Tumor‐targeted pH/redox dual‐sensitive unimolecular nanoparticles for efficient siRNA delivery

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Journal of Controlled Release

• Publication date

  2017-08-10

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.jconrel.2017.01.042PMID 28159516PMCID PMC5538929
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• AB3-Loaded and Tumor-Targeted Unimolecular Micelles for Medullary Thyroid Cancer Treatment.

  2017cited by this paper
• Neuroendocrine Tumor‐Targeted Upconversion Nanoparticle‐Based Micelles for Simultaneous NIR‐Controlled Combination Chemotherapy and Photodynamic Therapy, and Fluorescence Imaging

  2017cited by this paper
• Aminoflavone-loaded EGFR-targeted unimolecular micelle nanoparticles exhibit anti-cancer effects in triple negative breast cancer.

  2016cited by this paper
• Chapter 3:Nanoparticle Carriers to Overcome Biological Barriers to siRNA Delivery

  2016cited by this paper
• KE108-conjugated unimolecular micelles loaded with a novel HDAC inhibitor thailandepsin-A for targeted neuroendocrine cancer therapy.

  2016cited by this paper
• Hydrogel Doped with Nanoparticles for Local Sustained Release of siRNA in Breast Cancer

  2015cited by this paper
• Highly efficient siRNA delivery from core-shell mesoporous silica nanoparticles with multifunctional polymer caps.

  2015cited by this paper
• Multi-functional self-fluorescent unimolecular micelles for tumor-targeted drug delivery and bioimaging.

  2015cited by this paper
• Cationic Polymer Modified Mesoporous Silica Nanoparticles for Targeted siRNA Delivery to HER2+ Breast Cancer

  2015cited by this paper
• Responsive pentablock copolymers for siRNA delivery

  2015cited by this paper
• Recent developments in the co-delivery of siRNA and small molecule anticancer drugs for cancer treatment

  2014cited by this paper
• pH-responsive dendritic core-multishell nanocarriers.

  2014cited by this paper
• Effects of surface displayed targeting ligand GE11 on liposome distribution and extravasation in tumor.

  2014cited by this paper
• Aptamer-conjugated and doxorubicin-loaded unimolecular micelles for targeted therapy of prostate cancer.

  2013cited by this paper
• Dual and multi-stimuli responsive polymeric nanoparticles for programmed site-specific drug delivery.

  2013cited by this paper
• Redox and pH-responsive degradable micelles for dually activated intracellular anticancer drug release.

  2013cited by this paper
• Small interfering RNA-based molecular therapy of cancers

  2013cited by this paper
• Image-guided and tumor-targeted drug delivery with radiolabeled unimolecular micelles.

  2013cited by this paper
• Opposites attract: influence of the molar mass of branched poly(ethylene imine) on biophysical characteristics of siRNA-based polyplexese

  2013cited by this paper
• Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

  2013cited by this paper
• Non-viral delivery of RNA interference targeting cancer cells in cancer gene therapy.

  2012cited by this paper
• Intracellular drug release nanosystems

  2012cited by this paper
• Endosomal escape and siRNA delivery with cationic shell crosslinked knedel-like nanoparticles with tunable buffering capacities.

  2012cited by this paper
• Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery.

  2011cited by this paper
• Water soluble poly(histamine acrylamide) with superior buffer capacity mediates efficient and nontoxic in vitro gene transfection

  2011cited by this paper
• RNA interference in the clinic: challenges and future directions

  2011cited by this paper
• The therapeutic potential of targeting the EGFR family in epithelial ovarian cancer

  2011cited by this paper
• Enhanced endosomal escape of siRNA-incorporating hybrid nanoparticles from calcium phosphate and PEG-block charge-conversional polymer for efficient gene knockdown with negligible cytotoxicity.

  2011cited by this paper
• EGFR expression and gene copy number in triple-negative breast carcinoma.

  2010cited by this paper
• Breaking down the barriers: siRNA delivery and endosome escape

  2010cited by this paper
• Amphiphilic multi-arm-block copolymer conjugated with doxorubicin via pH-sensitive hydrazone bond for tumor-targeted drug delivery.

