Intranasal siRNA administration reveals IGF2 deficiency contributes to impaired cognition in Fragile X syndrome mice.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  JCI Insight

• Publication date

  2017-03-23

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1172/jci.insight.91782PMID 28352664PMCID PMC5358485
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Changes in insulin‐like growth factor signaling alter phenotypes in Fragile X Mice

  2017cited by this paper
• CANEapp: a user-friendly application for automated next generation transcriptomic data analysis

  2016cited by this paper
• iRNA as a tool to improve the treatment of brain diseases : echanism , targets and delivery aria

  2015cited by this paper
• Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases.

  2015cited by this paper
• Histone deacetylases as therapeutic targets--from cancer to cardiac disease.

  2015cited by this paper
• Impairments in cognition and neural precursor cell proliferation in mice expressing constitutively active glycogen synthase kinase-3

  2015cited by this paper
• Enhanced memory consolidation in mice lacking the circadian modulators Sharp1 and -2 caused by elevated Igf2 signaling in the cortex

  2015cited by this paper
• Exogenous insulin-like growth factor 2 administration enhances memory consolidation and persistence in a time-dependent manner.

  2015cited by this paper
• Learning and behavioral deficits associated with the absence of the fragile X mental retardation protein: what a fly and mouse model can teach us

  2014cited by this paper
• Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

  2014cited by this paper
• Prolongation of life in rats with malignant glioma by intranasal siRNA/drug codelivery to the brain with cell-penetrating peptide-modified micelles.

  2014cited by this paper
• BDNF and memory processing.

  2014cited by this paper
• Histone deacetylases in memory and cognition

  2014cited by this paper
• Glycogen synthase kinase-3 inhibitors reverse deficits in long-term potentiation and cognition in fragile X mice.

  2014cited by this paper
• Glycogen synthase kinase-3 inhibitors: Rescuers of cognitive impairments.

  2014cited by this paper
• Lithium treatment alleviates impaired cognition in a mouse model of fragile X syndrome

  2013cited by this paper
• Loss of Histone Deacetylase 2 Improves Working Memory and Accelerates Extinction Learning

  2013cited by this paper
• Reduced Adult Hippocampal Neurogenesis and Working Memory Deficits in the Dgcr8-Deficient Mouse Model of 22q11.2 Deletion-Associated Schizophrenia Can Be Rescued by IGF2

  2013cited by this paper
• Novel siRNA delivery strategy: a new “strand” in CNS translational medicine?

  2013cited by this paper
• Histone Deacetylase 2 Cell Autonomously Suppresses Excitatory and Enhances Inhibitory Synaptic Function in CA1 Pyramidal Neurons

  2013cited by this paper
• A pivotal role of GSK-3 in synaptic plasticity

  2012cited by this paper
• An Essential Role for Histone Deacetylase 4 in Synaptic Plasticity and Memory Formation

  2012cited by this paper
• HDAC4 governs a transcriptional program essential for synaptic plasticity and memory.

  2012cited by this paper
• Memory enhancement: consolidation, reconsolidation and insulin-like growth factor 2.

  2012cited by this paper
• An epigenetic blockade of cognitive functions in the neurodegenerating brain

  2012cited by this paper
• Selective siRNA-mediated suppression of 5-HT1A autoreceptors evokes strong anti-depressant-like effects

  2012cited by this paper
• Nanomaterial-mediated CNS delivery of diagnostic and therapeutic agents.

  2012cited by this paper
• A critical role for IGF-II in memory consolidation and enhancement

  2011cited by this paper
• Glycogen Synthase Kinase-3: A Promising Therapeutic Target for Fragile X Syndrome

  2011cited by this paper
• GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS

  2011cited by this paper
• HDAC3 Is a Critical Negative Regulator of Long-Term Memory Formation

  2010cited by this paper
• Deficiency in the Inhibitory Serine-Phosphorylation of Glycogen Synthase Kinase-3 Increases Sensitivity to Mood Disturbances

  2010cited by this paper
• Targeting the correct HDAC(s) to treat cognitive disorders.

  2010cited by this paper
• Lithium ameliorates altered glycogen synthase kinase-3 and behavior in a mouse model of fragile X syndrome.

  2010cited by this paper
• HDAC2 negatively regulates memory formation and synaptic plasticity

  2009cited by this paper
• BDNF signaling in the formation, maturation and plasticity of glutamatergic and GABAergic synapses

  2009cited by this paper
• Blocked inhibitory serine-phosphorylation of glycogen synthase kinase-3alpha/beta impairs in vivo neural precursor cell proliferation.

  2009cited by this paper
• Nanoparticles for direct nose-to-brain delivery of drugs.

  2009cited by this paper
• BDNF: a key regulator for protein synthesis-dependent LTP and long-term memory?

  2008cited by this paper
• LTP inhibits LTD in the hippocampus via regulation of GSK3beta.

  2007cited by this paper
• Local knockdown of genes in the brain using small interfering RNA: a phenotypic comparison with knockout animals.

