Exposure of neonatal male rats to estrogen induces abnormal morphology of the penis and loss of fertility.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Reproductive Toxicology

• Publication date

  2004-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.REPROTOX.2003.12.001PMID 15019723
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Sex determination and differentiation.

  2004cited by this paper
• Neonatal Estrogen Exposure of Male Rats Alters Reproductive Functions at Adulthood1

  2003cited by this paper
• Direct Estrogen Effects on the Cardiovascular System

  2002cited by this paper
• Evidence for a Potential Role of Estrogen in the Penis: Detection of Estrogen Receptor-α and -β Messenger Ribonucleic Acid and Protein

  2002cited by this paper
• Evidence for a potential role of estrogen in the penis: detection of estrogen receptor-alpha and -beta messenger ribonucleic acid and protein.

  2002cited by this paper
• Diethylstilbestrol-Treated Adult Rats with Altered Epididymal Sperm Numbers and Sperm Motility Parameters, but Without Alterations in Sperm Production and Sperm Morphology1

  2001cited by this paper
• Age-, cell- and region-specific immunoexpression of estrogen receptor alpha (but not estrogen receptor beta) during postnatal development of the epididymis and vas deferens of the rat and disruption of this pattern by neonatal treatment with diethylstilbestrol.

  2001cited by this paper
• Neonatal Low- and High-Dose Exposure to Estradiol Benzoate in the Male Rat: I. Effects on the Prostate Gland1

  2001cited by this paper
• Suppression of androgen action and the induction of gross abnormalities of the reproductive tract in male rats treated neonatally with diethylstilbestrol.

  2001cited by this paper
• Bisphenol A inhibits penile erection via alteration of histology in the rabbit

  2001cited by this paper
• Characterization of the fertility of male aromatase knockout mice.

  2001cited by this paper
• Reproductive Malformation of The Male Offspring Following Maternal Exposure To Estrogenic Chemicals (44516)

  2000cited by this paper
• Estrogen Receptors α and β Prevalence of Estrogen Receptor β mRNA in Human Vascular Smooth Muscle and Transcriptional Effects

  2000cited by this paper
• Comparative effects of neonatal exposure of male rats to potent and weak (environmental) estrogens on spermatogenesis at puberty and the relationship to adult testis size and fertility: evidence for stimulatory effects of low estrogen levels.

  2000cited by this paper
• Oestrogen in fluid transport in efferent ducts of the male reproductive tract.

  2000cited by this paper
• Estrogen receptors alpha and beta: prevalence of estrogen receptor beta mRNA in human vascular smooth muscle and transcriptional effects.

  2000cited by this paper
• Intrauterine exposure to diethylstilbestrol: Long‐term effects in humans:

  2000cited by this paper
• Estrogen receptor null mice: what have we learned and where will they lead us?

  1999cited by this paper
• Postnatal sex reversal of the ovaries in mice lacking estrogen receptors alpha and beta.

  1999cited by this paper
• Reproductive function in rats exposed neonatally to bisphenol A and estradiol benzoate.

  1999cited by this paper
• Postnatal Sex Reversal of the Ovaries in Mice Lacking Estrogen Receptors α and β

  1999cited by this paper
• Permanent Effects of Neonatal Estrogen Exposure in Rats on Reproductive Hormone Levels, Sertoli Cell Number, and the Efficiency of Spermatogenesis in Adulthood1.

  1999cited by this paper
• Disruption of sexual behavior in male aromatase-deficient mice lacking exons 1 and 2 of the cyp19 gene.

  1998cited by this paper
• Coronary artery and cultured aortic smooth muscle cells express mRNA for both the classical estrogen receptor and the newly described estrogen receptor beta.

  1998cited by this paper
• Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene.

  1998cited by this paper
• Behavioral effects of estrogen receptor gene disruption in male mice.

  1997cited by this paper
• Estrogen receptor (alpha and beta) expression in the excurrent ducts of the adult male rat reproductive tract.

  1997cited by this paper
• Masculine sexual behavior is disrupted in male and female mice lacking a functional estrogen receptor alpha gene.

  1997cited by this paper
• Masculine Sexual Behavior Is Disrupted in Male and Female Mice Lacking a Functional Estrogen Receptor α Gene

  1997cited by this paper
• Discriminant analysis indicates a single sperm protein (SP22) is predictive of fertility following exposure to epididymal toxicants.