  2009cited by this paper
• Size‐Dependent Endocytosis of Nanoparticles

  2009cited by this paper
• Gold nanoparticles with a monolayer of doxorubicin-conjugated amphiphilic block copolymer for tumor-targeted drug delivery.

  2009cited by this paper
• Knocking down barriers: advances in siRNA delivery

  2009cited by this paper
• Mechanistic investigation of poly(ethylene imine)-based siRNA delivery: disulfide bonds boost intracellular release of the cargo.

  2008cited by this paper
• Engineering targeted viral vectors for gene therapy

  2007cited by this paper
• Polymer-based siRNA delivery: perspectives on the fundamental and phenomenological distinctions from polymer-based DNA delivery.

  2007cited by this paper
• Water-soluble pH-responsive dendritic core-shell nanocarriers for polar dyes based on poly(ethylene imine).

  2007cited by this paper
• Strategies for silencing human disease using RNA interference

  2007cited by this paper
• Nanocarriers as an emerging platform for cancer therapy.

  2007cited by this paper
• Gene therapy progress and prospects: non-viral gene therapy by systemic delivery

  2006cited by this paper
• Identification and characterization of a novel peptide ligand of epidermal growth factor receptor for targeted delivery of therapeutics

  2005cited by this paper
• Towards safe, non-viral therapeutic gene expression in humans

  2005cited by this paper
• The ins and outs of RNAi in mammalian cells.

  2004cited by this paper
• Vectors for RNA interference.

  2004cited by this paper
• Epidermal growth factor receptor expression in human pancreatic cancer: Significance for liver metastasis.

  2003cited by this paper
• EGFR and cancer prognosis.

  2001cited by this paper
• Mistletoe for cancer?

  2001cited by this paper
• Polymer-based gene delivery with low cytotoxicity by a unique balance of side-chain termini.

  2001cited by this paper
• Enzymatic reduction of disulfide bonds in lysosomes: characterization of a gamma-interferon-inducible lysosomal thiol reductase (GILT).

  2000cited by this paper
• Gamma-interferon-inducible lysosomal thiol reductase (GILT). Maturation, activity, and mechanism of action.

  2000cited by this paper

• Harnessing the Power of Nanocarriers to Exploit the Tumor Microenvironment for Enhanced Cancer Therapy

  2025cites this paper
• Unraveling Lyophilization and Redispersion Effects on Miktoarm Polymer-Based Nanoformulations

  2025cites this paper
• Tumor‐Targeted FABP5/STING Cascade Promote Radiofrequency Ablation Induced Ferroptosis and Intratumoral Immune Rewiring in Hepatocellular Carcinoma

  2025cites this paper
• Rational Design of Morphology Transformable Oligopeptide Self-Assembly for Specifically Inducing Lysosomal Membrane Permeabilization of Tumor Cell.

  2025cites this paper
• Gene Delivery with Dual pH- and GSH-Responsive Lipoamide Polymers from Controlled Polymerization of Protected Lipoic Acid.

  2025cites this paper
• Novel targeting liposomes with enhanced endosomal escape for co-delivery of doxorubicin and curcumin.

  2024cites this paper
• A Near-Infrared-II Fluorescent Nanoprobe Offering Real-Time Tracking of Fenton-Like Reaction for Cancer Chemodynamic Theranostics.

  2024cites this paper
• αvβ3 integrin-targeted pH-responsive dendritic nanocarriers for enhanced anti-tumor efficacy of docetaxel against breast cancer

  2024cites this paper
• Targeting Breast Cancer Signaling via Phytomedicine and Nanomedicine

  2023cites this paper
• Engineered extracellular vesicles: A new approach for targeted therapy of tumors and overcoming drug resistance

  2023cites this paper
• Glycyrrhetinic Acid Receptor-Mediated Zeolitic Imidazolate Framework-8 Loaded Doxorubicin as a Nanotherapeutic System for Liver Cancer Treatment

  2023cites this paper
• A Comprehensive Review of Small Interfering RNAs (siRNAs): Mechanism, Therapeutic Targets, and Delivery Strategies for Cancer Therapy

  2023cites this paper
• Facts and prospects of peptide in targeted therapy and immune regulation against triple-negative breast cancer

  2023influential citation
• Drug Self-delivery Nanorods Enhance Photodynamic Therapy of Triple-Negative Breast Cancer by inhibiting Oxidative Phosphorylation.

