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Extrahepatic portal vein thrombosis in children and adolescents: Influence of genetic thrombophilic disorders.

A. Pietrobattista,M. Luciani,J. Abraldes,M. Candusso,Simona Pancotti,M. Soldati,L. Monti,G. Torre,V. Nobili

Published 2010 in World Journal of Gastroenterology

ABSTRACT

AIM to explore the prevalence of local and genetic thrombophilic disorders as risk factors for portal vein thrombosis (PVT) in our series, the largest ever published in pediatric literature. METHODS we conducted a case-control study enrolling 31 children with PVT and 26 age-matched controls. All were screened for thrombophilia, including genetic disorders, protein C, protein S and homocysteine deficiencies. All coagulation parameters were studied at least 3 mo after the diagnosis of portal vein obstruction. RESULTS in our study we showed that most pediatric patients with PVT have local prothrombotic risk factors, which are probably the most important factors leading to PVT. However, there is a clear association between the presence of prothrombotic disorders and PVT, suggesting that these increase the risk of thrombosis in patients with local factors such as perinatal umbilical vein catheterization or sepsis. CONCLUSION patients with PVT should be screened for inherited prothrombotic disorders regardless of a history of an obvious local risk factor.

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