  2007cited by this paper
• Recovery of learning and memory is associated with chromatin remodelling

  2007cited by this paper
• Hypothalamic huntingtin-associated protein 1 as a mediator of feeding behavior

  2006cited by this paper
• Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis

  2005cited by this paper
• Central administration of small interfering RNAs in rats: a comparison with antisense oligonucleotides.

  2005cited by this paper
• Regulation of Histone Acetylation during Memory Formation in the Hippocampus*

  2004cited by this paper
• Acetylation of nuclear factor-kappaB in rat amygdala improves long-term but not short-term retention of fear memory.

  2004cited by this paper
• Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effect on beta-catenin in mouse hippocampus.

  2004cited by this paper
• Chromatin acetylation, memory, and LTP are impaired in CBP+/- mice: a model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration.

  2004cited by this paper
• Insulin Mimetic Action of Synthetic Phosphorylated Peptide Inhibitors of Glycogen Synthase Kinase-3

  2003cited by this paper
• BDNF–triggered events in the rat hippocampus are required for both short‐ and long‐term memory formation

  2002cited by this paper
• First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3beta) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease.

  2002cited by this paper
• Judging a Protein by More Than Its Name: GSK-3

  2001cited by this paper

• Upregulation of HDAC3 mediates behavioral impairment in the bile duct ligation model of hepatic encephalopathy.

  2025cites this paper
• Epigenetic reprogramming of HDAC2 in CA1 excitatory neurons determines Pb-induced non-spatial memory deficits.

  2025cites this paper
• Unlocking the therapeutic potential of protein kinase inhibitors in neurodegenerative and psychiatric disorders

  2025cites this paper
• Insulin-Like Growth Factor Signaling in Alzheimer’s Disease: Pathophysiology and Therapeutic Strategies

  2024cites this paper
• Pharmaceutical-mediated neuroimmune modulation in psychiatric/psychological adverse events.

  2024cites this paper
• Stress promotes the infiltration of peripheral immune cells to the brain.

  2023cites this paper
• New insights into glycogen synthase kinase-3: A common target for neurodegenerative diseases.

  2023cites this paper
• IGF2 in memory, neurodevelopmental disorders, and neurodegenerative diseases.

  2023cites this paper
• Insulin‐like growth factor‐2 is a promising candidate for the treatment and prevention of Alzheimer's disease

  2023cites this paper
• Neuronal activity drives IGF2 expression from pericytes to form long-term memory.

  2023cites this paper
• Glycogen Synthase Kinase-3 Inhibitors: Preclinical and Clinical Focus on CNS-A Decade Onward

  2022cites this paper
• Inhibition of HDAC3 and ATXN3 by miR-25 prevents neuronal loss and ameliorates neurological recovery in cerebral stroke experimental rats

  2022cites this paper
• Insulin-like Growth Factor 2: Beyond its Role in Hippocampal-dependent Memory

  2021cites this paper
• Mechanisms and Therapeutic Implications of GSK-3 in Treating Neurodegeneration

  2021cites this paper
• Neuronal fragile X mental retardation protein activates glial insulin receptor mediated PDF-Tri neuron developmental clearance

  2021cites this paper
• Insulin-Like Growth Factor 2 As a Possible Neuroprotective Agent and Memory Enhancer—Its Comparative Expression, Processing and Signaling in Mammalian CNS

  2021influential citation
• Deciphering the roles of glycogen synthase kinase 3 (GSK3) in the treatment of autism spectrum disorder and related syndromes

  2021cites this paper
• Inhibition of GSK-3 ameliorates the pathogenesis of Huntington's disease.

  2021cites this paper
• Criss‐crossing autism spectrum disorder and adult neurogenesis

  2021cites this paper
• Epigenetics of Autism Spectrum Disorder: Histone Deacetylases.

  2021cites this paper
• Selective inhibition of glycogen synthase kinase 3α corrects pathophysiology in a mouse model of fragile X syndrome

  2020cites this paper
• Discovery and Design of Novel Small Molecule GSK-3 Inhibitors Targeting the Substrate Binding Site

  2020cites this paper
• Nuclear Accumulation of Histone Deacetylase 4 (HDAC4) by PP1-Mediated Dephosphorylation Exerts Neurotoxicity in Pb-exposed neural cells.

  2020cites this paper
• Identification of a hippocampal lncRNA-regulating network in cognitive dysfunction caused by chronic cerebral hypoperfusion

  2020cites this paper
• Anti-inflammatory IL-10 administration rescues depression-associated learning and memory deficits in mice

  2020cites this paper
• Insulin growth factor 2 (IGF2) as an emergent target in psychiatric and neurological disorders. Review.

  2019cites this paper
• Inhibition of histone deacetylase 3 by MiR-494 alleviates neuronal loss and improves neurological recovery in experimental stroke

  2019cites this paper
• Novel Modality of GSK-3 Inhibition For Treating Neurodegeneration

  2018cites this paper
• Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and Learning Impairments in a Mouse Model of Fragile X Syndrome.

  2018cites this paper