Leptin alters the structural and functional characteristics of adipose tissue before birth

No abstract is available for this paper.

• Publication year

  2003

• Venue

  The FASEB Journal

• Publication date

  2003-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1096/fj.02-0756fjePMID 12709410
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Circulating Leptin Concentrations Are Positively Related to Leptin Messenger RNA Expression in the Adipose Tissue of Fetal Sheep in the Pregnant Ewe Fed at or Below Maintenance Energy Requirements During Late Gestation1

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• Fetal Leptin Is a Signal of Fat Mass Independent of Maternal Nutrition in Ewes Fed at or above Maintenance Energy Requirements1

  2002cited by this paper
• Determinants of leptin gene expression in fat depots of lean mice.

  2002cited by this paper
• Spatial and developmental regulation of leptin in fetal sheep.

  2002cited by this paper
• Ontogeny and insulin regulation of fetal ovine white adipose tissue leptin expression.

  2002cited by this paper
• Differential effects of leptin on thermoregulation and uncoupling protein abundance in the neonatal lamb

  2002cited by this paper
• Plasma leptin concentration in fetal sheep during late gestation: ontogeny and effect of glucocorticoids.

  2002cited by this paper
• Emergence during development of the white-adipocyte cell phenotype is independent of the brown-adipocyte cell phenotype.

  2001cited by this paper
• Effects of leptin on the differentiation and metabolism of human adipocytes

  2001cited by this paper
• Responses of the fetal pituitary-adrenal axis to acute and chronic hypoglycemia during late gestation in the sheep.

  2001cited by this paper
• Leptin in ruminants. Gene expression in adipose tissue and mammary gland, and regulation of plasma concentration.

  2001cited by this paper
• Effects of recombinant ovine leptin on in vitro lipolysis and lipogenesis in subcutaneous adipose tissue from lactating and nonlactating sheep.

  2001cited by this paper
• Circulating leptin during ovine pregnancy in relation to maternal nutrition, body composition and pregnancy outcome.

  2001cited by this paper
• Maternal food restriction reduces the exchange surface area and increases the barrier thickness of the placenta in the guinea-pig.

  2001cited by this paper
• Level of nutrition affects leptin concentrations in plasma and cerebrospinal fluid in sheep.

  2000cited by this paper
• Central Leptin Regulates the UCP1 and obGenes in Brown and White Adipose Tissue via Different β-Adrenoceptor Subtypes*

  2000cited by this paper
• Fetal Plasma Leptin Concentrations: Relationship with Different Intrauterine Growth Patterns from 19 Weeks to Term

  2000cited by this paper
• Plasma leptin determination in ruminants: effect of nutritional status and body fatness on plasma leptin concentration assessed by a specific RIA in sheep.

  2000cited by this paper
• Cord Leptin Level and Fetal Macrosomia

  2000cited by this paper
• Adrenaline, insulin and glucagon do not have acute effects on plasma leptin levels in sheep: development and characterisation of an ovine leptin ELISA.

  2000cited by this paper
• Leptin Concentration in Cord Blood Correlates With Intrauterine Growth

  2000cited by this paper
• Central nervous system control of food intake

  2000cited by this paper
• Norepinephrine is required for leptin effects on gene expression in brown and white adipose tissue.

  1999cited by this paper
• Glucocorticoids Decrease Phenylethanolamine N‐Methyltransferase mRNA Expression in the Immature Foetal Sheep Adrenal

  1999cited by this paper
• Abundance of leptin mRNA in fetal adipose tissue is related to fetal body weight.

  1999cited by this paper
• Abundance of leptin mRNA in fetal adipose tissue is related to fetal body weight.

  1999cited by this paper
• Chronic leptin administration increases insulin-stimulated skeletal muscle glucose uptake and transport.

  1999cited by this paper
• Leptin I

  1999cited by this paper
• β2-Agonist ritodrine, unlike natural catecholamines, activates thermogenesis prematurely in fetal sheep.

  1998cited by this paper
• Large‐scale preparation of biologically active recombinant ovine obese protein (leptin)

  1998cited by this paper
• Leptin induction of UCP1 gene expression is dependent on sympathetic innervation.

  1998cited by this paper
• Leptin and the regulation of body weight in mammals

  1998cited by this paper
• Ontogeny of leptin in human fetuses and newborns: effect of intrauterine growth retardation on serum leptin concentrations.