  1997cited by this paper
• Estrogen Receptor (α and β) Expression in the Excurrent Ducts of the Adult Male Rat Reproductive Tract

  1997cited by this paper
• Expression of cytochrome P450 17alpha-hydroxylase/C17-20 lyase in the fetal rat testis is reduced by maternal exposure to exogenous estrogens.

  1996cited by this paper
• Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility.

  1996cited by this paper
• Male reproductive health and environmental xenoestrogens.

  1996cited by this paper
• Reduction in penis size and plasma testosterone concentrations in juvenile alligators living in a contaminated environment.

  1996cited by this paper
• Physiology of penile erection.

  1995cited by this paper
• Fertility in men exposed prenatally to diethylstilbestrol.

  1995cited by this paper
• The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth

  1994cited by this paper
• Human vascular smooth muscle cells contain functional estrogen receptor.

  1994cited by this paper
• Developmental abnormalities of the gonad and abnormal sex hormone concentrations in juvenile alligators from contaminated and control lakes in Florida.

  1994cited by this paper
• Oestradiol inhibits smooth muscle cell proliferation of pig coronary artery

  1993cited by this paper
• Androgen receptor levels in the rat penis are controlled differently in distinctive cell types.

  1991cited by this paper
• The physiology of penile erection.

  1991cited by this paper
• Regional differences in the morphology of the goat epididymis: a light microscopic and ultrastructural study.

  1991cited by this paper
• Androgen receptor of rat penis is down-regulated by androgen.

  1990cited by this paper
• The Physiology of reproduction

  1988cited by this paper
• Autoradiographic studies of the localisation of androgen-binding cells in the genital tubercles of fetal rats.

  1987cited by this paper
• A histological study of the development of the penis of wild-type and androgen-insensitive mice.

  1987cited by this paper
• Effect of estradiol-filled polydimethylsiloxane subdermal implants in adult male rats on the reproductive system, fertility, and progeny outcome.

  1987cited by this paper
• Acquisition of estradiol-mediated regulatory mechanism of steroidogenesis in cultured fetal rat Leydig cells.

  1986cited by this paper
• Development of the os penis in genital tubercles cultured beneath the renal capsule of adult rats.

  1986cited by this paper
• Histogenesis of the Os Penis and Os Clitoridis in Rats

  1984cited by this paper
• Identification, partial characterization and age-related changes of a cytoplasmic androgen receptor in the rat penis.

  1980cited by this paper
• Modifications induced by neonatal steroids in reproductive organs and behavior of male rats.

  1979cited by this paper
• Synergistic interaction of testosterone and oestradiol inhibits permatogenesis in rats

  1977cited by this paper
• The effect of neonatal treatment of male mice with antiandrogens and of females with androgens on the development of the os penis and os clitoridis.

  1976cited by this paper
• Hormones and Sexual Behavior in the Male

  1975cited by this paper
• Altered sexual development in male rats after oestrogen administration during the neonatal period.

  1975cited by this paper
• Effects of perinatal androgen treatment on responses of male rats to gonadal hormones in adulthood.

  1969cited by this paper
• Manual of histologic staining methods of the Armed forces institute of pathology

  1968cited by this paper
• The Anatomy of the Rat

  1956cited by this paper

• Identification of miR‐34c‐5p as a potential regulatory molecule associated with testicular development of black goat

  2025cites this paper
• Novel control for erectile dysfunction research.

  2025cites this paper
• Estrogenic endocrine disruptor exposure directly impacts erectile function

  2024cites this paper
• Neonatal exposure to bisphenol analogues disrupts genital development in male mice.

  2023cites this paper
• Erectile Dysfunction in Men on the Rise: Is There a Link with Endocrine Disrupting Chemicals?

  2021cites this paper
• High levels of androgens cause chondrocyte accumulation and loss of smooth muscle in the mouse penile body†

  2020cites this paper
• The loss of ERE-dependent ERα signaling potentiates the effects of maternal high-fat diet on energy homeostasis in female offspring fed an obesogenic diet.

