Xanthatin and xanthinosin from the burs of Xanthium strumarium L. as potential anticancer agents.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Canadian Journal of Physiology and Pharmacology

• Publication date

  2007-11-21

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1139/Y07-104PMID 18066118
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2005cited by this paper
• Two cytotoxic sesquiterpene lactones from the leaves of Xanthium strumarium and their in vitro inhibitory activity on farnesyltransferase.

  2003cited by this paper
• Natural products as sources of new drugs over the period 1981-2002.

  2003cited by this paper
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  2002cited by this paper
• In vitro cytotoxicity of norviburtinal and isopinnatal from Kigelia pinnata against cancer cell lines.

  2000cited by this paper
• Plants used against cancer - an extension of the work of Jonathan Hartwell.

  2000cited by this paper
• Natural sesquiterpenoids (1999)

  2000cited by this paper
• In vitro cytotoxic and antitumor property of Emilia sonchifolia (L.) DC in mice.

  2000cited by this paper
• Discovery and Development of Antineoplastic Agents from Natural Sources

  1999cited by this paper
• Low concentrations of the feverfew component parthenolide inhibit in vitro growth of tumor lines in a cytostatic fashion.

  1999cited by this paper
• Discovery and development of antineoplastic agents from natural sources.

  1999cited by this paper
• Low concentrations of the feverfew component parthenolide inhibit in vitro growth of tumor lines in a cytostatic fashion.

  1999cited by this paper
• Sesquiterpene lactones specifically inhibit activation of NF-kappa B by preventing the degradation of I kappa B-alpha and I kappa B-beta.

  1998cited by this paper
• The Pharmacology of Chinese Herbs

  1998cited by this paper
• Ethnopharmacology of Mexican asteraceae (Compositae).

  1998cited by this paper
• High-Volume Screening

  1997cited by this paper
• The NCI In Vitro Anticancer Drug Discovery Screen

  1997cited by this paper
• Plant drug analysis : a thin layer chromatography atlas

  1996cited by this paper
• Herbal Medicines: A Guide for Healthcare Professionals

  1996cited by this paper
• Plants of the Western Boreal Forest and Aspen Parkland

  1995cited by this paper
• The MTT Tetrazolium Salt Assay Scrutinized: How to Use this Assay Reliably to Measure Metabolie Activity of Cell Cultures in vitro for the Assessment of Growth Characteristics, IC50-Values and Cell Survival

  1995cited by this paper
• The scientific contributions of Jonathan L. Hartwell, Ph.D

  1995cited by this paper
• Cytotoxic activity of xanthatin and the crude extracts of Xanthium strumarium.

  1994cited by this paper
• Plants of the Pacific Northwest Coast

  1994cited by this paper
• Antimicrobial activity of xanthatin from Xanthium spinosum L.

  1994cited by this paper
• Xanthanolides from Xanthium: absolute configuration of xanthanol, isoxanthanol and their C-4 epimers

  1993cited by this paper
• Chinese Drugs of Plant Origin: Chemistry, Pharmacology, and Use in Traditional and Modern Medicine

  1992cited by this paper
• Chinese Drugs of Plant Origin

  1992cited by this paper
• Antibiotic screening of medicinal plants of the British Columbian native peoples.

  1992cited by this paper
• Echinacea: Nature's Immune Enhancer

  1991cited by this paper
• Geigeria aspera Harv.: In Vitro Culture and Medicinal Value of Sesquiterpene Lactones

  1989cited by this paper
• Separation of Diterpenoid Alkaloid Mixtures Using Vacuum Liquid Chromatography

  1986cited by this paper
• Plant anticancer agents, XLI. Cardiac glycosides from Streblus asper.

  1985cited by this paper
• Natural plant chemicals: sources of industrial and medicinal materials.

  1985cited by this paper
• Plants used against cancer. A survey.

  1984cited by this paper
• Novel antitumor agents from plants

  1984cited by this paper
• Medicinal and other uses of the Compositae by Indians in the United States and Canada.

