Similarities and differences in mechanisms of phrenic and hypoglossal motor facilitation.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Respiratory Physiology & Neurobiology

• Publication date

  2011-10-15

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1016/j.resp.2011.06.022PMID 21745601PMCID PMC3183164
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Reduced respiratory neural activity elicits phrenic motor facilitation.

  2011cited by this paper
• Serotonin 2A and 2B receptor-induced phrenic motor facilitation: differential requirement for spinal NADPH oxidase activity.

  2011influential reference
• Should we standardize protocols and preparations used to study respiratory plasticity?

  2011cited by this paper
• Spinal 5‐HT7 receptor activation induces long‐lasting phrenic motor facilitation

  2011influential reference
• Testosterone restores respiratory long term facilitation in old male rats by an aromatase‐dependent mechanism

  2011influential reference
• Carotid chemoafferent activity is not necessary for all phrenic long-term facilitation following acute intermittent hypoxia.

  2011cited by this paper
• Spinal Vascular Endothelial Growth Factor Induces Phrenic Motor Facilitation via Extracellular Signal-Regulated Kinase and Akt Signaling

  2011cited by this paper
• Phrenicotomy alters phrenic long-term facilitation following intermittent hypoxia in anesthetized rats.

  2010influential reference
• Increased ventral spinal TNF‐alpha following hypocapnia‐induced respiratory neural inactivity

  2010cited by this paper
• Spinal plasticity following intermittent hypoxia: implications for spinal injury

  2010cited by this paper
• Multiple pathways to long-lasting phrenic motor facilitation.

  2010cited by this paper
• Spinal adenosine A2A receptor inhibition enhances phrenic long term facilitation following acute intermittent hypoxia

  2010influential reference
• Glossopharyngeal long-term facilitation requires serotonin 5-HT2 and NMDA receptors in rats.

  2010influential reference
• Identification of a Novel Form of Noradrenergic-Dependent Respiratory Motor Plasticity Triggered by Vagal Feedback

  2010influential reference
• Changes in androgen receptor, estrogen receptor alpha, and sexual behavior with aging and testosterone in male rats.

  2010cited by this paper
• Differential expression of respiratory long-term facilitation among inbred rat strains.

  2010cited by this paper
• Episodic spinal serotonin receptor activation elicits long‐lasting phrenic motor facilitation by an NADPH oxidase‐dependent mechanism

  2009cited by this paper
• Attenuated phrenic long-term facilitation in orexin neuron-ablated mice.

  2009cited by this paper
• Daily intermittent hypoxia augments spinal BDNF levels, ERK phosphorylation and respiratory long-term facilitation.

  2009cited by this paper
• NADPH oxidase activity is necessary for acute intermittent hypoxia‐induced phrenic long‐term facilitation

  2009influential reference
• Episodic hypoxia induces long‐term facilitation of upper airway muscle activity in spontaneously breathing anaesthetized rats

  2009influential reference
• Determinants of frequency long-term facilitation following acute intermittent hypoxia in vagotomized rats.

  2008cited by this paper
• Simulated apnoeas induce serotonin‐dependent respiratory long‐term facilitation in rats

  2008cited by this paper
• Respiratory long-term facilitation following intermittent hypoxia requires reactive oxygen species formation.

  2008influential reference
• Long-term facilitation of genioglossus activity is present in normal humans during NREM sleep.

  2008cited by this paper
• Okadaic Acid-Sensitive Protein Phosphatases Constrain Phrenic Long-Term Facilitation after Sustained Hypoxia

  2008cited by this paper
• Spinal Adenosine A2a Receptor Activation Elicits Long-Lasting Phrenic Motor Facilitation

  2008cited by this paper
• Serotonin and NMDA receptors in respiratory long-term facilitation.

  2008cited by this paper
• Noradrenergic stimulation of BDNF synthesis in astrocytes: Mediation via α1- and β1/β2-adrenergic receptors

  2008cited by this paper
• Reactive oxygen species and respiratory plasticity following intermittent hypoxia.

  2008cited by this paper
• Plasticity in glutamatergic NTS neurotransmission.

  2008cited by this paper
• Noradrenergic stimulation of BDNF synthesis in astrocytes: mediation via alpha1- and beta1/beta2-adrenergic receptors.

  2008cited by this paper
• Bilateral vagotomy differentially alters the magnitude of hypoglossal and phrenic long-term facilitation in anesthetized mechanically ventilated rats.

  2008cited by this paper
• Acute intermittent hypoxia increases both phrenic and sympathetic nerve activities in the rat

  2007influential reference
• Respiratory plasticity following intermittent hypoxia: roles of protein phosphatases and reactive oxygen species.