  1998cited by this paper
• Neonatal Cord Blood Leptin: Its Relationship to Birth Weight, Body Mass Index, Maternal Diabetes, and Steroids

  1998cited by this paper
• Leptin affects pancreatic endocrine functions through the sympathetic nervous system.

  1998cited by this paper
• Leptin induction of UCP1 gene expression is dependent on sympathetic innervation.

  1998cited by this paper
• In vitro lipolytic effect of leptin on mouse adipocytes: evidence for a possible autocrine/paracrine role of leptin.

  1997cited by this paper
• Leptin Impairs Metabolic Actions of Insulin in Isolated Rat Adipocytes*

  1997cited by this paper
• Direct effects of leptin on brown and white adipose tissue.

  1997cited by this paper
• Leptin secretion from adipose tissue in women. Relationship to plasma levels and gene expression.

  1997cited by this paper
• Immunohistochemical localization of leptin and uncoupling protein in white and brown adipose tissue.

  1997cited by this paper
• Leptin and leptin receptor mRNA and protein expression in the murine fetus and placenta.

  1997cited by this paper
• Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women: effects of dietary fat content and sustained weight loss.

  1996cited by this paper
• Effect of fetal thyroidectomy on brown adipose tissue and thermoregulation in newborn lambs.

  1996cited by this paper
• Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes.

  1995cited by this paper
• Identification and expression cloning of a leptin receptor, OB-R.

  1995cited by this paper
• Expression of beta 1- and beta 3-adrenergic-receptor messages and adenylate cyclase beta-adrenergic response in bovine perirenal adipose tissue during its transformation from brown into white fat.

  1994cited by this paper
• Effect of maternal cold exposure on brown adipose tissue and thermogenesis in the neonatal lamb.

  1992cited by this paper
• Brown adipose tissue thermogenesis: interdisciplinary studies

  1990cited by this paper
• Complete cDNA-derived amino acid sequence of rat brown fat uncoupling protein.

  1986cited by this paper
• The nucleotide sequence of a rat 18 S ribosomal ribonucleic acid gene and a proposal for the secondary structure of 18 S ribosomal ribonucleic acid.

  1984cited by this paper
• Ultrastructural development of adipose tissue in foetal sheep.

  1978influential reference
• Quantitative development of adipose tissue in foetal sheep.

  1978cited by this paper
• Journal of Clinical Endocrinology and Metabolism Printed in U.S.A. Copyright © 1997 by The Endocrine Society CLINICAL REVIEW 90 Leptin and Clinical Medicine: A New Piece in the Puzzle

  year unknowncited by this paper
• Journal of Clinical Endocrinology and Metabolism Printed in U.S.A. Copyright © 1997 by The Endocrine Society Levels of Leptin in Maternal Serum, Amniotic Fluid, and Arterial and Venous Cord Blood: Relation to Neonatal and Placental Weight

  year unknowncited by this paper

• Early adversity and the comorbidity between metabolic disease and psychopathology.

  2025cites this paper
• Hormonal Determinants of Growth and Weight Gain in the Human Fetus and Preterm Infant

  2023cites this paper
• Programming of metabolism by adipokines during development

  2023cites this paper
• Developmental programming by maternal obesity: Lessons from animal models

  2021cites this paper
• PPARγ activation in late gestation does not promote surfactant maturation in the fetal sheep lung

  2021cites this paper
• Ovine prenatal growth-restriction and sex influence fetal adipose tissue phenotype and impact postnatal lipid metabolism and adiposity in vivo from birth until adulthood

  2020cites this paper
• C-Peptide and leptin system in dichorionic, small and appropriate for gestational age twins—possible link to metabolic programming?

  2020cites this paper
• Brown Adipose Tissue and Body Weight Regulation

  2018cites this paper
• Uterine artery leptin receptors during the ovarian cycle and pregnancy regulate angiogenesis in ovine uterine artery endothelial cells

  2017cites this paper
• Erratum: Uterine artery leptin receptors during the ovarian cycle and pregnancy regulate angiogenesis in ovine uterine artery endothelial cells

  2017cites this paper
• Developmental programming, adiposity, and reproduction in ruminants.

