1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors: lead optimization studies resulting in the identification of N-(1-(2-(methylamino)ethyl)-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carboximidamide as a preclinical development candidate.

J. Ramnauth,P. Renton,P. Dove,Subhash C. Annedi,Joanne Speed,Sarah Silverman,G. Mladenova,Shawn P. Maddaford,Salvatore Zinghini,S. Rakhit,J. Andrews,David K. H. Lee,Dongqin Zhang,F. Porreca

Published 2012 in Journal of Medicinal Chemistry

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