Cholinergic degeneration is associated with increased plaque deposition and cognitive impairment in APPswe/PS1dE9 mice.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Behavioural Brain Research

• Publication date

  2013-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.bbr.2012.11.012PMID 23178660
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Erythropoietin improves memory function with reducing endothelial dysfunction and amyloid‐beta burden in Alzheimer’s disease models

  2012cited by this paper
• Impaired Performance of Female APP/PS1 Mice in the Morris Water Maze Is Coupled with Increased Aβ Accumulation and Microglial Activation

  2012cited by this paper
• Impairments of exploration and memory after systemic or prelimbic D1-receptor antagonism in rats.

  2011cited by this paper
• Which Memory System is Impaired First in Alzheimer's Disease?

  2011cited by this paper
• Different effects of scopolamine on the retrieval of spatial memory and fear memory.

  2011cited by this paper
• Induced LC degeneration in APP/PS1 transgenic mice accelerates early cerebral amyloidosis and cognitive deficits.

  2010cited by this paper
• Amyloid β-Induced Neuronal Hyperexcitability Triggers Progressive Epilepsy

  2009cited by this paper
• Effects of donepezil on amyloid-beta and synapse density in the Tg2576 mouse model of Alzheimer's disease.

  2009cited by this paper
• Visuospatial memory in healthy elderly, AD and MCI: a review.

  2009cited by this paper
• Age-related cognitive decline and nesting behavior in an APPswe/PS1 bigenic model of Alzheimer's disease.

  2009cited by this paper
• Dopamine Modulates Cholinergic Cortical Excitability in Alzheimer's Disease Patients

  2009cited by this paper
• Neuroanatomical and behavioral effects of a novel version of the cholinergic immunotoxin mu p75‐saporin in mice

  2008cited by this paper
• Allen reference atlas : a digital color brain atlas of the C57Black/6J male mouse

  2008cited by this paper
• MGlu5 antagonism impairs exploration and memory of spatial and non-spatial stimuli in rats.

  2008cited by this paper
• Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo.

  2008cited by this paper
• Effects of progesterone administration and APPswe+PSEN1Deltae9 mutation for cognitive performance of mid-aged mice.

  2008cited by this paper
• Age‐related decrease in stimulated glutamate release and vesicular glutamate transporters in APP/PS1 transgenic and wild‐type mice

  2008cited by this paper
• Interactions between the amyloid and cholinergic mechanisms in Alzheimer's disease.

  2008cited by this paper
• The value of incomplete mouse models of Alzheimer’s disease

  2008cited by this paper
• Decreased vesicular acetylcholine transporter and alpha(4)beta(2) nicotinic receptor density in the rat brain following 192 IgG-saporin immunolesioning.

  2007cited by this paper
• Cortical cholinergic deficiency enhances amphetamine-induced dopamine release in the accumbens but not striatum.

  2007cited by this paper
• Impaired spatial learning in the APPSwe + PSEN1ΔE9 bigenic mouse model of Alzheimer’s disease

  2007cited by this paper
• Effect of Selective Cholinergic Denervation on the Serotonergic System: Implications for Learning and Memory

  2006cited by this paper
• Cholinergic-serotonergic imbalance contributes to cognitive and behavioral symptoms in Alzheimer's disease.

  2005cited by this paper
• Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: relationships to beta-amyloid deposition and neurotransmitter abnormalities.

  2005cited by this paper
• Interactions between beta-amyloid and central cholinergic neurons: implications for Alzheimer's disease.

  2004cited by this paper
• Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase.

  2004cited by this paper
• Interactions between β-amyloid and central cholinergic neurons: implications for Alzheimer’s disease

  2004cited by this paper
• Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase

  2004cited by this paper
• Alzheimer's disease: interactions between cholinergic functions and beta-amyloid.

  2004cited by this paper
• The T-maze continuous alternation task for assessing the effects of putative cognition enhancers in the mouse.

  2004cited by this paper
• Gender differences in the amount and deposition of amyloidbeta in APPswe and PS1 double transgenic mice.

  2003cited by this paper
• Activation of Muscarinic Receptors Inhibits β-Amyloid Peptide-induced Signaling in Cortical Slices*

  2003cited by this paper
• Effects of working memory deficits on the communicative functioning of Alzheimer's dementia patients.

  2003cited by this paper
• D1 dopamine receptors in the mouse prefrontal cortex: Immunocytochemical and cognitive neuropharmacological analyses

  2003cited by this paper
• The mouse brain in stereotaxic coordinates

  2003cited by this paper
• Behavioral characterization of the Tg2576 transgenic model of Alzheimer's disease through 19 months.