  1982cited by this paper
• New sesquiterpene lactones from Inula species

  1978cited by this paper
• Higher plants--the sleeping giant of drug development.

  1976cited by this paper
• Sesquiterpene lactones of Xanthium strumarium in a texas population and in experimental hybrids

  1975cited by this paper
• Systematic implications of the sesquiterpene lactones in the “strumarium” morphological complex (Xanthium strumarium, Asteraceae) of Europe, Asia and Africa

  1975influential reference

• Exploring the seasonal dietary practice of consuming 101 leafy vegetables during the Assamese festival of Bohag Bihu: a study of traditional heritage and ethnomedicinal perception in Assam.

  2025cites this paper
• Advancements in the therapeutic potential of sesquiterpenoids for the treatment of hepatocellular carcinoma (Review)

  2025cites this paper
• Xanthatin: A promising natural product in combating disease.

  2025cites this paper
• Prominent Naturally Derived Oxidative-Stress-Targeting Drugs and Their Applications in Cancer Treatment

  2025cites this paper
• Interaction of xanthatin as a bioactive sesquiterpene lactone with cyclin-dependent kinase-6 enzyme to regulate prostate cancer cell proliferation.

  2025cites this paper
• Phytochemical analysis and antioxidant, antimicrobial, and cytotoxic activities of Xanthium strumarium L. (Asteraceae)

  2024cites this paper
• In vitro cytogenetic and cytotoxic activity of Xanthium strumarium plant extract on human breast cancer cell line

  2024cites this paper
• Study on the Phototoxicity and Antitumor Activity of Plant Extracts from Tanacetum vulgare L., Epilobium parviflorum Schreb., and Geranium sanguineum L.

  2023cites this paper
• Green synthesis of gold and silver nanoparticles as antidiabetic and anticancerous agents

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• An In Vitro and In Vivo Assessment of Antitumor Activity of Extracts Derived from Three Well-Known Plant Species

  2023cites this paper
• A Review on Medicinal Plants Having Anticancer Properties of Northeast India and Associated Endophytic Microbes and their Future in Medicinal Science

  2022cites this paper
• Xanthatin inhibits non‐small cell lung cancer proliferation by breaking the redox balance

  2022cites this paper
• Review on Some Bangladeshi Medicinal Plants with Anticancer Properties

  2022cites this paper
• Natural plant extracts mediated expression regulation of TGF-β receptors and SMAD genes in human cancer cell lines

  2022cites this paper
• Cloning and Functional Characterization of Two Germacrene A Oxidases Isolated from Xanthium sibiricum

  2022cites this paper
• Guaianolide Derivatives from the Invasive Xanthium spinosum L.: Evaluation of Their Allelopathic Potential

  2022cites this paper
• (–)-Xanthatin as a Killer of Human Breast Cancer MCF-7 Mammosphere Cells: A Comparative Study with Salinomycin

  2022cites this paper
• A Novel Sesquiterpene Lactone Xanthatin-13-(pyrrolidine-2-carboxylic acid) Isolated from Burdock Leaf Up-Regulates Cells’ Oxidative Stress Defense Pathway

  2021cites this paper
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  2021cites this paper
• In vitro Antioxidant and Cytotoxic Activities of Extracts of Endemic Tanacetum erzincanense Together with Phenolic Content by LC-ESI-QTOF-MS.

  2021cites this paper
• Phytochemical and anticancer evaluation of stems and leaves extract of Hypochaeris Radicata (L.)

  2021cites this paper
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  2021cites this paper
• Biologically Active Constituents from Plants of the Genus Xanthium.

  2021cites this paper
• Phytochemical constituents from Xanthium strumarium L. and evaluation of their in vitro antimalarial activities

  2020cites this paper
• Turning Meadow Weeds Into Valuable Species for the Romanian Ethnomedicine While Complying With the Environmentally Friendly Farming Requirements of the European Union’s Common Agricultural Policy

  2020cites this paper
• The investigation of the potential anti-depressant like activity of Xanthium orientale subsp. italicum (Moretti) Greuter in rodents.