  2022cites this paper
• Unprotonatable and ROS-Sensitive Nanocarrier for NIR Spatially Activated siRNA Therapy with Synergistic Drug Effect.

  2022cites this paper
• Smart drug delivery systems for precise cancer therapy

  2022cites this paper
• Challenges for the application of EGFR-targeting peptide GE11 in tumor diagnosis and treatment.

  2022cites this paper
• Stimuli-responsive and core cross-linked micelles developed by NiCCo-PISA of helical poly(aryl isocyanide)s

  2022cites this paper
• Activatable “Matryoshka” nanosystem delivery NgBR siRNA and control drug release for stepwise therapy and evaluate drug resistance cancer

  2022cites this paper
• Synchronous conjugation of i-motif DNA and therapeutic siRNA on the vertexes of tetrahedral DNA nanocages for efficient gene silence

  2021cites this paper
• The Role of Autophagy at the Nano/Bio Interface - Underlying Mechanisms and Therapeutic Potential in Cancer

  2021cites this paper
• Polypeptide-based materials prepared by ring-opening polymerisation of anionic-based α-amino acid N-carboxyanhydrides: A platform for delivery of bioactive-compounds

  2021cites this paper
• Cytosolic protein delivery using pH-responsive, charge-reversible lipid nanoparticles

  2021cites this paper
• Polydopamine nanoparticles with different sizes for NIR-promoted gene delivery and synergistic photothermal therapy.

  2021cites this paper
• Calcium phosphate-polymeric nanoparticle system for co-delivery of microRNA-21 inhibitor and doxorubicin.

  2021cites this paper
• Novel Approaches of Dysregulating Lysosome Functions in Cancer Cells by Specific Drugs and Its Nanoformulations: A Smart Approach of Modern Therapeutics

  2021cites this paper
• 2,2-Bis(hydroxymethyl) propionic acid based cyclic carbonate monomers and their (co)polymers as advanced materials for biomedical applications.

  2021cites this paper
• Polypeptide-based drug delivery systems for programmed release.

  2021cites this paper
• In vivo targeted delivery of nucleic acids and CRISPR genome editors enabled by GSH-responsive silica nanoparticles.

  2021cites this paper
• Biomedical application of hyperbranched polymers: Recent Advances and challenges

  2021cites this paper
• A Review of Nanoparticle Drug Delivery Systems Responsive to Endogenous Breast Cancer Microenvironment.

  2021cites this paper
• Silencing of BCSG1 with specific siRNA via nanocarriers for breast cancer treatment.

  2021cites this paper
• Robust and smart polypeptide-based nanomedicines for targeted tumor therapy.

  2020cites this paper
• pH-responsive polydopamine nanoparticles for photothermally promoted gene delivery.

  2020cites this paper
• Synthesis and functionalization of hyperbranched polymers for targeted drug delivery.

  2020influential citation
• Photoactivation of Sulfonated Polyplexes enables localized gene silencing by DsiRNA in breast Cancer cells.

  2020cites this paper
• Tumor extracellular pH-sensitive polymeric nanocarrier-grafted platinum(iv) prodrugs for improved intracellular delivery and cytosolic reductive-triggered release

  2020cites this paper
• Long‐Circulating Drug‐Dye‐Based Micelles with Ultrahigh pH‐Sensitivity for Deep Tumor Penetration and Superior Chemo‐Photothermal Therapy

  2020cites this paper
• Strategies and challenges to improve the performance of tumor-associated active targeting.

  2020cites this paper
• CX3CR1-Targeted PLGA Nanoparticles Reduce Microglia Activation and Pain Behavior in Rats with Spinal Nerve Ligation

  2020cites this paper
• Facile preparation of pH/reduction dual-stimuli responsive dextran nanogel as environment-sensitive carrier of doxorubicin

  2020cites this paper
• Fluorescence for biological logic gates

  2020cites this paper
• Silver Nanoparticles Surface-Modified with Carbosilane Dendrons as Carriers of Anticancer siRNA

  2020cites this paper
• Hybrid micelles based on Pt (IV) polymeric prodrug and TPGS for the enhanced cytotoxicity in drug-resistant lung cancer cells.

