The pandemic (H1N1) 2009 influenza virus is resistant to mannose-binding lectin

BackgroundMannose-binding lectin (MBL) is an important component of innate immunity because it promotes bacterial clearance and neutralization of human influenza A viruses. Since a majority of humans have no neutralizing antibody against the pandemic (H1N1) 2009 influenza (pandemic 2009) virus, innate immunity may be crucial and MBL susceptibility may therefore influence viral pathogenesis.ResultsWe examined MBL susceptibility of influenza A viruses and observed that the pandemic 2009 virus was resistant to MBL, whereas all seasonal influenza A viruses tested were susceptible. The mortality of mice infected with a seasonal H1N1 influenza virus was evidently enhanced on transient blockage of MBL activity by simultaneous inoculation of mannan, whereas mannan inoculation had no effect on mice infected with a pandemic 2009 virus. This indicates that MBL protects mice against infection with the seasonal virus but not against that with the pandemic 2009 virus.ConclusionsThese results indicate that the pandemic 2009 virus is not susceptible to MBL, an important component of innate immunity.

• Publication year

  2011

• Venue

  Virology Journal

• Publication date

  2011-02-04

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1186/1743-422X-8-50PMID 21294904PMCID 3045344
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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