Transthyretin Accelerates Vascular Aβ Deposition in a Mouse Model of Alzheimer's Disease

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Brain Pathology

• Publication date

  2009-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1750-3639.2008.00166.xPMID 18429966PMCID PMC8094645
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Amyloid Hypothesis of Alzheimer ’ s Disease : Progress and Problems on the Road to Therapeutics

  2009cited by this paper
• Accelerated Aβ Deposition in APPswe/PS1ΔE9 Mice with Hemizygous Deletions of TTR (Transthyretin)

  2007cited by this paper
• Transthyretin and Alzheimer's disease: where in the brain?

  2007cited by this paper
• Clearance of amyloid-beta by circulating lipoprotein receptors.

  2007cited by this paper
• Accelerated Abeta deposition in APPswe/PS1deltaE9 mice with hemizygous deletions of TTR (transthyretin).

  2007influential reference
• Clearance of amyloid-β by circulating lipoprotein receptors

  2007cited by this paper
• Blocking the apolipoprotein E/amyloid-β interaction as a potential therapeutic approach for Alzheimer's disease

  2006cited by this paper
• Transthyretin knockouts are a new mouse model for increased neuropeptide Y

  2006cited by this paper
• β-Amyloid Degradation and Alzheimer's Disease

  2006cited by this paper
• Differential post‐translational modifications of transthyretin in Alzheimer's disease: A study of the cerebral spinal fluid

  2006cited by this paper
• Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis.

  2006cited by this paper
• Comparative analysis of cortical gene expression in mouse models of Alzheimer's disease.

  2006cited by this paper
• Curcumin Inhibits Formation of Amyloid β Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo*

  2005cited by this paper
• Faculty Opinions recommendation of Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice.

  2005cited by this paper
• Transthyretin inhibition of amyloid beta aggregation and toxicity.

  2005cited by this paper
• Neuropathological stageing of Alzheimer-related changes

  2004cited by this paper
• Exclusive association and simultaneous appearance of congophilic plaques and AT8-positive dystrophic neurites in Tg2576 mice suggest a mechanism of senile plaque formation and progression of neuritic dystrophy in Alzheimer’s disease

  2004influential reference
• Clearing amyloid through the blood–brain barrier

  2004cited by this paper
• Cerebrovascular disease and the pathophysiology of Alzheimer's disease. Implications for therapy.

  2004cited by this paper
• Deposition of transthyretin amyloid is not accelerated by the same amyloid in vivo

  2004cited by this paper
• Neutralization of Transthyretin Reverses the Neuroprotective Effects of Secreted Amyloid Precursor Protein (APP) in APPSw Mice Resulting in Tau Phosphorylation and Loss of Hippocampal Neurons: Support for the Amyloid Hypothesis

  2004influential reference
• [Hemovigilance and pediatrics. Self assessment questions].

  2004cited by this paper
• Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease

  2003cited by this paper
• Pathogenesis of cerebral amyloid angiopathy.

  2003cited by this paper
• Novel Therapeutic Approach for the Treatment of Alzheimer's Disease by Peripheral Administration of Agents with an Affinity to β-Amyloid

  2003cited by this paper
• Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to beta-amyloid.

  2003cited by this paper
• The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

  2002cited by this paper
• The Relationship between Aβ and Memory in the Tg2576 Mouse Model of Alzheimer's Disease

  2002cited by this paper
• Serum insulin-like growth factor I regulates brain amyloid-beta levels.

  2002cited by this paper
• The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease.

