Amyloid-β Protein Precursor Gene Expression in Alzheimer's Disease and Other Conditions

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Journal of Alzheimer's Disease

• Publication date

  2012-02-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3233/JAD-2011-111148PMID 22045488
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Clinical diagnosis of Alzheimer's disease: Report of the NINCDS—ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease

  2011cited by this paper
• A rare SMN2 variant in a previously unrecognized composite splicing regulatory element induces exon 7 inclusion and reduces the clinical severity of spinal muscular atrophy

  2010cited by this paper
• Genome wide profiling of altered gene expression in the neocortex of Alzheimer's disease

  2009cited by this paper
• Age‐dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model

  2009cited by this paper
• Identification of independent APP locus duplication in Japanese patients with early-onset Alzheimer disease

  2009cited by this paper
• Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set.

  2008cited by this paper
• Gene expression profiling in the adult Down syndrome brain.

  2007cited by this paper
• Variations in the APP gene promoter region and risk of Alzheimer disease

  2007cited by this paper
• Expression of APP pathway mRNAs and proteins in Alzheimer's disease.

  2007cited by this paper
• Transcriptional profiling of Alzheimer blood mononuclear cells by microarray.

  2007cited by this paper
• Classification of human chromosome 21 gene-expression variations in Down syndrome: impact on disease phenotypes.

  2007cited by this paper
• Natural gene-expression variation in Down syndrome modulates the outcome of gene-dosage imbalance.

  2007cited by this paper
• APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy.

  2006cited by this paper
• APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy

  2006cited by this paper
• Genetic risk and transcriptional variability of amyloid precursor protein in Alzheimer's disease.

  2006cited by this paper
• Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer disease.

  2006cited by this paper
• Mean age‐of‐onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Aβ42 and decreased Aβ40

  2006cited by this paper
• Gene expression variation and expression quantitative trait mapping of human chromosome 21 genes.

  2005cited by this paper
• The prevalence of amyloid (A4) protein deposits within the cerebral and cerebellar cortex in Down's syndrome and Alzheimer's disease

  2004cited by this paper
• Incipient Alzheimer's disease: Microarray correlation analyses reveal major transcriptional and tumor suppressor responses

  2004cited by this paper
• Gene Expression Profile Analysis in Human T Lymphocytes from Patients with Down Syndrome

  2004cited by this paper
• Tumor necrosis factor alpha serum levels and inflammatory response in acute ischemic stroke patients

  2004cited by this paper
• Amyloid precursor protein mRNA levels in Alzheimer's disease brain.

  2004cited by this paper
• Enhanced production of amyloid precursor protein mRNA by peripheral mononuclear blood cell in Alzheimer's disease

  2003cited by this paper
• Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: Transcription and neurotrophic factor down‐regulation and up‐regulation of apoptotic and pro‐inflammatory signaling

  2002cited by this paper
• Transcriptome analysis of human autosomal trisomy.

  2002cited by this paper
• Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

  2002cited by this paper
• Regulation of Promoter Activity of the APP Gene by Cytokines and Growth Factors

  2002cited by this paper
• A Gene Expression Profile of Alzheimer's Disease

  2001cited by this paper
• Expression and Distribution of Beta Amyloid Precursor Protein and Beta Amyloid Peptide in Reactive Astrocytes After Transient Middle Cerebral Artery Occlusion

  2001cited by this paper
• Microarray analysis of hippocampal gene expression in global cerebral ischemia

  2001cited by this paper
• Enhancement of amyloid beta 42 secretion by 28 different presenilin 1 mutations of familial Alzheimer's disease.

  1999cited by this paper
• Increased IL-1beta, IL-8, and IL-17 mRNA expression in blood mononuclear cells observed in a prospective ischemic stroke study.

  1999cited by this paper
• Increased Cytokine Release from Peripheral Blood Cells after Acute Stroke

  1999cited by this paper
• Enhancement of beta-amyloid precursor protein transcription and expression by the soluble interleukin-6 receptor/interleukin-6 complex.

