10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway.

T. Marsilje,M. Labroli,Michael P. Hedrick,Qing Jin,J. Desharnais,S. Baker,L. T. Gooljarsingh,J. Ramcharan,A. Tavassoli,Yan Zhang,I. Wilson,G. Beardsley,S. Benkovic,D. Boger

Published 2002 in Bioorganic & Medicinal Chemistry

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