  2007cited by this paper
• Is there a link between intermittent hypoxia‐induced respiratory plasticity and obstructive sleep apnoea?

  2007cited by this paper
• Episodic Stimulation of α1-Adrenoreceptors Induces Protein Kinase C-Dependent Persistent Changes in Motoneuronal Excitability

  2007influential reference
• Long-term facilitation of ventilation and genioglossus muscle activity is evident in the presence of elevated levels of carbon dioxide in awake humans.

  2006cited by this paper
• Conversion from testosterone to oestradiol is required to modulate respiratory long‐term facilitation in male rats

  2006influential reference
• Serotonin-induced in vitro long-term facilitation exhibits differential pattern sensitivity in cervical and thoracic inspiratory motor output.

  2006influential reference
• Phrenic long‐term facilitation requires NMDA receptors in the phrenic motonucleus in rats

  2005influential reference
• Ageing and gonadectomy have similar effects on hypoglossal long‐term facilitation in male Fischer rats

  2005influential reference
• Ventilatory long-term facilitation is greater in 1- vs. 2-mo-old awake rats.

  2005cited by this paper
• Episodic hypoxia induces long-term facilitation of neural drive to tongue protrudor and retractor muscles.

  2005cited by this paper
• Serotonin receptor subtypes involved in vagus nerve stimulation-induced phrenic long-term facilitation in rats.

  2004influential reference
• Synaptic activity-independent persistent plasticity in endogenously active mammalian motoneurons

  2004influential reference
• BDNF is necessary and sufficient for spinal respiratory plasticity following intermittent hypoxia

  2004cited by this paper
• Episodic hypoxia evokes long‐term facilitation of genioglossus muscle activity in neonatal rats

  2004cited by this paper
• 5-HT2 receptors.

  2004influential reference
• Episodic phrenic‐inhibitory vagus nerve stimulation paradoxically induces phrenic long‐term facilitation in rats

  2003influential reference
• Selected contribution: chronic intermittent hypoxia enhances respiratory long-term facilitation in geriatric female rats.

  2003cited by this paper
• Invited Review: Neuroplasticity in respiratory motor control

  2003cited by this paper
• Selected Contribution: Intermittent hypoxia induces phrenic long-term facilitation in carotid-denervated rats

  2003cited by this paper
• Induction of sensory long-term facilitation in the carotid body by intermittent hypoxia: Implications for recurrent apneas

  2003cited by this paper
• Brain-derived neurotrophic factor/TrkB signaling in memory processes.

  2003cited by this paper
• Reactive oxygen species in the plasticity of respiratory behavior elicited by chronic intermittent hypoxia.

  2003cited by this paper
• Postnatal development of serotonin 1B, 2 A and 2C receptors in brainstem motoneurons

  2003cited by this paper
• Neuroplasticity in respiratory motor control.

  2003cited by this paper
• Breathing: rhythmicity, plasticity, chemosensitivity.

  2003cited by this paper
• Age and gender effects on serotonin-dependent plasticity in respiratory motor control.

  2002influential reference
• Adenosine release in nucleus tractus solitarii does not appear to mediate hypoxia‐induced respiratory depression in rats

  2002cited by this paper
• Phrenic Long-Term Facilitation Requires Spinal Serotonin Receptor Activation and Protein Synthesis

  2002cited by this paper
• Effect of episodic hypoxia on upper airway mechanics in humans during NREM sleep.

  2002cited by this paper
• Long-term modulation of respiratory network activity following anoxia in vitro.

  2002cited by this paper
• Selected contribution: Time-dependent hypoxic respiratory responses in female rats are influenced by age and by the estrus cycle.

  2001influential reference
• Chronic Intermittent Hypoxia Elicits Serotonin-Dependent Plasticity in the Central Neural Control of Breathing

  2001cited by this paper
• Long term facilitation of respiratory motor output decreases with age in male rats

  2001influential reference
• Expression of hypoglossal long-term facilitation differs between substrains of Sprague-Dawley rat.

  2001influential reference
• Phrenic long-term facilitation requires 5-HT receptor activation during but not following episodic hypoxia.

  2001influential reference
• Distribution of serotonin 2A and 2C receptor mRNA expression in the cervical ventral horn and phrenic motoneurons following spinal cord hemisection.

  2001cited by this paper
• Respiratory plasticity: differential actions of continuous and episodic hypoxia and hypercapnia.

  2001cited by this paper
• Serotonin 2A receptor-like immunoreactivity is detected in astrocytes but not in oligodendrocytes of rat spinal cord.

  2001cited by this paper
• Plasticity in respiratory motor control: intermittent hypoxia and hypercapnia activate opposing serotonergic and noradrenergic modulatory systems.

