Optimal tetanic conditioning of heteronymous monosynaptic reflexes.

Post-tetanic potentiation of the monosynaptic reflex response was first described by Lloyd (1949) who recorded from spinal ventral roots and demonstrated the phenomenon by testing after long bursts of tetanic stimulation of the afferent pathway. Eccles & Rall (1951a), testing at brief time intervals after short bursts of tetanic stimulation, obtained increased reflex responses which were due to 'early potentiation'. RalI (1955) and Araki, Eccles & Ito (1960) subsequently made use of this technique to raise reflex discharges in monosynaptic pathways to sizes which were convenient for their experiments. Job (1953) and Beswick & Evanson (1954) showed that during the 'late' potentiation (Lloyd, 1959), which follows prolonged tetanic stimulation, single volleys in the afferent fibres of one muscle could cause the discharge of motoneurones of synergistic muscles: potentiated monosynaptic reflex responses recorded from ventral roots did not, however, permit a distinction to be made between homonymous and heteronymous motoneurones. Beswick & Conroy (1961) recording from muscle nerves, found that repeated short bursts of tetanic stimulation of muscle afferents produced an increasing heteronymous response to single stimuli. With 'optimal conditioning' (Beswick & Conroy, 1964a), the heteronymous responses reached a maximum which could then be maintained for periods up to 5 hr. In the experiments described here, the circumstances under which such repetitive tetanic conditioning produces a maximum effect are defined and some characteristics of such conditioning described.

• Publication year

  1965

• Venue

  Journal of Physiology

• Publication date

  1965-09-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1113/jphysiol.1965.sp007693PMID 5860218PMCID PMC1357372
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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