  2020cites this paper
• Xanthatin induces glioma cell apoptosis and inhibits tumor growth via activating endoplasmic reticulum stress-dependent CHOP pathway

  2019cites this paper
• Echinacea for Cancer Patients: To Give or Not to Give

  2019cites this paper
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  2019cites this paper
• Plants with Anticancer Potential

  2019cites this paper
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  2019cites this paper
• A Comprehensive Review on Ethnomedicinal, Pharmacological and Phytochemical Basis of Anticancer Medicinal Plants of Pakistan.

  2019cites this paper
• Xanthatin induces apoptosis by activating endoplasmic reticulum stress in hepatoma cells

  2019cites this paper
• Traditional Uses, Botany, Phytochemistry, Pharmacology, Pharmacokinetics and Toxicology of Xanthium strumarium L.: A Review

  2019cites this paper
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  2019cites this paper
• Xanthium strumarium – a potential cheap resource of plant substances for medicinal use

  2019cites this paper
• Phytotoxic Compounds Isolated from Leaves of the Invasive Weed Xanthium spinosum

  2018cites this paper
• Xanthatin Promotes Apoptosis via Inhibiting Thioredoxin Reductase and Eliciting Oxidative Stress.

  2018cites this paper
• Integrated in silico-in vitro strategy for screening of some traditional Egyptian plants for human aromatase inhibitors.

  2018cites this paper
• A Review on Antitumor and Antiviral Potential of Cranberries (Vaccinium Vitis-Idaea) Origin from Bulgaria

  2018cites this paper
• Búsqueda de nuevos agentes con propiedades antineoplásicas en la flora medicinal cubana: xanthium strumarium l., y el papel de las xantatinas en su actividad antitumoral

  2018cites this paper
• Morphology, Anatomy, Chlorogenic Acid Content and Antioxidant Capacity of Xanthium strumarium L. and Xanthium spinosum L.

  2018cites this paper
• ALLELOPATHY EVALUATION OF WEEDS FOR ENVIRONMENTAL RISK ASSESSMENT

  2017cites this paper
• Comparative studies on the antimicrobial and cytotoxic activities of Tanacetum vulgare L. essential oil and methanol extracts

  2017cites this paper
• Xanthium strumarium extract inhibits mammalian cell proliferation through mitotic spindle disruption mediated by xanthatin.

  2016cites this paper
• Valkova Antiviral activity of plant extract from Tanacetum vulgare against Cucumber Mosaic Virus and Potato Virus Y

  2016cites this paper
• Cytotoxic Compounds from Aerial Organs of Xanthium Strumarium

  2016cites this paper
• Possible involvement of FosB in (–)-xanthatin-mediated anti-proliferative effects in human cancer MDA-MB-231 cells

  2016influential citation
• Biochemical Features of Common Cocklebur (Xanthium strumarium L.)

  2015cites this paper
• Differential microRNA Analysis of Glandular Trichomes and Young Leaves in Xanthium strumarium L. Reveals Their Putative Roles in Regulating Terpenoid Biosynthesis

  2015cites this paper
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  2015cites this paper
• Sesquiterpenes with TRAIL-resistance overcoming activity from Xanthium strumarium.

  2015cites this paper
• Traditional Ayurvedic medicines : pathway to develop anti-cancer drugs

  2015cites this paper
• Selective phytotoxicity of xanthinin and xanthatin from invasive weed Xanthium italicum Morretti on test plants.

  2015cites this paper
• (–)-Xanthatin-mediated marked up-regulation of RhoB, a sensor for damaged DNA

  2015cites this paper
• Natural product extracts of the Canadian prairie plant, Thermopsis rhombifolia, have anti-cancer activity in phenotypic cell-based assays

  2015cites this paper
• In vitro Antifungal Activities of Extracts of Fruits and other Morphological Parts of Xanthium strumarium Against the Plant Pathogen, Rhizoctonia solani

  2014cites this paper
• Chemical analysis of the Tibetan herbal medicine Carduus acanthoides by UPLC/DAD/qTOF-MS and simultaneous determination of nine major compounds.