  2001influential reference
• No evidence for long-term facilitation after episodic hypoxia in spontaneously breathing, anesthetized rats.

  2000cited by this paper
• Long term facilitation of phrenic motor output.

  2000cited by this paper
• Synaptic control of motoneuronal excitability.

  2000cited by this paper
• Episodic but not continuous hypoxia elicits long‐term facilitation of phrenic motor output in rats

  2000influential reference
• Neurotrophin signal transduction in the nervous system.

  2000cited by this paper
• Time-dependent hypoxic ventilatory responses in rats: effects of ketanserin and 5-carboxamidotryptamine.

  1999cited by this paper
• Time-dependent hypoxic ventilatory responses in rats: effects of ketanserin and 5-carboxamidotryptamine.

  1999cited by this paper
• Cultured astrocytes express messenger RNA for multiple serotonin receptor subtypes, without functional coupling of 5-HT1 receptor subtypes to adenylyl cyclase.

  1998cited by this paper
• Time domains of the hypoxic ventilatory response.

  1998cited by this paper
• Long-term facilitation of upper airway muscle activities in vagotomized and vagally intact cats.

  1997influential reference
• Expression of c‐fos in the rat brainstem after exposure to hypoxia and to normoxic and hyperoxic hypercapnia

  1997cited by this paper
• Long‐term facilitation of phrenic nerve activity in cats: responses and short time scale correlations of medullary neurones.

  1996cited by this paper
• Hypoxia-induced long-term facilitation of respiratory activity is serotonin dependent.

  1996influential reference
• Long‐term facilitation of inspiratory intercostal nerve activity following carotid sinus nerve stimulation in cats.

  1994influential reference
• Time-dependent phrenic nerve responses to carotid afferent activation: intact vs. decerebellate rats.

  1993cited by this paper
• Hormones and sexual behavior in relationship to aging in male rats.

  1992cited by this paper
• Fos-like protein is induced in neurons of the medulla oblongata after stimulation of the carotid sinus nerve in awake and anesthetized rats.

  1991influential reference
• Brain adenosine concentration during hypoxia in rats.

  1981cited by this paper
• Prolonged stimulation of respiration by a new central neural mechanism.

  1980influential reference
• highlighted topics Physiological and Genomic Consequences of Intermittent Hypoxia Selected Contribution: Phrenic long-term facilitation requires 5-HT receptor activation during but not following episodic hypoxia

  year unknowninfluential reference
• highlighted topics Physiological and Genomic Consequences of Intermittent Hypoxia Invited Review: Intermittent hypoxia and respiratory plasticity

  year unknowninfluential reference

• The development but not the maintenance of phrenic and sympathetic long-term facilitation after acute intermittent hypoxia requires nucleus tractus solitarii H2O2.

  2025cites this paper
• Tongue exercise ameliorates structural and functional upper airway deficits in a rodent model of hypoglossal motor neuron loss

  2024cites this paper
• Spinal TNF-α receptor 1 is differentially required for phrenic long-term facilitation (pLTF) over the course of motor neuron death in adult rats

  2024cites this paper
• Inactivity-induced phrenic motor facilitation requires PKCζ activity within phrenic motor neurons.

  2024cites this paper
• Low level CO2 supplementation maintains isocapnia and reveals ventilatory long-term facilitation in rats.

  2023cites this paper
• Respiratory neuroplasticity: Mechanisms and translational implications of phrenic motor plasticity.

  2022cites this paper
• The combination of intermittent electrical stimulation with acute intermittent hypoxia strengthens genioglossus muscle discharge in chronic intermittent hypoxia-pretreated rats.

  2021cites this paper
• Daily acute intermittent hypoxia enhances serotonergic innervation of hypoglossal motor nuclei in rats with and without cervical spinal injury.

  2021cites this paper
• Nonsteroidal anti-inflammatory drug (ketoprofen) delivery differentially impacts phrenic long-term facilitation in rats with motor neuron death induced by intrapleural CTB-SAP injections.

  2021cites this paper
• THE PLASTICITY OF NERVE FIBRES: THE PROLONGED EFFECTS OF POLARIZATION OF AFFERENT FIBRES.

  2021cites this paper
• Competing mechanisms of plasticity impair compensatory responses to repetitive apnoea

  2019cites this paper
• Development of ventilatory long-term facilitation is dependent on estrous cycle stage in adult female rats.

  2019cites this paper
• Cervical Spinal 5-HT2A and 5-HT2B receptors are both necessary for moderate acute intermittent hypoxia-induced phrenic long-term facilitation.

  2019cites this paper
• Intermittent but not sustained moderate hypoxia elicits long-term facilitation of hypoglossal motor output.