  2002cited by this paper
• Evidence That Synaptically Released β-Amyloid Accumulates as Extracellular Deposits in the Hippocampus of Transgenic Mice

  2002cited by this paper
• Lack of Neurodegeneration in Transgenic Mice Overexpressing Mutant Amyloid Precursor Protein Is Associated with Increased Levels of Transthyretin and the Activation of Cell Survival Pathways

  2002influential reference
• Amyloid cored plaques in Tg2576 transgenic mice are characterized by giant plaques, slightly activated microglia, and the lack of paired helical filament-typed, dystrophic neurites

  2002cited by this paper
• Brain Aβ amyloidosis in APPsw mice induces accumulation of presenilin‐1 and tau

  2001cited by this paper
• Aβ amyloidosis induces the initial stage of tau accumulation in APPSw mice

  2001cited by this paper
• Age-Dependent Changes in Brain, CSF, and Plasma Amyloid β Protein in the Tg2576 Transgenic Mouse Model of Alzheimer's Disease

  2001cited by this paper
• Co-expression of multiple transgenes in mouse CNS: a comparison of strategies.

  2001cited by this paper
• Abeta amyloidosis induces the initial stage of tau accumulation in APP(Sw) mice.

  2001cited by this paper
• Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.

  2001cited by this paper
• Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease.

  2000cited by this paper
• Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss.

  2000cited by this paper
• Lipoprotein‐free amyloidogenic peptides in plasma are elevated in patients with sporadic Alzheimer's disease and Down's syndrome

  1999cited by this paper
• Progression of Cerebral Amyloid Angiopathy: Accumulation of Amyloid-ß40 in Affected Vessels

  1998cited by this paper
• Cerebrospinal fluid transthyretin: aging and late onset Alzheimer’s disease

  1997cited by this paper
• Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins.

  1997cited by this paper
• APPSW Transgenic Mice Develop Age‐related Aβ Deposits and Neuropil Abnormalities, but no Neuronal Loss in CA1

  1997influential reference
• Serum amyloid P component enhances induction of murine amyloidosis.

  1997cited by this paper
• Amyloid deposition is delayed in mice with targeted deletion of the serum amyloid P component gene

  1997cited by this paper
• The length of Amyloid-β in Hereditary Cerebral Hemorrhage with Amyloidosis, Dutch Type

  1996cited by this paper
• Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

  1996cited by this paper
• Interaction of transthyretin with amyloid beta-protein: binding and inhibition of amyloid formation.

  1996cited by this paper
• The length of amyloid-beta in hereditary cerebral hemorrhage with amyloidosis, Dutch type. Implications for the role of amyloid-beta 1-42 in Alzheimer's disease.

  1996cited by this paper
• Arresting amyloidosis in vivo using small-molecule anionic sulphonates or sulphates: implications for Alzheimer's disease

  1995cited by this paper
• Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins.

  1995cited by this paper
• Serum amyloid P component prevents proteolysis of the amyloid fibrils of Alzheimer disease and systemic amyloidosis.

  1995cited by this paper
• Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques.

  1995cited by this paper
• Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans.

  1995cited by this paper
• Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments.

  1994cited by this paper
• Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

  1994cited by this paper
• Transthyretin sequesters amyloid beta protein and prevents amyloid formation.

  1994cited by this paper
• High tissue content of soluble beta 1-40 is linked to cerebral amyloid angiopathy.

  1994cited by this paper
• Disruption of the transthyretin gene results in mice with depressed levels of plasma retinol and thyroid hormone.

  1993cited by this paper
• Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

  1992influential reference
• Production of the Alzheimer amyloid beta protein by normal proteolytic processing.

  1992cited by this paper
• Protein chemical and immunocytochemical studies of meningovascular beta-amyloid protein in Alzheimer's disease and normal aging.

  1988influential reference
• Differences Between Vascular and Plaque Core Amyloid in Alzheimer's Disease

  1988influential reference

• Intracellular and Extracellular Localization of Transthyretin and Its Association With Amyloid‐β in Alzheimer's Disease Brains

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  2018cites this paper
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  2017cites this paper
• Amyloid β-interacting partners in Alzheimer's disease: From accomplices to possible therapeutic targets.