  1998cited by this paper
• Serial measurement of interleukin-6, transforming growth factor-beta, and S-100 protein in patients with acute stroke.

  1996cited by this paper
• Polymerase chain reaction quantification of lymphoid amyloid precursor protein mRNAs in Alzheimer's disease and Down's syndrome.

  1995cited by this paper
• Down's syndrome: up-regulation of beta-amyloid protein precursor and tau mRNAs and their defective coordination.

  1994cited by this paper
• Amyloid precursor protein mRNA levels in the mononuclear blood cells of Alzheimer's and Down's patients.

  1993cited by this paper
• Amyloid precursor protein accumulates in regions of neurodegeneration following focal cerebral ischemia in the rat.

  1992cited by this paper
• Expression of amyloid beta-protein precursor mRNAs in familial Alzheimer's disease.

  1991cited by this paper
• Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells.

  1989cited by this paper
• Clinical diagnosis of Alzheimer's disease

  1984cited by this paper

• Altered gene expression associated with Alzheimer's disease in the SH-SY5Y neuroblastoma cell model: Enhanced intracellular GSK3β and Cyclophilin A, as key neuropathology-inducing factors.

  2026cites this paper
• Systematic review and evidence gap mapping of Alzheimer's disease biomarker studies in those with intellectual and developmental disability

  2025cites this paper
• Lessons from genetic studies in Alzheimer disease.

  2024cites this paper
• Recent advances in Alzheimer disease genetics

  2024influential citation
• Neuroinflammation in Alzheimer disease

  2024cites this paper
• APP dyshomeostasis in the pathogenesis of Alzheimer’s disease: implications for current drug targets

  2024cites this paper
• Phenotype and imaging features associated with APP duplications

  2023cites this paper
• Génétique de la maladie d’Alzheimer

  2022cites this paper
• Genetica della malattia di Alzheimer

  2022cites this paper
• Early-Onset Cerebral Amyloid Angiopathy and Alzheimer Disease Related to an APP Locus Triplication

  2021cites this paper
• Regulation of PPARα by APP in Alzheimer disease affects the pharmacological modulation of synaptic activity

  2021cites this paper
• Copy Number Variants in miR-138 as a Potential Risk Factor for Early-Onset Alzheimer’s Disease

  2019cites this paper
• Summary, Perspective, and Direction for Future Research on Neurotraumatic Diseases

  2018cites this paper
• Interprétation des biomarqueurs du liquide céphalorachidien dans la maladie d’Alzheimer et les dégénérescences lobaires fronto-temporales

  2017cites this paper
• APP as a Protective Factor in Acute Neuronal Insults

  2017influential citation
• Seizures in dominantly inherited Alzheimer disease

  2016cites this paper
• Genetica delle demenze degenerative

  2015cites this paper
• De novo deleterious genetic variations target a biological network centered on Aβ peptide in early-onset Alzheimer disease

  2015cites this paper
• Mutation in the 3’untranslated region of APP as a genetic determinant of cerebral amyloid angiopathy

  2015cites this paper
• Heteromers of amyloid precursor protein in cerebrospinal fluid

  2015cites this paper
• Génétique des démences dégénératives

  2015cites this paper
• Vascular Aspects of Cognitive Impairment and Dementia

  2013cites this paper
• Cellular and animal models for high-throughput screening of therapeutic agents for the treatment of the diseases of the elderly in general and Alzheimer’s disease in particular†

  2013cites this paper
• Amyloid-Related Imaging Abnormalities in AβPP Duplication Carriers

  2013cites this paper
• Génétique des formes autosomiques dominantes de maladie d’Alzheimer

  2013cites this paper
• Identification, par criblage génomique à haut débit, de Variations du Nombre de Copies impliquées dans les formes précoces de Maladie d'Alzheimer

  2012cites this paper
• MD beta-amyloid in alzheimer ’ s Disease Current and Emerging Implications for Diagnosis and Treatment

  2012cites this paper
• The French Series of Autosomal Dominant Early Onset Alzheimer's Disease Cases: Mutation Spectrum and Cerebrospinal Fluid Biomarkers

  2012cites this paper