Changes of atrial natriuretic peptide and antidiuretic hormone in children with postural tachycardia syndrome and orthostatic hypertension: a case control study

Background The abnormal blood volume regulation is one of the most important pathogenesis in postural tachycardia syndrome in children. This study was designed to investigate the plasma atrial natriuretic peptide and antidiuretic hormone levels in postural tachycardia syndrome children, and their associations with the changes in heart rate and blood pressure in head‐up test. Methods Twenty‐one postural tachycardia syndrome patients ((12±2) years) and 26 healthy children ((12±1) years) were included. According to blood pressure changes in head‐up test, the postural tachycardia syndrome patients were divided into two subgroups: postural tachycardia syndrome with orthostatic hypertension and postural tachycardia syndrome without orthostatic hypertension. The plasma atrial natriuretic peptide and antidiuretic hormone levels were measured using enzyme‐linked immunosorbent assay. Results The plasma atrial natriuretic peptide level in postural tachycardia syndrome patients was higher than the control (P=0.004), whereas the difference in plasma antidiuretic hormone level between postural tachycardia syndrome and controls was not significant (P=0.222). The plasma antidiuretic hormone level of patients suffering from postural tachycardia syndrome with orthostatic hypertension was much higher than that of children having postural tachycardia syndrome without orthostatic hypertension (P <0.05). In postural tachycardia syndrome patients, the upright max heart rate was positively correlated with the plasma atrial natriuretic peptide level (r=0.490, P<0.05) and the upright systolic blood pressure was positively correlated with the plasma antidiuretic hormone levels (r=0.472, P <0.05). Conclusions There was a disturbance of plasma atrial natriuretic peptide and antidiuretic hormone in postural tachycardia syndrome children. Chin Med J 2014;127 (10): 1853‐1857

• Publication year

  2014

• Venue

  Chinese Medical Journal

• Publication date

  2014-05-20

• Fields of study

  Medicine

• Identifiers
  DOI 10.3760/cma.j.issn.0366-6999.20140336PMID 24824244
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• [Natriuretic peptides. History of discovery, chemical structure, mechanism of action and the removal routes. Basis of diagnostic and therapeutic use].

  2013cited by this paper
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  2012cited by this paper
• [Clinical analysis of orthostatic hypertension in children].

  2012cited by this paper
• Postural tachycardia in children and adolescents: what is abnormal?

  2012cited by this paper
• New insights into the dynamic regulation of water and acid-base balance by renal epithelial cells.

  2012cited by this paper
• Vasopressin V1a and V1b receptors: from molecules to physiological systems.

  2012cited by this paper
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  2012cited by this paper
• Desmopressin acutely decreases tachycardia and improves symptoms in the postural tachycardia syndrome.

  2012cited by this paper
• Abnormalities of angiotensin regulation in postural tachycardia syndrome.

  2011cited by this paper
• Postural tachycardia syndrome from a pediatrics perspective.

  2011cited by this paper
• A diagnosis-based health economic analysis of postural orthostatic tachycardia syndrome in Chinese children.

  2011cited by this paper
• Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome.

  2011cited by this paper
• Postural orthostatic tachycardia syndrome: diagnosis and treatment.

  2011influential reference
• Flow-mediated vasodilation and endothelium function in children with postural orthostatic tachycardia syndrome.

  2010cited by this paper
• Orthostatic intolerance and the headache patient.

  2010cited by this paper
• Postural tachycardia syndrome and reflex syncope: similarities and differences.

  2009cited by this paper
• Postural tachycardia syndrome.

  2008cited by this paper
• A review of postural orthostatic tachycardia syndrome.

  2008cited by this paper
• Arterial baroreflex control of heart rate during exercise in postural tachycardia syndrome.

  2007cited by this paper
• Review Article The Postural Tachycardia Syndrome (POTS): Pathophysiology, Diagnosis & Management

  2006cited by this paper
• Hyperadrenergic Postural Tachycardia Syndrome in Mast Cell Activation Disorders

  2005cited by this paper
• Renin-Aldosterone Paradox and Perturbed Blood Volume Regulation Underlying Postural Tachycardia Syndrome

  2005cited by this paper
• The Postural Tachycardia Syndrome: A Concise Guide to Diagnosis and Management

  2005cited by this paper
• Chronic orthostatic intolerance and the postural tachycardia syndrome (POTS).

  2004cited by this paper
• Postural variation in intraocular pressure in primary chronic autonomic failure

  2002cited by this paper
• Human muscle sympathetic neural and haemodynamic responses to tilt following spaceflight

  2002cited by this paper
• U-curve relationship between orthostatic blood pressure change and silent cerebrovascular disease in elderly hypertensives: orthostatic hypertension as a new cardiovascular risk factor.

  2002cited by this paper
• Are Natriuretic Peptides Clinically Useful as Markers of Heart Failure?

  2001cited by this paper
• Are natriuretic peptides clinically useful as markers of heart failure?

  2001cited by this paper
• Enzyme Immunoassays for Fragments (Epitopes) of Human Proatrial Natriuretic Peptides

  2000cited by this paper
• Baroreflex control of muscle sympathetic nerve activity after 120 days of 6° head-down bed rest

  2000cited by this paper
• Baroreflex control of muscle sympathetic nerve activity after 120 days of 6 degrees head-down bed rest.

  2000cited by this paper
• Effects of cardiac natriuretic peptides on oxidized low-density lipoprotein- and lysophosphatidylcholine-induced human mesangial cell migration.

  2000cited by this paper
• Postural tachycardia syndrome: clinical features and follow-up study.

  1999cited by this paper

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  2024cites this paper
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  2023cites this paper
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  2022cites this paper
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  2018cites this paper
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  2014cites this paper