p53 Inactivation leads to impaired motor synchronization in mice

No abstract is available for this paper.

• Publication year

  2003

• Venue

  European Journal of Neuroscience

• Publication date

  2003-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1046/j.1460-9568.2003.02631.xPMID 12786980
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The use of a plus-maze to measure anxiety in the mouse

  2004cited by this paper
• Neurobiological effects of a null mutation depend on genetic context: comparison between two hotfoot alleles of the delta-2 ionotropic glutamate receptor.

  2001cited by this paper
• A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid β‐peptide

  2001cited by this paper
• A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide.

  2001cited by this paper
• Motor performance and regional brain metabolism of spontaneous murine mutations with cerebellar atrophy.

  2001cited by this paper
• Behavioral alterations associated with apoptosis and down-regulation of presenilin 1 in the brains of p53-deficient mice.

  2000cited by this paper
• Suppression of p53: a new approach to overcome side effects of antitumor therapy.

  2000cited by this paper
• Comparative analysis of brain proteins from p53‐deficient mice by two‐dimensional electrophoresis

  2000cited by this paper
• ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation.

  2000cited by this paper
• Myosin isoforms, muscle fiber types, and transitions

  2000cited by this paper
• Quantification of p53 expression in the nervous system.

  2000cited by this paper
• Critical Period for Activity-Dependent Synapse Elimination in Developing Cerebellum

  2000cited by this paper
• An unsteady platform test for measuring static equilibrium in mice.

  1999cited by this paper
• Hu‐Bcl‐2 transgenic mice with supernumerary neurons exhibit timing impairment in a complex motor task

  1999cited by this paper
• A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy.

  1999cited by this paper
• Mechanisms of p53-mediated apoptosis

  1999cited by this paper
• p53 expression and regulation by NMDA receptors in the developing rat brain

  1999cited by this paper
• Tissue-specific p53 expression in the nervous system.

  1999cited by this paper
• ATM: the product of the gene mutated in ataxia-telangiectasia.

  1999cited by this paper
• Contents of myosin heavy chains in denervated slow and fast rat leg muscles.

  1999cited by this paper
• The cerebellum and postural sensorimotor learning in mice and rats.

  1998cited by this paper
• Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation.

  1998cited by this paper
• Microcircuitry and function of the inferior olive.

  1998cited by this paper
• Alpha7 nicotinic receptor subunits are not necessary for hippocampal-dependent learning or sensorimotor gating: a behavioral characterization of Acra7-deficient mice.

  1998cited by this paper
• Differential effects of a six-day immobilization on newborn rat soleus muscles at two developmental stages

  1998cited by this paper
• Persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking mGluR1.

  1997cited by this paper
• Transgenic mice with p53‐responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo

  1997cited by this paper
• Incomplete regression of multiple climbing fibre innervation of cerebellar Purkinje cells in mGluR1 mutant mice

  1997cited by this paper
• Cycloheximide phase‐shifts, but does not prevent, de novo Krox‐24 protein expression

  1997cited by this paper
• Effect of Cerebellar Granule Cell Depletion on Learning of the Equilibrium Behaviour: Study in Postnatally X‐irradiated Rats

  1997cited by this paper
• Increased inferior olivary neuron and cerebellar granule cell numbers in transgenic mice overexpressing the human Bcl-2 gene.

  1997cited by this paper
• Mammalian skeletal muscle fiber type transitions.

  1997cited by this paper
• De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome

  1997cited by this paper
• Molecular genetic analysis of synaptic plasticity, activity-dependent neural development, learning, and memory in the mammalian brain.

  1997cited by this paper
• Role of the inferior olivary complex in motor skills and motor learning in the adult rat.

  1997cited by this paper
• A role for the tumour suppressor gene p53 in regulating neuronal apoptosis.

  1997cited by this paper
• Impaired Cerebellar Synaptic Plasticity and Motor Performance in Mice Lacking the mGluR4 Subtype of Metabotropic Glutamate Receptor

  1996influential reference
• Atm-deficient mice: a paradigm of ataxia telangiectasia.

  1996cited by this paper
• Loss of the p53 tumor suppressor gene protects neurons from kainate- induced cell death

  1996cited by this paper
• Evidence for p53-Mediated Modulation of Neuronal Viability

  1996cited by this paper
• Deficient cerebellar long-term depression, impaired eyeblink conditioning, and normal motor coordination in GFAP mutant mice.

  1996cited by this paper
• UBE3A/E6-AP mutations cause Angelman syndrome

  1996cited by this paper
• p53 in signaling checkpoint arrest or apoptosis.

  1996cited by this paper
• Increased cerebellar Purkinje cell numbers in mice overexpressing a human Bcl‐2 transgene

  1996cited by this paper
• Changes in myosin mRNA and protein expression in denervated rat soleus and tibialis anterior.

  1996cited by this paper
• Impairment of motor coordination, Purkinje cell synapse formation, and cerebellar long-term depression in GluR delta 2 mutant mice.

