TEC family kinases in health and disease – loss‐of‐function of BTK and ITK and the gain‐of‐function fusions ITK–SYK and BTK–SYK

No abstract is available for this paper.

• Publication year

  2011

• Venue

  The FEBS Journal

• Publication date

  2011-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1742-4658.2011.08134.xPMID 21518255
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Identification of novel non-pathogenic mutation in SH3 domain of Btk in an XLA patient.

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• The Tec Kinases Itk and Rlk Regulate NKT Cell Maturation, Cytokine Production, and Survival1

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• The linker between SH2 and kinase domains positively regulates catalysis of the Tec family kinases.

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• XIAP deficiency in humans causes an X-linked lymphoproliferative syndrome

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• Defective NKT cell development in mice and humans lacking the adapter SAP, the X-linked lymphoproliferative syndrome gene product

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