Translation initiation factor eIF-5A expressed from either of two yeast genes or from human cDNA. Functional identity under aerobic and anaerobic conditions.

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Journal of Biological Chemistry

• Publication date

  1993-07-05

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 8314769
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The two genes encoding protein synthesis initiation factor eIF-5A in Saccharomyces cerevisiae are members of a duplicated gene cluster

  1992cited by this paper
• Translation initiation factor 5A and its hypusine modification are essential for cell viability in the yeast Saccharomyces cerevisiae

  1991cited by this paper
• Translational control in mammalian cells.

  1991cited by this paper
• The ANB1 locus of Saccharomyces cerevisiae encodes the protein synthesis initiation factor eIF-4D.

  1990cited by this paper
• Sequence determination and cDNA cloning of eukaryotic initiation factor 4D, the hypusine-containing protein.

  1989cited by this paper
• Molecular cloning, primary structure and disruption of the structural gene of aldolase from Saccharomyces cerevisiae.

  1989cited by this paper
• Protein synthesis initiation factor eIF-4D. Functional comparison of native and unhypusinated forms of the protein.

  1989cited by this paper
• A mammalian translation initiation factor can substitute for its yeast homologue in vivo.

  1989cited by this paper
• Eukaryotic initiation factor 4D, the hypusine-containing protein, is conserved among eukaryotes.

  1987cited by this paper
• Negative regulation of the Saccharomyces cerevisiae ANB1 gene by heme, as mediated by the ROX1 gene product

  1986cited by this paper
• Yeast/E. coli shuttle vectors with multiple unique restriction sites

  1986cited by this paper
• A rapid, efficient method for isolating DNA from yeast.

  1986cited by this paper
• Transformation of intact yeast cells treated with alkali cations.

  1984cited by this paper
• Sequences that regulate the divergent GAL1-GAL10 promoter in Saccharomyces cerevisiae

  1984cited by this paper
• A positive selection for mutants lacking orotidine-5′-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance

  1984cited by this paper
• The major promoter element of rRNA transcription in yeast lies 2 kb upstream.

  1984cited by this paper
• The biosynthesis of hypusine (N epsilon-(4-amino-2-hydroxybutyl)lysine). Alignment of the butylamine segment and source of the secondary amino nitrogen.

  1984cited by this paper
• A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

  1983cited by this paper
• Identification of the hypusine-containing protein hy+ as translation initiation factor eIF-4D.

  1983cited by this paper
• Modulator sequences mediate oxygen regulation of CYC1 and a neighboring gene in yeast.

  1983cited by this paper
• High-frequency transformation of yeast: autonomous replication of hybrid DNA molecules.

  1979cited by this paper
• Purification and characterization of protein synthesis initiation factors eIF-1, eIF-4C, eIF-4D, and eIF-5 from rabbit reticulocytes.

  1978cited by this paper
• High resolution two-dimensional electrophoresis of proteins.

  1975cited by this paper
• Detection of specific sequences among DNA fragments separated by gel electrophoresis.

  1975cited by this paper

• Girolline is a sequence context-selective modulator of eIF5A activity

  2025cites this paper
• SUMOylation modulates eIF5A activities in both yeast and pancreatic ductal adenocarcinoma cells

  2024cites this paper
• eIF5A promotes +1 programmed ribosomal frameshifting in Euplotes octocarinatus.

  2023cites this paper
• Role of eIF5A in Mitochondrial Function

  2022cites this paper
• Hypusinated eIF5A Promotes Ribosomal Frameshifting during Decoding of ODC Antizyme mRNA in Saccharomyces cerevisiae

  2022cites this paper
• Post-translational formation of hypusine in eIF5A: implications in human neurodevelopment

  2021cites this paper
• Iron in Translation: From the Beginning to the End

  2021cites this paper
• Hypusinated eIF5A is required for the translation of collagen

  2021cites this paper
• Yeast Translation Elongation Factor eIF5A Expression Is Regulated by Nutrient Availability through Different Signalling Pathways

  2020cites this paper
• Rewired cellular signaling coordinates sugar and hypoxic responses for anaerobic xylose fermentation in yeast

  2019cites this paper
• Eukaryotic translation initiation factor 5A2 promotes metabolic reprogramming in hepatocellular carcinoma cells

  2017cites this paper
• Differential Proteome Analysis of a Flor Yeast Strain under Biofilm Formation

  2017influential citation
• Evolutionary conserved role of eukaryotic translation factor eIF5A in the regulation of actin-nucleating formins

  2017cites this paper
• Posttranslational hypusination of the eukaryotic translation initiation factor-5A regulates Fusarium graminearum virulence

  2016cites this paper
• Hipusinación del factor de traducción eIF5A dependiente de poliaminas

  2015cites this paper
• 2-DE Mapping of the Blue Mussel Gill Proteome: The Usual Suspects Revisited

  2015cites this paper
• The translation factor eIF5A and human cancer.

