Comment on: Hosogai et al. (2007) Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation. Diabetes 56:901–911, 2007

M. R. Negrão,R. Monteiro,C. Calhau,R. Soares,I. Azevedo

Published 2008 in Diabetes

ABSTRACT

In their most opportune and valuable article (1), Hosogai et al. provide a clear and quite extensive concatenation of data that indicate a very important role for hypoperfusion and hypoxia of adipose tissue in the dysregulated production of adipocytokines and metabolic syndrome. We had previously published a study on the role of adipocyte rupture—the more facile the bigger the adipocyte—in the inflammatory process …

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