  2019cites this paper
• Estrogen for Male Function: Effect of Changes in the Sex Hormone Milieu on Erectile Function

  2018cites this paper
• Effects of Endocrine-Disrupting Chemicals on Penile Tissue Development, Histoarchitecture, and Erectile Physiology

  2018cites this paper
• Estrogen imprinting compromises male sexual behavior and affects the number of androgen‐receptor‐expressing hypothalamic neurons†

  2018cites this paper
• Flutamide-induced hypospadias in rats: A critical assessment.

  2017cites this paper
• Constitutive luteinizing hormone receptor signaling causes sexual dysfunction and leydig cell adenomas in male mice†

  2017cites this paper
• hypospadias in rats: A critical assessment.

  2017cites this paper
• Timing of androgen receptor disruption and estrogen exposure underlies a spectrum of congenital penile anomalies

  2015cites this paper
• The Effects of Maternal Low Protein and Estrogen on Sexual Behavior and Testicular Maturation in Male Rats

  2015cites this paper
• Neonatal exposure to diethylstilbestrol causes granulomatous orchitis via epididymal inflammation

  2014cites this paper
• Effects of Alternate Treatment of Estrogen Receptor Antagonist and Agonist on Morphology of Male Reproductive Organs of Adult Mice

  2013cites this paper
• Comparison of effect of sex hormone manipulation during neonatal period, on mRNA expression of Slc9a4, Nr3c2, Htr5b and Mas1 in hippocampus and frontal cortex of male and female rats.

  2013cites this paper
• [Perinatal clomiphene citrate treatment changes sexual orientations of male mice].

  2013cites this paper
• Environmental Review & Case Study: Evaluating the Significance of Certain Pharmaceuticals and Emerging Pathogens in Raw Water Supplies

  2011cites this paper
• Genetically induced estrogen receptor α mRNA (Esr1) overexpression does not adversely affect fertility or penile development in male mice.

  2011cites this paper
• Exogenous androgen during development alters adult partner preference and mating behavior in gonadally intact male rats.

  2010cites this paper
• Estrogen-Induced Developmental Disorders of the Rat Penis Involve Both Estrogen Receptor (ESR)- and Androgen Receptor (AR)-Mediated Pathways1

  2009cites this paper
• Effects of Estrogen Receptor $\alpha$-Selective Agonist Propyl Pyrazole Triol on the Morphology of Accessory Genital Glands of Male Mouse

  2009cites this paper
• Activation of Penile Proadipogenic Peroxisome Proliferator-Activated Receptor γ with an Estrogen: Interaction with Estrogen Receptor Alpha during Postnatal Development

  2008influential citation
• Role of estrogen in induction of penile dysmorphogenesis: a review.

  2007influential citation
• Estrogen receptor alpha mediates estrogen-inducible abnormalities in the developing penis.

  2007influential citation
• Testosterone and erectile function: from basic research to a new clinical paradigm for managing men with androgen insufficiency and erectile dysfunction.

  2007cites this paper
• Are androgens critical for penile erections in humans? Examining the clinical and preclinical evidence.

  2006cites this paper
• Weapons of penile smooth muscle destruction: Androgen deficiency promotes accumulation of adipocytes in the corpus cavernosum

  2005cites this paper
• Estrogen-induced abnormal accumulation of fat cells in the rat penis and associated loss of fertility depends upon estrogen exposure during critical period of penile development.

  2005influential citation
• Permanent induction of morphological abnormalities in the penis and penile skeletal muscles in adult rats treated neonatally with diethylstilbestrol or estradiol valerate: a dose-response study.

  2005cites this paper
• The physiological role of androgens in penile erection: regulation of corpus cavernosum structure and function.

  2005cites this paper
• Adipocyte accumulation in penile corpus cavernosum of the orchiectomized rabbit: a potential mechanism for veno-occlusive dysfunction in androgen deficiency.

  2005cites this paper
• ORIGINAL RESEARCH—ENDOCRINOLOGY: The Physiological Role of Androgens in Penile Erection: Regulation of Corpus Cavernosum Structure and Function

  2005cites this paper
• Abnormal Morphology of the Penis in Male Rats Exposed Neonatally to Diethylstilbestrol Is Associated with Altered Profile of Estrogen Receptor-α Protein, but Not of Androgen Receptor Protein: A Developmental and Immunocytochemical Study1

  2004cites this paper