Liver-Specific Alpha 2 Interferon Gene Expression Results in Protection from Induced Hepatitis

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Journal of Virology

• Publication date

  2000-05-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/jvi.74.10.4816-4823.2000PMID 10775620PMCID PMC112004
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pillars Article: Virus Interference. I. The Interferon. Proc R Soc Lond B Biol Sci. 1957. 147: 258-267.

  2015cited by this paper
• Prolonged Expression and Effective Readministration of Erythropoietin Delivered with a Fully Deleted Adenoviral Vector

  2000cited by this paper
• Characterization of the effects of hepatitis C virus nonstructural 5A protein expression in human cell lines and on interferon‐sensitive virus replication

  1999cited by this paper
• Adenovirus-mediated regulable target gene expression in vivo.

  1999cited by this paper
• Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein.

  1999cited by this paper
• Viral clearance without destruction of infected cells during acute HBV infection.

  1999cited by this paper
• NS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein 2 adaptor protein in a Src homology 3 domain/ligand-dependent manner and perturbs mitogenic signaling.

  1999cited by this paper
• Enhanced inhibition of hepatitis B virus production by asialoglycoprotein receptor-directed interferon

  1999cited by this paper
• Site-specific integration mediated by a hybrid adenovirus/adeno-associated virus vector.

  1999cited by this paper
• An adenoviral vector deleted for all viral coding sequences results in enhanced safety and extended expression of a leptin transgene.

  1998cited by this paper
• Inhibition of Hepatitis B Virus Replication during Adenovirus and Cytomegalovirus Infections in Transgenic Mice

  1998cited by this paper
• Antiviral activities of individual murine IFN-alpha subtypes in vivo: intramuscular injection of IFN expression constructs reduces cytomegalovirus replication.

  1998cited by this paper
• Interferon-beta gene therapy inhibits tumor formation and causes regression of established tumors in immune-deficient mice.

  1998cited by this paper
• Interferon alfa-2b alone or in combination with ribavirin for the treatment of relapse of chronic hepatitis C. International Hepatitis Interventional Therapy Group.

  1998cited by this paper
• Efficacy of high dose of recombinant alpha 2b interferon on long term response in chronic hepatitis C and cirrhosis: prospective randomized multicentre study.

  1998cited by this paper
• Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays.

  1998cited by this paper
• Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity

  1998cited by this paper
• Strain difference in the induction of T‐cell activation–associated, interferon gamma–dependent hepatic injury in mice

  1998cited by this paper
• Randomised, double-blind, placebo-controlled trial of interferon alpha-2b with and without ribavirin for chronic hepatitis C. The Swedish Study Group.

  1998cited by this paper
• Randomised, double-blind, placebo-controlled trial of interferon α-2b with and without ribavirin for chronic hepatitis C

  1998cited by this paper
• Identification of genes differentially regulated by interferon α, β, or γ using oligonucleotide arrays

  1998cited by this paper
• Interferons and Other Cytokines

  1997cited by this paper
• Fulminant Hepatic Failure in Murine Hepatitis Virus Strain 3 Infection: Tissue-Specific Expression of a Novel fgl2 Prothrombinase

  1997cited by this paper
• A helper-dependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signal.

  1996cited by this paper
• Immune responses to transgene–encoded proteins limit the stability of gene expression after injection of replication–defective adenovirus vectors

  1996cited by this paper
• The type-I interferon receptor. The long and short of it.

  1996cited by this paper
• Efficient generation of recombinant adenovirus vectors by homologous recombination in Escherichia coli

  1996cited by this paper
• Enhancement In Vivo of the Antiinflammatory and Antitumor Activities of Type I Interferon by Association with the Synthetic Immunomodulator Murabutide

  1996cited by this paper
• The woodchuck: an animal model for hepatitis B virus infection in man.

  1995cited by this paper
• Transcription factors in interferon signaling.

  1995cited by this paper
• Decreased expression of hepatocyte nuclear factor 3 alpha during the acute-phase response influences transthyretin gene transcription

  1995cited by this paper
• Single-step assembly of a gene and entire plasmid from large numbers of oligodeoxyribonucleotides.

  1995cited by this paper
• The route of administration is a major determinant of the transduction efficiency of rat tissues by adenoviral recombinants.

  1995cited by this paper
• Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy.

  1994cited by this paper
• Complementation of the interferon alpha response in resistant cells by expression of the cloned subunit of the interferon alpha receptor. A central role of this subunit in interferon alpha signaling.

  1994cited by this paper
• Clinical Pharmacokinetics of Interferons

  1990cited by this paper
• Primary structure and translation of a defective interfering rna of murine coronavirus

  1988cited by this paper
• Protective effect of recombinant murine interferon beta against mouse hepatitis virus infection.

  1987cited by this paper
• Regulation by interferons of the local inflammatory response to bacterial lipopolysaccharide.