  2015cites this paper
• The hypusine-containing translation factor eIF5A

  2014influential citation
• TDP-43 and Translational Regulation in Amyotrophic Lateral Sclerosis and Related Neurodegenerative Diseases

  2014cites this paper
• Increased expression of EIF5A2, via hypoxia or gene amplification, contributes to metastasis and angiogenesis of esophageal squamous cell carcinoma.

  2014cites this paper
• eIF5A and EF‐P: two unique translation factors are now traveling the same road

  2014cites this paper
• An investigation into the proteins responsible for the translational inhibition seen in the yeast Saccharomyces cerevisiae following fusel alcohol exposure

  2013cites this paper
• Roles of Eukaryotic Initiation Factor 5A2 in Human Cancer

  2013cites this paper
• Análise da interação funcional de eIF5A com a tradução, repressão da tradução e degradação de mRNA em Saccharomyces cerevisiae

  2011cites this paper
• Breaking Down the Final Steps in 40S Ribosomal Subunit Assembly.

  2011cites this paper
• Eukaryotic translation initiation factor (eIF) 5A stimulates protein synthesis in Saccharomyces cerevisiae

  2011cites this paper
• Caracterização de mutantes condicionais do gene da desoxi-hipusina sintase em Saccharomyces cerevisiae

  2011cites this paper
• Análise estrutural e funcional de eIF5A selvagem e mutadas

  2010cites this paper
• Functional significance of eIF5A and its hypusine modification in eukaryotes

  2010cites this paper
• Involvement of Snf7p and Rim101p in the transcriptional regulation of TIR1 and other anaerobically upregulated genes in Saccharomyces cerevisiae.

  2010cites this paper
• Dimerization of the yeast eukaryotic translation initiation factor 5A requires hypusine and is RNA dependent

  2009cites this paper
• Gene Responses to Oxygen Availability in Kluyveromyces lactis: an Insight on the Evolution of the Oxygen-Responding System in Yeast

  2009cites this paper
• Insights on eukaryotic translation initiation factor 5A (eIF5A) in the brain and aging.

  2008cites this paper
• Involvement of eukaryotic translation initiation factor 5A (eIF5A) in skeletal muscle stem cell differentiation

  2008cites this paper
• Structural modeling and mutational analysis of yeast eukaryotic translation initiation factor 5A reveal new critical residues and reinforce its involvement in protein synthesis

  2008cites this paper
• Assembly of Omegatetravirus virus-like particles in the yeast Saccharomyces cerevisiae

  2008cites this paper
• Mutational analyses of human eIF5A‐1 – identification of amino acid residues critical for eIF5A activity and hypusine modification

  2008cites this paper
• Characterization of the pro-apoptotic function of eIF5A in human cancer cell lines

  2007cites this paper
• Specificity of the Deoxyhypusine Hydroxylase-Eukaryotic Translation Initiation Factor (eIF5A) Interaction

  2007cites this paper
• Is there a role for eIF5A in translation?

  2007cites this paper
• Transgenic Plants as Tool to Study the Evolution of Pyrrolizidine Alkaloids

  2006cites this paper
• Proteomic analysis of Saccharomyces cerevisiae under high gravity fermentation conditions.

  2006cites this paper
• Temperature-sensitive eIF5A Mutant Accumulates Transcripts Targeted to the Nonsense-mediated Decay Pathway*

  2006cites this paper
• Top-down approaches for measuring expression ratios of intact yeast proteins using Fourier transform mass spectrometry.

  2006cites this paper
• eIF5A: uma proteína essencial para a viabilidade celular cuja função permanece obscura

  2006cites this paper
• Antisense Suppression of Deoxyhypusine Synthase in Tomato Delays Fruit Softening and Alters Growth and Development1

  2005cites this paper
• Antisense suppression of deoxyhypusine synthase by vacuum‐infiltration of Agrobacterium enhances growth and seed yield of canola

  2005cites this paper
• Translation initiation factor eIF-5A from Plasmodium falciparum.