  1995cited by this paper
• Impairment of motor coordination, Purkinje cell synapse formation, andcerebellar long-term depression in GluR δ 2 mutant mice

  1995cited by this paper
• Motor behavior of heterozygous staggerer mutant (+/sg) versus normal (+/+) mice during aging.

  1995cited by this paper
• Impairment of motor coordination, Purkinje cell synapse formation, and cerebellar long-term depression in GluRδ2 mutant mice

  1995cited by this paper
• Impaired synapse elimination during cerebellar development in PKCγ mutant mice

  1995influential reference
• Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKCγ mutant mice

  1995cited by this paper
• Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKC gamma mutant mice.

  1995cited by this paper
• Dynamic organization of motor control within the olivocerebellar system

  1995cited by this paper
• Impaired synapse elimination during cerebellar development in PKC gamma mutant mice.

  1995influential reference
• Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice.

  1994cited by this paper
• Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice.

  1994cited by this paper
• Developmental studies of the inferior olivary nucleus in staggerer mutant mice.

  1994cited by this paper
• Tumor spectrum analysis in p53-mutant mice.

  1994influential reference
• Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1.

  1994cited by this paper
• Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1

  1994cited by this paper
• Bcl-2 and neuronal selection during development of the nervous system.

  1994cited by this paper
• The effect of denervation on myosin isoform synthesis in rabbit slow-type and fast-type muscles during terminal differentiation. Denervation induces differentiation into slow-type muscles.

  1994cited by this paper
• p53 is required for radiation-induced apoptosis in mouse thymocytes

  1993cited by this paper
• Thymocyte apoptosis induced by p53-dependent and independent pathways

  1993cited by this paper
• Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

  1992cited by this paper
• Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the 'phosphocreatine circuit' for cellular energy homeostasis.

  1992cited by this paper
• Synaptic‐ and agonist‐induced excitatory currents of Purkinje cells in rat cerebellar slices.

  1991cited by this paper
• Effects of cerebellectomy at day 15 on the ontogenesis of the equilibrium behavior in the rat.

  1990cited by this paper
• Cell loss in the inferior olive of the staggerer mutant mouse is an indirect effect of the gene.

  1990cited by this paper
• Role of the cerebellum in the ontogenesis of the equilibrium behavior in the young rat: a behavioral study.

  1989cited by this paper
• Three myosin heavy chain isoforms in type 2 skeletal muscle fibres

  1989cited by this paper
• Decreased number of cells in the inferior olivary nucleus of the developing staggerer mouse.

  1985cited by this paper
• Neuronal death and synapse elimination in the olivocerebellar system. II. Cell counts in the inferior olive of adult X‐irradiated rats and weaver and reeler mutant mice

  1985cited by this paper
• Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat.

  1985cited by this paper
• Effects of alpha-adrenoceptor agonists and antagonists in a maze-exploration model of ‘fear’-motivated behaviour

  1984cited by this paper
• Environmental features determining successful rearing in the mutant mouse staggerer.

  1984cited by this paper
• The cerebellum and neural control

  1984cited by this paper
• Direct correlation between Purkinje and granule cell number in the cerebella of lurcher chimeras and wild-type mice.

  1983cited by this paper
• Interaction of granule, Purkinje and inferior olivary neurons in lurcher chimeric mice. II. Granule cell death.

  1982cited by this paper
• Ontogenesis of olivocerebellar relationships. I. Studies by intracellular recordings of the multiple innervation of Purkinje cells by climbing fibers in the developing rat cerebellum

  1981cited by this paper
• Ontogenesis of olivocerebellar relationships. II. Spontaneous activity of inferior olivary neurons and climbing fibermediated activity of cerebellar Purkinje cells in developing rats

  1981cited by this paper
• Evidence for a multiple innervation of Purkinje cells by climbing fibers in the immature rat cerebellum.

  1976cited by this paper
• A method to correct adequately for the change in neuronal size when estimating neuronal numbers after nerve growth factor treatment

  1976cited by this paper
• Qualitative differences between actomyosin ATPase of slow and fast mammalian muscle.

  1969influential reference
• Interactions between motoneurones and muscles in respect of the characteristic speeds of their responses

  1960cited by this paper
• A Histochemical Method for Localizing Cholinesterase Activity.*

  1949cited by this paper

• Genetic Deficiency of p53 Leads to Structural, Functional, and Synaptic Deficits in Primary Somatosensory Cortical Neurons of Adult Mice

  2022cites this paper
• The HERC2 ubiquitin ligase is essential for embryonic development and regulates motor coordination

  2016cites this paper
• Gas7-Deficient Mouse Reveals Roles in Motor Function and Muscle Fiber Composition during Aging

  2012cites this paper
• Role of p53 in mitochondrial biogenesis and apoptosis in skeletal muscle.

  2009cites this paper
• Inhibition of ataxia telangiectasia-p53-E2F-1 pathway in neurons as a target for the prevention of neuronal apoptosis.

  2007cites this paper
• Post‐lesion transcommissural growth of olivary climbing fibres creates functional synaptic microzones

  2003cites this paper