  1987cited by this paper
• Effect of exogenous mouse interferon on murine fulminant hepatitis induced by mouse hepatitis virus type 2

  1986cited by this paper
• Double-stranded RNA-dependent protein kinase and 2-5A system are both activated in interferon-treated, encephalomyocarditis virus-infected HeLa cells

  1985cited by this paper
• Cytopathic effect inhibition assay for interferon: microculture plate assay.

  1981cited by this paper
• Interferon in experimental viral infections in mice: tissue interferon levels resulting from the virus infection and from exogenous interferon therapy

  1980cited by this paper
• Virus interference. I. The interferon

  1957cited by this paper

• Interferon-α exacerbates neuropsychiatric phenotypes in lupus-prone mice

  2019cites this paper
• Gene Therapy for Chronic HBV—Can We Eliminate cccDNA?

  2018cites this paper
• Helper-dependent adenoviral vectors expressing anti-HBV pri-miR sequences from the liver-specific PEPCK promoter

  2017cites this paper
• Utility of Adenoviral Vectors in Animal Models of Human Disease III: Acquired Diseases

  2016cites this paper
• Inhibition of Hepatitis B Virus Replication by Helper Dependent Adenoviral Vectors Expressing Artificial Anti-HBV Pri-miRs from a Liver-Specific Promoter

  2014cites this paper
• EXPRESSION OF ANTI-HBV PRIMARY MICRO-RNA SHUTTLES USING AN INDUCIBLE PROMOTER SYSTEM

  2013cites this paper
• Safety profile, efficacy, and biodistribution of a bicistronic high-capacity adenovirus vector encoding a combined immunostimulation and cytotoxic gene therapy as a prelude to a phase I clinical trial for glioblastoma.

  2013cites this paper
• Reduction of serum free fatty acids and triglycerides by liver-targeted expression of long chain acyl-CoA synthetase 3.

  2011cites this paper
• Therapeutic potential of adenoviral vectors for delivery of expressed RNAi activators

  2010cites this paper
• Murine Coronavirus Delays Expression of a Subset of Interferon-Stimulated Genes

  2010cites this paper
• Type I Interferons and Receptors

  2010cites this paper
• Murine Coronavirus Cell Type Dependent Interaction with the Type I Interferon Response

  2009cites this paper
• Interferon and cytokine responses to SARS-coronavirus infection

  2008cites this paper
• Advances in helper-dependent adenoviral vector research.

  2008cites this paper
• Antiviral Agents for SARS

  2008cites this paper
• Role of ISGF3 in modulating the anti‐hepatitis B virus activity of interferon‐alpha in vitro

  2008cites this paper
• Synergistic effect of gene‐electro transfer and adjuvant cytokines in increasing the potency of hepatitis C virus genetic vaccination

  2008cites this paper
• Inhibition of the Alpha/Beta Interferon Response by Mouse Hepatitis Virus at Multiple Levels

  2007influential citation
• Animal Models of Autoimmune Liver Diseases

  2007cites this paper
• Immunomodulation as an option for the treatment of chronic hepatitis B virus infection: preclinical studies in the woodchuck model

  2007cites this paper
• Transgenic avian-derived recombinant human interferon-alpha2b (AVI-005) in healthy subjects: an open-label, single-dose, controlled study.

  2007cites this paper
• Tratamiento de la enfermedad hepática crónica inducida por el virus de la hepatitis C: bases moleculares y celulares.

  2006cites this paper
• Delivery of human apolipoprotein (apo) E to liver by an (E1 - , E3 - , polymerase - , pTP - ) adenovirus vector containing a liver-specific promoter inhibits atherogenesis in immunocompetent apoE-deficient mice

  2006cites this paper
• Genetic vaccines against Ep‐CAM break tolerance to self in a limited subset of subjects: Initial identification of predictive biomarkers

  2006cites this paper
• Overexpression of acyl-CoA synthetase-1 increases lipid deposition in hepatic (HepG2) cells and rodent liver in vivo.

  2006cites this paper
• Transcriptional profiling of acute cytopathic murine hepatitis virus infection in fibroblast-like cells.

  2006cites this paper
• Regulated and Liver-Specific Tamarin Alpha Interferon Gene Delivery by a Helper-Dependent Adenoviral Vector

  2005cites this paper
• COLABORACIÓN ESPECIAL Terapia génica: ¿Qué es y para qué sirve? Gene therapy: what is it and what is its use?

  2005cites this paper
• IFN-alpha gene therapy for woodchuck hepatitis with adeno-associated virus: differences in duration of gene expression and antiviral activity using intraportal or intramuscular routes.