  2016cites this paper
• Selection of transthyretin amyloid inhibitors

  2016cites this paper
• Transthyretin Suppresses Amyloid-β Secretion by Interfering with Processing of the Amyloid-β Protein Precursor

  2016cites this paper
• Influence of Coding Variability in APP-Aβ Metabolism Genes in Sporadic Alzheimer’s Disease

  2016cites this paper
• Transthyretin Stabilization by Iododiflunisal Promotes Amyloid-β Peptide Clearance, Decreases its Deposition, and Ameliorates Cognitive Deficits in an Alzheimer's Disease Mouse Model

  2014cites this paper
• Identifying aging-related genes in mouse hippocampus using gateway nodes

  2014cites this paper
• Role of TTR in A β peptide brain efflux - Impact in Alzheimer's disease

  2014cites this paper
• Transthyretin: a multifaceted protein

  2014cites this paper
• Genetic mouse models of brain ageing and Alzheimer's disease.

  2014cites this paper
• Blood–brain-barriers in aging and in Alzheimer’s disease

  2013cites this paper
• Efficient in vivo delivery of antisense oligonucleotide to choroid plexus.

  2013cites this paper
• Search for early TTR-related biomarkers in a transgenic AD mouse model

  2013cites this paper
• Nongenomic Actions of Thyroid Hormones: From Basic Research to Clinical Applications. An Update

  2013cites this paper
• Neurotoxicity and Memory Deficits Induced by Soluble Low-Molecular-Weight Amyloid-β1–42 Oligomers Are Revealed In Vivo by Using a Novel Animal Model

  2012cites this paper
• Identification of Novel Fluid Biomarkers for Alzheimer's Disease

  2012cites this paper
• Transthyretin: roles in the nervous system beyond thyroxine and retinol transport

  2012cites this paper
• ELF MF – Melatonin Production – Alzheimer ’ s Disease and Breast Cancer 2012

  2012cites this paper
• Modulation of iron metabolism in aging and in Alzheimer's disease: relevance of the choroid plexus

  2012cites this paper
• Neuronal Production of Transthyretin in Human and Murine Alzheimer's Disease: Is It Protective?

  2011cites this paper
• Gender-Dependent Transthyretin Modulation of Brain Amyloid-β Levels: Evidence from a Mouse Model of Alzheimer's Disease

  2011cites this paper
• Transthyretin and the brain re-visited: Is neuronal synthesis of transthyretin protective in Alzheimer's disease?

  2011cites this paper
• Key Enzymes and Proteins in Amyloid-Beta Production and Clearance

  2011cites this paper
• Association of Electrophoretically Resolved Low Molecular Weight Protein Fractions with Senile Dementia in Elderly People

  2011cites this paper
• Identification and Validation of Novel Cerebrospinal Fluid Biomarkers for Staging Early Alzheimer's Disease

  2011cites this paper
• Association of TTR polymorphisms with hippocampal atrophy in Alzheimer disease families.

  2011cites this paper
• Possible Involvement of Transthyretin in Hippocampal β-Amyloid Burden and Learning Behaviors in a Mouse Model of Alzheimer’s Disease (TgCRND8)

  2010cites this paper
• Transthyretin as a potential CSF biomarker for Alzheimer’s disease and dementia with Lewy bodies: effects of treatment with cholinesterase inhibitors

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• Characterization of the interaction of β-amyloid with transthyretin monomers and tetramers.

  2010cites this paper
• Clearance of amyloid-β peptide across the blood-brain barrier: Implication for therapies in Alzheimer’s disease

  2009cites this paper
• Differential modification of Cys10 alters transthyretin's effect on beta-amyloid aggregation and toxicity.

  2009cites this paper
• Mobile and cordless telephones, serum transthyretin and the blood-cerebrospinal fluid barrier: a cross-sectional study

  2009cites this paper
• Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease.

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• Transthyretin Null Mice as a Model to Study the Involvement of Transthyretin in Neurobiology: From Neuropeptide Processing to Nerve Regeneration

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• What Have We Learned from Transthyretin-Null Mice: Novel Functions for Transthyretin?

  2009cites this paper
• Transthyretin: more than meets the eye.

  2009cites this paper
• Molecular Neuroscience Review Article Molecular Basis for Certain Neuroprotective Effects of Thyroid Hormone

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