  2016cites this paper
• Effects of hypothyroidism on pancreatic islet development and tissue insulin signalling pathways in the ovine fetus

  2016cites this paper
• The Impact of Antenatal Exercise in Overweight and Obese Women on Maternal and Offspring Health

  2015cites this paper
• Long-Term Gestational Hypoxia Modulates Expression of Key Genes Governing Mitochondrial Function in the Perirenal Adipose of the Late Gestation Sheep Fetus

  2015cites this paper
• Undernutrition and stage of gestation influence fetal adipose tissue gene expression.

  2015cites this paper
• Altitude, attitude and adaptation.

  2014cites this paper
• InUtero Programming of Later Adiposity : The Role of Fetal Growth Restriction

  2014cites this paper
• Impact of intrauterine growth restriction on long-term health

  2014cites this paper
• Preadipocyte and adipose tissue differentiation in meat animals: influence of species and anatomical location.

  2014cites this paper
• Maternal and Child Nutrition: The First 1,000 Days: 74th Nestl Nutrition Institute Workshop, Goa, March 2012

  2013cites this paper
• Differential associations of leptin with adiposity across early childhood

  2013cites this paper
• Introduction: Celebrating Emeritus Scientia Professor Eugenie R Lumbers AM and Professor Caroline McMillen

  2013cites this paper
• Basic Experimental and Clinical Advances in the Mechanisms Underlying Abnormal Pregnancy Outcomes

  2013cites this paper
• Endocrine interactions in the control of fetal growth.

  2013cites this paper
• Impact of embryo number and periconceptional undernutrition on factors regulating adipogenesis, lipogenesis, and metabolism in adipose tissue in the sheep fetus.

  2013cites this paper
• The Australian Early Origins of Hypertension Workshop: A celebration of the scientific contributions made by Emeritus Scientia Professor Eugenie R Lumbers AM and Professor Caroline McMillen

  2013cites this paper
• Epigenetic Factors before and during Pregnancy

  2013cites this paper
• Adipocyte Growth and Factors Influencing Adipocyte Life Cycle

  2012cites this paper
• Critical Periods for the Development of Obesity

  2012cites this paper
• Foetal bovine intermuscular adipose tissue exhibits histological and metabolic features of brown and white adipocytes during the last third of pregnancy.

  2012cites this paper
• Relationship between placental expression of the imprinted PHLDA2 gene, intrauterine skeletal growth and childhood bone mass☆

  2012cites this paper
• Leptin in Early Life: A Key Factor for the Development of the Adult Metabolic Profile

  2012cites this paper
• In Utero Programming of Later Adiposity: The Role of Fetal Growth Restriction

  2012cites this paper
• Adipose Tissue Biology

  2012cites this paper
• Early Origins of Obesity and Developmental Regulation of Adiposity

  2012cites this paper
• Adipocyte metabolism and cellularity are related to differences in adipose tissue maturity between Holstein and Charolais or Blond d'Aquitaine fetuses.

  2011cites this paper
• Adipose tissue development--impact of the early life environment.

  2011cites this paper
• Perinatal programming of body weight control by leptin: putative roles of AMP kinase and muscle thermogenesis.

  2011cites this paper
• Genes and Nutrition

  2010cites this paper
• Maternal undernutrition alters fat cell size distribution, but not lipogenic gene expression, in the visceral fat of the late gestation guinea pig fetus.

  2010cites this paper
• Fetal growth restriction, catch-up growth and the early origins of insulin resistance and visceral obesity

  2010cites this paper
• The development and endocrine functions of adipose tissue.

  2010cites this paper
• Effects of cold acclimation on body mass, serum leptin level, energy metabolism and thermognesis in Eothenomys miletus in Hengduan Mountains region ☆

  2010cites this paper
• [Update of knowledge, recommendations and full consensus about the role of long chain polyunsaturated fatty acids in pregnancy, lactating period and first year of life.Asociación Española de Pediatría. Sociedad Española de Ginecología y Obstetricia. Sociedad Española de Nutrición Comunitaria. Academ

  2010cites this paper
• Nutritional models of the developmental programming of adult health and disease

  2009cites this paper
• Intrauterine growth restriction and adult disease: the role of adipocytokines.

