Isopentenyl pyrophosphate, a mycobacterial non-peptidic antigen, triggers delayed and highly sustained signaling in human gamma delta T lymphocytes without inducing eown-modulation of T cell antigen receptor.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Journal of Biological Chemistry

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 11278429
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• γδ T cells, their T cell receptor usage and role in human diseases

  2004cited by this paper
• The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling

  2000cited by this paper
• T cell activation and the cytoskeleton.

  2000cited by this paper
• Activation of human Vgamma9Vdelta2 T cells by a Brucella suis non-peptidic fraction impairs bacterial intracellular multiplication in monocytic infected cells.

  2000cited by this paper
• From synapses to immunological memory: the role of sustained T cell stimulation.

  2000cited by this paper
• Tumor necrosis factor-alpha production is differently regulated in gamma delta and alpha beta human T lymphocytes.

  2000cited by this paper
• Signal transduction by the TCR for antigen.

  2000cited by this paper
• SHP-1 Regulates Lck-induced Phosphatidylinositol 3-Kinase Phosphorylation and Activity*

  1999cited by this paper
• Human gamma delta T cells recognize alkylamines derived from microbes, edible plants, and tea: implications for innate immunity.

  1999cited by this paper
• CD45-induced tumor necrosis factor alpha production in monocytes is phosphatidylinositol 3-kinase-dependent and nuclear factor-kappaB-independent.

  1999cited by this paper
• Wortmannin inhibits translation of tumor necrosis factor-alpha in superantigen-activated T cells.

  1999cited by this paper
• RWJ 67657, a potent, orally active inhibitor of p38 mitogen-activated protein kinase.

  1999cited by this paper
• Serial TCR engagement and down-modulation by peptide:MHC molecule ligands: relationship to the quality of individual TCR signaling events.

  1999cited by this paper
• Aggregation of Lipid Rafts Accompanies Signaling via the T Cell Antigen Receptor

  1999cited by this paper
• The immunological synapse: a molecular machine controlling T cell activation.

  1999cited by this paper
• The real LAT steps forward.

  1998cited by this paper
• Expansion of Vgamma9 Vdelta2 T cells is triggered by Francisella tularensis-derived phosphoantigens in tularemia but not after tularemia vaccination.

  1998cited by this paper
• Phenotypic and cytokine analysis of human peripheral blood gamma delta T cells expressing NK cell receptors.

  1997cited by this paper
• Functional Inactivation in the Whole Population of Human Vγ9/Vδ2 T Lymphocytes Induced By a Nonpeptidic Antagonist

  1997cited by this paper
• Understanding the Mechanisms of Sustained Signaling and T Cell Activation

  1997cited by this paper
• In vivo and in vitro activation and expansion of gammadelta T cells during Listeria monocytogenes infection in humans

  1997cited by this paper
• Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the Pleckstrin homology domain of inducible T cell kinase.

  1997cited by this paper
• Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function.

  1996cited by this paper
• Cytokine profiles for human V gamma 9+ T cells stimulated by Plasmodium falciparum.

  1995cited by this paper
• V gamma 2V delta 2 TCR-dependent recognition of non-peptide antigens and Daudi cells analyzed by TCR gene transfer.

  1995cited by this paper
• Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

  1995cited by this paper
• Modification of Ser59 in the unique N-terminal region of tyrosine kinase p56lck regulates specificity of its Src homology 2 domain.

  1995cited by this paper
• Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton

  1995cited by this paper
• Direct presentation of nonpeptide prenyl pyrophosphate antigens to human gamma delta T cells.

  1995cited by this paper
• Natural and synthetic non-peptide antigens recognized by human gamma delta T cells.

  1995cited by this paper
• Human V gamma 9-V delta 2 cells are stimulated in a cross-reactive fashion by a variety of phosphorylated metabolites.

  1995cited by this paper
• Early activation of human V gamma 9V delta 2 T cell broad cytotoxicity and TNF production by nonpeptidic mycobacterial ligands.

  1995cited by this paper
• Nonpeptide ligands for human gamma delta T cells.

  1994cited by this paper
• Distinct intracellular localization of Lck and Fyn protein tyrosine kinases in human T lymphocytes

  1994cited by this paper
• Transient increase in circulating gamma/delta T cells during Plasmodium vivax malarial paroxysms

  1994cited by this paper
• Stimulation of human gamma delta T cells by nonpeptidic mycobacterial ligands.

  1994cited by this paper
• Lymphocytes bearing the gamma delta T cell receptor in acute Brucella melitensis infection.

  1993cited by this paper
• Anti-CD3 and phorbol ester induce distinct phosphorylated sites in the SH2 domain of p56lck.

  1993cited by this paper
• Human immunodeficiency virus gp120 and derived peptides activate protein tyrosine kinase p56Ick in human CD4 T lymphocytes

  1993cited by this paper
• Phosphorylation of Ser-42 and Ser-59 in the N-terminal region of the tyrosine kinase p56lck.