  2002cited by this paper
• The neurobiological basis of spontaneous alternation.

  2002cited by this paper
• Overexpression of hAPPswe impairs rewarded alternation and contextual fear conditioning in a transgenic mouse model of Alzheimer's disease.

  2002cited by this paper
• Central Serotonergic Activity is Related to the Aggressive Behaviors of Alzheimer's Disease

  2002cited by this paper
• Alzheimer's disease and the basal forebrain cholinergic system: relations to beta-amyloid peptides, cognition, and treatment strategies.

  2002cited by this paper
• Intra- and intertask relationships in a behavioral test battery given to Tg2576 transgenic mice and controls.

  2002cited by this paper
• Co-expression of multiple transgenes in mouse CNS: a comparison of strategies.

  2001cited by this paper
• Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes.

  2001cited by this paper
• Increased susceptibility to generalized seizures after immunolesions of the basal forebrain cholinergic neurons in rats.

  2000cited by this paper
• The Cholinergic Deficit Coincides with Aβ Deposition at the Earliest Histopathologic Stages of Alzheimer Disease

  2000cited by this paper
• Lesion of septal-hippocampal neurons with 192 IgG-saporin alters function of M1 muscarinic receptors.

  1999cited by this paper
• Cognitive functions of the basal forebrain.

  1999cited by this paper
• A new continuous alternation task in T-maze detects hippocampal dysfunction in mice. A strain comparison and lesion study.

  1998cited by this paper
• The effects of muscarinic cholinergic receptor blockade in the rat anterior cingulate and Prelimbic/Infralimbic cortices on spatial working memory.

  1998cited by this paper
• A re-examination of the role of basal forebrain cholinergic neurons in spatial working memory.

  1998cited by this paper
• Chronic cognitive deficits and amyloid precursor protein elevation after selective immunotoxin lesions of the basal forebrain cholinergic system

  1998cited by this paper
• Mutant genes in familial Alzheimer's disease and transgenic models.

  1998cited by this paper
• Basal Forebrain Cholinergic Immunolesion by 192IgG-Saporin: Evidence for a Presynaptic Location of Subpopulations of α2-and β-Adrenergic as Well as 5-HT2A Receptors on Cortical Cholinergic Terminals

  1997cited by this paper
• Cognitive functions of cortical acetylcholine: toward a unifying hypothesis.

  1997cited by this paper
• Basal forebrain cholinergic immunolesion by 192IgG-saporin: evidence for a presynaptic location of subpopulations of alpha 2- and beta-adrenergic as well as 5-HT2A receptors on cortical cholinergic terminals.

  1997cited by this paper
• Amyloid load and neural elements in Alzheimer's disease and nondemented individuals with high amyloid plaque density.

  1996cited by this paper
• Chronic elevation of secreted amyloid precursor protein in subcortically lesioned rats, and its exacerbation in aged rats

  1995cited by this paper
• Comparison of executive and visuospatial memory function in Huntington's disease and dementia of Alzheimer type matched for degree of dementia.

  1995cited by this paper
• Time course of cholinergic and monoaminergic changes in rat brain after immunolesioning with 192 IgG-saporin.

  1994cited by this paper
• Impaired phosphoinositide hydrolysis in Alzheimer's disease brain.

  1994cited by this paper
• Behavioural changes after ablation of subdivisions of the rat prefrontal cortex.

  1993cited by this paper
• Neuroreceptor changes in Alzheimer disease.

  1992cited by this paper
• Loss of high‐affinity agonist binding to M1 muscarinic receptors in Alzheimer's disease: Implications for the failure of cholinergic replacement therapies

  1991cited by this paper
• Increased biosynthesis of Alzheimer amyloid precursor protein in the cerebral cortex of rats with lesions of the nucleus basalis of Meynert.

  1991cited by this paper
• The decline of working memory in Alzheimer's disease. A longitudinal study.

  1991cited by this paper
• Equivalent impairment of spatial and nonspatial memory following damage to the human hippocampus

  1991cited by this paper
• Seizures and myoclonus in patients with Alzheimer's disease

  1986cited by this paper
• A rapid radiochemical method for the determination of choline acetyltransferase

  1975cited by this paper
• Alternation and exploration in rats with hippocampal lesions.

