Stability of polyribosomes isolated from rat liver after phenobarbital administration.

The effect of daily injections of phenobarbital (75 mg/kg) on the degradation of rat liver polyribosome suspensions during storage in vitro at 0-4° was examined. Sucrose gradient analysis of polysomes isolated from animals treated for 3-5 days with 0.9% NaCl revealed that after 24-48 hr of storage at 0-4° a disaggregation of large polysome species occurred, together with an increase of 50-85% in the number of monomer and dimer species. In contrast, polyribosomes derived from rats treated with phenobarbital for 3-5 days were shown to be almost completely resistant to degradation under the same conditions.

• Publication year

  1971

• Venue

  Molecular Pharmacology

• Publication date

  1971-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/s0026-895x(25)12725-9PMID 5113239
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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