  1993cited by this paper
• Gamma/delta cells.

  1993cited by this paper
• Most gamma delta T cells develop normally in the absence of MHC class II molecules.

  1993cited by this paper
• Lymphocytes bearing the gamma delta T-cell receptor in acute toxoplasmosis.

  1992cited by this paper
• p59fyn tyrosine kinase associates with multiple T-cell receptor subunits through its unique amino-terminal domain.

  1992cited by this paper
• Gamma interferon and interleukin 2, but not interleukin 4, are detectable in gamma/delta T-cell cultures after activation with bacteria

  1992cited by this paper
• Gamma delta T lymphocytes in human tuberculosis.

  1992cited by this paper
• Predominant activation and expansion of V gamma 9-bearing gamma delta T cells in vivo as well as in vitro in Salmonella infection.

  1992cited by this paper
• Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor.

  1992cited by this paper
• Both T cell receptor (TcR)‐CD3 complex and CD2 increase the tyrosine kinase activity of p56lck. CD2 can mediate TcR‐CD3‐independent and CD45‐dependent activation of p56lck

  1992cited by this paper
• Molecular and Cellular Mechanisms of Receptor-Mediated Endocytosis

  1991cited by this paper
• A subset of gamma delta lymphocytes is increased during HIV-1 infection.

  1991cited by this paper
• Gamma delta T cell receptor-bearing lymphocytes during Epstein-Barr virus infection.

  1990cited by this paper
• Increased gamma delta T cells in acute Plasmodium falciparum malaria.

  1990cited by this paper
• Evidence for extrathymic changes in the T cell receptor gamma/delta repertoire

  1990cited by this paper
• The lymphocyte‐specific protein tyrosine kinase p56lck is hyperphosphorylated on serine and tyrosine residues within minutes after activation via T cell receptor or CD2

  1989cited by this paper
• The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex.

  1989cited by this paper
• Lymphocyte activation provokes modification of a lymphocyte-specific protein tyrosine kinase (p56lck).

  1989cited by this paper
• Human lymphocytes bearing T cell receptor gamma/delta are phenotypically diverse and evenly distributed throughout the lymphoid system

  1989cited by this paper
• Post-translational alterations of the tyrosine kinase p56lck in response to activators of protein kinase C.

  1988cited by this paper
• Alterations of the lymphocyte-specific protein tyrosine kinase (p56lck) during T-cell activation

  1988cited by this paper

• Gamma delta T cells: Multifaceted mediators in pregnancy and the pathogenesis of miscarriage.

  2025cites this paper
• Characterization and anti-tuberculosis effects of γδ T cells expanded and activated by Mycobacterium tuberculosis heat-resistant antigen

  2025cites this paper
• γδT cells, a key subset of T cell for cancer immunotherapy

  2025cites this paper
• EGFR-Targeted Antibody–Drug Conjugate to Different Aminobisphosphonates: Direct and Indirect Antitumor Effects on Colorectal Carcinoma Cells

  2024cites this paper
• Advances in pathogenesis and treatment of ocular involvement in Behcet’s disease

  2023cites this paper
• Characterization of Expanded Gamma Delta T Cells from Atypical X-SCID Patient Reveals Preserved Function and IL2RG-Mediated Signaling

  2022cites this paper
• How to Train Your Dragon: Harnessing Gamma Delta T Cells Antiviral Functions and Trained Immunity in a Pandemic Era

  2021cites this paper
• A comparative view on vitamin C effects on αβ‐ versus γδ T‐cell activation and differentiation

  2020cites this paper
• Characterization of human peripheral blood γδ T cells in patients with sepsis

  2020cites this paper
• Boning up: amino-bisphophonates as immunostimulants and endosomal disruptors of dendritic cell in SARS-CoV-2 infection

  2020cites this paper
• Immunopathogenesis of Behcet's Disease

  2019cites this paper
• Anti-CD3 Fab Fragments Enhance Tumor Killing by Human γδ T Cells Independent of Nck Recruitment to the γδ T Cell Antigen Receptor

  2018cites this paper
• Human Vδ2 T cells are a major source of interleukin-9

  2016cites this paper
• CD73 Expressed on γδ T Cells Shapes Their Regulatory Effect in Experimental Autoimmune Uveitis

  2016cites this paper
• Human γδ T cells: From a neglected lymphocyte population to cellular immunotherapy: A personal reflection of 30years of γδ T cell research.

  2016cites this paper
• Isopentenyl pyrophosphate secreted from Zoledronate-stimulated myeloma cells, activates the chemotaxis of γδT cells.

  2015cites this paper
• The Endocytosis and Signaling of the γδ T Cell Coreceptor WC1 Are Regulated by a Dileucine Motif

  2015cites this paper
• Opportunities and challenges in development of phosphoantigens as Vγ9Vδ2 T cell agonists.

