Inhibition of Testosterone Aromatization by the Indole-3-carbinol Derivative CTet in CYP19A1-overexpressing MCF-7 Breast Cancer Cells.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Anti-Cancer Agents in Medicinal Chemistry

• Publication date

  2015-08-31

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.2174/1871520615666150121123053PMID 25612679
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Leishmania infantum Induces Mild Unfolded Protein Response in Infected Macrophages

  2016cited by this paper
• Adherence to Endocrine Therapy in Breast Cancer Adjuvant and Prevention Settings

  2014cited by this paper
• The Indole-3-carbinol cyclic tetrameric derivative CTet synergizes with cisplatin and doxorubicin in triple-negative breast cancer cell lines.

  2013cited by this paper
• Antitumoral activity of indole-3-carbinol cyclic tri- and tetrameric derivatives mixture in human breast cancer cells: in vitro and in vivo studies.

  2013cited by this paper
• Induction of Endoplasmic Reticulum Stress Response by the Indole-3-Carbinol Cyclic Tetrameric Derivative CTet in Human Breast Cancer Cell Lines

  2012cited by this paper
• Overcoming acquired resistance to letrozole by targeting the PI3K/AKT/mTOR pathway in breast cancer cell clones.

  2012cited by this paper
• Effectiveness and molecular interactions of the clinically active mTORC1 inhibitor everolimus in combination with tamoxifen or letrozole in vitro and in vivo

  2012cited by this paper
• Modulation of CYP19 expression by cabbage juices and their active components: indole-3-carbinol and 3,3′-diindolylmethene in human breast epithelial cell lines

  2012cited by this paper
• Palytoxin and an Ostreopsis Toxin Extract Increase the Levels of mRNAs Encoding Inflammation-Related Proteins in Human Macrophages via p38 MAPK and NF-κB

  2012cited by this paper
• Exemestane for breast-cancer prevention in postmenopausal women.

  2011cited by this paper
• The indole-3-carbinol cyclic tetrameric derivative CTet inhibits cell proliferation via overexpression of p21/CDKN1A in both estrogen receptor-positive and triple-negative breast cancer cell lines

  2011cited by this paper
• EGFR/HER2 inhibitor AEE788 increases ER-mediated transcription in HER2/ER-positive breast cancer cells but functions synergistically with endocrine therapy

  2010cited by this paper
• Biological reprogramming in acquired resistance to endocrine therapy of breast cancer

  2010cited by this paper
• Synthesis and Biological Evaluation of a γ-Cyclodextrin-based Formulation of the Anticancer Agent 5,6,11,12,17,18,23,24-Octahydrocyclododeca[1,2-b:4,5-b’:7,8-b’’:10,11-b’’’]tetraindole (CTet)

  2010cited by this paper
• Drug combination studies and their synergy quantification using the Chou-Talalay method.

  2010cited by this paper
• Aromatase inhibitors in breast cancer.

  2009cited by this paper
• The vascular endothelial growth factor receptor inhibitor PTK787/ZK222584 inhibits aromatase.

  2009cited by this paper
• Natural products as aromatase inhibitors.

  2008cited by this paper
• Tamoxifen resistance in breast tumors is driven by growth factor receptor signaling with repression of classic estrogen receptor genomic function.

  2008cited by this paper
• The role of hormonal therapy in the management of hormonal-receptor-positive breast cancer with co-expression of HER2

  2008cited by this paper
• IBIS II: a breast cancer prevention trial in postmenopausal women using the aromatase inhibitor anastrozole

  2008cited by this paper
• Akt-induced endocrine therapy resistance is reversed by inhibition of mTOR signaling.

  2007cited by this paper
• Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies

  2006cited by this paper
• Molecular targets of dietary agents for prevention and therapy of cancer.

  2006cited by this paper
• Grape seed extract is an aromatase inhibitor and a suppressor of aromatase expression.

  2006cited by this paper
• Molecular Targets and Anticancer Potential of Indole-3-Carbinol and Its Derivatives

  2005cited by this paper
• Dual Inhibition of mTOR and Estrogen Receptor Signaling In vitro Induces Cell Death in Models of Breast Cancer

  2005cited by this paper
• Estrogen-receptor biology: continuing progress and therapeutic implications.

  2005cited by this paper
• Aromatase inhibitors: combinations with fulvestrant or signal transduction inhibitors as a strategy to overcome endocrine resistance.

  2005cited by this paper
• Growth factor-driven mechanisms associated with resistance to estrogen deprivation in breast cancer: new opportunities for therapy.

  2004cited by this paper
• Cancer chemoprevention with dietary phytochemicals

  2003cited by this paper
• A new indole-3-carbinol tetrameric derivative inhibits cyclin-dependent kinase 6 expression, and induces G1 cell cycle arrest in both estrogen-dependent and estrogen-independent breast cancer cell lines.

  2003cited by this paper
• Enhanced Estrogen Receptor (ER) α, ERBB2, and MAPK Signal Transduction Pathways Operate during the Adaptation of MCF-7 Cells to Long Term Estrogen Deprivation*

  2003cited by this paper
• Truncated Estrogen Receptor &agr; 46-kDa Isoform in Human Endothelial Cells: Relationship to Acute Activation of Nitric Oxide Synthase

  2003cited by this paper
• Plasma membrane localization and function of the estrogen receptor α variant (ER46) in human endothelial cells

  2003cited by this paper
• Cellular functions of plasma membrane estrogen receptors.

  2002cited by this paper
• 2,3,7,8-Tetrachlorodibenzo-p-dioxin and diindolylmethanes differentially induce cytochrome P450 1A1, 1B1, and 19 in H295R human adrenocortical carcinoma cells.

  2001cited by this paper
• Estrogen receptor: current understanding of its activation and modulation.

  2001cited by this paper
• The major cyclic trimeric product of indole-3-carbinol is a strong agonist of the estrogen receptor signaling pathway.

  2000cited by this paper
• Biological effects of stable overexpression of aromatase in human hormone-dependent breast cancer cells.

  1994cited by this paper
• Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors.

  1984cited by this paper

• Breast Cancer Cytochromes P450: Chemopreventive and/or Therapeutic Targets for Naturally Occurring Phytochemicals

  2025cites this paper
• Transcriptional signatures in human macrophage-like cells infected by Leishmania infantum, Leishmania major and Leishmania tropica

  2024cites this paper
• Synthetic Methodologies and Therapeutic Potential of Indole-3-Carbinol (I3C) and Its Derivatives

  2023cites this paper
• Natural Products for the Prevention, Treatment and Progression of Breast Cancer

  2023cites this paper
• Effects of indole-3-carbinol on steroid hormone profile and tumor progression in a mice model of canine inflammatory mammarycancer

  2018cites this paper
• Structure-activity relationships and docking studies of synthetic 2-arylindole derivatives determined with aromatase and quinone reductase 1.

  2017cites this paper
• Leishmania infantum Induces Mild Unfolded Protein Response in Infected Macrophages

  2016cites this paper
• One-Pot Synthesis of Biheterocycles Based on Indole and Azole Scaffolds Using Tryptamines and 1,2-Diaza-1,3-dienes as Building Blocks†

  2016cites this paper