  2009cites this paper
• Workshop on 'Nutritional models of the developmental origins of adult health and disease' Nutritional models of the developmental programming of adult health and disease

  2009cites this paper
• The impact of diet during early life and its contribution to later disease: critical checkpoints in development and their long-term consequences for metabolic health

  2009cites this paper
• Adipose Tissue Development in Extramuscular and Intramuscular Depots in Meat Animals

  2009cites this paper
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  2009cites this paper
• The hungry fetus? Role of leptin as a nutritional signal before birth

  2009cites this paper
• Glucose Tolerance by Uteroplacental Insufficiency in Male Rat Offspring Improved Lactational Nutrition and Postnatal Growth Ameliorates Impairment of

  2008cites this paper
• Study of hypothalamic leptin receptor expression in low-birth-weight piglets and effects of leptin supplementation on neonatal growth and development.

  2008cites this paper
• Birth weight and gender determine expression of adipogenic, lipogenic and adipokine genes in perirenal adipose tissue in the young adult sheep.

  2008cites this paper
• Maternal nutrition and the programming of obesity

  2008cites this paper
• Role of leptin in the regulation of growth and carbohydrate metabolism in the ovine fetus during late gestation

  2008influential citation
• Early life programming of obesity and metabolic disease.

  2008cites this paper
• Role of leptin during perinatal metabolic programming and obesity.

  2008cites this paper
• The effect of fetal growth restriction and sex on the development and function of adipose tissue.

  2008cites this paper
• Long-term hypoxia modulates expression of key genes regulating adipose function in the late-gestation ovine fetus.

  2007cites this paper
• Leptin in embryos from control and diabetic rats during organogenesis: a modulator of nitric oxide production and lipid homeostasis

  2007cites this paper
• Differential regulation of suppressor of cytokine signaling-3 in the liver and adipose tissue of the sheep fetus in late gestation.

  2006cites this paper
• Leptin in Pregnancy: An Update1

  2006cites this paper
• Regulation of leptin synthesis and secretion before birth: implications for the early programming of adult obesity.

  2006cites this paper
• Prolactin and the expression of suppressor of cytokine signaling-3 in the sheep adrenal gland before birth.

  2006cites this paper
• Leptin in Farm Animals

  2006cites this paper
• Sexual dimorphism in the levels of amniotic fluid leptin in pregnancies at 16 weeks of gestation: relation to fetal growth.

  2006cites this paper
• Fetal and neonatal nutrition – lipid and carbohydrate requirements and adaptations to altered supply at birth

  2006cites this paper
• Fetal origins of insulin resistance and obesity

  2005cites this paper
• Maternal nutritional programming of fetal adipose tissue development: differential effects on messenger ribonucleic acid abundance for uncoupling proteins and peroxisome proliferator-activated and prolactin receptors.

  2005cites this paper
• Early origins of obesity: programming the appetite regulatory system

  2005cites this paper
• Prenatal programming of postnatal obesity

  2005cites this paper
• Impact of glucose infusion on the structural and functional characteristics of adipose tissue and on hypothalamic gene expression for appetite regulatory neuropeptides in the sheep fetus during late gestation

  2005cites this paper
• Nutrition-Gene Interactions (Post-Genomics)

  2005cites this paper
• Chronic maternal feed restriction impairs growth but increases adiposity of the fetal guinea pig.

  2005cites this paper
• Developmental origins of the metabolic syndrome: prediction, plasticity, and programming.

  2005cites this paper
• Adult Obesity as a Consequence of in Utero Programming

  2004cites this paper
• Effects of Leptin on Fetal Plasma Adrenocorticotropic Hormone and Cortisol Concentrations and the Timing of Parturition in the Sheep1

  2004cites this paper
• Timing of nutrient restriction and programming of fetal adipose tissue development

  2004cites this paper
• The relation of insulin, leptin and IGF‐1 to birthweight in offspring of women with type 1 diabetes

  2004cites this paper
• Prolactin potentiates insulin-stimulated leptin expression and release from differentiated brown adipocytes.

  2004cites this paper
• Prenatal programming of postnatal obesity: fetal nutrition and the regulation of leptin synthesis and secretion before birth

  2004cites this paper
• Endocrine and nutritional regulation of fetal adipose tissue development.

  2003cites this paper
• Determinants of fetal leptin synthesis, fat mass, and circulating leptin concentrations in well-nourished ewes in late pregnancy.

  2003cites this paper
• Intrauterine Growth Restriction and Adult Disease: the Role of Adipocytokines Intrauterine Growth Restriction the Developmental Origins of Adult Disease

  year unknowncites this paper