Pharmacological targeting of adenosine receptor signaling.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Molecular Aspects of Medicine

• Publication date

  2017-06-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.mam.2016.12.002PMID 28088486
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Dipyridamole reduces urinary albumin excretion in diabetic patients with normo- or microalbuminuria.

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