A cell surface antigenic determinant present on mouse plasmacytes and only about half of mouse thymocytes.

A new surface antigenic determinant present on a subpopulation of normal thymus cells of individual mice has been detected with rabbit antiserum obtained by immunization with cells of a mouse IgM-producing plasma cell tumor, MOPC-104E, and purified by in vivo absorption in mice. Cells of MOPC-104E and several other plasma cell tumors as well as a subpopulation of about 50% of normal mouse thymus cells were found to possess this antigen by cytotoxicity test. Although the present antigen is not plasmacyte-specific since it is also detected on thymocytes, it is not present on liver, kidney, or brain cells, as shown by absorption tests. Hence, it is clearly different from another mouse plasma cell antigen, which has been detected by rabbit antisera prepared similarly against the IgA-producing and IgG-producing plasma cell tumors, ADJ-PC-22A and MOPC-21, respectively, and which is common to liver, kidney, and brain.

• Publication year

  1974

• Venue

  Journal of Immunology

• Publication date

  1974-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.112.5.1774PMID 4131875
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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