  2020cites this paper
• Polymeric nano-carriers for on-demand delivery of genes via specific responses to stimuli.

  2020cites this paper
• Actively targeted nanomedicines for precision cancer therapy: Concept, construction, challenges and clinical translation.

  2020cites this paper
• Progress on GE 11 Peptide-Modified EGFR-Targeting Nano Delivery System and the Delivery Barriers to Solid Tumor

  2020cites this paper
• A Strategy to Fight against Triple-Negative Breast Cancer: pH-Responsive Hexahistidine-Metal Assemblies with High-Payload Drugs.

  2020cites this paper
• Precise design strategies of nanomedicine for improving cancer therapeutic efficacy using subcellular targeting

  2020cites this paper
• Hybrid Graphene‐Gold Nanoparticle‐Based Nucleic Acid Conjugates for Cancer‐Specific Multimodal Imaging and Combined Therapeutics

  2020cites this paper
• Application of Nanomaterials for Cancer Diagnosis and Therapy

  2020cites this paper
• Biodegradable dendritic Boltorn™ nanoconstructs: A promising avenue for cancer theranostics.

  2020cites this paper
• Reducible Branched Ester-Amine Quadpolymers (rBEAQs) Codelivering Plasmid DNA and RNA Oligonucleotides Enable CRISPR/Cas9 Genome Editing.

  2019cites this paper
• Smart triblock dendritic unimolecular micelles as pioneering nanomaterials: Advancement pertaining to architecture and biomedical applications

  2019cites this paper
• Saporin‐loaded CD44 and EGFR dual‐targeted nanogels for potent inhibition of metastatic breast cancer in vivo

  2019cites this paper
• Multi-functional self-assembled nanoparticles for pVEGF-shRNA loading and anti-tumor targeted therapy.

  2019cites this paper
• Amphiphilic redox-sensitive NIR BODIPY nanoparticles for dual-mode imaging and photothermal therapy.

  2019cites this paper
• Branched and Dendritic Polymer Architectures: Functional Nanomaterials for Therapeutic Delivery

  2019cites this paper
• Nanomaterial designing strategies related to cell lysosome and their biomedical applications: A review.

  2019cites this paper
• A Multi-crosslinking Nanocapsule-based Serial-Stimuli-Responsive Leakage Free Drug Delivery System in Vitro.

  2019cites this paper
• Bioreducible and acid-labile polydiethylenetriamines with sequential degradability for efficient transgelin-2 siRNA delivery.

  2019cites this paper
• Cancer Nanomedicines Based on Synthetic Polypeptides.

  2019cites this paper
• Nanoparticles Targeted Drug Delivery Aystem via Epidermal Growth Factor Receptor: a Review

  2019influential citation
• Overcoming Hurdles in Nanoparticle Clinical Translation: The Influence of Experimental Design and Surface Modification

  2019cites this paper
• Novel dual responsive alginate-based magnetic nanogels for onco-theranostics.

  2019cites this paper
• Programmed co-delivery of platinum nanodrugs and gemcitabine by a clustered nanocarrier for precision chemotherapy for NSCLC tumors.

  2019cites this paper
• Dual-drug delivery based charge-conversional polymeric micelles for enhanced cellular uptake and combination therapy

  2019cites this paper
• Molecular determinants as therapeutic targets in cancer chemotherapy: An update.

  2019cites this paper
• Current Development of siRNA Bioconjugates: From Research to the Clinic

  2019cites this paper
• Virus‐inspired and mimetic designs in non‐viral gene delivery

  2019cites this paper
• A conveniently synthesized Pt (IV) conjugated alginate nanoparticle with ligand self-shielded property for targeting treatment of hepatic carcinoma.

  2019cites this paper
• Intratumorally Injected Photothermal Agent-Loaded Photodynamic Nanocarriers for Ablation of Orthotopic Melanoma and Breast Cancer.

