper
• Brain systems in cocaine abstinence-induced anxiety-like behavior in rodents: A review.

  2022cites this paper
• Adolescent kratom exposure affects cognitive behaviours and brain metabolite profiles in Sprague-Dawley rats

  2022cites this paper
• Adaptations in Nucleus Accumbens Neuron Subtypes Mediate Negative Affective Behaviors in Fentanyl Abstinence.

  2022cites this paper
• Alcohol-specific transcriptional dynamics of memory reconsolidation

  2022cites this paper
• Chronic Physical and Vicarious Psychosocial Stress Alter Fentanyl Consumption and Nucleus Accumbens Rho GTPases in Male and Female C57BL/6 Mice

  2021cites this paper
• The microbial metabolite p-Cresol induces autistic-like behaviors in mice by remodeling the gut microbiota

  2021cites this paper
• Drug addiction co-morbidity with alcohol: Neurobiological insights.

  2021cites this paper
• A cAMP-Related Gene Network in Microglia Is Inversely Regulated by Morphine Tolerance and Withdrawal

  2021cites this paper
• Coordination of social behaviors by the bed nucleus of the stria terminalis

  2020cites this paper
• The Negative Affect of Protracted Opioid Abstinence: Progress and Perspectives From Rodent Models.

  2020cites this paper
• Long-lasting pseudo-social aggressive behavior in opiate-withdrawn mice.

  2020cites this paper
• The orphan receptor GPR88 blunts the signaling of opioid receptors and multiple striatal GPCRs

  2020cites this paper
• Ketamine blocks the correlation between morphine-induced conditioned place preference and anxiety-like behaviors in mice

  2020cites this paper
• Nukleus akumbens core bölgesinde L-NAME ve agmatinin morfin yoksunluğuna etkileri

  2020cites this paper
• Ketamine Blocks Morphine-Induced Conditioned Place Preference and Anxiety-Like Behaviors in Mice

  2020cites this paper
• Facilitating mGluR4 activity reverses the long-term deleterious consequences of chronic morphine exposure

  2020cites this paper
• Chronic nicotine impairs sparse motor learning via striatal fast‐spiking parvalbumin interneurons

  2020cites this paper
• Affective Disruption During Forced Ethanol Abstinence in C57BL/6J and C57BL/6NJ Mice.

  2020cites this paper
• Drug-Induced Conditioned Place Preference and Its Practical Use in Substance Use Disorder Research

  2020cites this paper
• Protracted Abstinence From Extended Cocaine Self-Administration Is Associated With Hypodopaminergic Activity in the VTA but Not in the SNc

  2020cites this paper
• The microbial metabolite p-Cresol induces autistic-like behaviors in mice by remodeling the gut microbiota

  2020cites this paper
• Characterization of ethanol-related phenotypic differences between C57BL/6J and C57BL/6NJ substrains: Role of Cyfip2?

  2019cites this paper
• Image‐guided cranial irradiation‐induced ablation of dentate gyrus neurogenesis impairs extinction of recent morphine reward memories

  2019cites this paper
• Endogenous Opiates and Behavior: 2017.

  2019cites this paper
• Modeling and testing compulsive eating behaviors in animals

  2019cites this paper
• Endocannabinoid Signaling in the Central Amygdala and Bed Nucleus of the Stria Terminalis: Implications for the Pathophysiology and Treatment of Alcohol Use Disorder.

  2019cites this paper
• Neuroepigenetics and addictive behaviors: Where do we stand?

  2019cites this paper
• Escalation of drug use in persons dually diagnosed with opioid and cocaine dependence: Gender comparison and dimensional predictors.

  2019cites this paper
• Current status of opioid addiction treatment and related preclinical research

  2019cites this paper
• Mu opioid receptors in GABAergic neurons of the forebrain promote alcohol reward and drinking

  2019cites this paper
• Heroin versus cocaine: opposite choice as a function of context but not of drug history in the rat

  2018cites this paper
• Le récepteur 5-HT6 et la dynamique de son réceptosome : rôle dans la différenciation neuronale et potentiel thérapeutique pour le traitement des troubles de spectre de l'autisme

  2018cites this paper
• Arc and homer 1a expression following intravenous administration of heroin and cocaine : a novel application of the catFISH technique

  2018cites this paper
• Bioligands Acting on the Cannabinoid Receptor CB1 for the Treatment of Withdrawal Syndrome Caused by Cannabis sativa

  2018cites this paper
• Wnt7a in Mouse Insular Cortex Contributes to Anxiety-like Behavior During Protracted Abstinence from Morphine.

  2018cites this paper
• Back-translating behavioral intervention for autism spectrum disorders to mice with blunted reward restores social abilities

  2018cites this paper
• Prolonged abstinence from cocaine or morphine disrupts separable valuations during decision conflict

  2018cites this paper
• Opioid receptors: drivers to addiction?

  2018cites this paper
• μ opioid receptor, social behaviour and autism spectrum disorder: reward matters

  2018cites this paper
• Addiction research and theory: a commentary on the Surgeon General's Report on alcohol, drugs, and health

  2018cites this paper
• Cocaine Seeking During Initial Abstinence Is Driven by Noradrenergic and Serotonergic Signaling in Hippocampus in a Sex-Dependent Manner

  2017cites this paper
• Medications for substance use disorders (SUD): emerging approaches

  2017cites this paper
• Neuroinflammation-a co-occurring phenomenon linking chronic pain and opioid dependence.

  2017cites this paper
• Long-Term Transcriptional Consequences of Drug Exposure as Cues to Understand Vulnerability to Relapse: Advances and Perspectives.

  2016cites this paper