  1962cited by this paper

• Evolution of Alzheimer’s Disease Therapeutics: From Conventional Drugs to Medicinal Plants, Immunotherapy, Microbiotherapy and Nanotherapy

  2025cites this paper
• Dynamic prediction of goal location by coordinated representation of prefrontal-hippocampal theta sequences.

  2024cites this paper
• Search for unknown neural link between the masticatory and cognitive brain systems to clarify the involvement of its impairment in the pathogenesis of Alzheimer’s disease

  2024cites this paper
• Are the promnestic effects of neurokinin 3 receptor mediated by hippocampal neurogenesis in a Aβ‐induced rat model of Alzheimer's disease?

  2024cites this paper
• Basal forebrain volume and metabolism in carriers of the Colombian mutation for autosomal dominant Alzheimer’s disease

  2024cites this paper
• Hypocretin/orexin influences chronic sleep disruption injury in the hippocampus

  2022cites this paper
• Amyloid β, Lipid Metabolism, Basal Cholinergic System, and Therapeutics in Alzheimer’s Disease

  2022cites this paper
• Small molecule modulation of TrkB and TrkC neurotrophin receptors prevents cholinergic neuron atrophy in an Alzheimer's disease mouse model at an advanced pathological stage.

  2021cites this paper
• Nucleus basalis of Meynert degeneration predicts cognitive impairment in Parkinson's disease.

  2021cites this paper
• Integrated Phylogeny of the Human Brain and Pathobiology of Alzheimer's Disease: A Unifying Hypothesis.

  2021cites this paper
• Loss of cholinergic innervation differentially affects eNOS-mediated blood flow, drainage of Aβ and cerebral amyloid angiopathy in the cortex and hippocampus of adult mice

  2021cites this paper
• Improving Anti-Neurodegenerative Benefits of Acetylcholinesterase Inhibitors in Alzheimer’s Disease: Are Irreversible Inhibitors the Future?

  2020cites this paper
• Nasal delivery of a CRMP2-derived CBD3 adenovirus improves cognitive function and pathology in APP/PS1 transgenic mice

  2020cites this paper
• Neuroprotective Role of Dietary Supplementation with Omega-3 Fatty Acids in the Presence of Basal Forebrain Cholinergic Neurons Degeneration in Aged Mice

  2020cites this paper
• in Alzheimer’s Disease

  2020cites this paper
• Behavioral, neuromorphological, and neurobiochemical effects induced by omega-3 fatty acids following basal forebrain cholinergic depletion in aged mice

  2020cites this paper
• Natural silibinin modulates amyloid precursor protein processing and amyloid-β protein clearance in APP/PS1 mice

  2019cites this paper
• 3D Reconstruction of the Neurovascular Unit Reveals Differential Loss of Cholinergic Innervation in the Cortex and Hippocampus of the Adult Mouse Brain

  2019cites this paper
• Regulation of cholinergic basal forebrain development, connectivity, and function by neurotrophin receptors

  2019cites this paper
• Young Blood Rescues the Cognition of Alzheimer's Model Mice by Restoring the Hippocampal Cholinergic Circuit.

  2019cites this paper
• The effect of cholinergic loss on the structure and function of the neurovascular unit: implications for cerebral amyloid angiopathy

  2019cites this paper
• Urine Is an Ideal Biomarker Resource in Early Detecting Neurodegenerative Diseases

  2019cites this paper
• Rosuvastatin ameliorates cognitive impairment in rats fed with high-salt and cholesterol diet via inhibiting acetylcholinesterase activity and amyloid beta peptide aggregation

  2018cites this paper
• Acute Down-regulation of BDNF Signaling Does Not Replicate Exacerbated Amyloid-β Levels and Cognitive Impairment Induced by Cholinergic Basal Forebrain Lesion

  2018cites this paper
• Neuroprotective Effect of Durio zibithinus against Beta Amyloid

  2018cites this paper
• Cannabinoid Receptor 2-Deficiency Ameliorates Disease Symptoms in a Mouse Model with Alzheimer’s Disease-Like Pathology

  2018cites this paper
• Removal of p75 Neurotrophin Receptor Expression from Cholinergic Basal Forebrain Neurons Reduces Amyloid-β Plaque Deposition and Cognitive Impairment in Aged APP/PS1 Mice

  2018cites this paper
• Exercise-induced brain-derived neurotrophic factor expression: Therapeutic implications for Alzheimer's dementia.

