Development of Cyclooxygenases in the Treatment of Pain, Fever and Inflammation.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Research & Reviews: Journal of Pharmaceutics and Nanotechnology

• Publication date

  2014-12-24

• Fields of study

  Medicine, Chemistry

• Identifiers

  No identifiers available.

• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Synergism between COX-3 inhibitors in two animal models of pain

  2010cited by this paper
• [COX-3: is it the target of acetaminophen?].

  2010cited by this paper
• [The effect of COX-1 and COX-3 inhibitors on blood nitric oxide concentration].

  2009cited by this paper
• Acetaminophen: antipyretic or hypothermic in mice? In either case, PGHS-1b (COX-3) is irrelevant.

  2008cited by this paper
• Intrathecally administered COX-2 but not COX-1 or COX-3 inhibitors attenuate streptozotocin-induced mechanical hyperalgesia in rats.

  2007cited by this paper
• Cloning of cyclooxygenase-1b (putative COX-3) in mouse

  2006cited by this paper
• COX-3 and the mechanism of action of paracetamol/acetaminophen.

  2005cited by this paper
• COX-3: fact or fancy?

  2004cited by this paper
• COX-3: a splice variant of cyclooxygenase-1 in mouse neural tissue and cells.

  2003cited by this paper
• [Mechanism of inhibition OF COX-2 and COX-3 in gastrointestinal damage induced by NSAID in rats ].

  2003cited by this paper
• COX-3: in the wrong frame in mind.

  2003cited by this paper
• COX‐3—a virtual pain target in humans?

  2003cited by this paper
• COX-1 and COX-3 inhibitors.

  2003cited by this paper
• COX-3 the enzyme and the concept: steps towards highly specialized pathways and precision therapeutics?

  2003cited by this paper
• The spinal phospholipase-cyclooxygenase-prostanoid cascade in nociceptive processing.

  2002cited by this paper
• Valdecoxib, a COX-2–Specific Inhibitor, Is an Efficacious, Opioid-Sparing Analgesic in Patients Undergoing Hip Arthroplasty

  2002cited by this paper
• Cyclooxygenase-2: a therapeutic target.

  2002cited by this paper
• Comparison of the analgesic efficacy of rofecoxib and enteric-coated diclofenac sodium in the treatment of postoperative dental pain: a randomized, placebo-controlled clinical trial.

  2002cited by this paper
• Peripheral prostanoid levels and nonsteroidal anti‐inflammatory drug analgesia: Replicate clinical trials in a tissue injury model

  2002cited by this paper
• Up‐regulation of COX‐2 by inhibition of COX‐1 in the rat: a key to NSAID‐induced gastric injury

  2002cited by this paper
• Cyclooxygenase-3 (COX-3): Filling in the gaps toward a COX continuum?

  2002cited by this paper
• Cardiovascular pharmacology of nonselective nonsteroidal anti-inflammatory drugs and coxibs: clinical considerations.

  2002cited by this paper
• Pharmacology of cyclooxygenase-2 inhibition in the kidney.

  2002cited by this paper
• Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H2 synthases

  2002cited by this paper
• COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression

  2002cited by this paper
• Efficacy of celecoxib, a cyclooxygenase 2-specific inhibitor, in the treatment of ankylosing spondylitis: a six-week controlled study with comparison against placebo and against a conventional nonsteroidal antiinflammatory drug.

  2001cited by this paper
• Interleukin-1β-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity

  2001cited by this paper
• Antipyretics: mechanisms of action and clinical use in fever suppression.

  2001cited by this paper
• Aspirin: new cardiovascular uses for an old drug.

  2001cited by this paper
• The fight against rheumatism: from willow bark to COX-1 sparing drugs.

  2000cited by this paper
• COX-1, COX-2, and COX-3 and the future treatment of chronic inflammatory disease.

  2000cited by this paper
• Paracetamol: Past, Present, and Future

  2000cited by this paper
• Paracetamol-inhibitable COX-2.

  2000cited by this paper
• Induction of an acetaminophen-sensitive cyclooxygenase with reduced sensitivity to nonsteroid antiinflammatory drugs.

  1999cited by this paper
• Cyclo‐oxygenase‐2: pharmacology, physiology, biochemistry and relevance to NSAID therapy

  1999cited by this paper
• Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis.

  1999cited by this paper
• The febrile response to lipopolysaccharide is blocked in cyclooxygenase-2(-/-), but not in cyclooxygenase-1(-/-) mice.

  1999cited by this paper
• Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

  1997cited by this paper
• Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX‐2 inhibitor

  1997cited by this paper
• Variability in risk of gastrointestinal complications with individual non-steroidal anti-inflammatory drugs: results of a collaborative meta-analysis

  1996cited by this paper
• Flexibility of the NSAID binding site in the structure of human cyclooxygenase-2

  1996cited by this paper
• Endothelial cells of the rat brain vasculature express cyclooxygenase-2 mRNA in response to systemic interleukin-1 beta: a possible site of prostaglandin synthesis responsible for fever.

  1996cited by this paper
• Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs

  1994cited by this paper
• Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.

  1993cited by this paper
• Structure of the mitogen-inducible TIS10 gene and demonstration that the TIS10-encoded protein is a functional prostaglandin G/H synthase.

  1992cited by this paper
• cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase.

  1992cited by this paper
• Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.

  1991cited by this paper
• TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue.

  1991cited by this paper
• Pronounced reduction of in vivo prostacyclin synthesis in humans by acetaminophen (paracetamol).

  1989cited by this paper
• From studies of biochemical mechanism to novel biological mediators: prostaglandin endoperoxides, thromboxanes, and leukotrienes. Nobel Lecture, 8 December 1982.

  1983cited by this paper
• From studies of biochemical mechanism to novel biological mediators: Prostaglandin endoperoxides, thromboxanes, and leukotriences

  1983cited by this paper
• Inhibition of Prostaglandin Synthetase in Brain explains the Anti-pyretic Activity of Paracetamol (4-Acetamidophenol)

  1972cited by this paper
• Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.

  1971cited by this paper
• For Personal Use. Only Reproduce with Permission from the Lancet Publishing Group

  year unknowncited by this paper

• No citing papers are available for this paper.