  2004cites this paper
• Repeated Evolution of the Pyrrolizidine Alkaloid–Mediated Defense System in Separate Angiosperm Lineages w⃞

  2004cites this paper
• Identification and characterization of eukaryotic initiation factor 5A-2.

  2003cites this paper
• Spermidine but not spermine is essential for hypusine biosynthesis and growth in Saccharomyces cerevisiae: Spermine is converted to spermidine in vivo by the FMS1-amine oxidase

  2003cites this paper
• Cofactor Requirements for Nuclear Export of Rev Response Element (Rre)–And Constitutive Transport Element (Cte)–Containing Retroviral Rnas

  2001cites this paper
• Human eIF5A2 on chromosome 3q25-q27 is a phylogenetically conserved vertebrate variant of eukaryotic translation initiation factor 5A with tissue-specific expression.

  2001cites this paper
• Identification of lysine350 of yeast deoxyhypusine synthase as the site of enzyme intermediate formation

  1999cites this paper
• Coexpression of alpha1,2 galactosyltransferase and UDP-galactose transporter efficiently galactosylates N- and O-glycans in Saccharomyces cerevisiae.

  1999cites this paper
• Deoxyhypusine Synthase Activity Is Essential for Cell Viability in the Yeast Saccharomyces cerevisiae *

  1998cites this paper
• Functional analysis of homologs of translation initiation factor 2gamma in yeast.

  1997cites this paper
• The 39-kilodalton subunit of eukaryotic translation initiation factor 3 is essential for the complex's integrity and for cell viability in Saccharomyces cerevisiae

  1997cites this paper
• Biochemical and immunological characterization of deoxyhypusine synthase purified from the yeast Saccharomyces carlsbergensis.

  1997cites this paper
• Functional analysis of homologs of translation initiation factor 2γ in yeast

  1997cites this paper
• Is hypusine essential for eukaryotic cell proliferation?

  1997cites this paper
• Cellular eukaryotic initiation factor 5A content as a mediator of polyamine effects on growth and apoptosis.

  1997cites this paper
• Enzyme-Substrate Intermediate Formation at Lysine 329 of Human Deoxyhypusine Synthase*

  1997cites this paper
• Inhibition of HIV-1 Replication in Lymphocytes by Mutants of the Rev Cofactor eIF-5A

  1996cites this paper
• Proteolytically active 2A proteinase of human rhinovirus 2 is toxic for Saccharomyces cerevisiae but does not cleave the homologues of eIF-4 gamma in vivo or in vitro.

  1996cites this paper
• The translation initiation factor eIF4A from Schizosaccharomyces pombe is closely related to its mammalian counterpart

  1996cites this paper
• Purification of Deoxyhypusine Synthase from Neurospora crassa to Homogeneity by Substrate Elution Affinity Chromatography (*)

  1995cites this paper
• Deoxyhypusine Synthase from Rat Testis: Purification and Characterization (*)

  1995cites this paper
• Identification of YHR068w in Saccharomyces cerevisiae Chromosome VIII as a Gene for Deoxyhypusine Synthase

  1995cites this paper
• Isolation of a Protein Complex Containing Translation Initiation Factor Prt1 from Saccharomyces cerevisiae(*)

  1995cites this paper
• Characterization of Yeast Translation Initiation Factor 1A and Cloning of Its Essential Gene (*)

  1995cites this paper
• The function of the hypusine-containing proteins of yeast and other eukaryotes is well conserved

  1994cites this paper
• The yeast Saccharomyces cerevisiae system: a powerful tool to study the mechanism of protein synthesis initiation in eukaryotes.

  1994cites this paper
• Deoxyhypusine synthase assay based on the use of polyhistidine-tagged substrate and metal chelate-affinity chromatography.

  1994cites this paper
• Genes conserved in yeast and humans.

  1994cites this paper
• The role of hypusine depletion in cytostasis induced by S-adenosyl-L-methionine decarboxylase inhibition: new evidence provided by 1-methylspermidine and 1,12-dimethylspermine.

  1994cites this paper
• Effect of initiation factor eIF-5A depletion on protein synthesis and proliferation of Saccharomyces cerevisiae.

  1994cites this paper
• Translation initiation factor eIF-5A, the hypusine-containing protein, is phosphorylated on serine in Saccharomyces cerevisiae.

  1993cites this paper
• Hypusine is essential for eukaryotic cell proliferation.

  1993cites this paper