  2014cites this paper
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  2014cites this paper
• Xanthium strumarium L. Extracts Produce DNA Damage Mediated by Cytotoxicity in In Vitro Assays but Does Not Induce Micronucleus in Mice

  2014cites this paper
• In vitro antitumor potential of Bulgarian Tanacetum vulgare L. on human breast adenocarcinoma cells

  2014cites this paper
• ANTI-DIABETIC ACTIVITY OF AERIAL PARTS OF XANTHIUM STRUMARIUM LINN.

  2014cites this paper
• Determination of xanthatin by ultra high performance liquid chromatography coupled with triple quadrupole mass spectrometry: application to pharmacokinetic study of xanthatin in rat plasma.

  2014cites this paper
• Identifying Three Ecological Chemotypes of Xanthium strumarium Glandular Trichomes Using a Combined NMR and LC-MS Method

  2013cites this paper
• Anticancer Properties of Phytochemicals Present in Medicinal Plants of North America

  2013cites this paper
• Two new glycosides from Carduus acanthoides

  2013cites this paper
• Characterization of xanthatin: anticancer properties and mechanisms of inhibited murine melanoma in vitro and in vivo.

  2013cites this paper
• Non-Small Cell Lung Cancer Cells

  2013cites this paper
• Preliminary evaluation of in vitro cytotoxicity and in vivo antitumor activity of Xanthium strumarium in transplantable tumors in mice.

  2013cites this paper
• Xanthatin Induces G2/M Cell Cycle Arrest and Apoptosis in Human Gastric Carcinoma MKN-45 Cells

  2012cites this paper
• Seasonal variation of the cytotoxicity of Iva hayesiana on the human breast cancer cell line MDA-MB-231

  2012cites this paper
• Sesquiterpene lactones from the aerial parts of Xanthium sibiricum and their cytotoxic effects on human cancer cell lines

  2012cites this paper
• Control of foliar diseases of tea with Xanthium strumarium leaf extract

  2012cites this paper
• Phytotoxic Effects and a Phytotoxin from the Invasive Plant Xanthium italicum Moretti

  2012cites this paper
• Inhibition of Melanogenesis by Xanthium strumarium L.

  2012cites this paper
• Target analysis of α-alkylidene-γ-butyrolactones in uropathogenic E. coli.

  2012cites this paper
• Xanthatin Induces Cell Cycle Arrest at G2/M Checkpoint and Apoptosis via Disrupting NF-κB Pathway in A549 Non-Small-Cell Lung Cancer Cells

  2012cites this paper
• Acute and subacute toxicity of chloroform and hexaneextracts of root of Xanthium strumarium

  2012cites this paper
• Biological Activities of Xanthatin from Xanthium strumarium Leaves

  2011influential citation
• Prácticas agrícolas para el cultivo de Xanthium strumarium L. (guizazo de caballo) con fines terapéuticos

  2010cites this paper
• Total synthesis of xanthanolides

  2010cites this paper
• Essential oils: anti-microbial, antihelminthic, antiviral, anticancer and anti-insect properties.

  2010cites this paper
• Agricultural practices for the culture of Xanthium strumanium L. (guizazo de caballo) with therapeutic aims.

  2010cites this paper
• Muscle spasm associated with therapeutic use of Cang Er Zi Wan

  2010cites this paper
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  2010cites this paper
• The Xanthium Genus

  2010cites this paper
• Effects of 5 h wetting of sun-dried cassava tuber meal on the hydrocyanide content and dietary value of the meal for laying hens.

  2009cites this paper
• Natural sesquiterpenoids.

  2008cites this paper
• The Effects of Hydroalcoholic Extract of Xanthium Strumarium on L 929 Tumor Cell Line

  year unknowncites this paper