  2018cites this paper
• Remodeling of cholinergic input to the hippocampus after noise exposure and tinnitus induction in Guinea pigs

  2018cites this paper
• The beneficial effects of dietary grape supplementation on improving cognitive deficits in APP/PS1 double transgenic mice

  2018cites this paper
• Early Candidate Urine Biomarkers for Detecting Alzheimer’s Disease Before Amyloid-β Plaque Deposition in an APP (swe)/PSEN1dE9 Transgenic Mouse Model

  2018cites this paper
• Rodent Models for Alzheimer’s Disease in Drug Discovery

  2017cites this paper
• Maternal separation exacerbates Alzheimer's disease‐like behavioral and pathological changes in adult APPswe/PS1dE9 mice

  2017cites this paper
• DL0410 Ameliorates Memory and Cognitive Impairments Induced by Scopolamine via Increasing Cholinergic Neurotransmission in Mice

  2017cites this paper
• Rendimiento cognitivo en envejecimiento: efecto del sueño, del ejercicio y de la TMS en Octodon degus

  2017cites this paper
• The role of perivascular innervation and neurally mediated vasoreactivity in the pathophysiology of Alzheimer's disease.

  2017cites this paper
• Enriched endogenous n-3 polyunsaturated fatty acids alleviate cognitive and behavioral deficits in a mice model of Alzheimer's disease.

  2016cites this paper
• Basal Forebrain Cholinergic Circuits and Signaling in Cognition and Cognitive Decline.

  2016cites this paper
• Subtle learning and memory impairment in an idiopathic rat model of Alzheimer's disease utilizing cholinergic depletions and β-amyloid.

  2016cites this paper
• Graphene quantum dots conjugated neuroprotective peptide improve learning and memory capability.

  2016cites this paper
• Cholinergic Basal Forebrain Lesion Decreases Neurotrophin Signaling without Affecting Tau Hyperphosphorylation in Genetically Susceptible Mice

  2016cites this paper
• Cholinergic Mechanisms in the Cerebral Cortex

  2016cites this paper
• Valproic Acid Alleviates Memory Deficits and Attenuates Amyloid-β Deposition in Transgenic Mouse Model of Alzheimer’s Disease

  2015cites this paper
• Silibinin inhibits acetylcholinesterase activity and amyloid β peptide aggregation: a dual-target drug for the treatment of Alzheimer's disease.

  2015cites this paper
• Levetiracetam might act as an efficacious drug to attenuate cognitive deficits of Alzheimer's disease.

  2015cites this paper
• Improving the predictive value of interventional animal models data.

  2015cites this paper
• Rôle et potentialités thérapeutiques des cellules T régulatrices dans la physiopathologie de la maladie d'Alzheimer

  2015cites this paper
• Hippocampal P3-Like Auditory Event-Related Potentials are Disrupted in a Rat Model of Cholinergic Degeneration in Alzheimer's Disease: Reversal by Donepezil Treatment

  2014cites this paper
• Fluoxetine improves behavioral performance by suppressing the production of soluble β-amyloid in APP/PS1 mice.

  2014cites this paper
• Memantine prevents reference and working memory impairment caused by sleep deprivation in both young and aged Octodon degus.

  2014cites this paper
• IGF2 Ameliorates Amyloidosis, Increases Cholinergic Marker Expression and Raises BMP9 and Neurotrophin Levels in the Hippocampus of the APPswePS1dE9 Alzheimer’s Disease Model Mice

  2014cites this paper
• Glia in Alzheimer's disease and aging: Molecular mechanisms underlying astrocyte and microglia reactivity

  2014cites this paper
• Impaired hippocampal acetylcholine release parallels spatial memory deficits in Tg2576 mice subjected to basal forebrain cholinergic degeneration.

  2014cites this paper
• Enhancement of the nonamyloidogenic pathway by exogenous NGF in an Alzheimer transgenic mouse model.

  2014cites this paper
• Cholinergic neurons—keeping check on amyloid β in the cerebral cortex

  2013cites this paper
• Drain of the brain: low-affinity p75 neurotrophin receptor affords a molecular sink for clearance of cortical amyloid β by the cholinergic modulator system.

  2013influential citation
• The nucleus basalis of Meynert: a new target for deep brain stimulation in dementia?

  2013cites this paper
• BMP9 ameliorates amyloidosis and the cholinergic defect in a mouse model of Alzheimer’s disease

  2013cites this paper
• [Expression of STAT3 and P-STAT3 in the brain of a transgenic mouse model of Alzheimer's disease].

  2013cites this paper
• Regulation of expression and cellular release of acetylcholinesterase

  2013cites this paper