  2017influential citation
• Pharmacological modulation of hypoxia-induced respiratory neuroplasticity.

  2017cites this paper
• Cyclooxygenase enzyme activity does not impair respiratory motor plasticity after one night of intermittent hypoxia.

  2017cites this paper
• Respiratory neuroplasticity - Overview, significance and future directions.

  2017cites this paper
• Premedication with fentanyl-midazolam improves sevoflurane anesthesia for surgical intervention in laboratory mice

  2017cites this paper
• Plasticity in respiratory motor neurons in response to reduced synaptic inputs: A form of homeostatic plasticity in respiratory control?

  2017cites this paper
• α2-Adrenergic blockade rescues hypoglossal motor defense against obstructive sleep apnea.

  2017cites this paper
• Intermittent apnea elicits inactivity-induced phrenic motor facilitation via a retinoic acid- and protein synthesis-dependent pathway.

  2017cites this paper
• Acute intermittent hypoxia induces hypoglossal nerve metaplasticity in a 5-HT 2 A R-activated protein kinase C dependent manner in chronic intermittent hypoxia-pretreated rats

  2016cites this paper
• Power spectral analysis of hypoglossal nerve activity during intermittent hypoxia-induced long-term facilitation in mice.

  2016cites this paper
• Ampakine CX717 potentiates intermittent hypoxia-induced hypoglossal long-term facilitation.

  2016cites this paper
• Evidence that some long‐lasting effects of direct current in the rat spinal cord are activity‐independent

  2016cites this paper
• Intermittent hypoxia: a low-risk research tool with therapeutic value in humans.

  2015cites this paper
• Effect of Systemic Application of 5-Hydroxytryptamine on Hypoglossal Nerve Discharge in Anesthetized Rats

  2015cites this paper
• TNFα-independent, atypical PKC-dependent inactivity-induced phrenic

  2015cites this paper
• intermittent vs. sustained neural apnea facilitation are differentially expressed following Inactivity-induced phrenic and hypoglossal motor

  2015cites this paper
• The role of high loop gain induced by intermittent hypoxia in the pathophysiology of obstructive sleep apnoea.

  2015cites this paper
• Phrenic Long-Term Facilitation Requires PKCθ Activity within Phrenic Motor Neurons

  2015cites this paper
• Intermittent reductions in respiratory neural activity elicit spinal TNF-α-independent, atypical PKC-dependent inactivity-induced phrenic motor facilitation.

  2015cites this paper
• Adenosine 2A Receptor Inhibition Enhances Intermittent Hypoxia-Induced Diaphragm but Not Intercostal Long-Term Facilitation

  2014cites this paper
• Spinal NMDA receptor activation constrains inactivity-induced phrenic motor 1

  2014cites this paper
• induction non-invasive d'une plasticité de la commande ventilatoire chez l'humain sain

  2014cites this paper
• Decreased spinal synaptic inputs to phrenic motor neurons elicit localized inactivity-induced phrenic motor facilitation.

  2014cites this paper
• Spinal NMDA receptor activation constrains inactivity-induced phrenic motor facilitation in Charles River Sprague-Dawley rats.

  2014cites this paper
• Adrenergic α₁ receptor activation is sufficient, but not necessary for phrenic long-term facilitation.

  2014cites this paper
• Sevoflurane and isoflurane monoanesthesia abolished the phrenic long-term facilitation in rats.

  2013cites this paper
• Chronic ethanol exposure during development: disturbances of breathing and adaptation.

  2013cites this paper
• Inactivity-induced respiratory plasticity: protecting the drive to breathe in disorders that reduce respiratory neural activity.

  2013cites this paper
• Hypoxia‐induced phrenic long‐term facilitation: emergent properties

  2013cites this paper
• Remifentanil reversibly abolished phrenic long term facilitation in rats subjected to acute intermittent hypoxia.

  2013cites this paper
• Spinal 5-HT7 receptors and protein kinase A constrain intermittent hypoxia-induced phrenic long-term facilitation.

  2013influential citation
• Spinal TNFα is necessary for inactivity‐induced phrenic motor facilitation

  2013influential citation
• Inactivity-induced phrenic and hypoglossal motor facilitation are differentially expressed following intermittent vs. sustained neural apnea.

  2013cites this paper
• Spinal Atypical Protein Kinase C Activity Is Necessary to Stabilize Inactivity-Induced Phrenic Motor Facilitation

  2012influential citation
• Sympathetic and Catecholaminergic Alterations in Sleep Apnea with Particular Emphasis on Children

  2012cites this paper
• Respiratory muscles and motoneurons.

  2011cites this paper