  2005cites this paper
• Inhibition of Beta Interferon Induction by Severe Acute Respiratory Syndrome Coronavirus Suggests a Two-Step Model for Activation of Interferon Regulatory Factor 3

  2005cites this paper
• Immune responses against tetracycline‐dependent transactivators affect long‐term expression of mouse erythropoietin delivered by a helper‐dependent adenoviral vector

  2005cites this paper
• Gutless adenovirus: last-generation adenovirus for gene therapy

  2005cites this paper
• Helper-Dependent Adenoviral Vector-Mediated Delivery of Woodchuck-Specific Genes for Alpha Interferon (IFN- (cid:2) ) and IFN- (cid:3) : IFN- (cid:2) but Not IFN- (cid:3) Reduces Woodchuck Hepatitis Virus Replication in Chronic Infection In Vivo

  2004cites this paper
• Adenoviral Vectors for Gene Replacement Therapy

  2004cites this paper
• Undermining tumor angiogenesis by gene therapy: an emerging field.

  2004cites this paper
• Helper-Dependent Adenoviral Vector-Mediated Delivery of Woodchuck-Specific Genes for Alpha Interferon (IFN-α) and IFN-γ: IFN-α but Not IFN-γ Reduces Woodchuck Hepatitis Virus Replication in Chronic Infection In Vivo

  2004influential citation
• Helper-Dependent Adenoviral Vectors Containing Modified Fiber for Improved Transduction of Developing and Mature Muscle Cells

  2004cites this paper
• Helper-dependent adenoviral vector-mediated delivery of woodchuck-specific genes for alpha interferon (IFN-alpha) and IFN-gamma: IFN-alpha but not IFN-gamma reduces woodchuck hepatitis virus replication in chronic infection in vivo.

  2004cites this paper
• Hepatitis B virus enhances transduction of human hepatocytes by SV40-based vectors.

  2004cites this paper
• The glycosylation status of the murine hepatitis coronavirus M protein affects the interferogenic capacity of the virus in vitro and its ability to replicate in the liver but not the brain

  2003cites this paper
• New approaches to rapidly control foot-and-mouth disease outbreaks

  2003cites this paper
• Recommended Reading Materials

  2003cites this paper
• Adenoviral Vectors for Gene Delivery

  2003cites this paper
• The promise of gene therapy in gastrointestinal and liver diseases

  2003cites this paper
• Gene transfer methods for transplantation.

  2002cites this paper
• A DNA-Based Method to Assay Total and Infectious Particle Contents and Helper Virus Contamination in High-Capacity Adenoviral Vector Preparations

  2002cites this paper
• Transient transfection of mouse fibroblasts with type I interferon transgenes provides various degrees of protection against herpes simplex virus infection.

  2002cites this paper
• Helper-dependent adenoviral vectors.

  2002cites this paper
• Absence of PKR Attenuates the Anti-HSV-1 Activity of an Adenoviral Vector Expressing Murine IFN-β

  2002cites this paper
• Cancer therapy utilizing an adenoviral vector expressing only E1A

  2002cites this paper
• Regulated and prolonged expression of mIFNα in immunocompetent mice mediated by a helper-dependent adenovirus vector

  2002cites this paper
• Superior Tissue-Specific Expression from Tyrosinase and Prostate-Specific Antigen Promoters/Enhancers in Helper-Dependent Compared with First-Generation Adenoviral Vectors

  2002cites this paper
• Expression of a New Woodchuck IFN-α Gene by a Helper-Dependent Adenoviral Vector in Woodchuck Hepatitis Virus-Infected Primary Hepatocytes

  2002cites this paper
• The woodchuck interferon‐α system: Cloning, family description, and biologic activity

  2002cites this paper
• Gene therapy for liver diseases: recent strategies for treatment of viral hepatitis and liver malignancies

  2002cites this paper
• Inhibition of duck hepatitis B virus replication by intrahepatic expression of an antiviral resistance gene

  2002cites this paper
• Chapter 20 – Utility of Adenoviral Vectors in Animal Models of Human Disease III: Acquired Diseases

  2002cites this paper
• The woodchuck interferon-alpha system: Cloning, family description, and biologic activity.

  2002cites this paper
• Antiviral Actions of Interferons

  2001cites this paper
• Antitumor activity of recombinant adenoviral vectors expressing murine IFN-α in mice injected with metastatic IFN-resistant tumor cells

  2001cites this paper
• Tamarin alpha‐interferon is active in mouse liver upon intramuscular gene delivery

  2001cites this paper
• High-capacity 'gutless' adenoviral vectors.

  2001cites this paper
• An improved helper-dependent adenoviral vector allows persistent gene expression after intramuscular delivery and overcomes preexisting immunity to adenovirus

  2001cites this paper
• Gene therapy strategies for the treatment of chronic viral hepatitis

  2001cites this paper
• Adenoviral vector-mediated gene transfer for human gene therapy.

  2001cites this paper
• Terapia génica: el desafío terapéutico del siglo XXI

  2001cites this paper
• Selection of in vivo retrovirally transduced hepatocytes leads to efficient and predictable mouse liver repopulation

  2001cites this paper