  2019cites this paper
• Platinum complexes of curcumin delivered by dual-responsive polymeric nanoparticles improve chemotherapeutic efficacy based on the enhanced anti-metastasis activity and reduce side effects

  2019cites this paper
• Synthesis and biological evaluation of phthalocyanine-peptide conjugate for EGFR-targeted photodynamic therapy and bioimaging

  2019cites this paper
• Two-in-One Chemogene Assembled from Drug-Integrated Antisense Oligonucleotides To Reverse Chemoresistance.

  2019cites this paper
• pH and reduction dual-responsive micelles based on novel polyurethanes with detachable poly(2-ethyl-2-oxazoline) shell for controlled release of doxorubicin

  2019cites this paper
• Sequential delivery of VEGF siRNA and paclitaxel for PVN destruction, anti‐angiogenesis, and tumor cell apoptosis procedurally via a multi‐functional polymer micelle

  2018cites this paper
• p38 siRNA-encapsulated PLGA nanoparticles alleviate neuropathic pain behavior in rats by inhibiting microglia activation.

  2018cites this paper
• A review on core–shell structured unimolecular nanoparticles for biomedical applications

  2018cites this paper
• Recent Advances in Nanoparticle-Based Cancer Drug and Gene Delivery.

  2018cites this paper
• A Universal GSH-Responsive Nanoplatform for the Delivery of DNA, mRNA, and Cas9/sgRNA Ribonucleoprotein.

  2018cites this paper
• Controlled construction of gold nanoparticles in situ from β-cyclodextrin based unimolecular micelles for in vitro computed tomography imaging.

  2018cites this paper
• Reduction‐sensitive polymeric nanomedicines: An emerging multifunctional platform for targeted cancer therapy

  2018cites this paper
• Design of Mannose-Functionalized Curdlan Nanoparticles for Macrophage-Targeted siRNA Delivery.

  2018cites this paper
• Redox-responsive micelles from disulfide bond-bridged hyaluronic acid-tocopherol succinate for the treatment of melanoma.

  2018cites this paper
• Thiabicyclononane-Based Hyperbranched Polycations for Low-Dose Oligonucleotide Delivery

  2018cites this paper
• pH-Sensitive assembly/disassembly gold nanoparticles with the potential of tumor diagnosis and treatment

  2018cites this paper
• Enhancing the In Vitro and In Vivo Stabilities of Polymeric Nucleic Acid Delivery Nanosystems.

  2018cites this paper
• Free Adriamycin-Loaded pH/Reduction Dual-Responsive Hyaluronic Acid-Adriamycin Prodrug Micelles for Efficient Cancer Therapy.

  2018cites this paper
• Stimuli-responsive drug delivery nanocarriers in the treatment of breast cancer.

  2018cites this paper
• Peptide‐decorated polymeric nanomedicines for precision cancer therapy

  2018cites this paper
• Synthesis and biological evaluation of redox/NIR dual stimulus-responsive polymeric nanoparticles for targeted delivery of cisplatin.

  2018cites this paper
• Nanomedicine applications in the treatment of breast cancer: current state of the art

  2017cites this paper
• NIR‐induced spatiotemporally controlled gene silencing by upconversion nanoparticle‐based siRNA nanocarrier

  2017cites this paper
• Preliminary study on fabrication, characterization and synergistic anti-lung cancer effects of self-assembled micelles of covalently conjugated celastrol–polyethylene glycol–ginsenoside Rh2

  2017influential citation
• An intelligent re‐shieldable targeting system for enhanced tumor accumulation

  2017cites this paper
• Trigger-Responsive Gene Transporters for Anticancer Therapy

  2017cites this paper
• CuS-Based Theranostic Micelles for NIR-Controlled Combination Chemotherapy and Photothermal Therapy and Photoacoustic Imaging.

  2017cites this paper
• EGFR and CD44 Dual-Targeted Multifunctional Hyaluronic Acid Nanogels Boost Protein Delivery to Ovarian and Breast Cancers In Vitro and In Vivo.

  2017cites this paper
• PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis

  2017cites this paper