Roles of Deletion and Regulation in Creating Mixed Chimerism and Allograft Tolerance Using a Nonlymphoablative Irradiation-Free Protocol

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Journal of Immunology

• Publication date

  2005-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.175.1.51PMID 15972631
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Mechanisms of transplant tolerance induction using costimulatory blockade.

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• Tracking the Immunoregulatory Mechanisms Active During Allograft Tolerance1

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• Th1 cytokines, programmed cell death, and alloreactive T cell clone size in transplant tolerance.

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• CD25+CD4+ Regulatory T Cells Prevent Graft Rejection: CTLA-4- and IL-10-Dependent Immunoregulation of Alloresponses1

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• Cd4+Cd25+ Immune Regulatory Cells Are Required for Induction of Tolerance to Alloantigen via Costimulatory Blockade

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• Requirements for the promotion of allogeneic engraftment by anti-CD154 (anti-CD40L) monoclonal antibody under nonmyeloablative conditions.

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• Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment

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• Cutting Edge: Administration of Anti-CD40 Ligand and Donor Bone Marrow Leads to Hemopoietic Chimerism and Donor-Specific Tolerance Without Cytoreductive Conditioning1

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• Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

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• CTLA4 signals are required to optimally induce allograft tolerance with combined donor-specific transfusion and anti-CD154 monoclonal antibody treatment.

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• Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance

  1999cited by this paper
• Asialo GM1(+) CD8(+) T cells play a critical role in costimulation blockade-resistant allograft rejection.

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• Infectious tolerance.

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• Durable mixed allogeneic chimerism and tolerance by a nonlethal radiation-based cytoreductive approach.

  1996cited by this paper
• Thymic dependence of loss of tolerance in mixed allogeneic bone marrow chimeras after depletion of donor antigen. Peripheral mechanisms do not contribute to maintenance of tolerance.

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• Ex vivo coating of islet cell allografts with murine CTLA4/Fc promotes graft tolerance.

  1995cited by this paper
• TOLERANCE INDUCTION IN A FULLY ALLOGENEIC COMBINATION USING ANTI‐T CELL RECEPTOR-αβ MONOCLONAL ANTIBODY, LOW DOSE IRRADIATION, AND DONOR BONE MARROW TRANSFUSION

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• Role of intrathymic clonal deletion and peripheral anergy in transplantation tolerance induced by bone marrow transplantation in mice conditioned with a nonmyeloablative regimen.

  1994cited by this paper
• Transient and permanent engraftment potential of murine hematopoietic stem cell subsets: differential effects of host conditioning with gamma radiation and cytotoxic drugs.

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• "Infectious" transplantation tolerance

  1993cited by this paper
• Mixed allogeneic chimeras prepared by a non-myeloablative regimen: requirement for chimerism to maintain tolerance.

  1992cited by this paper
• Cloning of self-major histocompatibility complex antigen-specific suppressor cells from adult bone marrow

  1990cited by this paper
• Specific tolerance induction across a xenogeneic barrier: production of mixed rat/mouse lymphohematopoietic chimeras using a nonlethal preparative regimen

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• Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. III. Further characterization of the CD4+ suppressor cell and its mechanisms of action

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• Mixed chimerism and permanent specific transplantation tolerance induced by a nonlethal preparative regimen

  1989cited by this paper
• Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts

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• Brief Definitive Report Identification of Regulatory T Cells in Tolerated Allografts

  year unknowncited by this paper

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