  2014cites this paper
• The CD3 conformational change in the γδ T cell receptor is not triggered by antigens but can be enforced to enhance tumor killing.

  2014cites this paper
• Molecules and Mechanisms Implicated in the Peculiar Antigenic Activation Process of Human Vγ9Vδ2 T Cells

  2014cites this paper
• Phenotype and regulation of immunosuppressive Vδ2-expressing γδ T cells

  2013cites this paper
• Expression of regulatory receptors on γδ T Cells and their cytokine production in Behcet's disease

  2013cites this paper
• The Multifunctionality of Human Vγ9Vδ2 γδ T Cells: Clonal Plasticity or Distinct Subsets?

  2012cites this paper
• Full Restoration of Brucella-Infected Dendritic Cell Functionality through Vγ9Vδ2 T Helper Type 1 Crosstalk

  2012cites this paper
• Role of NKG2D and its ligands in the anti‐infectious activity of Vγ9Vδ2 T cells against intracellular bacteria

  2011cites this paper
• γδ T cell Receptor Ligands and Modes of Antigen Recognition

  2011cites this paper
• Scavenger receptor WC1 contributes to the γδ T cell response to Leptospira.

  2011cites this paper
• F1-Adenosine Triphosphatase Displays Properties Characteristic of an Antigen Presentation Molecule for Vγ9Vδ2 T Cells

  2010cites this paper
• Effect of acetaminophen and fluvastatin on post-dose symptoms following infusion of zoledronic acid

  2010cites this paper
• NKG2D Costimulates Human Vγ9Vδ2 T Cell Antitumor Cytotoxicity through Protein Kinase Cθ-Dependent Modulation of Early TCR-Induced Calcium and Transduction Signals

  2010cites this paper
• Human Vgamma9Vdelta2 T cells: from signals to functions.

  2010cites this paper
• Molecule for V Properties Characteristic of an Antigen-Adenosine Triphosphatase Displays 1 F

  2010cites this paper
• gammadelta T-cells: basic features and potential role in vasculitis.

  2010cites this paper
• Phenotypic and functional alterations of Vγ2Vδ2 T cell subsets in patients with active nasopharyngeal carcinoma

  2009cites this paper
• Highly Active Microbial Phosphoantigen Induces Rapid yet Sustained MEK/Erk- and PI-3K/Akt-Mediated Signal Transduction in Anti-Tumor Human γδ T-Cells

  2009influential citation
• Bridging innate and adaptive immunity through gammadelta T-dendritic cell crosstalk.

  2008cites this paper
• Tuberculosis vaccine development: goals, immunological design, and evaluation.

  2008cites this paper
• IL‐2 triggers specific signaling pathways in human NKT cells leading to the production of pro‐ and anti‐inflammatory cytokines

  2008cites this paper
• Bridging innate and adaptive immunity through gd T - dendritic cell crosstalk

  2008cites this paper
• Of tolerance in mice and men : studies in APECED and Aire

  2008cites this paper
• Innate immune functions of human gammadelta T cells.

  2008cites this paper
• γδ T cells: novel initiators of adaptive immunity

  2007cites this paper
• Chemotherapy and zoledronate sensitize solid tumour cells to Vgamma9Vdelta2 T cell cytotoxicity.

  2007cites this paper
• Pro-inflammatory cellular immune response in Behçet’s disease

  2007cites this paper
• Impairment of TNF-α Production and Action by Imidazo[1,2- α] Quinoxalines, as Derivative Family Which Displays Potential Anti-Inflammatory Properties

  2006cites this paper
• Alkylamines cause Vgamma9Vdelta2 T-cell activation and proliferation by inhibiting the mevalonate pathway.

  2006cites this paper
• Alkylamines cause Vγ9Vδ2 T-cell activation and proliferation by inhibiting the mevalonate pathway

  2006cites this paper
• Regulation of the Mitogen-Activated Protein Kinases by Brucella spp. Expressing a Smooth and Rough Phenotype: Relationship to Pathogen Invasiveness

  2005cites this paper
• Brief report Alkylamines cause V (cid:1) 9V (cid:2) 2 T-cell activation and proliferation by inhibiting the mevalonate pathway

  2005cites this paper
• Integrated immune responses to infection - cross-talk between human gammadelta T cells and dendritic cells.

  2004cites this paper
• Antigenic prenylated peptide conjugates and polyclonal antibodies to detect protein prenylation.

  2004cites this paper
• Role of gammadelta T lymphocytes in tumor defense.

  2004cites this paper
• Uncoupling between immunological synapse formation and functional outcome in human gamma delta T lymphocytes.

  2003cites this paper
• Synaptic transfer by human gamma delta T cells stimulated with soluble or cellular antigens.

  2002cites this paper
• Structure of gammadelta T cell receptors and their recognition of non-peptide antigens.

  2002cites this paper
• Involvement of classical and novel protein kinase C isoforms in the response of human V gamma 9V delta 2 T cells to phosphate antigens.

  2002cites this paper